1,744,850 research outputs found
Total synthesis of TAN-1057 and analogues
Full text link1997 Spring.Includes bibliographical references.Part I. An asymmetric and stereochemically unambiguous construction of diaminopimelic acid and related system using the chiral, non-racemic diphenyl oxazinones glycinate templates has been developed. The preparations of (R,R)-DAP, (S,S)-DAP, (S,S)-2,7-diaminosuberic acid, and mono-N-protected (S,R)-DAP are described. The synthesis of γ-D(L)-glutamyl-L-meso-diaminopimelic acid dipeptide, a subunit of both FK-156 and FK-565, is also described. The availability of both optical antipodes of the glycinate templates renders this chemistry adaptable to prepare all possible diastereoisomers of substances based on the DAP skeleton in optically pure form.Part II. The first total synthesis of anti-MRSA dipeptides TAN-1057 A~D has been achieved. A new efficient method for preparation of amidinoureas has been developed and successfully applied to the total synthesis of TAN-1057. More importantly, this concise total synthesis paves the way for access to analogues that are not available from natural sources. Eight new analogues of TAN-1057 were designed, synthesized and assayed against MRSA. A new synthetic analogue 102 (CY-1800) showed very similar activity to that of TAN-1057. Other analogues prepared showed weak or no activity against Staphylococcus aureus up to 1 mg/mL. The success on discovery of a new potent anti-MRSA analogue proved the usefulness of this highly flexible strategy for the development of better analogues than the natural ones for the potential use as antibiotics
El Decreto Legislativo 1057 y sus efectos en la contratación de los obreros de la Municipalidad distrital de Barranco, 2020.
Full text linkLa presente investigación titulada “EL DECRETO LEGISLATIVO 1057 Y SUS EFECTOS EN
LA CONTRATACION DE LOS OBREROS DE LA MUNICIPALIDAD DISTRITAL DE
BARRANCO, 2020”, tiene como objetivo, determinar cuáles son los efectos que produce el decreto
legislativo Nº 1057 en los derechos laborales de los obreros municipales de limpieza pública, que
por disposición legal deberían estar sujetos al régimen laboral de la actividad privada en la
municipalidad de Barranco en el año 2020. Para ello, se empleó el método de investigación
inductivo – deductivo, siendo el tipo de carácter jurídico social, de nivel explicativo, con un diseño
no experimental. La población se constituyó por 135 obreros municipales contratados bajo el
régimen CAS, siendo la muestra 60 obreros municipales dedicados a las actividades de limpieza
pública. Se concluyó que Existe suficiente evidencia estadística para confirmar la existencia de
correlación o relación causa-efecto, entre el decreto legislativo Nº 1057 y los derechos laborales de
los obreros municipales de limpieza pública sujetos al régimen laboral de la actividad privada, con
un Chi cuadrado de Pearson: 28,421 y p Valor (Sig.): 0.000, por lo que existe correlación perfecta
entre ambos y confirmando la hipótesis alterna Ha0, se afirma que el decreto legislativo Nº 1057,
tiene efectos vulneratorios en los derechos laborales de los obreros municipales de limpieza pública
sujetos al régimen laboral de la actividad privada en la municipalidad de Barranco en el año 2020
Santa Fe (ATSF) 1057
No full textA photograph print showing the Santa Fe (ATSF) 1057, 2-6-2 (BLW, class 1050), Cheyenne, OK
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Chicago, Milwaukee, St. Paul & Pacific (MILW) 1057
No full textA photograph postcard showing the Chicago, Milwaukee, St. Paul & Pacific (MILW) 1057, 0-4-0 (class J-2a), orig. No. 37 in 1885, renumbered 58 (7/1898, and 1057 (4/1899)
94. Jōchō (?-1057)
No full textIwao Seiichi, Iyanaga Teizō, Ishii Susumu, Yoshida Shōichirō, Fujimura Jun'ichirō, Fujimura Michio, Yoshikawa Itsuji, Akiyama Terukazu, Iyanaga Shōkichi, Matsubara Hideichi. 94. Jōchō (?-1057). In: Dictionnaire historique du Japon, volume 10, 1984. Lettre J. p. 47
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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