1,720,982 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Research of dynamic differentiation and morphogenesis in 3-D epithelial tubulogenesis
Full text link本研究では、3-D培養における上皮組織化や浸潤性獲得の分子基盤を明らかにすることを主たる目的とした。研究全体を通して以下の成果を得た。
1) 乳腺上皮細胞のin vitro組織化において4倍体細胞の形成とその後の動態・増殖能を解析し、細胞増殖は核の倍数性に影響されないという結果を得た。
2) 腫瘍細胞の3-D浸潤には細胞膜のMT1-MMPによって活性化されるMMP-2が必要であること、3-D培養で選択的におこるMMP-2の活性化にはMT1-MMPの細胞膜局在の増加によって引き起こされることを明らかにした。MMP-2の発現制御はエピジェネテイックに制御されており、その分子機構と標的遺伝子群を明らかにした。
3) Metの発現の有無によって、乳腺上皮細胞や悪性黒色腫の分化転換を検出できる示唆を得た。分化転換の動態やその分子機構を明らかにする基盤を得た。We aimed to elucidate molecular mechanisms of epithelial cell invasiveness and differentiation underlying epithelial cell morphogenesis. Our results are as follows.
1) Mammary epithelial cell replication is not influenced by polyploidy.
2) Activation of MMP-2 by MT1-MMP is required for 3-D invasiveness. Cell surface localization of MT1-MMP was depend on 3-D. MMP-2 expression was strongly correlated to invasiveness and regulated by epigenetics. We identified epigenetic factors and these target genes possibly involved in cancer malignancy.
3) Cell surface Met was heterogeneously expressed in mammary epithelial cells and malignant melanomas. This might reflect invasive and malignant cell phenotypes.研究課題/領域番号:23790221, 研究期間(年度):2011-2012出典：研究課題「3-D上皮細胞組織化モデルにおける動的細胞分化転換と形態制御の研究」課題番号23790221
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23790221/23790221seika/）を加工して作成金沢大学がん進展制御研究所research repor
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
リガンド受容能不全の変異ペプチドホルモン受容体に対する人工リガンド創製の基盤研究
Full text link増殖因子受容体に対する人工リガンド技術は疾患や再生医療に応用可能である。本研究では環状ペプチドスクリーニングを用いて、インスリン受容体に対する人工リガンドの取得と、人工アゴニスト環状ペプチドの性状に関する基盤研究を行った。組換えIRタンパク質は活性を保ったままでの生成が困難であり、ナノディスクによる可溶化IRの精製を試行している。環状ペプチドアゴニストが本来のリガンドとほとんど同じ活性を持ち得ること、不完全アゴニスト環状ペプチドを用いることで本来のリガンドと異なる選択的な細胞応答性を誘導できること、ユニークな環状ペプチドータンパク質の結合様式を立証し、人工リガンド技術確立のための知見を得た。Artificial ligands for growth factor receptors are clinically applicable. We here tried identification of artificial ligands for insulin receptor (IR) using macrocyclic peptide screening, and characterized MET-agonist macrocyclic peptides to establish artificial ligand technology based on macrocyclic peptide. Expression and purification of IR protein with its kinase activity was difficult. Now, purification of IR in nanodiscs is being investigated. We have proved that 1) artificial ligands based on macrocyclic peptide are able to have similar activity compared to natural ligands, 2) partial agonists based on macrocyclic peptide are able to induced biased or selective cellular responses compared to natural ligands, and 3) macrocyclic peptides interact with thier target protein in an unique manner. These results illustrate potential of artificial ligands based on macrocyclic peptides.研究課題/領域番号:16K08544, 研究期間(年度):2016-04-01 - 2019-03-31出典：研究課題「リガンド受容能不全の変異ペプチドホルモン受容体に対する人工リガンド創製の基盤研究」課題番号16K08544
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08544/16K08544seika/）を加工して作成research repor
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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