1,753,833 research outputs found
Structural Basis for Reaction Mechanism and Drug Delivery System of Chromoprotein Antitumor Antibiotic C-1027
No full textAntitumor antibiotic C-1027, which is regarded as a natural model of a drug delivery system, consists
of a carrier apoprotein (Apo) and an enediyne chromophore (Chr). We have compared three solution structures
of the DNA−Chr complex, Apo−Chr complex, and free Chr determined by high-resolution NMR experiments.
The guest molecule, C-1027 chromophore, showed two distinct binding modes fitted to binding sites of the
hosts (target DNA and carrier Apo). The novel Chr interacts with DNA through its benzoxazolinate and
aminosugar moieties, and also with Apo through the benzoxazolinate and macrocyclic moieties. The
superposition of Chrs in these three states clearly revealed conformational deviation of the 16-membered
macrocyclic moiety containing an intra-chlorophenol ring. Ab initio calculations supported good correlation
between the reactivity and the conformational alteration of Chr induced in the hosts. The present results provide
a molecular basis and implication for the host-recognition mode, the reaction mechanism, and the drug delivery
system of chromoprotein C-1027
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Crítica de género. E. 1027: Eileen Gray vs. Le Corbusier en Cap Martin
No full textThe villa E.1027 has remained silenced for years in the historiography of modern architecture despite its sophisticated modernity and its wise understanding of the locus; perhaps due to its subtle criticism over the modern principles established during the 20’s and imposed over the following decades. This ominous oblivion has also included a woman, Eileen Gray, responsible for most of its authorship. Le Corbusier was not alien to either of them. This article analyzes the master’s behaviour regarding his obsession and subsequent occupation of the Maison en bord de mer and its surroundings, trying to uncover the causes that probably encouraged their desecration. It ends up summarizing Gray’s gender criticism presciently unfolded in E.1027 regarding corbusieran canon as early as 1926.La villa E.1027 ha permanecido durante años en un segundo plano en las historiografías del Movimiento Moderno a pesar de su sofisticada modernidad y su sabio entendimiento del lugar; tal vez por su crítica sutil a los principios de la modernidad instaurados en los años 20 e impuestos durante las décadas siguientes. Este ominoso olvido ha incluido también a una mujer, Eileen Gray, a quien corresponde la mayor parte de su autoría. Le Corbusier no fue ajeno ni a lo uno ni a lo otro. El artículo analiza el comportamiento del maestro en su obsesión y posterior ocupación de la Maison en bord de mer y su entorno próximo, tratando de desvelar las causas que probablemente animaron a su profanación; y finaliza con la crítica de género que premonitoriamente Gray desplegó en la E.1027 respecto del canon corbusierano ya en 1926
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
. 1027 Año 21 (2022) mayo. El Tlacuache
No full textCuando yo era niña soñaba que podía viajar en el tiempo, me imaginaba que podía ser una figura transparente, convertirme en una voyerista de la historia. Sin dudarlo, puedo decirles que eran viajes que disfruté siempre. Libros como el de “Corazón de piedra verde” escrito por Salvador de Madariaga, me permitieron explorar esos otros “tiempos-mundos” abriendo mi imaginación, mi fantasía y mi corazón, uno de mis más grandes regalos de la infancia ha sido esa convicción de que el mundo que imaginamos es real.- La pintura mural en el Estado de Morelos un viaje en el tiempo por Frida Itzel Mateos González.Pintura mural del monasterio agustino de San Mateo, Atlatlahucan, Morelos. Pintura mural del claustro monasterio agustino de San Mateo, Atlatlahucan, Morelos. Crédito: Mitzi de Lara Duarte. Marzo del 2019.Lazcarro Salgado, I. (2013) Yecapixtla en la geopolítica de los dioses. Una guerra de paz y sangre. Revista Dimensión Antropológica, 20(59), pp. 51-88. https://www.dimensionantropologica.inah.gob.mx/wp-content/uploads/02Dimension59.pdf González, Quezada R. (2019) Antiguos pueblos virreinales de Yecapixtla, Suplemento Cultural el tlacuache, Periódico el Sol de Cuernavaca, 879, pp. 29-32. https://www.inah.gob.mx/images/otros/20190426_tlacuache_879.pdf. González Quezada, R. (2013). Resistencia y transformación social en la sociedad virreinal de Yecapixtla fines del siglo XVI y principios del XVII. Suplemento Cultural el tlacuache. De la Jornada Morelos, No.555, pp.1-5. https://revistas.inah.gob.mx/index.php/eltlacuache/issue/view/1524/issue%201524 Rubial García, A. (2012). Hortus eremitarum. Las pinturas de Tebaidas en los claustros agustinos. Anales Del Instituto De Investigaciones Estéticas, 30(92), pp. 85-105. https://doi.
org/10.22201/iie.18703062e.2008.92.226
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