1,720,964 research outputs found
Development of prophylactic method and clarification of mechanism for anti-tumor drug-induced vascular pain by using approach both basic and clinical syudies
Full text linkゲムシタビン塩酸塩（GEM）やオキサリプラチン（L-OHP）を末梢静脈から投与した際に生じる血管痛は，がん薬物療法を行う上での大きな問題点となっている．血管痛を予防・軽減をするためには，血管痛の発現機序を明らかにしたうえで，予防対策を考案する必要がある．そこで，本申請課題では，基礎研究・臨床研究を統合し，発痛機序および予防対策について検討した．その結果，血管痛は投与する抗がん剤の投与量に依存することから，単位時間当たりの投与量を少なくする（投与時間を延長する）ことで予防できることが示唆された．また，血管痛を起こす薬剤により，発痛機序が異なる可能性が示された．Vascular pain induced by administration of gemcitabine (GEM) or oxaliplatin (L-OHP) via peripheral venous is major problem in patients received cancer chemotherapy. To elucidate the mechanism of vascular pain will be required before prophylactic methods are established in clinical setting. The purpose of this study was to develop a useful prophylactic method for vascular pain in clinical setting and to clarify the inciting factor of pain that occur around the injection site or peripheral vein by using approach both basic and clinical studies. The results in this study suggested that vascular pain is depend on the dosage per unit of time, resulting from that extending the administration time of GEM or L-OHP could reduce the intensity of vascular pain and the mechanism of vascular pain could differ from agents associated with this pain.研究課題/領域番号:25860109, 研究期間(年度):2013-04-01 - 2016-03-31出典：研究課題「抗癌剤による血管痛の誘発要因および予防策の基礎・臨床統合的検証」課題番号25860109
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860109/25860109seika/）を加工して作成金沢大学医薬保健研究域薬学系research repor
Research of olfactory dysfunction induced by antitumor drug and its early detection for maintenance of adequate nutritional status in cancer patients
Full text link嗅覚障害は食欲低下の原因の一つであり,癌化学療法による嗅覚障害が癌患者の栄養状態に影響をおよぼしている可能性が考えらえる.そこで,本研究課題では,外来癌化学療法施行患者の嗅覚障害の実態調査および栄養状態との関連を解析した.外来化学療法施行患者の36%に嗅覚障害が生じていた.また,嗅覚障害を自覚していない癌患者は,その自覚がある癌患者と比較して, BMI,血中総タンパク質が有意に低下していた.本研究により,嗅覚障害は癌化学療法の副作用として注意すべき症状であり,化学療法施行患者の栄養状態に影響をおよぼすことが示唆された.Olfactory dysfunction, which is considered to be a cause of appetite loss, may influence nutrition status in patients receiving cancer chemotherapy. Therefore, we evaluated the current status of olfactory dysfunction induced by antitumor drugs and its relationship with the nutrition status of the patient. Olfactory dysfunction was observed in 36% patients receiving cancer chemotherapy. Body mass index and serum protein levels significantly decreased in the patients with subjective olfactory dysfunction than in those without. These results suggest that antitumor drugs are likely to cause olfactory dysfunction, which in turn affects nutrition status in patients receiving cancer chemotherapy.出典：研究課題「抗癌剤による嗅覚障害の実態とその早期発見による栄養状態の維持を指向した探索的研究」課題番号22792176
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22792176/22792176seika/）を加工して作成research repor
Development of new preventive strategy and elucidation of mechanism for cancer chemotherapy-induced vascular pain
Full text link大腸がん治療のKey drugであるオキサリプラチン（L-OHP）を末梢静脈から投与した際に生じる血管痛の発現機序および有効な予防対策の確立に取り組んだ。その結果、L-OHPによる血管痛は、プロカイン、ルテニウムレッド（TRP非選択的阻害薬）、HC030031（TRPA1選択的阻害薬）、PBN（抗酸化剤）で抑制された。この結果から、L-OHPによる血管痛には、TRPA1および活性酸素が関与していることが明らかとなった。TRPA1の活性化を抑制できる抗酸化剤は、有効性の高い血管痛の予防対策となる可能性があると考えられた。The purpose of this study is to elucidate the mechanism of vascular pain caused by oxaliplatin (L-OHP), a key drug for treatment of colorectal cancer, and to establish effective preventive methods in clinical practice. L-OHP-induced vascular pain was suppressed by procaine, ruthenium red (TRP non-selective inhibitor), HC030031 (TRPA1 selective inhibitor), and PBN (antioxidant). The TRPA1 suppressive therapy could be considered as highly effective preventive methods against L-OHP-induced vascular pain.研究課題/領域番号:16K08397, 研究期間(年度):2016-04-01 - 2020-03-31出典：「がん薬物療法における血管痛発現機序の解明および新規予防法の開発」研究成果報告書 課題番号16K08397
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K08397/16K08397seika/）を加工して作成金沢大学医薬保健研究域薬学系research repor
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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