1,720,964 research outputs found
エラスターゼ活性阻害による心筋保護と心血管前駆細胞の分化誘導
Get PDF心筋梗塞後の心拡大や心機能低下の程度は虚血障害の強度とそれに引き続く心筋リモデリングに依存し,特に蛋白分解活性による細胞外基質の変化が重要である。本研究では、エラスターゼ阻害因子の一つelafinの過剰発現マウス(本マウス)を用いて、エラスターゼ活性阻害による心筋保護作用について検討を行った。本マウスでの冠動脈結紮による心筋梗塞病変は、14日後野生マウス(対照)に比べて有意に抑制されることが示された(p<0.03)。これは冠動脈結紮後に対照で観察されるエラスターゼの完全な抑制と、ミエロペルオキシダーゼ、MMP2の活性抑制と関連していた。また本マウスにおける冠動脈結紮28日後の心筋収縮力は有意に維持されていた(p<0.03)。さらに、梗塞部位に前駆細胞と考えられるCD34陽性細胞が対照にくらべて集積している傾向があった。つまり、エラスターゼ阻害因子により構築を保たれた部位では、骨髄や末梢から誘導された前駆細胞を効率良く取り込み、心血管系細胞に分化誘導させ、対照では変性した細胞外基質がこれらをコラーゲン線維産生細胞と考えられる線維芽細胞に分化せしめ、心筋リモデリングを修飾し、晩期における心構築、心機能の差となる可能性が示唆された。この仮説を検証するため、X-Galを構成的に発現するROSA26マウスの骨髄を同系野生マウスに移植し、骨髄再構成後に心筋梗塞モデルを作成した。このモデルで、骨髄由来細胞の梗塞部位への集積と分化が観察されており、エラスターゼ阻害剤を投与することで現在エラスターゼの関与を検討している。一方、種々の細胞外基質を塗布した培養皿でマウス骨髄由来接着細胞を培養すると、様々な分化パターンを示すことが観察され、心血管前駆細胞の分化誘導における細胞外基質の重要性が示唆された。研究課題/領域番号:14770349, 研究期間(年度):2002-2003出典：「エラスターゼ活性阻害による心筋保護と心血管前駆細胞の分化誘導」研究成果報告書 課題番号14770349
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-14770349/)を加工して作成金沢大学医薬保健研究域医学系research repor
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Educational effect of remote facilitated simulation-based learning in the field of pediatric emergency medicine
Get PDF本研究の目的は卒前教育における国際的な遠隔シミュレーション・プログラムの実現可能性と参加者満足感を評価することである。米国フィラデルフィア小児病院の指導者が金沢大学医学部のシミュレータをインターネット回線を介して制御し、3つのウェブ・カメラによって、リアルタイムに受講者側の指導者と共同観察してシミュレーションを行った。医学部5年学生31グループ中19グループは遠隔教育を行ったが、その満足度、症例を管理する自信、シミュレーションの有効性については実地での指導を行った12グループと同等であった。Our objective was to assess feasibility and participant satisfaction with an international remote tele-facilitation simulation program.
Our group piloted remote tele-facilitated simulation connecting the Children's Hospital of Philadelphia, U. S. A and Kanazawa University School of Medicine, Japan since May, 2010. Remote co-facilitators carefully co-observed and debriefed the simulation real-time bi-directionally through the 3 web-camera internet audio-visual system. Of 31 simulation sessions(175 of all 188 5th year students), 12(n=66 students) were locally controlled and facilitated from Japan and 19(n=109 students) were remotely tele-controlled and tele-facilitated from the USA for 2 years. Survey results showed a high degree of satisfaction for educational effect, and self-confidence.研究課題/領域番号:21590558, 研究期間(年度):2009-2011出典：研究課題「小児救急医療におけるシミュレーション教育の効果の検証と遠隔教育への応用」課題番号21590558
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590558/21590558seika/）を加工して作成research repor
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The effectiveness of remote facilitation in simulation-based pediatric resuscitation training for medical students
Get PDFシミュレーション医学教育の有効性は様々な手技や知識に関して示されているが、チームワーク・コミュニケーションの技術についてその有効性を示したものは少ない。小児科臨床実習中の医学部学生に２回のシナリオセッションを含むトレーニングを行い、シナリオセッションにおけるチームワーク・コミュニケーションの技術をBehavioral Assessment Toolを用いて測定した。BATスコアは1回目のセッション7.9±4.1から2回目13.0±6.1（p=0.004）と有意に改善した。
医学生に対する小児急性期医療のシミュレーション教育は、チームワーク・コミュニケーションの技術を改善した。Recent evidence suggests that simulation-based medical education is effective for students to improve their knowledge and technical skills. However, there are insufficient evidence in regard to non technical skills. We hypothesized that our simulation-based training of acute pediatric care improved non technical skills such as teamwork or communication skills.
This is a retrospective cohort study. Participants were fifth grade medical students. We conducted 60-minute session including two case scenarios. Teamwork and communication skills were measured by using Behavioral Assessment Tool (BAT). The first and the second case scenarios were compared using t-test. 30 groups (176 students) had the trainings, and 15 (89) of the 30 groups were video recorded. BAT score improved significantly from 7.9±4.1 for the first case to 13.0±6.1 for the second one (p=0.004).
Our simulation-based training of pediatric acute care for medical students improved teamwork and communication skills.研究課題/領域番号:25460614, 研究期間(年度):2013-04-01 - 2016-03-31出典：研究課題「シミュレータの遠隔操作による小児救急医学教育の効果について」課題番号25460614
（KAKEN：科学研究費助成事業データベース（国立情報学研究所））
（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25460614/25460614seika/）を加工して作成金沢大学医薬保健研究域医学系research repor
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
- …
