1,794,939 research outputs found
Πολιτική επιστήμη Ι
No full textΣημειώσεις για το μάθημα "Πολιτική επιστήμη Ι" του Τμήματος Πολιτικής Επιστήμης και Ιστορίας για το ακαδημαϊκό έτος 2004-2005Περιέχει βιβλιογραφικές παραπομπέςΠολιτική Επιστήμη Ι, 11000
Μονόλογοι / Δημητρακοπούλου ; Δεληκατερίνη ; Καλαποθάκη ; Λάσκαρη ; Καλογεροπούλου ; Κοτσελοπούλου.
No full textΦάκελος επισ τολών Γιώργου Κουρτζή και Ι. Καραμάνου
No full textΠρόκειται για φάκελο επιστολών που περιέχει συνολικά 5 επιστολές του Ι. Καραμάνου και Γ. Κουρτζή για ζητήματα οικονομικά, τραπεζικά και ιδιοκτησιακά.Το τεκμήριο βρίσκεται σε πολύ κακή κατάστασ
Επισκόπηση της αγοράς των ηλεκτρονικών βιβλίων : εκδότες και διαθέτες
Get PDFPurpose: This paper provides an overview of the e-book marketplace players and their services against a context in which e-books are becoming an increasingly significant category of digital resource. This development of the availability e-books could have significant implications for the future role of libraries and for library strategies, policies and processes.
Design/methodology/approach: The paper starts with a brief overview of the literature on the global e-book market and e-book business models offered by vendors to libraries. Analysis of the websites of nine e-book publishers and eleven e-book aggregators was used as a basis for profiling the main features of e-books (user-oriented features and librarian-oriented features) and the services offered by e-book publishers and e-book aggregators.
Findings: The e-book market is under constant change and it is important to monitor its development, not just at national but also international level. Currently, the majority of e-book vendors market to library, typically academic libraries, and publishers increasingly using e-aggregators to distribute their titles. Collections of e-books are expanding gradually and there is evidence of increasing uptake. Current e-book business models are complex and range considerably.
Value: The paper draws attention to the potential of the future importance of e-books, and profiles the uptake of the e-book marketplace in terms of main players and their services
Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι
Get PDFSummaryPaneth cells are a highly specialized population of intestinal epithelial cells located in the crypt adjacent to Lgr5+ stem cells, from which they differentiate through a process that requires downregulation of the Notch pathway. Their ability to store and release antimicrobial peptides protects the host from intestinal pathogens and controls intestinal inflammation. Here, we show that PKCλ/ι is required for Paneth cell differentiation at the level of Atoh1 and Gfi1, through the control of EZH2 stability by direct phosphorylation. The selective inactivation of PKCλ/ι in epithelial cells results in the loss of mature Paneth cells, increased apoptosis and inflammation, and enhanced tumorigenesis. Importantly, PKCλ/ι expression in human Paneth cells decreases with progression of Crohn’s disease. Kaplan-Meier survival analysis of colorectal cancer (CRC) patients revealed that low PRKCI levels correlated with significantly worse patient survival rates. Therefore, PKCλ/ι is a negative regulator of intestinal inflammation and cancer through its role in Paneth cell homeostasis
Περί της ελεγείας ή ελεγειακής ποιήσεως των Αρχαίων Ελλήνων. / Θέσις Δ. Ι. Μαυροφρύδου, εκδιδομένη επιστασία και δαπάνη Περικλέους Ιασεμίδου.
No full textΚοινωνική Θεωρία Ι
No full textΣημειώσεις στο μάθημα "Κοινωνική Θεωρία Ι" του Τμήματος Πολιτικής Επιστήμης και ΙστορίαςΚοινωνική Θεωρία Ι(110005
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