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Literarni zgodovinarji o čustvenosti Simona Gregorčiča
No full textPrispevek prinaša poglede slovenskih, hrvaških in srbskih literarnih zgodovinarjev, nastale med letoma 1882 in 2006, o čustveni naravi pesnika Simona Gregorčiča. Njegova občutljivost in čustvenost izvirata iz njegove čiste duše ter nežnega in plemenitega srca. V Gregorčičevi osebnosti se prepletajo tri podobe: človek, pesnik in duhovnik. Nasprotja v njem so nastajala iz mnogih naključij in posebnosti njegove narave.This article deals with the views of Slovenian, Croatian, and Serbian literary historians from 1882 to 2006 on the emotional nature of the Slovenian poet Simon Gregorčič. Gregorčič’s sensitivity and emotionality originates from his pure soul and gentle and noble heart. Three images intertwine in his personality: man, poet, and priest. The contradictions in him arose from many coincidences and idiosyncrasies of his nature
Računalniška analiza čustev in tem v Wikiviru
No full textV prispevku predstavimo računalniško analizo tem in čustev v korpusu slovenske književnosti, prosto dostopni v repozitoriju Wikivir. Pri tem predstavimo tako pristop k izgradnji korpusa, ki ga želimo v analizo ponuditi tudi drugim raziskovalcem v okviru platforme SketchEngine in na repozitoriju Clarin, kot tudi metodo za analizo čustev in prevladujočih tematik v obsežnih podatkovnih zbirkah. Pri raziskavi poskušamo izpostaviti glavne tematske poudarke v različnih časovnih obdobjih, žanrih in pri različnih avtorjih ter prevladujoča čustva, pri čemer uporabimo tako leksikonski pristop kot tudi analizo sentimenta. Kljub neprecenljivemu bogastvu digitaliziranega slovenskega leposlovja na Wikiviru je bil ta vir zaradi zapletenosti označevalnika MediaWiki, razpršenosti prenesenih besedil ter zahtevnosti pretvarjanja in procesiranja besedil do zdaj slabo izkoriščen za obsežnejše raziskave, ki bi temeljile na računalniškem procesiranju naravnega jezika. Za namene te raziskave smo pripravili korpus prosto dostopne slovenske književnosti, ki zajema nekaj več kot 62 milijonov besed, nabranih iz 22.919 različnih besedil, ki so v Wikiviru (nekonsistentno) označena z več kot 2000 različnimi kategorijami oz. metapodatki (avtor, leto, stoletje, žanr ipd.). Te podatke poskušamo z uporabo računalniških pristopov tudi sistematizirati ter natančneje predstaviti distribucijo besedil, objavljenih v Wikiviru.This article presents a computational analysis of themes and emotions in the corpus of Slovenian literature, freely available on Wikivir (i.e., the Slovenian Wikisource). It presents the approach used to build the corpus, which is also made freely available to other researchers, as well as the method for analyzing emotions and predominant topics in large databases. The research highlights the main thematic emphases in different time periods, genres, and authors, as well as the predominant emotions, using both a lexical approach and sentiment analysis. Despite the invaluable wealth of the digitized Slovenian literature on Wikivir, this source has been underutilized for more extensive research based on natural language processing due to the complexity of the MediaWiki tagger, the dispersion of transferred texts, and the complexity of text conversion and processing. For the purposes of this research, a corpus of freely accessible Slovenian literature was compiled, comprising just over 62 million words collected from 22,919 texts, which are (inconsistently) annotated on Wikivir with over two thousand categories or metadata (author, year, century, genre, etc.). These data are also being systematized using automatized approaches, thus presenting a more accurate distribution of texts published on Wikivir
Determination of variants in the IDH1 and IDH2 genes by Sanger sequencing
No full textIzocitrat dehidrogenaza (IDH) je encim, ki katalizira oksidativno dekarboksilacijo izocitrata v α-ketoglutarat ter predstavlja enega izmed encimov Krebsovega cikla. Reakcija, ki jo katalizira izocitrat dehidrogenaza, pa predstavlja tudi eno izmed glavnih presnovnih poti nastanka molekule NADPH – pomembnega celičnega reducenta. Različice v genih IDH so pretežno somatske in se nahajajo v ključnih argininih v aktivnem mestu, ki so odgovorni za vezavo substrata izocitrata – to so R132 v IDH1 ter R140 in R172 v IDH2. Mutiran encim izocitrat dehidrogenaza pridobi neomorfno funkcijokatalizira pretvorbo α-ketoglutarata v onkometabolit 2-hidroksiglutarat. Posledice tega pa so metabolne spremembe, hipermetilacija DNA in histonov ter redoks neravnovesje. Različice v IDH1 ali IDH2 se pojavljajo pri 5–7 % bolnikov z mielodisplastičnimi novotvorbami in 20 % bolnikov z akutno mieloično levkemijo. Večinoma se pojavljajo pri starejših, imajo negativen prognostični pomen in so povezane s slabšim celokupnim preživetjem. Hkrati pa imajo različice v genih IDH tudi terapevtski pomen, saj je pri teh bolnikih poleg standardnega načina zdravljenja na voljo tudi tarčno zdravljenje s specifičnimi nizkomolekularnimi zaviralciivosidenib za IDH1 in enasidenib za IDH2. Ker je predvsem pri diagnozi akutne mieloične levkemije treba čim prej začeti zdravljenje, potrebujemo hitro metodo za določanje teh različic, za kar je primerna metoda sekvenciranje po Sangerju, s katero pridobimo rezultat že v nekaj dneh. Zato smo v okviru magistrske naloge izvedli validacijo metode sekvenciranja po Sangerju za določanje različice R132 v genu IDH1 ter različic R140 in R172 v genu IDH2, pri čemer smo se osredotočili na primerjavo naše metode z do sedaj uporabljano metodo sekvenciranja naslednje generacije, ki pa je za ta namen preveč časovno zamudna. Dokazali smo 100 % analitično občutljivost, 100 % analitično specifičnost, 100 % natančnost znotraj serije, 100 % natančnost med serijami in 100 % ponovljivost med aparati. Mejo zaznave smo postavili na 15 % mutirane DNA v vzorcu, kar je ustrezno glede na klinično uporabnost, saj imajo bolniki ob diagnozi akutne mieloične levkemije ali mielodisplastičnih novotvorb praviloma občutno višji delež mutirane DNA. Validacija je bila uspešna, saj smo dokazali, da je metoda ustrezna za predviden klinični namen in s tem pripravljena za uporabo v rutinski diagnostiki.Isocitrate dehydrogenase (IDH) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and is one of the enzymes of the Krebs cycle. The reaction catalyzed by isocitrate dehydrogenase also represents one of the major metabolic pathways for the formation of NADPH, an important cellular reducing agent. Variants in the IDH genes are predominantly somatic and are located at key arginine residues in the active site responsible for binding the substrate isocitrate—namely R132 in IDH1 and R140 and R172 in IDH2. The mutated isocitrate dehydrogenase enzyme acquires a neomorphic function, catalyzing the conversion of α-ketoglutarate into the oncometabolite 2-hydroxyglutarate. The consequences of this include metabolic alterations, DNA and histone hypermethylation, and redox imbalance. Variants in IDH1 or IDH2 occur in 5–7 % of patients with myelodysplastic syndromes and in 20 % of patients with acute myeloid leukemia. They occur predominantly in older patients, have a negative prognostic impact, and are associated with poorer overall survival. At the same time, variants in the IDH genes also have therapeutic significance, as in addition to standard treatment, targeted therapy with specific small-molecule inhibitors is available for these patients—ivosidenib for IDH1 and enasidenib for IDH2. Because in the diagnosis of acute myeloid leukemia it is crucial to initiate treatment as soon as possible, a rapid method for detecting these variants is required. Sanger sequencing is suitable for this purpose, as results can be obtained within a few days. Therefore, within the framework of the master’s thesis, we performed a validation of the Sanger sequencing method for the detection of the R132 variant in the IDH1 gene and the R140 and R172 variants in the IDH2 gene, focusing on a comparison of our method with the previously used next-generation sequencing method, which is too time-consuming for this purpose. We demonstrated 100 % analytical sensitivity, 100 % analytical specificity, 100 % within-run accuracy, 100 % between-run accuracy, and 100 % inter-instrument reproducibility. The limit of detection was set at 15 % mutated DNA in the sample, which is appropriate with regard to clinical applicability, as patients at the time of diagnosis of acute myeloid leukemia or myelodysplastic syndromes typically have a significantly higher proportion of mutated DNA. The validation was successful, as we demonstrated that the method is suitable for its intended clinical purpose and is therefore ready for use in routine diagnostics
Open Archive of Dusty Artworks: Proposal of an Art Center in Lendava
No full textLendava je majhno obmejno mesto s pomembno in bogato, včasih burno zgodovino, ki je močno zaznamovano s kulturo in svojo edinstveno geografsko umeščenostjo. Zaradi dolgoletne tradicije likovnih kolonij se mesto sooča s pomanjkanjem prostora za shranjevanje in razstavljanje umetnin, kar ogroža ohranitev te dediščine. Hkrati so mnoge stavbe v mestnem središču, predvsem na Glavni ulici, zapuščene in propadajo, kar prispeva k degradaciji mestnega tkiva.
Magistrsko delo raziskuje možnosti integracije novih stavbnih struktur v staro mestno jedro. Poglavitni namen dela je obuditev javnega programa, ki bi dopolnil potrebe galerije v Lendavi. Dodatno pa bi pripomogel k rešitvi prostorske stiske in oživil zapostavljene dele mesta. Tako delo prispeva k celostnemu pristopu revitalizacije mesta in krepitvi njegove kulturne ponudbe.Lendava is a small border town with a rich and sometimes turbulent history, strongly characterised by its culture and unique geographical location. Due to its long- standing tradition of art colonies, the town faces a shortage of space for storing and exhibiting artworks, which threatens the preservation of this heritage. At the same time, many buildings in the town centre, particularly on Glavna ulica, are abandoned and deteriorating, contributing to the degradation of the urban landscape.
This master’s thesis explores the possibilities of integrating new architectural structures into the old town. With the main aim of creating an public programme that addresses the needs of the gallery in Lendava. Additionally, it aims to provide solutions for revitalising neglected parts of the city. In doing so, the work contributes to a holistic approach to the city’s revitalisation and the enhancement of its cultural offerings
Architecture as an Instrument - Conceptual Design of Kranj\u27s Concert hall
No full textMagistrska naloga obravnava pomanjkanje koncertne dvorane v Kranju in priložnost za revitalizacijo degradiranega območja ob starem mestnem jedru. Kljub razširjeni glasbeni dejavnosti mesto Kranj nima ustreznega prostora za izvajanje raznovrstnih glasbenih produkcij, kar omejuje kulturno ponudbo in razvoj glasbene ustvarjalnosti. Lokacija v osrčju mesta, kjer je nekoč stala prva tovarna Sava, ponuja velik potencial za razvoj kulturnega središča. Nahaja se tik ob starem mestnem jedru in kanjonu reke Kokre ter je obdana s ključnimi mestnimi funkcijami. Uporablja se zgolj kot parkirišče, kar predstavlja luknjo v prostoru. Namen naloge je zasnovati prilagodljivo koncertno dvorano, ki rešuje ranljivo točko v mestnem središču ter uvaja drugačen pogled na zaznavanje glasbenega objekta v prostoru s pomočjo zvočnih inštalacij.
Rezultat je zasnova koncertne dvorane, ki združuje arhitekturo, glasbo in naravo. Dvorana se prilagaja različnim oblikam glasbenih produkcij, od koncertov klasične glasbe do koncertov sodobne glasbe ter manjših izvedb opere in baleta. Objekt dvorane vključuje prostore za vadbo in produkcijo glasbe, namenjene lokalnim glasbenikom, ter zvočne inštalacije, ki glasbo vnašajo v vsakdan mimoidočih. Delitev objekta na dva dela ustvari prehod, ki vzpostavi novo povezavo med mestom in kanjonom reke Kokre. Predlagana rešitev odgovarja na pomanjkanje kulturne infrastrukture in prispeva k oživitvi izbranega območja ter krepitvi kulturne identitete mesta Kranj.The master’s thesis examines the lack of a concert hall in Kranj and explores the opportunity for revitalizing a degraded area near the old town centre. Despite the city’s widespread musical activity, Kranj lacks a suitable venue for diverse musical performances, limiting cultural provision and the growth of musical creativity. Located at the heart of the city, where the first Sava factory once stood, this area holds great potential for the development of a cultural hub. It is positioned next to the old town centre and the Kokra River canyon, surrounded by key urban functions. However, the site is currently used solely as a parking lot, creating a gap in the urban fabric. The objective of this thesis is to design a flexible concert hall that addresses this vulnerable point in the city centre while offering a different perspective on the perception of a musical building within the urban landscape, through the use of sound installations. The proposed design combines architecture, music, and nature in a concert hall that adapts to a variety of musical productions, ranging from classical concerts to contemporary performances, as well as smaller opera and ballet performances. The building also includes spaces for rehearsal and music production intended for local musicians, along with sound installations that bring music into the everyday lives of passers-by. The division of the building into two sections creates a passage, establishing a new connection between the city and the Kokra River canyon. This solution not only addresses the lack of cultural infrastructure but also contributes to the revitalization of the area and the strengthening of cultural identity of Kranj
Impact of the menstrual cycle on oxidative stress, inflammation and iron status at high altitude
No full textHigh altitude may alter redox balance and promote inflammation. It remains unclear if ovarian hormone fluctuations influence redox status. We sought to investigate the impact of menstrual cycle (MC) phases on oxidative stress, nitric oxide metabolism, inflammation, iron biomarkers and acute mountain sickness (AMS) during high altitude sojourns in eumenorrheic women. Venous blood samples were collected at low altitude (1224 m) and after one night at 3375 m (Rifugio Torino, inspired O pressure: 96 ± 1 mmHg) during both the early follicular (EF) and mid-luteal (ML) phases. At high altitude, xanthine oxidase (XO: 0.140 ± 0.077 vs. 0.165 ± 0.084 μmol L minp = 1.00), total nitrites and nitrates (NOx: 38.9 ± 10.8 vs. 32.8 ± 6.1 μmol Lp = 1.00), interleukin-6 (IL-6: 17.3 ± 13.6 vs. 14.5 ± 13.2 ng mLp = 1.00) and serum iron concentration (19.7 ± 6.8 vs. 22.1 ± 4.6 μmol Lp = 1.00) were not significantly different between EF and ML. However, total protein concentrations were significantly lower in EF compared to ML (75.5 ± 2.0 vs. 80.0 ± 5.1 g Lp = 0.010). No significant differences were observed in Lake Louise scores (AMS) between EF and ML (2.17 ± 1.64 vs. 1.50 ± 1.83p = 0.180). High-altitude exposure increased XO, IL-6 and erythropoietin levels and decreased NOx, when compared to low altitude. These findings suggest that redox balance, nitric oxide bioavailability, inflammation and iron homeostasis are not influenced by the MC at high altitude. Overall, susceptibility to AMS was similar across MC phases
Sodelovanje učiteljev in umetnikov pri poučevanju in učenju
No full textThe new dimension of a stimulating, open and innovative learning environment in education is recognised in the integrative collaboration of all those involved in the educational process. Such an environment provides children with a variety of contextual experiences to enter the symbolic world of culture and art. Collaboration between artists and teachers has been identified as an essential approach to improving the quality of planned arts practice in kindergartens and schools. In order to improve collaborative teaching between teachers and artists in Slovenian preschools and primary schools, a design-based research methodology was used. The paper presents a snapshot of the pre-intervention situation and the impact of interventions that involved teachers in collaborative work with artists and children’s participation in the educational process. The study involved 116 preschool teachers and 148 primary school teachers. The results showed the importance of involving artists in the educational process. By involving artists in the pedagogical process, teachers can gain information about how children can participate experientially and expressively in artistic experiences, which 1) relieves the burden of predetermined and overstructured curricular practices, 2) enables pupils to participate experientially and expressively in artistic experiences, 3) provides teachers with insight into children’s experiential and expressive capacities/ competences, and 4) provides artists with insight into the possibilities of integrating authentic artistic experiences into education.Nova dimenzija spodbudnega, odprtega in inovativnega učnega okolja v izobraževanju se kaže v povezovalnem sodelovanju vseh vključenih v izobraževalni proces. Takšno okolje otrokom nudi raznolike kontekstualne izkušnje vstopanja v simbolni svet kulture in umetnosti. Sodelovanje med umetniki in učitelji je opredeljeno kot bistveni pristop za izboljšanje kakovosti načrtovane umetniške prakse v vrtcih in šolah. Za izboljšanje sodelovanja med učitelji in umetniki v slovenskih vrtcih in osnovnih šolah je bila uporabljena raziskava načrtovanih novosti pri pouku. V prispevku je predstavljeno stanje pred skupnim poučevanjem vzgojiteljev/učiteljev in umetnikov ter po njem. V študijo je bilo vključenih 116 vzgojiteljev in 148 učiteljev. Rezultati kažejo na pozitivno vlogo vključevanja umetnikov v vzgojno-izobraževalni proces. Z vključevanjem umetnikov v vzgojno-izobraževalni proces lahko učitelji pridobijo informacije o tem, kako lahko otroci izkustveno in izrazno sodelujejo v umetniških izkušnjah, kar 1) zmanjša obremenjenost z vnaprej določenimi in preveč strukturiranimi kurikularnimi praksami2) omogoča učencem, da izkustveno in izrazno sodelujejo v umetniških izkušnjah3) učiteljem omogoča vpogled v izkustvene in izrazne sposobnosti/kompetence otrok4) umetnikom omogoča vpogled v možnosti vključevanja avtentičnih umetniških izkušenj v izobraževanje
Ozaveščanje čustva jeze ob branju slikanic v zgodnjem otroštvu
No full textEno temeljnih razvojnih področij v zgodnjem otroštvu je čustvenosocialni razvoj, saj se otroci čustva šele učijo prepoznati, poimenovati, razumeti in obvladovati, k čustvenemu opismenjevanju pa pomembno prispeva branje literarnih slikanic. V prispevku se ob slikanici Aksinje Kermauner in Kristine Krhin O miški, ki je oklofutala medveda osredinimo na prikaz jeze kot enega temeljnih in najtežje obvladljivih čustev ter predstavimo besedišče, s katerim predšolski otroci ponotranjijo jezikovne spretnosti za lažjo krepitev socialnočustvene kompetence.A key developmental domain in early childhood is emotional and social development because children are just learning how to recognize, label, understand, and regulate emotions. Literary picture books play a significant role in fostering emotional literacy. This article examines the depiction of anger—one of the primary and most challenging emotions to regulate—through the lens of the fairy tale O miški, ki je oklofutala medveda (The Little Mouse That Slapped the Bear) by Aksinja Kermauner and Kristina Krhin. Furthermore, it explores the vocabulary that allows preschool children to internalize verbal skills essential for the development and reinforcement of their socioemotional competence
Protikrizni ščiti kot sredstvo za utrditev oblasti
No full textIn Poland, the pandemic coincided with and exacerbated the existing rule of law crisis, which had been ongoing for several years. The paper explores the Polish government\u27s response to the COVID-19 pandemic through public policy tools known as Anti-Crisis Shields (ACS). These shields, initially designed to mitigate the pandemic\u27s negative economic impact, were also used by the right-wing Law and Justice (PiS) party as a strategic instrument to consolidate political power. By analysing government’s promotional content and policy implementation during the pandemic, the paper reveals how the government leveraged economic aid to strengthen its electoral base and reinforce its authority. The research addresses questions about the instrumentalisation of public policies for political gain, the manipulation of crisis narratives, a turbulent election campaign and the effects on democratic backsliding in Poland. Ultimately, the paper discusses how crisis management, when politically driven, can undermine democratic norms and accountabilityNa Poljskem je pandemija sovpadla z že dlje časa obstoječo krizo pravne države ter jo še zaostrila. Članek raziskuje odziv poljske vlade na pandemijo COVID-19 z orodji javne politike, znanimi kot protikrizni ščiti (ACS). Ščite, ki so bili prvotno namenjeni ublažitvi negativnega gospodarskega vpliva pandemije, je uporabila tudi desničarska stranka Zakon in pravičnost (PiS) kot strateški instrument za utrjevanje politične moči. Z analizo vladne promocijske vsebine in izvajanja politike med pandemijo prispevek razkriva, kako je vlada izkoristila gospodarsko pomoč za okrepitev svoje volilne baze in avtoritete. Raziskava obravnava vprašanja o instrumentalizaciji javnih politik za politične koristi, manipulaciji kriznih narativov, turbulentni volilni kampanji in učinkih na procese demokratičnega nazadovanja na Poljskem. Navsezadnje članek razpravlja tudi o tem, kako lahko krizno upravljanje, kadar je politično usmerjeno, spodkopava demokratične norme in odgovornost
Univerzalno načrtovana trajnostna in zelena stavba za zdravje in dobro počutje
No full textVisokošolski učbenik Univerzalno načrtovana trajnostna in zelena stavba za zdravje in dobro počutje obravnava temeljne koncepte, cilje, načela in zakonodaj¬ne zahteve univerzalnega načrtovanja zdrave in udobne stavbe ter ponuja prak¬tične smernice za implementacijo v projektantski praksi. Namenjen je študentom gradbeništva, delovne terapije, sanitarnega inženirstva, arhitekture ter vsem stro¬kovnjakom, ki sodelujejo pri multidisciplinarnem načrtovanju in gradnji stavb. In¬formacije so uporabne tudi za oblikovalce politik in zakonodajalce, saj prispevajo k ustvarjanju vključujočega, varnega, zdravega in trajnostnega grajenega okolja, ki koristi vsem – še posebej ranljivim skupinam, kot so starejši, otroci, invalidi in osebe z začasnimi omejitvami.
Predlagane rešitve so usmerjene na izbrane cilje trajnostnega razvoja (TSG), opre¬deljene v Agendi 2030 Organizacije združenih narodov, in sicer: cilj 1 – odprava revščine, cilj 3 – zdravje in dobro počutje, cilj 9 – industrija, inovacije in infrastruk¬tura, cilj 10 – zmanjšanje neenakosti ter cilj 11 – trajnostna mesta in skupnosti