Publikationer från Uppsala Universitet
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Kvinnlig sorg i Lukasevangeliet : En narratologisk och sociohistorisk analys av sorg och genus i Lukasevangeliet 7:36-50 samt 23:26-31
No full textJag undersöker i denna uppsats hur sorg och genus skildras i Lukasevangeliet och då i synnerhet kvinnlig sorg som ett uttryck för agens i två utvalda perikoper. Mitt huvudsyfte är att förstå hur sorg skildras i evangelietexten och för att göra detta besvarar jag tre frågeställningar. Jag gör först en textnära läsning med hjälp av en narrativ metod. Här svarar jag på frågeställningen: ”Hur skildras och värderas känslor och uttryck av sorg, i Lukas 7:36-50 samt i 23:26-31, och hur fungerar skildringarna i textens narrativ?”. För att förstå hur sorg framställs i evangelietexten behövs även insikt i hur känslor, och i synnerhet sorg, förstods och uttrycktes i textens kontext. Jag gör därför även en kontextuell läsning med hjälp av en sociohistorisk metod. Frågeställningen jag besvarar är: ”Hur förstods känslor och uttryck av sorg i den antika grekisk-romerska och judiska kontexten?”. I användandet av båda dessa metoder har jag en feministisk teoretisk utgångspunkt. Jag undersöker två perikoper där kvinnliga karaktärer upplever och uttrycker sorg och undersöker också om det fanns könsskillnader i hur sorg förstods och uttrycktes i den antika kontexten. För att tydliggöra min feministiska utgångspunkt kan en tredje frågeställning tilläggas: ”Hur skildras och värderas karaktärernas känslor och uttryck av sorg i förhållande till antika könsroller?”. Utifrån min feministiska synvinkel undersöker jag vilka "känsloregler" som texten tycks uppmuntra och hur dessa förhåller sig till en patriarkal ideologi om kvinnlig underordning. Framkommer kvinnliga karaktärers sorg som passiv och maktlös eller som uttryck för kvinnlig ”överkänslighet”? Ytterligare ett syfte relaterat till en feministisk synvinkel ligger i att lyfta fram möjliga läsningar där evangeliets kvinnliga karaktärer har agens, snarare än ”enbart” betraktas som passiva typer, och att ifrågasätta tolkningar som befäster könsstereotyper på vad som kan ses som ett problematiskt och orättvist sätt
A membrane permeability database for nonpeptidic macrocycles
No full textThe process of developing new drugs is arduous and costly, particularly for targets classified as "difficult-to-drug." Macrocycles show a particular ability to modulate difficult-to-drug targets, including protein-protein interactions, while still allowing oral administration. However, the determination of membrane permeability, critical for reaching intracellular targets and for oral bioavailability, is laborious and expensive. In silico methods are a cost-effective alternative, enabling predictions prior to compound synthesis. Here, we present a comprehensive online database (https://swemacrocycledb.com/), housing 5638 membrane permeability datapoints for 4216 nonpeptidic macrocycles, curated from the literature, patents, and bioactivity repositories. In addition, we present a new descriptor, the "amide ratio" (AR), that quantifies the peptidic nature of macrocyclic compounds, enabling the classification of peptidic, semipeptidic, and nonpeptidic macrocycles. Overall, this resource fills a gap among existing databases, offering valuable insights into the membrane permeability of nonpeptidic and semipeptidic macrocycles, and facilitating predictions for drug discovery projects
Framing a New Economic Strategy : The Domestic and International Dimensions of Joe Biden’s “Foreign Policy for the Middle Class” (2021–2024)
No full textThis thesis analyzes Joe Biden’s foreign policy for the middle class, focusing on its industrial and trade policies. Departing from Alexander Wendt’s conception of national interest and by using Entman’s four frame functions for a frame analysis, the paper shows that the Biden administration identifies the economic paradigm consisting of the policy of “trickle-down economics” and trade liberalization as the culprit of a weakened United States domestically as well as abroad. An analysis of speeches by President Joe Biden and secretaries of the administration reveals that framing U.S. economic policy is largely shaped by the themes of paradigmatic change, jobs and manufacturing as an integral part of American identity. Through its policies, the Biden administration aims to restore the symbolic “backbone” of the U.S., the middle class. Internationally, economic policy is framed in terms of national security and less dependence with respect to China, and focused on supply chains, technological leadership and building alliances. Future research should study over the course of future administrations to what extent institutionalization of the Biden administration’s framing of a new economic policy took place domestically and globally
Exploring black hole mimickers : Electromagnetic and gravitational signatures of AdS black shells
No full textWe study electromagnetic and gravitational properties of anti-de Seitter (AdS) black shells (also referred to as AdS black bubbles)-a class of quantum gravity motivated black hole mimickers, that in the classical limit are described as ultracompact shells of matter. We find that their electromagnetic properties are remarkably similar to black holes. We then discuss the extent to which these objects are distinguishable from black holes, both for intrinsic interest within the black shell model, and as a guide for similar efforts in other subclasses of exotic compact objects (ECOs). We study photon rings and lensing band characteristics, relevant for very large baseline interferometry (VLBI) observations, as well as gravitational wave observables-quasinormal modes in the eikonal limit and the static tidal Love number for nonspinning shells-relevant for ongoing and upcoming gravitational wave observations
Effect of high energy ball milling, heat treatment and spark plasma sintering on structure, composition, thermal stability and magnetism in CoCrFeNiGax (x=0.5; 1) high entropy alloys
No full textNanocrystalline (similar to 10 nm) singe-fcc CoCrFeNiGax (x = 0.5, 1.0) high entropy alloy (HEA) particles with excellent structural and compositional homogeneity were prepared from elemental powders using single-step, short-term (190 min) high energy ball milling (HEBM) at room temperature (RT). Both HEA powders exhibit paramagnetic behaviour at RT with a small ferromagnetic contribution at low fields (saturation magnetization M-s= 4.5 - 7.5 Am-2/kg; average Curie temperature T-c = 130 K - 150 K). They are thermally stable up to 1295 K-1305 K despite the low melting temperature of Ga (302.9 K). Heat treatment up to 1000 K enhances M-s to 59.9 Am-2/kg and T-c to 740 K for the CoCrFeNiGa HEA powder due to an irreversible fcc -> bcc structural transformation, whereas the magnetic properties of CoCrFeNiGa0.5 do not show this enhancement. In-situ TEM heating reveals nanosized sigma-phase Cr-rich precipitates (< 50 nm) at 875 K only for the CoCrFeNiGa HEA powder. Spark plasma sintering (SPS) of powders produces homogeneous nanocrystalline bulk HEAs. SPS at 1073 K of the CoCrFeNiGa0.5 powder increased the crystallinity of the fcc phase. Three-dimensional local compositional mapping at atomic resolution by atom probe tomography indicates a homogeneous distribution of all elements. Bulk HEAs exhibit similar magnetic behavior as heat-treated HEA powders. Combining HEBM and SPS yields homogeneous bulk HEAs with low-melting Ga and enhanced structural, composition, and thermal stability, as well as improved magnetic properties (M-s = 55Am(2)/kg and T-c = 750 K), which is 45% and 47 K higher, respectively, compared to conventional melting approaches
Feasibility of Partnering for Change (P4C) to create inclusive learning environments in Swedish compulsory schools
No full textMany pupils experience restricted participation in Swedish schools due to a non-inclusive learning environment. Partnering for Change (P4C) is an evidence-based service delivery model, developed and employed successfully in Canada to create inclusive learning environments. P4C could potentially be used in Swedish schools, but its feasibility outside Canada is unknown. The aim of this study was to investigate the feasibility of P4C in Swedish compulsory schools. Fifteen interviews with teachers, occupational therapists (OT), and principals conducted after four months of applying P4C in seven classes, were analysed using deductive content analysis based on five feasibility areas. Quantitative questionnaire data concerning implemented interventions were analysed using descriptive statistics. Findings showed that participants considered P4C acceptable and its implementation possible. P4C integrated well with, and extended, schools’ existing work on inclusive learning environments. Teachers and OTs implemented 83 interventions, indicating a need for improvements in the learning environment, which P4C helped to address, as positive effects for both pupils and teachers were noted. In summary, P4C was considered feasible in fostering inclusive learning environments in Swedish compulsory schools, offering potential value to the pupil health team without requiring further adaptions
Effect of needle size on outcomes of vacuum-assisted excision of breast lesions : A randomized controlled trial
No full textBackground Utilizing a larger needle-size instead of a smaller one in vacuum-assisted excision of breast lesions might enhance the effectiveness of the method. We conducted a clinical trial to investigate the effects of needle size 7G compared to 10G regarding excision completeness and procedural efficiency. Materials and methods In this prospective, single-blinded, randomized clinical trial, the patients were enrolled between November 2019 and August 2022. Follow-up examinations were performed at 6 and 24 months after the procedure. In total, 208 patients were screened and enrolled, and following withdrawal of consent, the trial population comprised 194 patients. All patients with ultrasound-visible lesions of <30 mm in size and biopsy confirmation corresponding to a B2 or B3 lesion were included in the study. Additionally, patients with BI-RADS 3 and 4a microcalcifications measuring <15 mm were also eligible. Eighty-five percent of the patients attended the 6-month follow-up, and 65 % attended the 24-month follow-up. Results There were no significant difference between the two randomization arms in terms of age, and lesion size. The mean procedure time was 7.7 min and 8.5 min for 7G and 10G needle size, respectively (=0.126). Of the 164 patients who attended the 6-month follow-up, no remaining lesions were found in 90 % and 81.5 % (p = 0.109) patients for 7G and 10G needle size respectively. Thirty percent (6/20) of the patients with microcalcifications excised stereotactically, guided by mammography, had a residual lesion compared to 2.5 % (1/42) of the patients with intraductal lesions excised under ultrasound guidance. Conclusions Using a 10G compared to a 7G needle size resulted in no difference in procedure time or excision completeness. Among the analyzed parameters, only a larger lesion size was consistently associated with a longer procedure time and a higher risk of incomplete excision
A parametrization algorithm to compute lower dimensional elliptic tori in Hamiltonian systems
No full textWe present an algorithm for the construction of lower dimensional elliptic tori in parametric Hamiltonian systems by means of the parametrization method with the tangent and normal frequencies being prescribed. This requires that the Hamiltonian system has as many parameters as the dimension of the normal dynamics, and the algorithm must adjust these parameters. We illustrate the methodology with an implementation of the algorithm computing 2-dimensional elliptic tori in a system of 4 coupled anharmonic oscillators (4 degrees of freedom)
Explainable AI associates ECG aging effects with increased cardiovascular risk in a longitudinal population study
No full textAging affects the 12-lead electrocardiogram (ECG) and correlates with cardiovascular disease (CVD). AI-ECG models estimate aging effects as a novel biomarker but have only been evaluated on single ECGs—without utilizing longitudinal data. We validated an AI-ECG model, originally trained on Brazilian data, using a German cohort with over 20 years of follow-up, demonstrating similar performance (r2 = 0.70) to the original study (0.71). Incorporating longitudinal ECGs revealed a stronger association with cardiovascular risk, increasing the hazard ratio for mortality from 1.43 to 1.65. Moreover, aging effects were associated with higher odds ratios for atrial fibrillation, heart failure, and mortality. Using explainable AI methods revealed that the model aligns with clinical knowledge by focusing on ECG features known to reflect aging. Our study suggests that aging effects in longitudinal ECGs can be applied on population level as a novel biomarker to identify patients at risk early
Adherence to Oral Nutritional Supplements : A Review of Trends in Intervention Characteristics and Terminology Use Since the Year 2000
No full textResearch on disease-related malnutrition and adherence to oral nutritional supplements (ONS) has increased in recent years. To guide future studies, it is important to identify trends in terminology use and intervention characteristics. This review aimed to map characteristics of research investigating adherence to ONS in patients with disease-related malnutrition and explore changes over time. This review is a secondary analysis of quantitative studies from a systematic mixed-studies review. Online databases, including PubMed, Cinahl, Cochrane Central Register of Controlled Trials, and APA PsycInfo, were searched to identify studies published from 2000 to March 2022. A quantitative content analysis of extracted data was performed, and the Mixed Methods Appraisal Tool (MMAT) was used to assess methodological risk of bias. This review includes 137 articles, over half of which are randomized controlled trials (52%). The term "oral nutritional supplements" was used in 40% of the studies. Adherence to ONS was mainly described by the term "compliance" (69%). It was most common to offer ready-made milk-based ONS (56%) and ONS as a sole intervention (51%). The prescribed dose of ONS was fixed in 64% of studies and individualized in 22% of studies. There was variation in the methods used to assess adherence to ONS, and adherence was not reported in nearly a fifth of studies. There was an increase in methodological quality over time (p = 0.024). To ensure better understanding and increase the rigor and reproducibility of ONS intervention research, it is crucial to standardize the terminology used and to describe the interventions clearly