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Analysis of homogeneous glioblastoma samples with high-resolution genomic technologies
Get PDFIntra-tumor genomic heterogeneity is a common feature in human cancers. Normally, there are two copies of each gene
in a cell and all cells of an organism carries the same DNA sequence despite some exceptions. With mutations and
copy number changes in cancer , this well-defined structure is impaired and transformed into a chaotic structure. Cause
of these transformations and their role in tumor development and maintenance is an important problem of oncology.
Recent technological improvements allow generation of high-resolution genomic data which can be utilized to address
this problem. Obtaining high-resolution homogeneous samples that are obtained from a single cancer is critical to study
intra-tumor genomic heterogeneity. Both experimental and financial limitations create difficulties in obtaining detailed
data sets that includes such samples. Gioblastoma multiforme is the most common and most aggressive brain tumor
with a median survival of fifteen months post diagnosis. In this manuscript, analysis results of a data set that includes
high-resolution homogeneous and heterogeneous samples from a glioblastoma patient will be presented
Does Islamic banking offer a natural hedge for business cycles? Evidence from a dual banking system
No full textWe examine the lending patterns in the Turkish Islamic banking over business cycles. We find that, similar to conventional banks, Islamic banks in Turkey exhibit procyclical lending pattern. We also find that Islamic bank lending does not show significant difference from conventional bank lending. The results conflict with some of the findings that indicate Islamic banks as natural stabilizers in the banking systems. We emphasize that regulatory amendments of the last decade that are effective on Islamic banks could induce these banks to lend procyclically. To test the validity of this conjecture, we empirically examine how the state of competition in the Turkish banking system affects bank lending across business cycles by disentangling the effects separately for Islamic and conventional banks. The results suggest that the degree of competition spur bank lending procyclicality at the same magnitude, confirming the convergence between Islamic and conventional banks in their lending patterns. We also discuss several other issues in Islamic banking which may lead to the procyclicality of lending
Reputation based trust in human-agent teamwork without explicit coordination
No full textInteracting with strangers and agents through computer networks has become a routine aspect of our daily lives. In such environments, reputation plays a critical role in determining our future interactions and satisfaction derived from them. This paper empirically investigates the effects of agent reputation on human trust in and behavior towards "peer" level agent teammates over repeated interactions. We developed a team coordination game, the Game of Trust, in which a human player and an agent player repeatedly cooperate to complete team tasks without prior assignment of sub-tasks. Before the game begins, the agent player is introduced with either positive or negative reputation to the human player. The effects of agent reputation are evaluated by performing an extensive set of controlled experiments with participants recruited from Amazon Mechanical Turk, a crowdsourcing marketplace. We collect both teamwork performance data as well as surveys to gauge participants' trust in their agent teammates. The empirical results show that positive (negative) agent reputation led to greater (lower) human trust in agent teammates. Moreover, the interplay between the game expertise and expectation from agent teammate significantly affected the influence of reputation. These findings enhance our understanding of changes in human trust with respect to agent reputation towards achieving successful human-agent teamwork
Arama kararının hukuka aykırı şekilde icrasından elde edilen delilin hükme esas alınması sorunu üzerine karar incelemesi
Get PDFIn cases where the execution of the search warrant is carried out illegally, the issue of whether to make judgments based on evidence obtained in the execution of the search warrant is still a major problem in practice. In this study, the decision of the Constitutional Court dated November 19, 2014, application number 2013/6183, was examined. The decision was applied by Ya5ar Yilmaz to the court individually. The development of material facts, views of authorities, and determined legal issues have been covered in our review of the judgment. We explain these legal issues and propose solutions to them based on legal evaluation
Kablosuz doğalgaz borusu muayene robotu tasarımı
No full textIn this work, the design of a natural gas pipeline inspection robot that generates energy from gas flow, performs onboard image processing and handles propulsion through bio-metal fiber (BMF) driven arms is presented. For an in-pipe inspection of an explosive gas filled pipe to be performed properly in real operational conditions, the robot should be free of external cable to prevent gas leakage from the pipe, exproof to prevent any spark that can lead to a fire or explosion, and adaptive to highly varying pipe diameters and tight curvatures on L and T joints. Novel solutions that address the mentioned requirements are proposed for systems of propulsion, energy source, data acquisition and communication. Design of robot that combines all these solutions is explained in detail
Air-cured fiber-cement composite mixtures with different types of cellulose fibers
Get PDFThis present study was carried out to check the feasibility of different cellulose fibers obtained from cropped virgin cellulose, blenched eucalyptus, and araucaria pulps through different new environmentally friendly curing processes for fiber-cement production. The aim is to introduce the different sources of cellulose fibers with lower cost to produce the "fiber-cement without autoclave" (FCWA). The slurries used in the experiments contain approximately 8% wt. of cellulose. The influence of the waste marble powder addition to the cement mixture was also studied. The physical and mechanical properties of the products which were prepared with this method under different curing conditions were investigated. The mechanical properties of eucalyptus cellulose appear to offer the best combination, especially after longer air-cure cycles. The results showed that the production of FCW A is very economical by using waste marble powders. And moreover, two new types of cellulose fibers (eucalyptus and araucaria celluloses; EuC and ArC, resp.), which provide a better density and packing in the fiber-cement leading to better modulus of rupture (MOR) and modulus of elasticity (MOE) values as virgin cellulose (ViC), are very usable for production of the fiber-cement in industrial scale
The problem of political philosophy in Leo Strauss’ thought
No full textThis thesis begins with the character of political philosophy - classically, the quest for the good life - in the thought of twentieth-century political philosopher Leo Strauss. In this context, the relation of convention-nature and nature-philosophy will be handled. Since the thesis pertains to the modern era, the focus of the thesis will be the point that political philosophy has come as the result of modern challenges and the dilemmas it has confronted. The intellectual process resulting in the crisis of modernity will be examined using Strauss’ approach, and the political teachings of Niccolo Machiavelli, Thomas Hobbes, John Locke, Jean Jacques Rousseau, Friedrich Nietzsche, and Martin Heidegger will be discussed. Eventually, the way out of this crisis will be investigated and the immanent limits of the nature of political philosophy will be revealed through an esoteric re-reading of Plato.Abstract………………………………………………………………………………………………………………………iv Öz………………………………………………………………………………………………………………………………..v Dedication…………………………………………………………………………………………………………………..vi
Table of Contents….……………………………………………………………………………………………………vii
Introduction…….…………………………………………………………………………………………………………..1
CHAPTERS 1. Quest for the Good Life…………………………………………………………………………………………….5
1.1. Leo Strauss: An Intellectual Biography……………………………………………………....5
1.2. The Problem& of Political Philosophy………………………………………………………….13
2. The Crisis of Modernity……………………………………………………………………………………………21
2.1. Three Waves of Modernity……………………………………………………….……………….21
2.2. Positivism and Historicism…………………………………………………………………………30
2.3. Between Progress and Return……………………………………………………………………37
3. Rediscovery of Plato…………………………………………………………………………………………………44
3.1. Esoteric and Exoteric Writing…………………………………………………………………….44
3.2. Limits of the City……………………………………………………………………………………….50
3.3. Necessity of Poetry……………………………………………………………………………………61 Conclusion……………………………………………………………………………………………………...…......….65 Bibliography………………………………………………………………………………………………………………..7
Between risks and opportunities Social policies in contemporary Turkey
Get PDFThis book scrutinizes the last 15 years of exceptional growth in the Turkish economy, and presents a model for sustainable ongoing growth that has particular implications for other key emerging economies. The growth of the Turkish economy in the 2000's was based on two integrated fundamental factors: fixing deteriorating dynamics and implementing further reforms to stimulate economic activity. This basic formula led to pleasing rates of economic growth, fuelled particularly by domestic private investments along with revived consumption and exports. Driven by political stability established by single party governments in the post-2002 period, an improved economic outlook helped Turkey enjoy record levels of foreign investment, adding momentum to its growth story. The Turkish experience in the post-crisis period implies that in order to achieve a fast and - more importantly - sustainable onward growth, the economy needs a new generation of structural reforms that simultaneously heal fragility and vitalize economic activity. The papers in this book offer professional assessments and assistance - especially for policymakers, and present a new direction upon which the Turkish economy - and emerging markets - can progress successfully for a further 15 year
Profiling energy efficiency tendency:a case for Turkish households
No full textThere is no need to discuss the importance of energy and energy policies in the global agenda. Countries whose electricity demand rises steadily, and depends heavily on fossil fuels and imports, should consider energy efficiency in any aspects. As one of examples such a country, this study investigates the behaviors and attitudes of Turkish households regarding energy efficiency. An online survey of 526 Turkish households in 2014 gathered data on current habits including peak hour use, energy labeling, standby use, willingness for behavioral change, and policy options they would like to see implemented to improve energy efficiency. The results indicate the awareness level of energy efficiency among Turkish households is quite low, and should be promoted by demand side programs. Two-step cluster analysis is used to construct clusters to group households with respect to their policy preferences. Four different clusters are identified and characteristics of these clusters suggest the importance of having unique intervention strategies for successful behavioral change and for the attainment of energy efficiency
Ceza infaz kurumlarında çocukların eğitim hakkı ve ıslahı:Maltepe Çocuk ve Gençlik Ceza İnfaz Kurumu örneği
Get PDFBu çalışmanın amacı Çocuk ve Gençlik Ceza İnfaz Kurumlarında bulunan çocukların
eğitimlerine devam edip etmediklerini belirlemek, uygulamadakimesleki eğitimlerin
ve ıslah faaliyetlerinin yeterliliğini sorgulamaktır. Mesleki eğitimler ile ıslah
faaliyetlerinin çeşitliliği ceza adalet sisteminin modernleşmesinin bir getirisidir.
Ceza infaz kurumlarında çocuklara yönelik çeşitli kurslar verilmekte olup, yerel
yönetimler ve sivil toplum kuruluşları ile çalışmalar yapılmaktadır. Bu aktivitelerin
çocuklar üzerinde olumlu etkileri ölçülmeye çalışılmıştır. Ceza infaz kurumları
çocukların bir daha suç işlememeleri için üzerinde düşünülüp çocuğun iyileştirilmesi
amacı ile çocuğa yoğun bir program sunulması gereken kurumlarının başında
gelmektedir.
Çalışma bölümler halinde hazırlanmıştır. Çalışmanın kuramsal bölümünde tanımlara,
tarihsel süreçlere ve ulusal ve uluslararası alanda çocuk ceza mevzuatına
değinilmiştir. Kimi ülkelerdeki çocuk ceza infaz kurumlarının eğitime bakış açıları ele
alınmıştır. Son bölümde de Maltepe Çocuk ve Gençlik Kapalı Ceza İnfaz Kurumu’nda
bir anket çalışması yapılmış, çalışmada çocukların eğitim, ıslah ve iyileştirme
faaliyetlerine ve cezaevi eğitim ve psiko-sosyal destek personellerine ilişkin
görüşlerine yer verilmiştir. Çalışma kapsamında iyileştirme faaliyetlerinin yeterliliği
ve süregelen mevcut sorunlar ele alınmış, sosyal devlet ilkesine uygun
gerçekleştirilmesi umut edilen tavsiyelerde bulunulmuştur.Öz ................................................................................................................................ iv
Abstract ....................................................................................................................... vi
Teşekkür ..................................................................................................................... viii
İçindekiler .....................................................................................................................ix
Tablolar ....................................................................................................................... xii
Kısaltmalar .................................................................................................................. xiii
1. GİRİŞ ......................................................................................................................... 1
2. ÇOCUK, SUÇA SÜRÜKLENEN ÇOCUK VE EĞİTİM HAKKI KAVRAMLARI, SUÇA
SÜRÜKLENEN ÇOCUĞUN EĞİTİMİNE VE ISLAHINA YÖNELİK BİRLEŞMİŞ MİLLETLER
DÜZENLEMELERİ .......................................................................................................... 4
2.1.Genel Olarak Çocuk Kavramı Ve Ulusal Ve Uluslararası Mevzuata Göre
Çocuk……………………………………………………………………………………………………………………4
2.1.1. Çocuk Kavramı ............................................................................................... 4
2.1.2. Ulusal Mevzuat Kapsamında Çocuk Kavramı ................................................ 6
2.1.3. Uluslararası Mevzuatta Çocuk Kavramı ......................................................... 8
2.2. Genel Olarak Çocuk Hakları Kavramı Ve Çocuk Haklarının Tarihsel
Gelişimi….. ............................................................................................................... 10
2.2.1. Çocuk Hakları Kavramı ................................................................................. 10
2.2.2. Çocuk Hakları Tarihsel Gelişimi ................................................................... 13
2.3. Suça Sürüklenen Çocuk Kavramı ................................................................. 19
2.3.1. Suça Sürüklenen Çocuk Kavramı ve Masumiyet Karinesi ............................ 19
2.3.2. Suça Sürüklenen Çocuğun Ceza Adalet Sistemi İçerisindeki Yeri ................ 23
2.3.3. Çocuk Ceza Adalet Sistemi Ve Sınıflandırılması ........................................... 27
2.4. Genel Olarak Eğitim Ve Eğitim Hakkı Kavramı ............................................. 33
2.4.1. Eğitim kavramı ............................................................................................. 33
2.4.2. Eğitim Hakkı Kavramı ................................................................................... 34
2.4.3. Eğitim Hakkı Kapsamında Fırsat Eşitliği Ve Ayrımcılık Yasağı ...................... 36
2.4.4. Eğitim Hakkı Kapsamında Çocuğun Yüksek Yararı Ve Gelişme Hakkı .......... 39
2.5. Suça Sürüklenen Çocuğun Eğitimi Ve Islahı Üzerine BM Düzenlemeleri .... 42
2.5.1. BM Çocuk Ceza Adaleti Sisteminin Uygulanması Hakkında Asgari Standart
Kurallar (Pekin Kuralları) ........................................................................................ 44
2.5.2. Özgürlüğünden Yoksun Bırakılmış Çocukların Korunmasına İlişkin Birleşmiş
Milletler Kuralları (Havana Kuralları) ..................................................................... 49
2.5.3. Çocuk Suçluluğunun Önlenmesine İlişkin Birleşmiş Milletler Yönlendirici
İlkeleri (Riyad İlkeleri) ............................................................................................ 52
3. KARŞILAŞTIRMALI HUKUKTA VE TÜRK HUKUKUNDA SUÇA SÜRÜKLENENÇOCUĞUN
CEZA İNFAZ KURUMUNDA EĞİTİM HAKKI VE İYİLEŞTİRME FAALİYETLERİ ................. 54
3.1. Karşılaştırmalı Hukukta Suça Sürüklenen Çocuğun Eğitimi Ve Islahı .............. 54
3.1.1. Genel Olarak ................................................................................................ 54
3.2. Almanya Örneğinde Çocuk Ceza Hukukunda Eğitim ........................................ 56
3.2.1. Alman Ceza Adalet Sistemi ve Tarihi Gelişimi ............................................. 56
3.2.2. Alman Çocuk Ceza Mevzuatı ....................................................................... 59
3.2.3. Diversion Ve Islah Amacıyla Eğitim ............................................................. 63
3.3. Amerika Birleşik Devletleri Örneğinde Çocuk Ceza Hukukunda Eğitim ........... 68
3.4. İngiltere Örneğinde Çocuk Ceza Hukukunda Eğitim ........................................ 73
3.5. Fransa Örneğinde Çocuk Ceza Hukukunda Eğitim ........................................... 80
3.6. İtalya Örneğinde Çocuk Ceza Hukukunda Eğitim ............................................. 81
3.7. İspanya Örneğinde Çocuk Ceza Hukukunda Eğitim .......................................... 83
3.8. Avusturya Örneğinde Çocuk Ceza Hukukunda Eğitim ...................................... 84
3.9. Türk Hukukunda Suça Sürüklenen Çocuğun Eğitimi........................................ 86
3.9.1. Suça Sürüklenen Çocuğun Eğitim Hakkı ...................................................... 86
3.9.1.1. Suça Sürüklenen Çocuğun Çocuk Kapalı Ceza İnfaz Kurumunda Eğitim
Hakkı .................................................................................................................... 91
3.9.1.2. Suça Sürüklenen Çocuğun Eğitim Evlerinde Eğitim Hakkı ...................... 92
3.9.2. Suça Sürüklenen Çocukların Islahı Kapsamında İyileştirme Faaliyetleri ..... 95
3.9.2.1. Suça Sürüklenen Çocuğun Eğitimi Bağlamında Din Eğitimi ................... 99
3.9.3.Suça Sürüklenen Çocuk Hakkında Uygulanan Güvenlik Ve Koruma
Tedbirleri…………………………………………………………………………………………………………101
3.9.3.1. Güvenlik Tedbirlerinde İzlenecek Usul ................................................. 102
3.9.3.2. Suça Sürüklenen Çocuk İçin Koruyucu Ve Destekleyici Tedbir Olarak
Eğitim ................................................................................................................. 105
3.9.3.3.Denetimli Serbestlik Ve Eğitim Tedbiri .................................................. 108
3.9.4.Diversion Kurumunun Türk Hukukuna Yansıması ...................................... 110
4. SUÇA SÜRÜKLENEN ÇOCUKLARIN EĞİTİMİNDE BİR ÖRNEK: MALTEPE ÇOCUK VE
GENÇLİK KAPALI CEZA İNFAZ KURUMU ................................................................... 117
4.1. Türkiye Genelinde Ceza İnfaz Kurumları, Suça Sürüklenen Çocukların Eğitim
Profilleri Ve Suç Dağılımları ................................................................................... 117
4.1.1. Çocuk Eğitim Evleri Ve Çocuk Ve Gençlik Kapalı Ceza İnfaz Kurumları ..... 117
4.1.2. Çocukların Eğitim Profilleri ........................................................................ 122
4.1.3. Çocukların Suç Dağılımları ......................................................................... 127
4.2. Maltepe Çocuk Ve Gençlik Kapalı Ceza İnfaz Kurumu Hakkında Bulgular ..... 128
4.2.1. Kurumun Fiziki Şartları .............................................................................. 128
4.2.2. Kurum Personel Servisi ............................................................................. 130
4.2.3. Kurum Eğitim Servisi .................................................................................. 132
4.2.4. Kurum Sağlık Servisi ................................................................................... 134
4.2.5. Kurum Psiko-Sosyal Servis ......................................................................... 134
4.2.6. Suça Sürüklenen Çocuk ve Aile İlişkisi ....................................................... 137
4.2.7. BİSİS Sistemi ve Uygulama ......................................................................... 141
4.3. Kuruma İlişkin Değerlendirme ........................................................................ 142
4.3.1. Kurumun Fiziki ve Mali Yeterliliğine İlişkin Tespitler Ve Öneriler ............. 142
4.3.2. Kurumun Eğitim Servisi Ve İyileştirme Faaliyetlerine İlişkin Tespitler Ve
Öneriler ................................................................................................................ 145
4.3.3.Kurumun Psiko-Sosyal Servisinin Yeterliliğine İlişkin Tespitler Ve Öneriler149
5. SONUÇ .................................................................................................................. 152
KAYNAKÇA ................................................................................................................ 156
EKLER………………………………………………………………………………………………………………….165
A. Ceza İnfaz Kurumlarında Çocukların Eğitim Hakkı Ve Islahı Ve Maltepe Çocuk Ceza
İnfaz Kurumu Örneği” Konulu Yüksek Lisans Tezi Çalışması Kişisel Bilgi Formu ...... 165
B.“Ceza İnfaz Kurumlarında Çocukların Eğitim Hakkı Ve Islahı: Maltepe Çocuk Ve
Gençlik Ceza İnfaz Kurumu Örneği” Konulu Yüksek Lisans Tezi Çalışması Kişisel Bilgi
Formunun Uygulanabilmesi İçin Velilerden İzin Yazısı ............................................. 171
C. Adalet Bakanlığı Ceza ve Tevfik Evleri Genel Müdürlüğü İzin Yazısı .................... 17