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Inflammatory Bowel Diseases and Primary Immunodeficiency
No full textInflammatory bowel diseases (IBD) such as Crohnʼs disease and ulcerative colitis are critical disease, characterized by abdominal pain, diarrhea, bleeding and malabsorption. Approximately 25％ of IBD patients are diagnosed before the age of 18 years, particularly during puberty. Recently, biological therapies have modified the treatment strategies and have been shown to be effective and safe not only in adults but also children. Although IBD are suggested to result from dysregulation of immune system and environmental factors, the accurate etiology of IBD remains unknown. The genetic background of IBD has been focused for several years. According to recent studies, the number of IBD association loci has increased to about 200. The majority of IBD associated genes are involved in immune system. Indeed, IBD is one of the most common complications of primary immunodeficiency （PID). Thus, when we see IBD patients, PID should not be missed because prognosis and medical management are different from idiopathic IBD patients
Improving Estimation Precision of the Convergence Point of Individuals Using Weight-based Moving Vectors
No full text第13回進化計算学会研究会 : 2017年9月1-2日 : 立命館大学 : 滋賀進化パスは個体群の進化方向を示す有用な情報を持っている．親個体から子個体への方向ベクトルを移動ベクトルと呼ぶことにすると（本論文での親個体と子個体を，各々，低fitness 個体，高fitness個体と読み替えてもよい），進化計算の収束点はこれら移動ベクトルから推定可能で，しかも，その収束点は数学的に計算できることを示した1, 2) ．筆者等はこの成果を進化計算高速化に結びつけるために，第１段階として，双極タスクの二つの局所最適解領域を移動ベクトルの方向から分離する手法と収束点の推定精度を向上させる手法を開発し3, 4) ，これらの手法が一般的なベンチマーク関数でも高速化に寄与することを示した5) ．さらに研究を進め，一般的な多峰性タスクの局所解領域を逐次的に分離する手法を開発した6) ．現在この手法を組み込んだ進化計算の高速化について評価中である．本論文の目的は，進化計算個体群の収束点推
定精度を向上させる新たな手法を提案することである．具体的には，従来法で推定した個体群の収束点と各移動ベクトルの向きから，各々の移動ベクトルに信頼性の重みを付与し，再度収束点を推定する手法である．従来の我々の推定
方法では，推定に用いる移動ベクトルを選択することはしたが，選択された移動ベクトルは同じ重要度で収束点推定計算に用いていた．
以下，第２節で簡単に個体群の収束点の推定方法を簡単に説明し，第３節で提案する移動ベクトルへの重みを説明し，第４節でテスト関数を用いてその効果を評価する．最後に，第５節と第６節で考察と結論を述べる
新しい箱玉系のルールとその解析
No full text応用力学研究所研究集会報告No.28AO-S6「非線形波動研究の深化と展開」Reports of RIAM Symposium No.28AO-S6 Deepening and expansion of nonlinear wave scienceProceedings of a symposium held at Chikushi Campus, Kyushu Universiy, Kasuga, Fukuoka, Japan, November 3 - November 5, 2016最近の研究の中で，高橋・薩摩の箱玉系の有限オートマトン表示に対する考察の中から，新しい箱玉系のルールがいくつか見出されている．本稿では，“箱飛ばしルール” と “空箱ルール” のそれぞれを導入する．特に，一つ飛ばしルールで与えられる箱玉系については，その線形化の手続きについて紹介する
可積分確率過程に現れる対称関数
No full text応用力学研究所研究集会報告No.28AO-S6「非線形波動研究の深化と展開」Reports of RIAM Symposium No.28AO-S6 Deepening and expansion of nonlinear wave scienceProceedings of a symposium held at Chikushi Campus, Kyushu Universiy, Kasuga, Fukuoka, Japan, November 3 - November 5, 2016種々の量が具体的に計算できるという意味で「可積分」な確率モデルの研究が, 近年ひろく行われている ([1, 2]およびこれらに引用されている文献を参照していただきたい). 数学的な観点から見たとき, これらのモデルの構成・解析においては, 従来の表現論や特殊関数論, 組合せ論のあ る種の変形のようなものが使われている.本稿では, Sasamoto-Wadati [5] によって導入された可積分確率過程である q-boson ゼロレンジ過程の拡張と見なされる二つのモデルを題材として, これらに現れる新たな特殊関数を紹介する. 以下では関数の定義と, それが確率モデルのどのような量として現れるかに焦点を絞って概説する. 数学的な背景としては, アフィンヘッケ代数の変形と見なされる非可換代数の表現論や, 量子アフィン代数の表現論があるのだが, この点については言及しない. 引用した文献を参照していただきたい
隣接サイトの状態に依存する吸脱着機構を持つ完全非対称単純排他過程と複雑ネットワークへの応用
No full text応用力学研究所研究集会報告No.28AO-S6「非線形波動研究の深化と展開」Reports of RIAM Symposium No.28AO-S6 Deepening and expansion of nonlinear wave scienceProceedings of a symposium held at Chikushi Campus, Kyushu Universiy, Kasuga, Fukuoka, Japan, November 3 - November 5, 2016前方の隣接サイトの状態に依存する吸脱着機構を持つ一次元開放系の完全非対称単純排他過程に関して，平均場近似を用いて定常状態について解析した結果を紹介する．また，最後に，この模型の今後の展望の一つとして，複雑ネットワークへの応用について言及する
Kyushu Imperial University Faculty of Law & Letters and YOSHINO Sakuzo (2) : The Mediator of the Infighting at 1927 in Kyushu Imperial University Faculty of Law & Letters
No full text一、序に代えて / 二、九州帝国大学法文学部の創設と吉野作造 / 三、法文学部内訌事件と吉野作造 (以上前号) / 四、結びに代え
[029]ICER Newsletter
No full text福岡市博物館展示報告:鴻臚館のWeb教材/VR教材[金子晃介准教授(協力教員)] / 電子教材著作権講習会のご案内[河野由起子(テクニカルスタッフ)] / 「先生の森動画版」撮影秘話:病院撮影編[谷澤亜里助教] / 2D/3D教材開発システムの紹介:vol.6[岡田義広教授(教材開発センター長)] / 3次元CGやVR/ARを活用したWeb教材の開発に挑戦してみませんか?[岡田義広教授(教材開発センター長)] / 教材開発支援教材システムの貸し出しについ
Occurrence of Spontaneous Polyembryony in Lilium lancifolium Thunb.
No full textWe examined spontaneous polyembryony in Lilium lancifolium Thunb. by determining the occurrence of polyembryonic seeds in intraspecific crosses and open pollination, and by analyzing the genetic origins of polyembryos with simple–sequence repeat (SSR) markers. Forty–one polyembryonic seeds (0.2% of total) were detected from 17,583 seeds. Of the polyembryonic seeds, 36 were duplets and five were triplets. Eighteen seedling sets (three triplets and 15 duplets) were cultured and grown to maturity. Flow cytometry revealed that all were diploids, and results of analyses with SSR markers indicated that all the multiple embryos, except for two triplet seeds, originated from a zygotic embryo through cleavage embryony. The SSR profiles confirmed that the seedlings from polyembryos resulted from cross–fertilizations and did not from unfertilized somatic embryos. Six seedlings rescued from the two triplets occurring in 2x × 3x combinations were heterozygous with respect to SSR, and thus they may have their origin in multiple embryo sacs and/or polyspermy. The occurrence of polyembryonic seeds was remarkably greater in one accession collected from Wan–do (Wan island) than the others. This suggested that the frequency of polyembryony depends on the genotypes of L. lancifolium
Effect of Glutathione on Cryopreservation of Buck Spermatozoa
No full textThe aim of this study was to assay supplementation of glutathione into the traditional egg yolk extender for cryopreservation of goat spermatozoa. Semen ejaculates were collected from three fertile baladie bucks, aged 2–3 years using artificial vagina. Collected semen was divided into four aliquots; the first was diluted with Tris–egg yolk extender without any supplementation (Control), while the others were diluted with Tris–egg yolk extender supplemented with glutathione at levels of 2, 4 and 6 mM. Semen diluted at a rate of 1:4 and placed into a refrigerator at 5°C for 4 h to equilibrate. At the end of equilibration period, extended semen was packaged in liquid 0.25 ml French straws and stored in liquid nitrogen at –196°C. Thereafter, frozen semen was thawed by dipping the straws into a water bath at 37°C for 30 seconds. Percentages of progressive motility, live sperm, sperm abnormalities, plasma membrane and acrosome integrity were evaluated post dilution, equilibration period and post–thawing of spermatozoa. The results revealed that there were significant differences (P<0.05) of various sperm characteristics (percentages of sperm motility, live spermatozoa and sperm abnormalities, plasma membrane and acrosome integrity) in post–diluted, post equilibration and post thawing of goat semen. Treatment supplemented with 6 mM of glutathione led to significantly (P<0.05) improve the percentages of progressive motility, live spermatozoa and sperm abnormalities, plasma membrane and acrosome integrity of buck spermatozoa during different stages of cryopreservation compared to control and other levels of glutathione addition. While the extender supplanted with 2 mM glutathione was recorded the lowest value of semen parameters approximately. In conclusion, supplementation of Tris–egg yolk extender used for buck semen extender during freezing–thawing process with 6 mM of glutathione improves percentages of progressive motility, live spermatozoa, sperm abnormalities, plasma membrane and acrosome integrity of frozen–thawed buck spermatozoa
The Effects of Unmanned Control Systems for Optimum Pest Control in Protected Paprika Cultivation Facilities
No full textIn this study, the spraying effects of unmanned controllers for the efficient control and safe use of pesticides in protected paprika cultivation facilities were reviewed. Whether or not pesticides were deposited and the quantities of active components and pest control effects of the pesticides according to the plant length and locations of paprika were examined. Experimental plots consisting of nine sections (comprising three repetitions of three different experimental chemical treatments) were arranged in a 13,500m2 wide test field to conducts experiments with Leveillula taurica, Bemisia tabaci, and Aphis gossypii that occurred in protected paprika cultivation facilities. Deposit degrees following pesticide spraying with unmanned fogging type controllers were measured; according to the results, water–sensitive papers showed a deposit rate of 100% in all experimental plots. With regard to pest control, when Pyrifluquinazon 6.5% SC was sprayed, 93.5% of Bemisia tabaci was controlled and 93.9% of Aphis gossypii was controlled. In the case of Leveillula taurica, diseased leaf rates were examined 7 days after the final treatment with Fluopyram 40% SC; the results showed that, as chemical control effects, diseased leaf rates were 52.2% in untreated plots while being approximately 8.8% in the treated plots, indicating that the control value was at least 83.2%. According to the results of examination of the quantities of active components on the front and rear of the leaves, chemical effects persisted when the quantities of active components on the front and rear of the leaves were on average 1.30 (μg/50 cm2) and 1.05 (μg/50 cm2) respectively, in the case of spraying of Fluopyram 40% SC; when the quantities of active components on the front and rear of the leaves were on average 0.62 (μg/50 cm2), 0.49 (μg/50 cm2), respectively, in the case of spraying of Pyrifluquinazon 6.5% SC; the overall deposit amounts on the front and rear were not considerably different