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KuQuinone-sensitized cobalt oxide nanoparticles for photoelectrocatalytic oxygen evolution with visible light
Full text linkPhotocatalytic nanomaterials offer promising solutions for conducting chemical transformations under safe, green and sustainable conditions. In particular, the storage of solar energy into chemical bonds is an appealing but challenging goal in the field of artificial photosynthesis. Using water as the source of electrons and protons through the photodriven water oxidation (WO) reaction is at the core of this endeavour. In this work, we disclose photoactive hybrid nanomaterials designed through a dyadic approach. We exploit Co3O4 nanoparticles (NPs) covalently functionalized with a fully organic pentacyclic polyquinoid KuQuinone (KuQ) dye, providing a rare example of a noble metal-free photocatalytic dyadic nanomaterial (hereafter denoted as KuQ3Pn@Co3O4). KuQ3Pn@Co3O4 NPs have been characterized by electron microscopy and optical and core-level spectroscopy studies. When cast onto a SnO2 photoanode, they are active towards WO upon visible light irradiation (400-580 nm) with a faradaic efficiency for O2 evolution of ca. 90%. This work provides a novel contribution to the rational design and mechanistic understanding of hybrid photocatalytic nanomaterials relevant for energy and sustainable synthesis applications
Incompatibilità nei concorsi universitari: il confine tra colleganza e conflitto d’interessi nella giurisprudenza amministrativa
No full textFunzioni della pena e obbiettivi giudiziari (note a margine di un recente studio)
No full textGli scopi della sanzione criminale sono oggetto di una letteratura sterminata, oggi arricchita dagli studi su forme non carcerarie e sui percorsi riparativi. C’è da chiedersi se – pur dinanzi a simili tendenze evolutive – la dinamica giudiziaria non nasconda, in via del tutto eterodossa, caratteristiche che tradizionalmente accompagnano la pena, tradendo l’obbiettivo naturale del processo: stabilire la regola applicabile al caso concreto
Author correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids
No full textCorrection to: Nature Medicinehttps://doi.org/10.1038/s41591-024-02807-z, published online 4 March 2024. In the version of this article initially published, there were inconsistences, where in the Methods “AF collection and isolation of the viable cell fraction” paragraph, the first sentence, now reading “AF samples (amniocenteses and amniodrainages) were collected from UCLH FMU and UZ Leuven as part of standard patient clinical care”, was initially preceded by “Euploid,” though the sample contained two chromosomal abnormalities; and in Supplementary Table 1, where for sample code HO680, the sex was listed as female following prenatal clinical data, whereas the sample was identified and processed in further analysis as male. The changes have been made in Supplementary Table 1 and in the HTML and PDF versions of the article
Interaction domains of pile groups in cohesive soils under generalised loads
No full textThis work focuses on the undrained bearing capacity of pile groups subjected to combined vertical, moment, and lateral loads. Advanced 3D FE analyses were used to identify the possible plastic mechanisms occurring within the soil-foundation system, as well as the most relevant factors affecting its limit behaviour. The numerical results show a strong coupling between the lateral capacity of the group and the applied vertical/moment loads, resulting from a different degree of mobilisation of the axial and bending capacity of the piles. Based on the numerical findings, a new theoretical lower bound solution was developed to compute the 3D failure domain of pile groups in clay, overcoming limitations and inconsistencies of theoretical solutions recently proposed in the technical literature. The method accounts for the combined effect of group geometry, structural and geotechnical capacity of the single piles, and loading direction on the actual plastic mechanism occurring within the group and the corresponding failure envelope
Qualche riflessione atmosferologica. Una anti-critica.
No full textViene presentata una anti-critica che respinge alcune obiezioni presenti del pur interessante articolo di Santamato (2025), focalizzato sulle contraddizioni dell’atmosferologia e sui rischi della sua adozione psicopatologica. Che tale progetto radicalmente esternalista (le atmosfere sono sentimenti presenti nello spazio) sia controverso non è però un deficit ma un valore aggiunto (quanto meno filosoficamente). Va inoltre sia corretta l’interpretazione di Santamato di alcuni concetti chiave (atmosfere spurie, corpo vissuto, aspetti normativi, etc.), sia respinta l’obiezione di una complessiva contraddittorietà. L’articolo, semplicemente, adotta un paradigma (intenzionalità delle atmosfere, introiezionismo affettivo, etc.) del tutto estraneo ai presupposti atmosferologici (primato del patico e del corpo vissuto, critica della autonomia razionale del soggetto, etc.). Ma ha davvero senso abbracciare il paradigma atmosferologico privandolo di questi rivoluzionari presupposti ontologici?
The Enhanced Recovery After Surgery Pathway Is Safe, Feasible and Cost-Effective in Delayed Graft Function After Kidney Transplant
Full text linkBackground/Objectives: Enhanced recovery after surgery (ERAS) pathways
are still underutilized in kidney transplantation (KT), and their feasibility after delayed
graft function (DGF) is unknown. We aimed to evaluate safety and cost savings after
ERAS implementation in KT recipients with DGF. Methods: A retrospective analysis of
KT recipients enrolled in the ERAS program with DGF (≥1 dialytic treatment during the
first postoperative week or creatinine≥ 2.5 mg/dL on postoperative day 10) between 2010
and 2019 was performed. Recipient, donor, and transplant data, outcomes, and 1-year
post-KT costs were collected, comparing recipients within the ERAS target (≤5 days, “early
discharge group”) to those discharged later (>5 days, “late discharge group”). Results: Out
of 170 KT recipients with DGF, 33 (19.4%) were in the “early discharge group” and 137
(80.5%) in the “late discharge group”. Recipient, donor, and transplant characteristics were
similar in the two groups. The length of hospital stay (LOS) of the “early discharge group”
was significantly shorter, with fewer in-hospital dialysis sessions (p < 0.001) compared to
the “late discharge group”. One year post-KT, no significant differences were observed
in postoperative complications, readmissions, or number of outpatient visits. Five-year
graft and patient survival along with five-year graft function were similar between the two
cohorts. First-year costs were significantly higher in the “late discharge group” (p < 0.001),
with a median excess cost (∆) of EUR 4515.76/patient. Factors influencing first-year costs
post-KT were LOS for KT, recipient age, and use of expanded-criteria grafts. Conclusions:
The ERAS approach is safe in KT recipients with DGF and allows for economic savings,
while its implementation does not cause worse clinical outcomes in recipients
Restricted physical activity and maternal rest improve fetal growth: should we look for the reason in the cardiovascular modifications?
No full textIntrauterine growth restriction seems to be characterized
by a high-resistance, low cardiac output state that is detectable
at 22 to 24 weeks’ gestation in the preclinical stages of the
disease.2 This cardiovascular profile seems to be present at
different degrees of expression in the early and the late forms
of the disease. The low cardiac output may be because of 2
main reasons, namely the hypovolemic state and the possible
mechanical compression of the inferior vena cava.
During physical activity, the blood flow may be redirected
to the muscles. In case of normal plasma volume expansion
and maternal cardiovascular performance, physical activity
may have no effect on placental perfusion and fetal growth. If
plasma volume is not adequate and cardiac output is lower
than it should be, the redirection of part of the blood flow to
the muscles might steal precious blood from the placenta
ERN ReCONNET–SLICC–SLEuro expert consensus on the therapeutic management of rare systemic lupus erythematosus manifestations
No full text: Existing guidelines for systemic lupus erythematosus (SLE) predominantly focus on common and major organ involvements. An international taskforce involving experts from three SLE expert groups (ie, the European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases, the Systemic Lupus Erythematosus International Collaborating Clinics group, and the European Lupus Society) was established. A total of 119 participants contributed to the development of consensus therapeutic strategies for 24 rare SLE manifestations, using a multistep process. For SLE enteritis and pancreatitis, experts recommended hydroxychloroquine, glucocorticoids, and cyclophosphamide or mycophenolate mofetil. Rare lung conditions such as pneumonitis were also managed with cyclophosphamide if severe or with mycophenolate mofetil if not severe. SLE for myocarditis with hydroxychloroquine, glucocorticoids, and cyclophosphamide or mycophenolate mofetil, are recommended based on severity. For CNS manifestations, hydroxychloroquine, glucocorticoids, and cyclophosphamide or mycophenolate mofetil were common choices for treatment. For rare skin manifestations, the preferred strategy was a combination of hydroxychloroquine and glucocorticoids with anifrolumab or mycophenolate mofetil. This expert-based consensus provides a valuable framework for guiding therapeutic decisions where the available recommendations might be insufficient or inapplicable