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Total Cost of Ownership and Evaluation of Google Cloud Resources for the ATLAS Experiment at the LHC
No full textThe ATLAS Google Project was established as
part of an ongoing evaluation of the use of commercial clouds
by the ATLAS Collaboration, in anticipation of the potential
future adoption of such resources by WLCG grid sites
to fulfil or complement their computing pledges. Seamless
integration of Google cloud resources into the worldwide
ATLAS distributed computing infrastructure was achieved
at large scale and for an extended period of time, and hence
cloud resources are shown to be an effective mechanism to
provide additional, flexible computing capacity to ATLAS.
For the first time a total cost of ownership analysis has been
performed, to identify the dominant cost drivers and explore
effective mechanisms for cost control. Network usage significantly
impacts the costs of certain ATLAS workflows,
underscoring the importance of implementing such mechanisms.
Resource bursting has been successfully demonstrated,
whilst exposing the true cost of this type of activity.
A follow-up to the project is underway to investigate methods
for improving the integration of cloud resources in dataintensive
distributed computing environments and reducing
costs related to network connectivity, which represents the
primary expense when extensively utilising cloud resources
Conferimenti in società
No full textLa voce si propone di offrire una ricostruzione uniforme della fattispecie e della disciplina dei conferimenti in società, la quale, pur non ignorando le differenze esistenti nella regolamentazione dei singoli tipi societari, individui in termini generali i requisiti caratterizzanti dell'istituto e i tratti costanti dello stesso
Adjusting natriuretic peptide decision limits for BMI for a more personalized diagnosis of heart failure
No full textMeasurement of Immunoglobulin Intraclonal diversification refines the clinical impact of IGHV mutational status in chronic lymphocytic leukemia
No full textChronic lymphocytic leukemia (CLL) cells may bear mutations in IGHV genes, the 2%-cutoff allowing to discriminate two subsets, unmutated (U)- or mutated (M)-CLL, with different clinical course. IGHV genes may also incorporate additional ongoing mutations, a phenomenon known as intraclonal diversification (ID). Here, through an original bioinformatic workflow for NGS data, we used the inverse Simpson Index (iSI) as diversity measure among IGHV sequences to dichotomize cases with different ID levels into IDhigh (iSI ≥ 1.2) vs. IDlow (iSI < 1.2) both in CLL (n = 983) and in other lymphoproliferative disorders (LPD; n = 127). In CLL, IDhigh cases accounted for 14.6%, overrepresented in M-CLL (P = 0.0028), while higher percentages were documented in GC-derived LPD. In M-CLL (n = 396), IDhigh patients (n = 69) experienced longer time-to-first treatment than IDlow patients (P = 0.015), and multivariate analyses (n = 299) confirmed ID as independent variable. IGHV gene mutations of IDhigh cases had molecular signatures indicating ongoing activity of the AID)/Polη-dependent machinery; consistently, IDhigh M-CLL expressed higher levels of AID transcripts than IDlow M-CLL (P = 0.012). In conclusion, we propose a robust NGS protocol to quantitatively evaluate ID in CLL, demonstrating that: i) all CLL patients presented ID although at various degree; ii) high degree of ID has clinical relevance identifying a M-CLL subset with better outcome
Energy scale and resolution for anti- jets with radius parameters and 0.6 measured in proton-proton collisions at TeV with the ATLAS detector
Full text linkJets with different radius parameters R are an important tool for probing quantum chromodynamics processes at different angular scales. Jetswith small R = 0.2 are instrumental in measurements of the substructure of large-R jets resulting from collimated hadronic decays of energetic W, Z, and Higgs bosons, top quarks, and of potential new resonances. This paper presents measurements of the energy scale, resolution, and associated uncertainties of jets with radius parameters R = 0.2 and 0.6, obtained using the ATLAS detector. The results are based on 37 fb−1 of proton-proton collision data from the Large Hadron Collider at a centre-of-mass energy of root s = 13TeV. A new in situ method for measuring jet energy scale differences between data and Monte Carlo simulations is presented. The systematic uncertainties in the jet energy scale for central jets (|eta| < 1.2) typically vary from 1% to about 5% as a function of |eta| at very low transverse momentum, pT, of around 20 GeV for both R = 0.2 and 0.6 jets. The relative energy resolution ranges from (35 +- 6)% at pT = 20 GeV to (6 +- 0.5)% at pT = 300 GeV for central R = 0.2 jets, and is found to be slightly worse for R = 0.6 jets. Finally, the effect of close-by hadronic activity on the jet energy scale is investigated and is found to be well modelled by the ATLAS Monte Carlo simulations
Generic and disease‐specific caregiver contribution to self‐care in a population with multiple chronic conditions: A comparative study
No full textAimDescribe and compare generic and disease-specific caregiver contribution (CC) to self-care behaviours in the dimensions of self-care maintenance, self-care monitoring and self-care management in multiple chronic conditions (MCCs).DesignMulticentre cross-sectional study.MethodsWe enrolled caregivers of patients with MCC, from April 2017 to November 2022, if they were (a) 18 years of age or older and (b) identified by the patient as the principal unpaid informal caregiver. The Caregiver Contribution to Self-Care of Chronic Illness Inventory, Caregiver Contribution to Self-Care of Heart Failure Index, Caregiver Contribution to Self-Care of COPD Inventory and Caregiver Contribution to Self-care of Diabetes Inventory were used to measure generic and disease-specific contribution to patient self-care. Descriptive statistics, Student's t-tests and Pearson's correlation coefficients were used.ResultsWe found adequate generic CC for self-care monitoring but inadequate CC in self-care maintenance and management. All CC to disease-specific self-care maintenance, monitoring and management scales' scores were inadequate, except for caregivers of diabetic patients in which we observed an adequate score in the CC to self-care maintenance and self-care management scales in those practice insulin therapy.ConclusionCaregivers experience difficulties in performing behaviours of contribution to their patients affected by chronic conditions. Caregivers of patients with MCCs contribute more to self-care in aspects related to provider prescriptions and less to lifestyle changes.Implications for the Profession and/or Patient CareHealthcare professionals have to know in which behaviours caregivers show gaps and reflect on the reasons for poor CC to self-care to develop interventions to enhance these behaviours.ImpactThis study underlines the importance of choosing the most appropriate instrument for measuring CC to self-care, considering the caregiver's characteristics.Reporting MethodWe adhered to STROBE guidelines.Patient or Public ContributionCaregivers of patients affected by MCCs were enrolled
Sanzioni ANAC e principio di colpevolezza: riflessioni critiche alla luce della sentenza del TAR Lazio n. 8723/2025
No full textAffective symptoms, cognitive function and self-care behaviours in adults with heart failure according to ejection fraction phenotype
Full text linkAims: The aim of this study was to compare affective symptoms, cognitive dysfunction, and self-care behaviors among different heart failure (HF) phenotypes and to explore their interrelationships, particularly examining how cognitive and affective factors influence self-care practices. Methods and results: This cross-sectional study involved 250 older adults hospitalized for acute decompensated HF, categorized into three groups based on left ventricular ejection fraction (EF): HF with reduced EF (HFrEF), mildly reduced EF (HFmrEF), and preserved EF (HFpEF). Affective symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire-9 (PHQ-9), while cognitive function was evaluated with the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). Self-care behaviors were measured using the European Heart Failure Self-Care Behavior Scale. Among participants, 42% had HFrEF, 18.4% had HFmrEF, and 39.6% had HFpEF. Cognitive dysfunction was more pronounced in HFpEF patients (MMSE median = 28.0, IQR = 26.0-29.0) compared to those with HFrEF (median = 28.0, IQR = 27.0-29.0) or HFmrEF (median = 29.0, IQR = 27.3-29.0, p = 0.008). Higher MMSE scores were significantly associated with better self-care behaviors in HFpEF patients (Spearman's r = -0.299, p = 0.003), but not in the other groups. Significant differences were found in specific self-care behaviors, including contacting healthcare providers and adherence to a low-sodium diet. Conclusion: Although variations in cognitive function and self-care behaviors were observed across heart failure phenotypes, these differences were not statistically significant after adjusting for demographic and clinical factors. Tailored interventions should be based on a comprehensive assessment of cognitive and emotional health, rather than heart failure phenotype alone
