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Epoxy as an Alternative Resin in Particleboard Production with Pine Wood Residues: Physical, Mechanical, and Microscopical Analyses of Panels at Three Resin Proportions
No full textGiven the construction challenges and the impacts of industrial waste generation and the implications of using chemical adhesives, this study aims to evaluate epoxy as an alternative resin, whose application in the production of wood particleboards is still underexplored. In this regard, its results were compared with those of widely used adhesives, such as urea-formaldehyde (UF). Pine wood particles were used, and epoxy resin was applied as a binder in 5%, 10%, and 15% proportions. Panels were manufactured under pressing parameters of 5 N/mm2 for 10 min at 110 °C. Physical and mechanical properties of panels were evaluated using Brazilian, European, and American standards. The results showed that epoxy resin is potentially convenient for the particleboard industry, as the 15% trait panels met the P4 class criteria in the Brazilian and European standards and D-2 for the American code, and the 10% trait panels achieved the M-3i class for the American document. Although 5% adhesive was insufficient to envelop wood particles, these traits with greater percentages reached high enveloping ratings in the scanning electron microscopy (SEM) test, making epoxy resin viable for the panel industry as a potential alternative to formaldehyde-based adhesives.Department of Civil Engineering Federal University of São Carlos (UFSCar), 235 km Washington Luis Highway, São CarlosDepartment of Civil Engineering São Paulo State University (UNESP) Ilha Solteira, 56 Brasil Sul AvenueDepartment of Architecture and Urbanism Federal University of Rio Grande do Norte (UFRN), Campus Universitário—Lagoa NovaDepartment of Civil Engineering Federal University of Rondônia (UNIR), 9.5 km BR 364 Highway, Porto VelhoFederal Institute of Education Science and Technology of Rondônia (IFRO), RO-257 Highway, AriquemesDepartment of Civil Engineering São Paulo State University (UNESP) Ilha Solteira, 56 Brasil Sul Avenu
Effect of extrinsic pigmentation and multiple firing cycles on the properties of a zirconia-containing lithium silicate ceramic
No full textPurpose: To assess the impact of staining and multiple firings on the mechanical, optical, and surface characteristics of zirconia-containing lithium silicate ceramics (ZLS). Materials and Methods: Ninety ZLS discs (Suprinity, VITA Zahnfabrick) were divided according to the “Number of firings” protocol: Ctr-control, no characterization; SC–single firing cycle (for characterization, crystallization and staining simultaneously); and DC–double firing cycle (crystallization firing cycle was performed separately from the staining firing). Extrinsic pigmentation was performed to replicate the characterization of a monolithic restoration. A layer of stain and glaze was applied with a fine brush to the ceramic surface. Specimens were fired two or four cycles, designed to simulate additional staining firings for potential characterization adjustments, but without applying new stain, resulting in six groups (n = 15): CtrII, CtrIV, SCII, SCIV, DCII, and DCIV. X-ray diffraction, color, translucency, and surface roughness analysis were also performed, and the samples were subjected to the biaxial flexural strength test. Data were subjected to one-way ANOVA, Tukey's test (α = 0.05), and Weibull analysis. Results: No changes in the diffractogram pattern were found, irrespective of the number of firings. The translucency (p = 0.02) and roughness (p < 0.01) of DCIV were significantly reduced compared to DCII. DCIV also showed the highest flexural strength (325.52AMPa), followed by SCII (271.64BMPa). Conclusions: Repeated firings increased the flexural strength of ZLS, where the double-step characterization technique demonstrated better statistical results than the other groups. Moreover, despite the ceramic showing good color stability, repeated firings significantly compromised its translucency.Department of Dentistry Centro Universitário Governador Ozanam Coelho (UNIFAGOC) Doutor Adjalme da Silva BotelhoDepartment of Dentistry Federal University of Rio Grande do Norte (UFRN) Lagoa NovaDepartment of Dental Materials and Prosthesis Institute of Science and Technology Paulista State University (UNESP), SPNational Institute of Spatial Researchs – INPE/LAS Jardim da Granja, São PauloDepartment of Restorative Dentistry Federal University of Juiz de Fora Campus UniversitárioDepartment of Dentistry Federal University of Juiz de Fora Campus Governador Valadares Rua São Paulo Centro, MGSchool of Dental Medicine Department of Preventive and Restorative Sciences University of PennsylvaniaDepartment of Dental Materials and Prosthesis Institute of Science and Technology Paulista State University (UNESP), S
Angiotensin II modulates the SARS-CoV-2 spike protein-induced Response on ACE2, AT1R, And MASR Expression and the Inflammatory response in human bronchial smooth muscle cells
No full textO SARS-CoV-2 utiliza sua proteína Spike (Sp) para se ligar à enzima conversora de angiotensina 2 (ECA2), facilitando a entrada viral nas células e desencadeando respostas inflamatórias nas vias aéreas. A ECA2 integra o sistema renina-angiotensina (SRA), que regula o equilíbrio entre as vias pró-inflamatória (ACE/Ang II/AT1R) e anti-inflamatória (ECA2/Ang-(1–7)/MASR). As células musculares lisas brônquicas (BSMCs) desempenham papel fundamental tanto na homeostase quanto na inflamação das vias aéreas. Este estudo teve como objetivo investigar os efeitos dos antagonistas do receptor AT1, losartana (LOS), e do receptor MAS, A-779, sobre a expressão de componentes do SRA e sobre a produção das citocinas pró-inflamatórias IL-1β e IL-8 em BSMCs expostas à proteína Sp ou à Ang II, e se a Ang II regula as respostas induzidas pela proteína Sp. As células foram submetidas a um protocolo experimental com diferentes concentrações de Sp (50, 100 ou 500 ng/mL) e Ang II (100 ng/mL), incluindo também grupos sensibilizados com Ang II por uma hora antes da estimulação com Sp. As análises foram realizadas após 3, 12 e 24 hs de estimulação. Para avaliar os efeitos moduladores dos receptores, realizou-se pré-tratamento com LOS e A-779 por 1h ou 2 hs antes da exposição a Sp e Ang II. Foram avaliadas a expressão gênica de ECA2, AT1R, MASR, IL-1β e IL-8 por RT-qPCR; os níveis proteicos de IL-1β e IL-8 por ELISA; a expressão proteica de ECA2 por imunofluorescência; e a viabilidade celular por ensaio de MTT. Os resultados demonstraram que tanto Sp quanto Ang II aumentaram a expressão de AT1R e MASR. O tratamento com LOS e A-779 evidenciou que a expressão desses componentes é mediada pelos receptores AT1R e MASR, sendo que a pré-sensibilização com Ang II modulou negativamente a indução desses receptores pela Sp. A expressão de ECA2 foi estimulada independentemente da ativação dos receptores, porém o bloqueio de MASR com A-779 potencializou esse efeito. Os níveis de proteína ECA2 foram aumentados pela Sp, possivelmente por via dependente do AT1R, enquanto Ang II influenciou a secreção da ECA2. Sp e Ang II, induziram a expressão e secreção de IL-1β e IL-8 nas BSMCs, com efeitos da Ang II mais evidentes após 12h. A LOS inibiu a produção das citocinas induzida por Sp, destacando o papel inflamatório da via Ang II/AT1R. Já o bloqueio de MASR com A-779 aumentou as citocinas nas primeiras horas, confirmando seu papel protetor. A pré-sensibilização com Ang II reduziu IL-1β e IL-8, modulando as respostas da Sp de forma tempo-dependente. Esses achados reforçam a participação ativa da via SRA na inflamação induzida por SARS-CoV-2 nas BSMCs das vias aéreas.SARS-CoV-2 utilizes its Spike protein (Sp) to bind to the angiotensin-converting enzyme 2 (ACE2), facilitating viral entry into host cells and triggering inflammatory responses in the airways. ACE2 is a key component of the renin-angiotensin system (RAS), which regulates the balance between the pro-inflammatory (ACE/Ang II/AT1R) and anti-inflammatory (ACE2/Ang-(1–7)/MASR) pathways. Bronchial smooth muscle cells (BSMCs) play a crucial role in both airway homeostasis and inflammation. This study aimed to investigate the effects of antagonists of the AT1 receptor, losartan (LOS), and the MAS receptor, A-779, on the expression of RAS components and on the production of the pro-inflammatory cytokines IL-1β and IL-8 in BSMCs exposed to Sp or angiotensin II (Ang II). Cells were subjected to an experimental protocol involving different concentrations of Sp (50, 100, or 500 ng/mL) and Ang II (100 ng/mL), including groups pre-sensitized with Ang II one hour prior to Sp stimulation. Analyses were performed at 3, 12, and 24 hours post-stimulation. To assess the modulatory effects of receptor antagonism, pre-treatment with LOS and A-779 was conducted for 1 and 2 hours before stimulation with Sp and Ang II. Gene expression of ACE2, AT1R, MASR, IL-1β, and IL-8 was evaluated by RT-qPCR; protein levels of IL-1β and IL-8 were measured by ELISA; ACE2 protein expression was analyzed via immunofluorescence; and cell viability was assessed using the MTT assay. The results showed that both Sp and Ang II increased the expression of AT1R and MASR. Treatment with LOS and A-779 demonstrated that the expression of these components is mediated by their respective receptors, with Ang II pre-sensitization negatively modulating the Sp-induced receptor expression. ACE2 expression was upregulated independently of receptor activation; however, MASR blockade with A-779 further enhanced this effect. ACE2 protein levels were increased by Sp, possibly through an AT1R-dependent mechanism, while Ang II modulated ACE2 secretion. Both Sp and Ang II induced the expression and secretion of IL-1β and IL-8 in BSMCs, with Ang II effects being more pronounced at 12 hours. LOS inhibited the Sp-induced production of cytokines, highlighting the pro-inflammatory role of the Ang II/AT1R pathway. In contrast, MASR blockade with A-779 elevated cytokine levels at early time points, confirming its protective role. Pre-sensitization with Ang II reduced IL-1β and IL-8 levels, modulating the effects of Sp in a time-dependent manner. These findings underscore the active participation of the RAS pathway in SARS-CoV-2-induced inflammation in the airways.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)CAPES: 001FAPESP: 2020/10711-
Interpersonal conflicts at school: dialoguing about autonomy and social-emotional competencies in physical education classes
No full textOs conflitos são inerentes ao convívio em sociedade e, no ambiente escolar, enquanto campo cotidiano de relações sociais, desempenham papel fundamental no desenvolvimento e amadurecimento dos alunos. Quando abordados de forma adequada, podem tornar-se oportunidades de aprendizado. Contudo, é evidente a falta de maturidade e autonomia para a resolução adequada dos conflitos, que frequentemente ocorre por meio de intervenções autoritárias dos docentes, dificultando abordagens assertivas que considerem os direitos, sentimentos e opiniões dos envolvidos. Diante disso, este estudo teve como objetivo promover a autonomia dos alunos na resolução de conflitos e ressignificar as competências socioemocionais para aprimorar as relações interpessoais no contexto escolar. A pesquisa foi desenvolvida com abordagem qualitativa, por meio da pesquisa-ação, envolvendo observações, questionários com as famílias e os alunos, rodas de conversa e produções de histórias em quadrinhos (HQs) como recurso educativo. Participaram da pesquisa 32 estudantes do 4º e 5º ano do ensino fundamental, com idades entre 9 e 11 anos, e seus respectivos familiares (25 mães, 4 pais e 3 avós). Os dados obtidos indicam uma tendência à adoção de estratégias de resolução de conflitos de natureza mais submissa entre os estudantes e respostas mais assertivas por parte das famílias, ainda que focadas, em sua maioria, em soluções individuais. No entanto, é necessário considerar que os questionários, sobretudo aqueles com situações hipotéticas, podem induzir a respostas direcionadas, o que limita a possibilidade de conclusões definitivas. Assim, faz-se imprescindível uma leitura crítica desses dados, reconhecendo os limites metodológicos e a complexidade que envolve o agir humano em contextos reais de conflito. As intervenções pedagógicas com base nas competências socioemocionais revelaram-se eficazes no curto e médio prazo, evidenciando a importância do diálogo, da escuta e da expressão dos sentimentos como caminhos para escolhas mais conscientes e relações mais saudáveis. Conclui-se que a Educação Física, ao articular competências socioemocionais e pedagogia crítica, pode consolidar-se como espaço fértil para a promoção da autonomia, do pensamento crítico e da resolução democrática dos conflitos, contribuindo para uma formação escolar mais humanizadora e transformadora.Conflicts are inherent to social coexistence, and within the school environment, as a daily field of social relations, they play a fundamental role in students’ development and maturation. When addressed appropriately, they can become opportunities for learning. However, there is an evident lack of maturity and autonomy in conflict resolution, which often occurs through authoritarian interventions by teachers, making it difficult to implement assertive approaches that consider the rights, feelings, and perspectives of those involved. This study aimed to promote students' autonomy in conflict resolution and to reframe socio-emotional competencies to improve interpersonal relationships within the school context. The research adopted a qualitative approach, through action research, involving observations, questionnaires with families and students, discussion circles, and the creation of comic strips (HQs) as an educational resource. The study involved a total of 32 students from 4th and 5th grades (ages 9 to 11) and their respective family members (25 mothers, 4 fathers, and 3 grandmothers). The data revealed a tendency among students to adopt more submissive conflict resolution strategies, while families provided more assertive, though predominantly individual-focused, responses. It is important to note, however, that questionnaires, especially those based on hypothetical situations, may lead to directed answers, limiting the possibility of definitive conclusions. Thus, a critical reading of the data is essential, acknowledging methodological limitations and the complexity of human behavior in real conflict contexts. The pedagogical interventions based on socio-emotional competencies proved effective in the short and medium term, highlighting the importance of dialogue, active listening, and emotional expression as pathways to more conscious decision-making and healthier relationships. It is concluded that physical education, by articulating socio-emotional competencies and critical pedagogy, can become a fertile ground for promoting autonomy, critical thinking, and the democratic resolution of conflicts, contributing to a more humanizing and transformative educational process.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Capes: 00
On the female body in Livy : female representations in book I of "Ab Urbe Condita" (1st century BC)
No full textEsta pesquisa analisa a representação do corpo feminino no primeiro livro da obra historiográfica "Ab Urbe Condita" (“Desde a fundação da cidade”), que é composta por 142 livros na sua totalidade, com apenas 35 preservados. A obra foi escrita pelo autor romano Tito Lívio no século I a.C, período marcado pelo fim da República e início do Império, com a ascensão de Augusto ao poder. O primeiro livro da obra
trata das origens de Roma e da realeza, com grande participação feminina. Compreender como as relações de gênero no mundo antigo têm sido estudadas na historiografia é um dos questionamentos de grande importância da presente pesquisa. Neste trabalho é levado em consideração a posição social do autor, pertencente a uma província romana. O livro pode ser um objeto de grande relevância nos estudos das relações sociais na Antiguidade Romana, pois apresenta indícios da visão e da interpretação do autor. São desenvolvidas discussões historiográficas a partir dos estudos de gênero, baseados em textos de Judith Butler.This research analyzes the representation of the female body in the first book of the historiographical work "Ab Urbe Condita" (“From the founding of the city”), which is composed of 142 books in total, with only 35 preserved. The work was written by the Roman author Livy in the 1st century BC. The period was marked by the end of the Republic and the beginning of the Empire, with the rise of Augustus to power.
The first book of the work deals with the origins of Rome and royalty, with great female participation. Understanding how gender relations in the Ancient World have been studied in historiography is one of the matters of great importance of this research. This work considers the social position of the author, who belonged to a Roman province. The book can be an object of great relevance in the studies of social relations in Roman Antiquity, as it presents evidence of the author's vision and interpretation. Historiographical discussions are developed based on gender studies, based on the writings of Judith Butler.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)CAPES: 001FAPESP: 2023/11533-
Long Noncoding RNAs Responding to Ethanol Stress in Yeast Seem Associated with Protein Synthesis and Membrane Integrity
No full textBackground/Objectives: Translation and the formation of membraneless organelles are linked mechanisms to promote cell stress surveillance. LncRNAs responsive to ethanol stress transcr_9136 of the SEY6210 strain and transcr_10027 of the BY4742 strain appear to act on tolerance to ethanol in these strains. Here, we investigate whether the ethanol responsiveness of transcr_9136 and transcr_10027 and their role in ethanol stress are associated with protein biogenesis and membraneless organelle assembly. Methods: SEY6210 transcr_9136∆ and BY4742 transcr_10027∆ and their wild-type counterparts were subjected to their maximum ethanol-tolerant stress. The expression of the transcr_9136, transcr_10027, ILT1, RRP1, 27S, 25S, TIR3, and FAA3 genes was accessed by qPCR. The level of DCP1a, PABP, and eIF4E proteins was evaluated by Western blotting. Bioinformatics analyses allowed us to check whether transcr_9136 may regulate the expression of RRP1 and predict the interaction between transcr_10027 and Tel1p. The cell death rate of SEY6210 strains under control and ethanol stress conditions was assessed by flow cytometry. Finally, we evaluated the total protein yield of all strains analyzed. Results: The results demonstrated that transcr_9136 of SEY6210 seems to control the expression of RRP1 and 27S rRNA and reduce the general translation. Furthermore, transcr_9136 seems to act on cell membrane integrity. Transcr_10027 of BY4742 appears to inhibit processing body formation and induce a general translation level. Conclusions: This is the first report on the effect of lncRNAs on yeast protein synthesis and new mechanisms of stress-responsive lncRNAs in yeast, with potential industrial applications such as ethanol production.Department of Bioprocess and Biotechnology School of Agriculture Sao Paulo State University (UNESP), SPLaboratory of Applied Biotechnology School of Medicine Sao Paulo State University (UNESP), SPDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP), SPDepartment of Bioprocess and Biotechnology School of Agriculture Sao Paulo State University (UNESP), SPLaboratory of Applied Biotechnology School of Medicine Sao Paulo State University (UNESP), SPDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP), S
Strengthening of Ti[sbnd]Nb alloys surfaces by plasma nitriding
No full textTiNb-based alloys are needed as mechanically biocompatible materials, despite having low wear resistance. This topic, not yet well-researched, is being addressed here. Titanium‑niobium alloys with 10, 25 and 35 Nb wt% were DC plasma nitrided at temperatures 600–900 °C. Originally, they featured distinct balances of α, β and α” phases. To probe the heating effects on the bulks, the alloys were thermally treated (TT) at the same nitriding temperatures. They disclose a strong structural and microstructural dependence with the nitriding temperatures and niobium fractions, which intricately rule the mechanical properties of both bulks and layer/substrate systems. The nitriding produces ∼1 μm thick nitride layers (TiN, Ti2N) at top surfaces, with high hardness (H) and elastic modulus (E). Beneath lie β-rich regions, spread over 20–50 μm thick layers, with embedded αN precipitates whose size vary inversely with the Nb wt% and heating conditions. These layers formation involve a competing effect between N and Nb, which are α and β stabilizers, respectively. The nitrided Ti10Nb present the highest variations compared to TT substrates: H ∼ 16 GPa (4.7×) and E ∼ 230 GPa (91 %). The H/E ratio, an indicative of tribological resistance, increases in all the nitrided surfaces, while it diminishes in the TT bulks. The overall conclusion is that parameters must be carefully chosen for each Ti[sbnd]Nb composition. However, under the requirements of low-modulus bulks and wear protective cases for use in bone prostheses, plasma nitridings must be carried out at temperatures near Tβ. The Ti25Nb nitrided at 700 °C meets these criteria best.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Financiadora de Estudos e ProjetosConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Physics Universidade Estadual de Ponta Grossa, PRDepartment of Physics and Meteorology UNESP - Universidade Estadual Paulista, SPDepartment of Physics and Meteorology UNESP - Universidade Estadual Paulista, SPCAPES: 001Financiadora de Estudos e Projetos: 0122/21CNPq: 306779/2021-8CNPq: 314.810/2021-8CNPq: 421.677/2023-
A Novel Machine Learning-based Predictive Model of Clinically Significant Prostate Cancer and Online Risk Calculator
No full textObjective: To create a machine-learning predictive model combining prostate imaging-reporting and data system (PI-RADS) score, PSA density, and clinical variables to predict clinically significant prostate cancer (csPCa). Methods: We evaluated a cohort of patients who underwent prostate biopsy for suspected prostate cancer (PCa) in New Zealand, Australia, and Switzerland. We collected data on age, body mass index (BMI), PSA level, prostate volume, PSA density (PSAD), PI-RADS scores, previous biopsy, and corresponding histology results. The dataset was divided into derivation (training) and validation (test) sets using random splits. An independent dataset was obtained from the Harvard Dataverse for external validation. A cohort of 1272 patients was analyzed. We fitted a Lasso model, XGBoost, and LightGBM to the training set and assessed their accuracy. Results: All models demonstrated ROC-AUC values ranging from 0.830 to 0.851. LightGBM was considered the superior model, with an ROC of 0.851 (95%CI: 0.804-0.897) in the test set and 0.818 (95% CI: 0.798-0.831) in the external dataset. The most important variable was PI-RADS, followed by PSA density, history of previous biopsy, age, and BMI. Conclusion: We developed a predictive model for detecting csPCa that exhibited a high ROC-AUC value for internal and external validations. This suggests that the integration of the clinical parameters outperformed each individual predictor. Additionally, the model demonstrated good calibration metrics, indicative of a more balanced model than the existing models.Tauranga Public Hospital, Bay of PlentyUniversity of AucklandUrology Department UNESP São Paulo State University, SPCollege of Medicine and Public Health Flinders UniversityDepartment of Urology University Hospital of ZurichDepartment of Urology Icahn School of Medicine at Mount SinaiDepartment of Internal Medicine UNESP São Paulo State University, SPUrology Department UNESP São Paulo State University, SPDepartment of Internal Medicine UNESP São Paulo State University, S
Marine Mycosilver Nanoparticles: Screening, Evaluation of Their Antimicrobial Properties, and Synthesis Optimization
No full textTwelve marine-derived fungal strains were evaluated for their ability to synthesize silver nanoparticles (AgNPs). Mycogenic AgNPs were preliminarily characterized using different techniques, and their antimicrobial activities were assessed. Penicillium citrinum IBCLP11 and Aspergillus niger IBCLP20 were selected for AgNPs’ synthesis optimization by varying parameters such as AgNO3 concentration, biomass, agitation, temperature, and pH. AgNPIBCLP11 and AgNPIBCLP20 were able to inhibit the growth of Pseudomonas aeruginosa IPT322, Staphylococcus aureus IPT246, and Klebsiella pneumoniae IPT412 at concentrations of 25 μg/mL or higher. Aspergillus niger IPT295 and Aspergillus parasiticus IPT729 were the most sensitive to AgNPIBCLP20. Further studies are needed to fully elucidate the effects of all parameters influencing mycogenic AgNPs synthesis. However, it is evident that maintaining optimal conditions, such as temperature and pH during agitation, is crucial for preventing undesirable reactions and ensuring nanoparticle stability.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Institute of Biosciences São Paulo State University (UNESP), São Vicente, SPInstitute of Advanced Studies on Ocean São Paulo State University (UNESP), São Vicente, SPBionanomanufacturing Center Technological Research Institute, São Vicente, SPState Key Laboratory of Lunar and Planetary Sciences (SKLPlanets) Macau University of Science and Technology (MUST)China National Space Administration Macau Center for Space Exploration and Science Macau SARLEAF-Linking Landscape Environment Agriculture and Food Research Center Associated Laboratory TERRA Instituto Superior de Agronomia Universidade de LisboaInstitute of Biosciences São Paulo State University (UNESP), São Vicente, SPInstitute of Advanced Studies on Ocean São Paulo State University (UNESP), São Vicente, SPFAPESP: #22/03562-9FAPESP: #22/05716-3FAPESP: #23/08202-3CAPES: #88882.469336/2019-01CAPES: #88887.822485/2023-0
Exploring Sustainable Urban Planning: A Global Analysis with a Focus on Brazil
No full textRapid global urbanisation is driving the planning of sustainable cities, where more than half of the world’s population already resides in urban areas, with projections indicating that two-thirds will be living in these areas by 2050. This interdisciplinary study adheres to the principles of the circular economy, industrial symbiosis, and urban metabolism. A systematic literature review reveals a growing concern with sustainable practices in urban areas, highlighting their importance for collaboration and the matching of waste and resources. However, there is a significant gap in case studies or analyses in Brazil. Given the numerous technology parks within Brazilian territory, industrial symbiosis emerges as a key strategy to integrate industries into the urban environment, promoting waste reduction and fostering economic circularity, both globally and locally.Faculty of Engineering UNESP—São Paulo State UniversityUFSCar—Federal University of São Carlos Lagoa Dos SinosFaculty of Engineering UNESP—São Paulo State Universit