Sivas Cumhuriyet Üniversitesi Kurumsal Akademik Arşivi - Sivas Cumhuriyet University Open Access System
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Relationship of Plasma Cell Infiltration Rates with 18F-FDG PET/CT Data and Hematological Parameters in Multiple Myeloma
No full textObjectives: This study aimed to evaluate the relationship between the degree of bone marrow involvement, hematological parameters, and 18F-fluorodeoxyglucose (18F-FDG)-positron emission tomography/computed tomography (PET/CT) data in patients diagnosed with multiple Methods: A total of 71 patients [19 females, 52 males, mean age 67 (36-83) years] who were diagnosed with multiple myeloma between 2014 and 2021, had not received any treatment yet, and underwent 18F-FDG-PET/CT for staging were included in the study. Results: No significant correlation was observed between bone marrow standardized uptake value (SUV)max and plasma cell infiltration (p=0.07). However, we found that patients with visually increased bone marrow counts also had higher plasma cell infiltration rates (p=0.037). No significant correlation was found between plasma cell infiltration rates and bone marrow SUVmax and systemic inflammatory index (SII) (p=0.187 and p=0.446, respectively). However, there was a significant correlation between the SUVmax of lytic lesions showing increased 18F-FDG uptake in bone and SII (p=0.025, r=0.330). Conclusion: We believe that 18F-FDG PET/CT may be an advantage over bone marrow biopsy in the diagnosis and evaluation of multiple myeloma recurrence and may prevent repeated bone marrow biopsies
Transforming waste polyethylene terephthalate (PET) into high-performance activated carbon-supported composites for pollutant degradation: A synergy of experiments and DFT insights
No full textTo date, the global demand for clean water and environmentally detrimental human activities are among the most significant challenges humans face. Therefore, an urgent need is to innovate and implement more effective, sustainable solutions to protect the environment and preserve our vital water resources. In particular, this study successfully developed a new and suitable nanocomposite catalyst from waste polyethylene terephthalate (PET) plastics-derived activated carbon (P-AC) and applied it for the enhanced photo-degradation of tetracycline (TCHCl). Based on the characterizations and density functional theory (DFT) calculations, we suggest that the synergistic effect of adsorption and photocatalysis by synthesizing oxygen vacancy-rich Bi4O5Br2 (BOB) and Co3(PO4)2 (COP) immobilized on P-AC play a critical role in enhancing effectively further the degradation efficiency. Interestingly, the proposed S-scheme charge transfer mechanism demonstrated an impressive TC-HCl degradation efficiency of 90.7 % within 90 min under light irradiation. It notes that the degradation mechanism involved the pre-adsorption of TC-HCl onto the surface of functional group-rich activated carbon, which assisted in hastening the attack of O2 center dot- and h+. Nine primary intermediates were identified, framing three degradation pathways for TC-HCl as per liquid chromatography - mass spectrometry (LC-MS). Lastly, results of consecutive quadruplicate degradation experiments advocated the stability and reusability of the nanocomposite, highlighting the potential of upcycling plastic waste into valuable photocatalytic materials support, offering an effective and environmentally friendly solution for removing priority pollutants from water.King Saud University, Riyadh, Saudi Arabia [RSP2025R6]The author (T. A.) thanks the Researchers Supporting Project number (RSP2025R6) , King Saud University, Riyadh, Saudi Arabia
A Deep Learning-Based Approach to Detect Lamina Dura Loss on Periapical Radiographs
No full textThis study aimed to develop a custom artificial intelligence (AI) model for detecting lamina dura (LD) loss around the roots of anterior and posterior teeth on intraoral periapical radiographs. A total of 701 periapical radiographs of the anterior and posterior regions retrieved from the Dentomaxillofacial Radiology archives were reviewed. Images were cropped to include only the teeth exhibiting LD loss and those without LD loss, which were labeled as 1 and 0, respectively. The dataset was diversified using image preprocessing and data augmentation techniques. Among the radiographs, 72% were used for training, 18% for validation, and 10% for testing. A custom AI model, consisting of 4 blocks and 49 layers, with a total of 21.2 million parameters, was developed using the TensorFlow library and residual blocks introduced in ResNet architecture. Sensitivity, specificity, accuracy, precision, F1 score, and kappa (kappa) coefficients (for intra-observer agreement) were calculated to evaluate the performance of the AI model. When applied to a test set of 71 images, the AI model showed good performance in detecting LD loss, achieving an average sensitivity of 0.730, specificity of 0.706, accuracy of 0.718, precision of 0.730, and an F1 score of 0.730, regardless of the dental region. This study represents the first known application of an AI algorithm tailored to detect LD loss on periapical radiographs. The developed AI model could aid clinicians in making accurate diagnosis and help prevent misdiagnosis
Çermik culture in Sivas
No full textHer birey dünyaya geldiği toplumun kültürel kodlarıyla büyür ve bu kodların bir sonraki nesle aktarılmasında bilerek ya da bilmeyerek rol oynar. Bu aktarımda her ne kadar değişiklikler meydana gelse de özünde, ortaya çıkan kültürü devam ettirme gayreti vardır. Her neslin, kendi doğduğu dönemin getirileriyle harmanlayarak ortaya koyduğu kültür ve bu kültür içerisinde ortaya çıkan ananeler, bir toplumu diğer toplumlardan ayıran en önemli unsurlardandır. Bu sebeple bir toplumun, kendi örf, adet, gelenek, görenek ve inançlarına yozlaşmadan, ona, yeni anlam ve değerler katarak devam ettirebilmesi durumunda kültür, bir toplumu tamamlayan ve o toplumun özünü koruyan bir kavram olarak karşımıza çıkmaya devam edecektir. Bu çalışmada da bir kültür haline gelmiş olan çermik ve çermik fonksiyonu gösteren şifalı su ziyaretleri ve bu ziyaretlerde ortaya çıkan bir takım folklorik unsurlar incelenerek, kaynak kişilerle yapılan görüşmeler sonucu değerlendirilmeye çalışılmıştır. Değerlendirmeler sonucunda ise bu kültür içerisinde folklorik unsurların ortaya çıktığı, ayrıca çermik kültürünün, bir takım değişikliklere uğrayarak halk tarafından hâlâ devam ettirildiği tespit edilmiştir.Every individual grows up with the cultural codes of the society in which he/she was born and knowingly or unknowingly plays a role in the transfer of these codes to the next generation. Although changes occur in this transmission, at its core there is an effort to continue the culture that has emerged. The culture that each generation creates by blending the results of the period in which they were born and the traditions that emerged within this culture are among the most important elements that distinguish a society from other societies. For this reason, a society has its own customs, traditions, customs and without corrupting their beliefs, giving it new meaning and culture is a complement to a society if it can continue to add values and will continue to appear as a concept that protects the essence of that society. In this study, the hot spring has become a culture and visits to healing waters that function as spas As a result of the evaluations, it was determined that folkloric elements emerged within this culture and that the spa culture, although undergoing some changes, was still continued by the people
The relationship between financial development and openness: An empirical examination in Türkiye
No full textFinansal gelişmişlik, sadece daha geniş finansman seçenekleri ve daha etkin risk yönetimi sunmakla kalmamakta, aynı zamanda ekonomik kaynakların daha verimli kullanılmasını ve böylece genel ekonomik verimliliği artırmayı da mümkün kılmaktadır. Uluslararası ticaret ve yatırımlar açısından bakıldığında, gelişmiş finansal sistemler, ülkelerin ve firmaların dış pazarlara açılmasına ve bu pazarlarda etkin bir şekilde rekabet etmesine olanak tanır. Bu rekabet, özellikle sermaye yoğun sektörlerde, daha yenilikçi ve teknoloji odaklı yatırımların önünü açar. Özellikle Türkiye gibi gelişmekte olan ülkelerde finansal gelişmişlik, küresel ekonomiye entegrasyon sürecinde kritik bir rol oynamaktadır. Bu çalışmada finansal gelişmişliğin, uluslararası piyasalarda rekabet eden firmalara sermaye desteği sağlayacağı ve bu yolla ülkelerin küresel ekonomiye entegrasyonunun artacağı hipotezi ile, Türkiye'de finansal gelişmişlik ve dışa açıklık arasındaki ilişki incelenmiştir. Çalışmada kullanılan veriler Uluslararası Para Fonu (IMF) veritabanından alınmıştır ve analiz dönemi 1985 ile 2021 yılları arasını kapsamaktadır. ARDL (Autoregressive Distributed Lag) modeli kullanılarak yapılan analizde, finansal kurumların ve pazarların erişimi ve derinliğini ifade eden endekslerin dışa açıklık üzerindeki etkisi değerlendirilmiştir. Analiz sonuçlarına göre, uzun dönemde finansal kurumlara ve pazarlara erişimin dışa açıklık üzerinde pozitif ve anlamlı bir etkisi olduğu görülmüş, finansal pazarların derinliğinin ise dışa açıklığı azaltıcı bir etki gösterdiği tespit edilmiştir.Financial development not only provides wider financing options and more effective risk management, but also enables more efficient use of economic resources and thus increases overall economic efficiency. In terms of international trade and investments, advanced financial systems allow countries and firms to open up to foreign markets and compete effectively in these markets. This competition paves the way for more innovative and technology-focused investments, especially in capital-intensive sectors. Especially in developing countries like Turkey, financial development plays a critical role in the integration process with the global economy. In this study, the relationship between financial development and openness in Turkey was examined with the hypothesis that financial development will provide capital support to firms competing in international markets and thus increase the integration of countries into the global economy. The data used in the study were taken from the International Monetary Fund (IMF) database and the analysis period covers the years between 1985 and 2021. In the analysis conducted using the ARDL model, the effect of financial development indicators on openness was evaluated. The analysis results show that access to financial institutions and access to financial markets have a positive and significant effect on openness in the long run. On the other hand, it is found that the depth of financial markets reduces openness in the long run. The depth of financial institutions does not have a significant effect on openness in the long run
MUTLU GEZEGEN ARAYIŞLARI: G-20 ÜLKELERİNDEN KANITLAR
No full textThe Happy Planet Index (HPI), first introduced by the New Economics Foundation (NEF) in 2006, is a sustainable well-being indicator that evaluates how efficiently countries utilize their limited environmental resources to provide long and happy lives for their citizens. HPI integrates three key components—life satisfaction, life expectancy at birth, and ecological footprint—to calculate the amount of 'happy life years' a country generates per unit of natural resources. This unique approach distinguishes HPI from other well-being or sustainability indices. The components of the HPI include life expectancy at birth, average subjective life satisfaction, and per capita ecological footprint. The Group of Twenty (G-20), which includes Turkey among its 19 member countries along with the European Union Commission, was established in 1999 to promote stability and sustainable growth in the global economy. It aims to coordinate policies among its members, act collectively to mitigate financial crisis risks, and develop a new international financial architecture. The aim of this study is to empirically analyze the relationships between under-5 child mortality rate, crude death rate, GDP per capita, unemployment rate, per capita carbon dioxide emissions, and Happy Planet Index scores, using a cross-sectional dataset covering the years 2006, 2009, 2012, 2016, 2019, and 2021, with a specific focus on G-20 countries. Within this context, when the results of six models, created separately for each year, are evaluated overall, it is observed that crude death rate, child mortality rate, and carbon emissions have a significant impact on the Happy Planet Index. On the other hand, unemployment rate and GDP per capita exhibit a relatively weaker influence on the index.Yeni Ekonomi Vakfı (NEF) tarafından ilk olarak 2006 yılında hazırlanan Mutlu Gezegen Endeksi (MGE), ülkelerin sınırlı çevresel kaynaklarını kullanarak vatandaşlarına ne kadar verimli bir şekilde uzun ve mutlu bir yaşam sunduklarını değerlendiren bir sürdürülebilir refah ölçütüdür. MGE; yaşam memnuniyeti, beklenen yaşam süresi ve ekolojik ayak izi gibi üç temel faktörü bir araya getirerek, bir ülkenin her bir doğal kaynak birimi başına ne kadar 'mutlu yaşam yılı' ürettiğini ortaya koymaktadır. Bu yaklaşım, MGE’'ni diğer refah veya sürdürülebilirlik endekslerinden ayıran önemli bir özelliktir. MGE’nin bileşenleri; doğumda beklenen yaşam süresi, ortalama öznel yaşam memnuniyeti ve kişi başına düşen ekolojik ayak izidir. Türkiye’nin de dâhil olduğu 19 ülke ve Avrupa Birliği Komisyonu küresel ekonomide istikrar ve sürdürülebilir büyümeyi sağlamak amacıyla; üyeleri arasında politika koordinasyonunu sağlamak, finansal kriz risklerine karşı birlikte hareket etmek ve yeni bir uluslararası finansal mimari oluşturmak üzere 1999 yılında bir araya gelerek Yirmiler Grubu (G-20)’nu oluşturmuştur. Bu çalışmanın amacı, 2006, 2009, 2012, 2016, 2019 ve 2021 yıllarını kapsayan kesit veri setini kullanarak, G-20 ülkeleri özelinde 5 yaş altı çocuk ölüm hızı, kaba ölüm oranı, kişi başına düşen GSYİH, işsizlik oranı, kişi başına karbondioksit emisyonu/salınımı ile Mutlu Gezegen Endeksi skorları arasındaki ilişkileri ampirik olarak analiz etmektir. Bu bağlamda çalışma sonucunda her yıl için ayrı oluşturulan altı model sonuçları genel olarak değerlendirildiğinde kaba ölüm oranı, çocuk ölüm oranı ve karbon salınımı değişkenlerinin mutlu gezegen endeksi üzerinde etkisinin yüksek olduğu görülmüştür. Öte yandan işsizlik oranı ve GSYİH değişkenlerine ise daha zayıf etki gücüne sahip olduğu sonucuna ulaşılmıştır
Experiences of migrant seasonal agricultural worker mothers in earthquakes: A phenomenological study
No full textObjective: Seasonal agricultural migration leads to both economic hardship and humanitarian challenges. Individuals involved in this migration face severe poverty and deprivation, with mothers critical participants in agrarian work, being especially vulnerable due to challenging conditions and family responsibilities. This study explores the experiences of migratory seasonal agricultural worker mothers and their children, particularly how the earthquake in Turkey impacted them on February 6, 2023.Method: This descriptive phenomenological study was conducted with seasonal agricultural worker mothers who participated in hazelnut harvest in northern Turkey between August and September 2023. Study data were obtained from 22 mothers who agreed to participate. Data were analyzed using the MAXQDA 2022 qualitative data analysis program.Results: It has been determined that the earthquake affects both mothers and children, creates confusion in mothers, creates fear, anxiety, and insecurity in children, and causes behavioral problems such as insomnia and loss of appetite. It has also been determined that positive changes occur in mothers' parenting practices and strengthen family ties. It has been revealed that mothers derive their psychological resilience from their belief systems and social interactions.Conclusions: It was concluded that earthquake experiences positively and negatively affected migratory seasonal agricultural worker mothers and caused emotional and behavioral problems in children
Comparison of Invasive Ductolobular Carcinoma and Lobular Carcinoma: An Observational Study
No full textBackground and Objectives: Mixed ductolobular carcinomas (mDLCs) are tumors that contain both ductal and lobular components. The clinicopathological characteristics and impacts on survival of the two components, which have distinct biological behaviors, are still not clearly understood. This study aimed to compare the clinicopathological characteristics, recurrence/metastasis patterns, and survival outcomes of mDLC and invasive lobular carcinoma (ILC), as well as to investigate the prognostic significance of both histopathologies. Materials and Methods: The outcomes of 132 patients who were followed and treated between 2010 and 2021 were analyzed. Patients were examined in two groups, ILC and mDLC. Chi-square tests were performed to compare the baseline clinicopathological characteristics and treatments. Survival rates were subsequently analyzed using the Kaplan-Meier method and compared using the Cox proportional hazards model. Results: In this study, 80 (61%) patients had ILC histopathology, while 52 (39%) had mDLC histopathology. Differences between the groups were observed in median age (p = 0.038), N stage (p = 0.046), estrogen receptor (ER) status (p = 0.005), lymphovascular invasion (p = 0.007), median tumor diameter (p = 0.050), and frequency of distant metastasis (p = 0.029). The treatments, relapse patterns, and metastasis patterns were similar (p > 0.05). No differences in overall survival (OS) and disease-free survival (DFS) were observed. In the multivariate analysis, mDLC histopathology was identified as a poor prognostic factor (HR: 2.95, CI 95%: 1.10-7.88, p = 0.030). Histopathology (ILC vs. mDCL) was not identified as a prognostic factor in the Cox regression analysis for DFS. Conclusion: Although mDLC has poor clinicopathological features (younger age, more advanced N stage, more ER negativity, more lymphovascular invasion, and more frequency of metastases) and appears more aggressive than ILC, these changes do not affect survival in this study. However, mDLC histopathology seems to be associated with poor prognosis for OS
MİLLİ MÜCADELE DÖNEMİNDE ORDU’DA BİR GENÇLİK CEMİYETİ: İNKILÂB-I İÇTİMAİ KULÜBÜ
No full textThe first attempts at community and national organization in the Ottoman Empire took place among minority elements in the early 19th century. The idea of nationalism spread by the French Revolution was undoubtedly influential in this. Statesmen who embraced the idea of Ottomanism against the separatist activities of minorities tried to keep nationalist ideas under control until the Second Constitutional Era. With the collapse of the policy of Ottomanism and the beginning of the independence of minority elements, the idea of Turkism, which began to sprout in Anatolia after the Second Constitutional Era, came to the fore. The events that developed after World War I and the occupation of Anatolia by the Allied Powers brought about the National Struggle, and national youth organizations were organized in different regions of Anatolia in order to support the National Struggle. In this context, the İnkılâb-ı İçtimaî Club, which is the subject of our study, was founded in Ordu in 1919. The club, which was established to support the National Struggle, was founded by the owner of Güneş newspaper and teacher İsmail Hakkı Bey. İsmail Hakkı Bey made the youth of Ordu aware of the separatist activities of the Pontic gangs and organized them against these activities. The purpose of the club was to raise awareness of the people and unite them around national feelings.Osmanlı Devleti’nde ilk cemiyetçilik ve milli örgütlenme girişimleri 19. yüzyılın başlarında azınlık unsurlar arasında cereyan etmiştir. Bunda hiç şüphesiz Fransız İhtilali’nin yaydığı milliyetçilik fikri etkili olmuştur. Azınlıkların bölücü faaliyetlerine karşı Osmanlıcılık fikrine sarılan devlet adamları II. Meşrutiyet dönemine kadar ulusçu fikirleri kontrol altında tutmaya çalışmıştır. Osmanlıcılık politikasının çökmesi ve azınlık unsurlarının bağımsızlıklarını kazanmaya başlamaları ile II. Meşrutiyet sonrası Anadolu’da filizlenmeye başlayan Türkçülük fikri ön plana çıkmıştır. I. Dünya Savaşı sonrası gelişen olaylar ve Anadolu’nun İtilaf Devletlerince işgali Milli Mücadeleyi ortaya çıkarmış ve Milli Mücadeleye destek olmak amacıyla Anadolu’nun farklı bölgelerinde milli gençlik örgütleri teşkilatlanmıştır. Bu bağlamda çalışmamıza konu olan İnkılâb-ı İçtimaî Kulübü 1919 yılında Ordu’da kurulmuştur. Milli Mücadeleye destek amacıyla kurulan kulüp, Güneş gazetesi sahibi ve öğretmen İsmail Hakkı Bey tarafından kurulmuştur. İsmail Hakkı Bey, Pontusçu çetelerin ayrılıkçı faaliyetlerine karşı Ordu’lu gençleri bilinçlendirmiş ve bu faaliyetlere karşı gençleri örgütlemiştir. Kulübün kuruluş amacı halkı bilinçlendirmek ve milli duygular çevresinde birleştirmek olmuştur
Bilim sanat merkezlerindeki özel yetenekli öğrencilerin müzik alanını seçmelerinde ailelerinin etkisi
No full textThis study aims to explore the musical backgrounds of families with students identified as musically gifted at Science and Art Centers (BİLSEM) and to understand how familial factors shape these musical talents. Grounded in Bronfenbrenner’s ecological systems theory, the research emphasizes the critical role families play in their children’s emotional, social, and cognitive development. The study considers parents, as the primary micro-environment, to determine the impact of family experiences on the musical talent development of gifted students. Conducted using qualitative research methods, data were collected through semi-structured interviews. The study group was selected using typical case sampling and comprised families of musically gifted students identified at BİLSEM schools in Ankara. Parents’ musical backgrounds, in-home musical activities, and the educational opportunities they provide significantly influence the depth of their children’s engagement with music. The data collected from interviews conducted with 20 families were analyzed using the content analysis method. By examining participants’ demographic characteristics and experiences in music education, the study scrutinizes families’ musical histories. Findings reveal the significant contributions of families to the development of musical talent, the frequency and diversity of in-home music activities, the types of musical support provided by families, and how children develop their musical abilities through these supports. Families’ attitudes toward their children’s music education, their participation in music-related activities, and the opportunities they offer play a decisive role in the development of musical abilities. Consequently, the study underscores the need to develop strategies that enhance family involvement, providing valuable insights for researchers, educators, and policymakers in the field of music education. This research offers important findings on how music education interacts with family dynamics. © 2025 The Author(s)