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New Wrapping Biomaterial Alternatives for Fascia in Diced Cartilage Grafts: A Comparative Study on Viability and Stability
No full textObjective The aim of this in vivo study is to compare cartilage viability within diced cartilage grafts from the perspective of three wrapping biomaterials Group A acellular dermal matrix (FlexHD (R)), Group T bovine pericardium (Tutopatch (R)), and Group F allogeneic human fascia for a possible implementation in the clinical use. Materials and Methods This in vivo study was conducted on 5 SCID (Severe Combined Immunodeficiency)/Gamma Mice with a duration of eight weeks. The cartilage within composite grafts were obtained from the remaining cartilage following secondary rhinoplasty performed on a single donor. Diced cartilage grafts were wrapped separately with acellular dermal matrix (ADM), bovine pericardium, and fascia to form three groups. A total of five mice were utilized in all three experimental groups, with a total of 15 experimental materials being examined. One composite graft from each group was implanted into the backs of the mice. The effects of the biomaterials on the viability and stability of the composite grafts were evaluated. Viability was evaluated through LIVE/DEAD cell analysis and histopathological examinations. Stability was assessed by comparing weight and volume changes of the grafts, measured using a precision balance and computed tomography, respectively. Results A significant increase in weight was found in the fascia group after implantation (p 0.05). A significant increase in volume was found in the ADM (Group A) group after implantation (p < 0.05). Flow cytometry showed the highest cartilage viability percentage in the fascia (Group F) and the lowest in the ADM (Group A). No significant difference was found in viability percentages between the groups. Histopathological examinations supported the flow cytometry findings. Conclusion Our study revealed that cartilage grafts wrapped in allogenic fascia (Group F) showed better viability and stability compared with ADM (Group A) and bovine pericardium (Group T). This suggests that while fascia may remain the gold standard, alternative biomaterials also hold potential. Further experimental and clinical studies with larger sample sizes are needed to support these findings
Panoptic Control and Surveillance Applications During the Covid-19 Pandemic Process
No full textYer küremiz resmi kayıtlara göre yaklaşık 3 yıldan fazla süren bir pandemi süreci yaşadı. Dünya Sağlık Örgütü (DSÖ)’nün verilerine göre 704.753.890 insan Covid-19 virüsüne yakalandı ve bunların 7.010.681’i virüsten veya virüsün neden olduğu semptomlardan dolayı yaşamı yitirdi. Covid-19 virüsünün hızla yayılması ve bulaşma yollarının çeşitliliği nedeniyle dünya genelinde birçok ülke, çeşitli tedbirler alınmıştır. Bunlardan bazıları maske zorunluluğu, sokağa çıkma kısıtlamaları, karantinalar, seyahat yasakları, sosyal mesafe kuralları ve hatta teknolojik takip sistemleri gibi uygulamalardır. Dünyanın birçok ülkesinde alınan karar/uygulamalar bir yandan da özgürlük ve gözetleme tartışmalarını gündeme getirmiştir. Alınan önlemler bireyler açısından özgürlüklerin kısıtlanması, askıya alınması anlamına gelmektedir. Bu tartışmalar 11 Eylül 2001 İkiz kulelere saldırı sonrasında alınmak istenen önlemlerle birlikte tartışmalar dünya gündemine yoğun olarak girmişti. Covid 19 pandemisinde de benzer tartışmalar “özgürlük-denetim” paradoksu ekseninde yapıldı. Küresel güç odaklarının yeni bir toplumsal denetleme mekanizmasının provasını yaptığı (!), gelecekte toplumların nasıl kontrol edilebileceği ile ilgili güvenlik testlerinin uygulandığı (!), siyasal mekanizmanın Covid-19 gerekçesiyle dünyanın otoriter eğilimlere kaymasının ön hazırlıklarını yaptığı (!), bu yolla dünyanın bazı bölgelerinde gözetleme, denetleme, takip etme, arşivleme gibi yol ve yöntemlerle küresel bir panoptikon sürecine girdiği (!) yönünde tartışma ve sorgulamalar entelektüel çevrelerinde yoğun olarak yapılmaktadır. Bu çalışmada pandemi sonrası toplumsal-siyasal düzen içinde iktidarların toplumu gözetleme ve denetim altına alması hakkında izledikleri politikalar incelenecek, teorik bağlamda tartışılacak ve sadece siyasal alandaki uygulamalarla sınırlı tutulacaktır.According to official records, our planet experienced a pandemic process lasting more than 3 years. According to data from the World Health Organization (WHO), 704,753,890 people contracted the Covid-19 virus, and 7,010,681 of them lost their lives. Due to the rapid spread of the COVID-19 virus and its many transmission methods, many governments have implemented mask-wearing, curfews, quarantines, travel bans, social distance, and technology tracking systems. Many nations’ policies have raised questions about freedom and surveillance. The measures restrict or suspend individual freedoms. These talks and the proposed responses to the September 11, 2001, Twin Tower attacks dominated the global agenda. Similar arguments about the ‘freedom-control’ dichotomy occurred during COVID-19 epidemic. In intellectual circles, there is intense debate and questioning regarding the following claims: that global power centres have rehearsed a new social surveillance mechanism (!), that security tests on how societies can be controlled in the future have been conducted (!), that the political mechanism has laid the groundwork for the world to shift toward authoritarian tendencies under the pretext of Covid-19 (!), and that, through these means, certain regions of the world have entered a global panopticon process involving methods such as surveillance, monitoring, tracking, and archiving (!). In this study, the policies pursued by governments in surveilling and controlling society within the post-pandemic socio-political order will be examined, discussed theoretically, and limited only applications in the political sphere
Graphene nanoplatelets inclusion effects on mechanical properties of the hybrid kevlar/basalt fiber reinforced epoxy composites
No full textThis study experimentally examined the effects of hybridizing Basalt and Kevlar fi bers on the tensile, and fl exural performance of composite materials with the inclusion of Graphene nanoplatelets ( GnPs ) . Various hybrid composites were fabricated, incorporating Basalt and Kevlar fi ber composites with 1, 3, and 5 wt% of GnPs as well as without GnPs, as well as hybrid composites featuring different weight content of GnPs reinforcing with with Basalt and Kevlar fi bers. The fi ndings of this study indicated that the mechanical properties of epoxy resin were significantly enhanced through the synergistic effects of hybridization with basalt and Kevlar fi bers, as well as the incorporation of graphene nanoplatelets ( GnPs ) . The significant increasing in mechanical properties was attributed to the strong interfacial interactions between the epoxy matrix and GnPs nanoparticles, which facilitate improved stress transfer from the fi bers and nanoparticles to the matrix. This enhanced stress transfer capability accounts for the superior resistance to fi ber pullout observed in composites reinforced with GnPs compared to those without nanoparticles
Performance Evaluation of G7 Countries in Terms of Patent Applications
No full textPatent, bir patent otoritesi tarafından verilen ve buluş sahibine veya devralana belirli bir süre için bir buluşu üretmek, kullanmak, satmak ve dağıtmak için münhasır haklar veren yasal bir haktır. Patent edinimi, buluşların korunması, rekabet gücünün artırılması, yatırımcıların çekilmesi, gelir elde edilmesi, inovasyonun desteklenmesi, pazarın genişletilmesi ve patente sahip olan kişi veya kuruluş için marka itibarının iyileştirilmesi ile ilgili çok sayıda avantaj sunmaktadır. Patent kavramının önemi göz önünde bulundurularak, bu araştırmada G7 ülkelerinin patent alımı konusundaki performansı bir çok kriterli karar verme (ÇKKV) problemi olarak ele alınmıştır. 2000-2020 yılları arasında dokuz farklı teknolojik alanda yapılan toplam patent başvuru sayısı üzerinden yapılan değerlendirmede kriter ağırlıkları MAXimum of Criterion (MaxC), Modified Preference Selection Index (MPSI) ve LOgarithmic Percentage Change-driven Objective Weighting (LOPCOW) yöntemleri ile belirlenmiştir. Bonferroni Mean Operator ile birleştirilen bu kriter ağırlıkları kullanılarak, G7 ülkelerinin patent alımı açısından performans sıralaması için MUltiple-TRIangles ScenarioS (MUTRISS) yöntemi kullanılmıştır. Çalışma sonucunda G7 ülkelerinin patent başvuruları açısından başarı sıralaması ABD, Japonya, Almanya, İngiltere, Fransa, Kanada ve İtalya olarak belirlenmiştir.A patent is a legal right granted by a patent authority that gives the inventor or assignee exclusive rights to produce, use, sell and distribute an invention for a specified period of time. Patent acquisition offers numerous advantages related to the protection of inventions, enhancement of competitiveness, attraction of investors, generation of income, support for innovation, market expansion, and improvement of brand reputation for the individual or entity that holds the patent. Given the significance of the patent concept, the performance of the G7 countries regarding patent acquisition is handled as multi-criteria decision-making (MCDM) problem in this research. In the evaluation made over the total number of patent applications submitted over nine different technological domains between 2000-2020, the criteria weights were determined by MAXimum of Criterion (MaxC), Modified Preference Selection Index (MPSI) and LOgarithmic Percentage Change-driven Objective Weighting (LOPCOW) methods. By using these criteria weights which are combined with the Bonferroni Mean Operator, the MUltiple-TRIangles ScenarioS (MUTRISS) method was utilised for the performance rankings of G7 countries in terms of patent acquisition. As a result of the study, the success ranking of G7 countries in terms of patent applications was determined as USA, Japan, Germany, UK, France, Canada and Italy
Probing anomalous Zγγγ couplings at a future muon collider
No full textThe sensitivity to anomalous quartic gauge couplings (AQGCs) of the gamma gamma gamma Z interaction is studied in the mu(+)mu(-) -> mu(+)gamma gamma mu(-) scattering at a future muon collider with unpolarized beams. The anomalous gamma gamma gamma Z vertex is described by two couplings, zeta(1) and zeta(2). The differential and total cross sections are calculated for the center-of-mass energies of 3 TeV, 14 TeV, and 100 TeV. For these values of the collision energy the 95% C.L. exclusion regions for AQGCs are obtained depending on the systematic error. In particular, for the 14 TeV muon collider with the integrated luminosity L = 20 ab(-1) the best sensitivities are derived to be zeta(1) = 3.1 x 10(-5) TeV-4 and zeta(2) = 6.5 x10(-5) TeV-4. These constraints are three orders of magnitude stronger than the bounds obtained for the 27 TeV HE-LHC with L = 15 ab(-1). At the 100 TeV muon collider with L = 1000 ab(-1) AQGCs can be probed up to 1.64 x 10(-8) TeV-4 and 3.4 x 10(-8) TeV-4 for zeta(1) and zeta(2), respectively. The partial-wave unitarity constraints on couplings zeta(1), zeta(2) are evaluated. It is shown that the unitarity is not violated in the region of the AQGCs examined in the present paper
Lie Ideals and Homoderivations in Semiprime Rings
No full textLet S be a 2-torsion free semiprime ring and U be a noncentral square-closed Lie ideal of S. An additive mapping & hbar; on S is defined as a homoderivation if & hbar;(ab)=& hbar;(a)& hbar;(b)+& hbar;(a)b+a & hbar;(a) for all a,b is an element of S. In the present paper, we shall prove that & hbar; is a commuting map on U if any one of the following holds: (i) & hbar;(a1a2)+a1a2 is an element of Z, (ii) & hbar;(a1a2)-a1a2 is an element of Z, (iii) & hbar;a1 degrees a2=0, (iv) & hbar;a1 degrees a2=a1,a2, (v) & hbar;a1,a2=0, (vi) & hbar;a1,a2= (a1 degrees a2), (vii) a1 & hbar;(a2)+/- a1a2 is an element of Z, (viii) a1 & hbar;(a2)+/- a2a1=0, (ix) a1 & hbar;(a2)+/- a1 degrees a2=0, (x) [& hbar;(a1),a2]+/- a1a2=0, (xi) [& hbar;(a1),a2]+/- a2a1=0, for all a1,a2 is an element of U, where & hbar; is a homoderivation on S.Deanship of Research and Graduate Studies at King Khalid University; [RGP2/293/45]The authors extend their appreciation to the Deanship of Research and Graduate Studies at King Khalid University for funding this work through the Large Research Project under grant number RGP2/293/45
The Role of Public Debt in Economic Growth: The Case of Türkiye (2000-2024)
No full textMaliye politikası araçlarından olan kamu borçlanmasındaki değişimler, kamu finansmanının sürdürülebilirliğinin önemli göstergelerindendir. Bu nedenle kamu borçluluğundaki değişimin ekonomi üzerindeki etkisinin takibi önem taşımaktadır. Çalışmada Türkiye’de kamu borçlarının iktisadi büyüme üzerindeki etkisi analiz edilmiştir. Bu amaçla, kamu borçlarının gayrisafi yurt içi hasıladaki payı ile reel gayrisafi yurt içi hasıla arasındaki ilişki En Küçük Kareler yöntemi kullanılarak incelenmiştir. Analiz sonucunda kamu borç stokundaki değişimin gayrisafi yurt içi hasıla üzerinde negatif yönlü ve istatistiksel olarak anlamlı bir etkiye sahip olduğu tahmin edilmiştir. Bulgular karar vericilere alınan borçların verimli alanlarda ve doğru biçimde kullanılması durumunda ekonomik büyüme üzerinde olumlu katkısının olabileceğini ima etmektedir.Since changes in public debt are indicators of the sustainability of public finances, it is important to monitor the effects of changes on the economy. The study analyzes the impact of public debt on economic growth in Türkiye. The relationship between the share of public debt in gross domestic product and real gross domestic product is examined using the OLS method and it is found that changes in public debt stock have a negative effect on gross domestic product. The findings imply to decision-makers that if borrowed funds are used correctly, they could have a positive contribution to economic growth.
Dose-Dependent Pulmonotoxic Effects of Favipiravir in Rats Biochemical and Histopathological Evaluation
No full textBackground and Objective: Favipiravir is associated with more serious side effects at higher doses. This experimental study proposed to investigate the effect of favipiravir on dose-dependent lung toxicity in rats biochemically and histopathologically. Materials and Methods: The rats were divided into four groups as healthy (HG), 100 mg/kg favipiravir (FAV-100), 200 mg/kg favipiravir (FAV-200) and 400 mg/kg favipiravir (FAV-400). Favipiravir 100, 200 and 400 mg/kg doses were administered by oral gavage to the other groups except HG. To the HG group, only distilled water (0.5 mL) was applied in the same way. This procedure was repeated twice a day for a week. Then, the rats were euthanised with high-dose anaesthesia and lung tissues were removed. Oxidative stress parameters such as malondialdehyde (MDA), Total Glutathione (tGSH), superoxide dismutase (SOD), total oxidant status (TOS) and total antioxidant status (TAS) were examined. After the one-way ANOVA, the Tukey's post hoc test was performed. Results: Favipiravir dose-dependently increased MDA and TOS also decreased tGSH, SOD and TAS in rat lung tissue. As favipiravir was given in increasing doses, it was easier to observe the changes between the different groups. This was also supported by the histopathological data. Histopathologically, interstitial pneumonia and lymphoid hyperplasia were mild in the 100 mg/kg favipiravir group, severe at high doses. Conclusion: As the dose of favipiravir increased, oxidant levels increased and antioxidant levels decreased in the lung tissue. In line with these results, it was observed that favipiravir caused a dose-dependent pulmonotoxic effect in rats.Scientific Research Projects of Erzincan Binali Yildirim University (BAP) [TDK-2022-849]This study was supported by the Scientific Research Projects of Erzincan Binali Yildirim University (BAP) with the project number TDK-2022-849
Anxiety and non-stress testing of midwife support provided to pregnant women the effect of the results
No full textAraştırma, gebelere sağlanan ebe desteğinin kaygı ve non stress test sonuçlarına etkisinin belirlenmesi amacıyla randomize kontrollü deneysel olarak yapılmıştır. Araştırmanın örneklemini, 1 Ocak-31 Mayıs 2024 tarihleri arasında Ankara Yıldırım Beyazıt Üniversitesi Yenimahalle Eğitim ve Araştırma Hastanesi NST Polikliniğine başvuran, araştırmaya katılmaya gönüllü olup araştırmaya dahil edilme kriterlerine uyan 45 gebe deney, 45 gebe ise kontrol grubunda olmak üzere 90 gebe oluşturmuştur. Deney grubundaki gebelere; NST işleminin en başından itibaren işlem sonuna kadar geçen süre içerisinde standart ebe bakımının yanında ebe desteği verilmiştir. Kontrol grubundaki gebelere ise standart ebe bakımı dışında herhangi bir girişimde bulunulmamıştır. Araştırmada veriler; Kişisel Bilgi Formu, Durumluk Kaygı Ölçeği ve NST Bulguları Formu kullanılarak toplanmıştır. Verilerin değerlendirilmesinde ki-kare analizi, bağımlı ve bağımsız gruplarda t testi kullanılmıştır. Anlamlılık düzeyi p0.05), son test karşılaştırmasında istatistiksel olarak anlamlı fark saptanmıştır (p0.05), a statistically significant difference was found in the post-test comparison (p<0.05). In the post-test, the mean anxiety value of the experimental group was found to be lower than the control group (p<0.05). It was found that the pregnant women in the experimental group experienced more positive emotions during the NST procedure than the pregnant women in the control group, 93.3% of the pregnant women in the experimental group were satisfied with the midwife support received during the NST procedure and would recommend the midwife support to other pregnant women. As a result of the study, it was determined that the midwife support given to pregnant women during NST had a positive effect on the NST results of pregnant women, the midwife support given to the experimental group positively affected anxiety, there was no increase in anxiety level and anxiety decreased. Midwife support did not affect the experimental group within the group but stabilized and prevented anxiety. In line with these results, midwife support is recommended to reduce the anxiety of pregnant women during NST
Synthesis, spectroscopic and electronic structure analyses, DFT studies and molecular docking applications of isatin hydrazone derivatives
No full textThe derivatives of isatin bis-hydrazone compounds formed by adding electron-withdrawing and electrondonating substituents (S1-S7) were synthesized. Chemical structure characterizations of the synthesized compounds were elucidated by spectroscopic (IR, 1H-NMR, 13C-NMR, LC-QTOF-MS) methods. S1-S7 compounds were optimized with B3LYP/6-31G(d,p) level. 1H-NMR and 13C-NMR spectra and chemical shifts were calculated for the compounds at the GIAO/B3LYP/6-31G(d,p) level. Experimental and calculated IR, 1H-NMR, and 13C-NMR data were compared with each other. Electronic differences created by substituent effects in the skeletal structure were investigated with frontier molecular orbitals contour diagrams and Molecular Electrostatic (MEP) maps. Activities of the designed chemicals against biological receptors at the molecular scale were calculated with docking studies. Compounds S1-S7 were docked to target proteins with PDB ID: 1JNX and 2HQ6 representing breast and colon cancer cells, respectively. Chemical structures with high activity potential were synthesized in the light of the information obtained from the docking results.Cumhuriyet University Scientific Research Projects Coordination Unit (CUBAP) [F-2022-670]The numerical calculations reported in this paper were performed at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TRUBA Resources) . Also, this paper was produced from the thesis of Ceylan ALKAYA YILDIZ. This study is a master's thesis project numbered F-2022-670 supported by Cumhuriyet University Scientific Research Projects Coordination Unit (CUBAP)