Sivas Cumhuriyet Üniversitesi Kurumsal Akademik Arşivi - Sivas Cumhuriyet University Open Access System
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Kasko Üretimi Yapan Sigorta Şirketlerin Performansının Hibrit ÇKKV Modeli ile Değerlendirilmesi
No full textPurpose: The purpose of these studies is to evaluate the role of exporters producing casco in the Turkish Insurance sector in 2022. Methodology: Seven performance criteria were determined, which are reported and stored jointly from the financial indicators included in the annual activity reports of the insurance reporting. The financial performances of 15 companies producing insurance for 2022 were evaluated. In the study, SWARA method was preferred as the subjective weighting method and MEREC-LOPCOW MCDM methods were preferred as the objective weighting method in weighting the criterias. The COBRA method was used in the performance evaluation. The results obtained from the three different weighting methods were combined with the common weighting method. The validity and consistency of the results of the proposed decision model were tested using various sensitivity analyses. Findings: According to the criterion weighting continuation, the most important criterion was the net earned premium, while the least important criterion was the normal rate. According to the COBRA ranking results, the company with the best performance among the insurance companies producing motor insurance premiums in 2022 was A1 (Anadolu Anonim Türk Sigorta Şirketi). Originality: The study contributes to the literature by including performance evaluation in the field of casco insurance, which has a growing share in the insurance field. However, the originality of the method is achieved by using both subjective and objective weighting methods together.Amaç: Bu çalışmanın amacı Türk Sigorta sektöründe kasko üretimi yapan şirketlerin 2022 yılı performansının değerlendirilmesidir. Yöntem: Sigorta şirketlerinin her yıl sunduğu faaliyet raporlarında yer alan finansal göstergelerden uzmanların ortak görüşleri alınarak yedi adet performans kriteri belirlenmiştir. Kasko üretimi yapan 15 şirket 2022 yılına ait finansal performansları değerlendirilmeye alınmıştır. Çalışmada kriterlerin ağırlıklandırılmasında subjektif ağırlıklandırma yöntemi olarak SWARA yöntemi ve objektif ağırlıklandırma yöntemi olarak MEREC-LOPCOW ÇKKV yöntemleri tercih edilmiştir. Üç farklı ağırlıklandırma yönteminden elde edilen sonuçlar ortak ağırlıklandırma yöntemiyle birleştirilmiştir. Performans değerlendirilmesinde ise COBRA yöntemi kullanılmıştır. Önerilen karar modelinin sonuçlarının geçerliliği ve tutarlılığı çeşitli duyarlılık analizleri kullanılarak test edilmiştir. Bulgular: Kriter ağırlıklandırma sonuçlarına göre en önemli kriter net kazanılmış prim iken, en önemsiz kriter ise bileşik oran olmuştur. COBRA sıralama sonuçlarına göre 2022 yılında kasko prim üretimi yapan sigorta şirketleri arasında en iyi performansa sahip şirket A1(Anadolu Anonim Türk Sigorta Şirketi) olmuştur. Özgünlük: Çalışmanın sigorta alanında giderek büyüyen bir paya sahip olan kasko sigortası alanında performans değerlendirilmesini içermesi bakımından literatüre katkı sağlayacağı düşünülmektedir. Bununla birlikte yöntem olarak hem subjektif hem de objektif ağırlıklandırma yöntemlerinin bir arada kullanılması çalışmanın özgünlüğü oluşturmaktadır
Examınatıon Of The Qualıty Of Lıfe Of Women Enterıng Menopause In The Early And Normal Age Range
No full textGiriş: Menopozal dönemdeki kadınlara verilen bakımın daha etkin ve bütüncül olabilmesi için ise sadece menopozun normal yaş aralığında değil aynı zamanda normal yaş aralığından sapması halinde de yaşam kalitesinin bundan nasıl etkileneceğinin belirlenmesi gereklidir. Amaç: Bu araştırma erken ve normal yaş aralığında menopoza giren kadınların yaşam kalitelerinin incelenmesi amacıyla tanımlayıcı olarak yapılmıştır. Yöntem: Araştırma 16 Ekim 2019-16 Ocak 2020 tarihleri arasında Sivas il merkezinde bulunan normal ya da erken menopoz tanısı konmuş 100 kadın ile gerçekleştirilmiştir. Araştırma verileri, Kişisel Bilgi Formu ve Menopoza Özgü Yaşam Kalitesi Ölçeği kullanılarak elde edilmiştir. Araştırma verilerinin değerlendirilmesinde SPSS (ver:23.0) programı kullanılmıştır. Verilerin normal dağılıp dağılmadığını belirlemek için Kolmogorov-Smirnov testi kullanılmıştır. Güvenirlik analizi ile ölçek ve alt boyutlarının Cronbach alpha katsayısı hesaplanmıştır. Araştırma verilerinin değerlendirilmesinde tanımlayıcı istatistik testleri ile sayı ve yüzdelik dağılımlar; T testi, Mann Whitney U testi, Kruskal Wallis H testi, Pearson Korelasyon analizi, ki kare analizi, Regresyon analizi kullanılmıştır. Bulgular: Kadınların menopoz gruplarına göre yaş, eğitim düzeyi, kronik hastalık öyküsü, düzenli egzersiz yapma durumu, sigara kullanma durumu, günlük kullanılan sigara ve son zamanlarda yaşamı etkileyen bir olay öyküsü arasında istatistiksel olarak anlamlı farklılık saptanmıştır (pBackground: In order for the care given to women in the menopausal period to be more effective and holistic, it is necessary to determine how the quality of life will be affected not only in the normal age range of menopause, but also in case it deviates from the normal age range. Objective: This study was conducted as descriptive to examine the quality of life of women who entered menopause in the early and normal age range. Methods:The study was conducted between October 16, 2019 and January 16, 2020 with 100 women diagnosed with normal or early menopause. Research data were obtained using the individual diagnostic form and the menopause-specific quality of life scale. The SPSS (ver:23.0) program was used to evaluate research data. The Kolmogorov-Smirnov test was used to determine whether the data was distributed normally. The cronbach alpha coefficient of the scale and its sub-dimensions was calculated by the reliability analysis. Number and percent distributions with descriptive statistical tests in the evaluation of research data; T test, Mann Whitney U test, Kruskal Wallis H test, Pearson Correlation analysis, Chi square analysis, regression analyses analysiswere used. Results:A statistically significant difference was found between the age, education level, chronic disease history, regular exercise status, smoking status, daily smoking, and a recent life-affecting event history of the women (
The Regulatory Effects of Exercise and Metformin on Biomarkers in Obesity: A Focus on Uric Acid, Irisin, Adiponutrin, Adropin, and Copeptin
No full textBackground and Objectives: Obesity has become one of the most significant health problems nowadays, with its prevalence rapidly increasing. Approaches such as diet and exercise play an important role in the treatment of obesity. This study aimed to investigate the responses of uric acid, irisin, adiponutrin, adropin, and copeptin levels to exercise and metformin intervention in obesity. Materials and Methods: Thirty-six male Sprague-Dawley rats were randomly divided into seven groups: healthy control (HC), sham (S), obese control (OC), metformin (M), exercise (E), metformin + exercise (ME), and decapitation (D). After obesity was induced through a 12-week high-fat diet, obese rats underwent a 4-week aerobic exercise and metformin intervention. Results: Uric acid, irisin, adiponutrin, adropin, and copeptin levels were determined using an ELISA method. Copeptin levels significantly decreased in the ME group (p 0.05). Conclusions: These findings suggest that exercise and metformin intervention may play an effective role in obesity management.Firat University Scientific Research Projects (FUBAP); [BSY.18.08]This research was funded by Firat University Scientific Research Projects (FUBAP), grant number BSY.18.08
Sustainable Synthesis of Multifunctionalized Amoxicillin-Loaded Biopolymer Foams
No full textThe development of biocompatible biopolymer foams loaded with antibiotics is crucial to advancing drug delivery systems in biomedical engineering. These materials offer controlled drug release and specialized functionalities for improved therapeutic outcomes. This study presents the development and characterization of antimicrobial polymeric biofoam materials loaded with the drug amoxicillin (AMX). The sustainable synthesis of these biopolymer foams involves a cost-effective, eco-friendly method that incorporates natural starch within poly(vinyl alcohol) (PVA) through an aldehyde cross-linking/stabilizing process. The highly porous structure of the biofoams enabled effective impregnation of the AMX drug using an innovative process involving ultrasonication and vacuum pressure to maximize efficiency and minimize biomaterial loss. The findings demonstrate the potential of these PVA/starch-based biofoams as versatile drug delivery systems with desirable physicochemical and biological characteristics. Detailed investigations were conducted to evaluate morphological features, chemical properties, swelling behavior, in vitro biodegradability, drug release profiles, cell culture, and antimicrobial activity tests of the prepared biofoam samples. Investigating the effect of controlled loading of AMX under laboratory conditions on its release profile and studying its biodegradation in various environments over time represent a critical aspect of this research. The optimal release profile under physiological conditions and the potent inhibition of bacterial growth against Escherichia coli and Staphylococcus aureus microorganisms by AMX-loaded biofoam materials highlight their potential for biomedical applications. These materials show promise for the in vivo administration and local treatment of bacterial infections
Graphene nanoplatelets inclusion effects on mechanical properties of hybrid carbon/glass composites
No full textThe incorporation of nanoparticles into hybrid carbon/glass composites significantly enhances their mechanical properties, making them suitable for various engineering applications. The primary aim of this study was to examine the effects of graphene nanoparticles (GNPs) on the mechanical and Charpy impact characteristics of carbon fiber/epoxy, glass fiber/epoxy, and their hybrid composite laminates across various laminate configurations. GNPs were uniformly dispersed in the epoxy matrix at different weight fractions of 0.1%, 0.25% and 0.5% (by weight). Experimental assessments encompassing flexural, tensile, and Charpy impact evaluations were carried out both with/without the incorporation of GNPs as reinforcing agents in the fabricated specimens. This research indicated that even a small addition of GNPs could lead to substantial improvements in tensile strength, flexural strength, and impact resistance due to better interfacial bonding between the fibers and the epoxy matrix. Upon introducing GNPs at a loading level of 0.1% (by weight), the experimental findings demonstrated a notable enhancement in the mechanical and impact properties of the hybrid composite laminates as a result of integrating GNPs into the epoxy matrix. This increase in strength can be attributed to the development of a strong interfacial bond among the fibers, epoxy, and GNPs leading to better load transferring from the matrix to the fibers
ScholarGPT's performance in oral and maxillofacial surgery
No full textObjective: The purpose of this study is to evaluate the performance of Scholar GPT in answering technical questions in the field of oral and maxillofacial surgery and to conduct a comparative analysis with the results of a previous study that assessed the performance of ChatGPT. Materials and Methods: Scholar GPT was accessed via ChatGPT (www.chatgpt.com) on March 20, 2024. A total of 60 technical questions (15 each on impacted teeth, dental implants, temporomandibular joint disorders, and orthognathic surgery) from our previous study were used. Scholar GPT's responses were evaluated using a modified Global Quality Scale (GQS). The questions were randomized before scoring using an online randomizer (www.randomizer.org). A single researcher performed the evaluations at three different times, three weeks apart, with each evaluation preceded by a new randomization. In cases of score discrepancies, a fourth evaluation was conducted to determine the final score. Results: Scholar GPT performed well across all technical questions, with an average GQS score of 4.48 (SD=0.93). Comparatively, ChatGPT's average GQS score in previous study was 3.1 (SD=1.492). The Wilcoxon Signed-Rank Test indicated a statistically significant higher average score for Scholar GPT compared to ChatGPT (Mean Difference = 2.00, SE = 0.163, p < 0.001). The Kruskal-Wallis Test showed no statistically significant differences among the topic groups (x(2) = 0.799, df= 3, p = 0.850, epsilon(2) = 0.0135). Conclusion: Scholar GPT demonstrated a generally high performance in technical questions within oral and maxillofacial surgery and produced more consistent and higher-quality responses compared to ChatGPT. The findings suggest that GPT models based on academic databases can provide more accurate and reliable information. Additionally, developing a specialized GPT model for oral and maxillofacial surgery could ensure higher quality and consistency in artificial intelligence-generated information. (c) 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies
Daniel Quinn’in İsmail Adlı Romanında İnsanın Doğa Üzerindeki Hâkimiyetine Karşı Bir Protesto
No full textDaniel Quinn’s 1992 novel Ishmael has initiated a profound re-examination of our connection with the natural world and has challenged the prevalent view of human supremacy. This research examines the pivotal insights and themes expounded in Ishmael, shedding light on their implications for our understanding of our position within the ecological community. At the heart of the novel lies Ishmael, a wise gorilla who assumes the role of an unconventional teacher on deeply established convictions about human superiority and the unchecked exploitation of Earth’s resources. Ishmael’s teachings underscore the complex interdependence of all life forms and emphasize the pressing need to listen to the voices of fellow forms in the tapestry of life. This study endeavors to explore the concept of human supremacy, examining its origins and the transformative potential inherent in embracing a more inclusive perspective regarding our bond with nature. It analyses the historical, religious, and cultural factors that have preserved human dominance and the resulting detrimental actions toward the environment generated by these beliefs. Eventually, this research concludes that Ishmael’s message remains relevant and urgent, beckoning us to critically evaluate our values, behaviors, and assumptions. It implores us to actively engage in reshaping our world by challenging prevailing narratives, interrogating societal structures, and adopting sustainable practices.Daniel Quinn’in romanı Ishmael (İsmail, ilk Türkçe baskı 2012), doğal dünyayla olan bağlantımızın derinlemesine yeniden incelenmesini sağladı ve insanın üstünlüğüne dair yaygın görüşe meydan okudu. Bu araştırma, İsmail’de açıklanan temel anlayışları ve temaları incelemekte ve bunların ekolojik topluluk içindeki konumumuza dair anlamlarına ışık tutmaktadır. Romanın merkezinde, insanın üstünlüğü ve dünya kaynaklarının kontrolsüzce sömürülmesi hakkındaki köklü inançlar konusunda alışılmadık bir öğretmen rolünü üstlenen bilge bir goril olan İsmail yatıyor. İsmail’in öğretileri, tüm yaşam formlarının karmaşık karşılıklı bağımlılığının altını çizer ve yaşamın dokusundaki ortak formların seslerini dinlemenin acil ihtiyacını vurgular. Bu çalışma, insan üstünlüğü kavramını, bu kavramın kökenlerini ve doğayla olan bağımıza ilişkin daha kapsayıcı bir bakış açısı benimsemenin doğasında var olan dönüştürücü potansiyeli incelemeye çalışmaktadır. İnsan egemenliğini koruyan tarihi, dini ve kültürel faktörleri ve bu inançların neden olduğu çevreye yönelik zararlı eylemleri analiz eder. Sonuç olarak bu araştırma, İsmail’in mesajının güncel ve acil olduğu sonucuna vararak bizi değerlerimizi, davranışlarımızı ve varsayımlarımızı eleştirel bir şekilde değerlendirmeye çağırır. Hakim anlatılara meydan okuyarak, toplumsal yapıları sorgulayarak ve sürdürülebilir uygulamaları benimseyerek dünyamızı yeniden şekillendirmeye aktif olarak katılmamız için bizi teşvik eder
Koyun Fetüslarının (İkinci ve Üçüncü Trimester) Dalağında Bağ Doku İpliklerinin Araştırılması
No full textNo financial support was received from any institution for this studyThe aim of this study was to reveal the development of connective tissue fibers in the spleen of sheep fetuses. For this purpose, two different study groups were formed, consisting of the second and third trimesters of pregnancy. In this study, a total of 12 sheep fetuses were used, with 6 fetuses in each group. The fetal spleen tissues were fixed in 10% formaldehyde. Subsequently, routine histological procedures were applied to the tissue samples. Tissue sections were stained using Gordon Sweet's silver staining method to identify reticular fibers, Masson's trichrome staining method to identify collagen fibers, and Verhoeff's Van Gieson staining method to identify elastic fibers. The collagen, elastic, and reticular fibers were observed in the capsules and trabeculae of the spleen of sheep fetuses in the second and third trimesters. The collagen fibers were long and wavy, while the elastic fibers were short and wavy in structure. The reticulum fibers formed networks by anastomosing. Additionally, the elastic fibers were interwoven with collagen fibers, and the collagen, reticular, and elastic fibers were denser in the third trimester compared to the second trimester. In addition, reticular fibers were dominant in the spleens of sheep fetuses in both trimesters. As a result, collagen, reticular, and elastic fibers were observed in the spleens of sheep fetuses during the second and third trimesters of pregnancy. It was determined that with fetal development, the connective tissue fibers developed.Bu çalışmanın amacı koyun fetüslarının dalağında bağ doku ipliklerinin gelişimini ortaya koymaktır. Bu amaçla gebeliğin ikinci ve üçüncü trimesteri olmak üzere iki farklı çalışma grubu oluşturuldu. Bu çalışmada her grupta 6 fetüs olmak üzere toplam 12 koyun fetüsü kullanıldı. Fetüsların dalak dokusu %10 formaldehitte tespit edildi. Daha sonra doku örneklerine rutin histolojik işlemler uygulandı. Retiküler iplikleri belirlemek için Gordon Sweet's gümüşleme boyama yöntemi, kollegen iplikleri belirlemek için Masson’s trichrome boyama yöntemi ve elastik iplikleri belirlemek için Verhoeff’ s Van Gieson boyama yöntemi ile doku kesitleri boyandı. İkinci ve üçüncü trimesterdeki koyun fetüslarının dalağının kapsül ve trabeküllerinde kollagen, elastik ve retiküler iplikler gözlendi. Kollagen iplikler uzun ve dalgalı, elastik iplikler ise kısa ve dalgalı yapıdaydı. Retikulum iplikler anastomozlaşarak ağlar oluşturmuştu. Ayrıca elastik iplikler kollagen iplikler ile örülü halde idi. Gebeliğin ikinci trimesterine kıyasla gebeliğin üçüncü trimesterinde kollagen, retiküler ve elastik ipliklerin daha yoğun olduğu gözlendi. Ayrıca her iki trimesterde koyun fetüslarının dalağında retiküler iplikler baskındı. Sonuç olarak gebeliğin ikinci ve üçüncü trimesterinde koyun fetüslarının dalağında kollagen, retiküler ve elastik iplikler gözlendi. Fötal gelişim ile birlikte bağ doku ipliklerinin geliştiği belirlendi
Synthesis, characterization, antimicrobial, antioxidant, and anti-cancer activity of new hybrid structures based on benzimidazole and thiadiazole
No full textHybrid structures containing multiple pharmacophore units with known activity have attracted attention due to their promising outcomes. In this study, several new hybrid structures containing benzimidazole and thiadiazole units were synthesized. The newly synthesized compounds were structurally analyzed using 1H-NMR, 13C-NMR, HRMS, and elemental analysis. The antimicrobial, in vitro anti-cancer, and antioxidant activities of all compounds were investigated. In vitro antimicrobial activities of the compounds were determined against Gram-positive (S. aureus ATCC 29213, E. faecalis ATCC 29212), Gram-negative (E. coli ATCC 25922, P. aeruginosa ATCC 27853) bacteria and fungi (C. albicans ATCC 10231) by using broth microdilution method. The compound 5g bearing 4-methoxyphenyl derivative showed the best activity with 32 mu g/mL against S. aureus ATCC 29213 and P. aeruginosa ATCC 27853. The MTT test was used to determine the cytotoxicity of the produced compounds on the MCF-7 (human breast cancer) and L-929 (fibroblast) cell lines. FRAP method was used to determine the antioxidant properties of synthesized compounds. The Ferric Reducing Antioxidant Power of the compounds 5a, 5b, and 5c showed more antioxidant properties than vitamin E. The compound 5g stands out in the series in that it is not toxic on the healthy cell line and has promising antimicrobial activity