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Endometrial staining of CD56 (Uterine Natural Killer), BCL-6, and CD138 (Plasma Cells) improve diagnosis and clinical pregnancy outcomes in unexplained infertility and recurrent IVF failures: Standardization of diagnosis with digital pathology
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In women with unexplained infertility (UI) and recurrent in vitro fertilization (IVF) failures, the etiology is often unclear. Endometrial immune perturbations and the use of immune markers associated with these dysregulations are of great interest in the diagnosis and treatment of UI. However, reliable biomarkers and standardized quantification methods are lacking. Here, to address endometrial immune dysregulation in UI patients with recurrent IVF failures, we performed endometrial tissue sampling and immunostaining of CD56 (uNK), CD138, and BCL-6. Of these cases, 57.9% had positive CD56 in the endometrial stroma, while 46.1% had positive BCL-6 in the glandular epithelium, and 14.5% of the cases were found to be positive for CD138. Combined staining rates were 60.5%, 68.4%, and 71.05% for (CD56 or BCL-6), (CD56 or CD138), and (CD56, BCL-6, or CD138), respectively. There was a significant correlation between CD56 and BCL-6 positivity, while CD138 positivity was an independent parameter. After the recommended targeted therapy, pregnancy rates were found to increase from 58.5% to 61.6% and 73.8% in CD56-positive, (CD56- or BCL-6-positive), and (CD56-, BCL-6-, or CD138-positive) cases, respectively. Notably, a retrospective evaluation of digital pathology and light microscopy results showed a significant correlation. This study suggests that the examination of CD56, BCL-6, and CD138 in the same endometrial sample may be an effective method in determining the etiology of UI and reaching an early diagnosis and treatment options. Moreover, digital pathology can be used in the evaluation of CD56 and BCL-6 to provide objective, rapid, and reliable results
Retrospective evaluation of the efficacy of daily paroxetine/tadalafil combination in patients with premature ejaculation and erectile dysfunction
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OBJECTIVE: Premature ejaculation (PE) and erectile dysfunction (ED) are sexual dysfunction diseases affecting males. The phosphodiesterase type 5 (PDE5) inhibitors such as tadalafil are used to treat ED whereas selective serotonin reuptake inhibitors (SSRIs) are preferred for PE. Most of the patients with ED also suffer from PE simultaneously. The combined drug therapies are commonly preferred as they favor elevated intra-vaginal ejaculation latency time (IELT) scores and improved sexual function. The study aimed to evaluate the efficacy and safety of daily paroxetine and tadalafil combination therapy in patients with PE and ED. PATIENTS AND METHODS: A total of 81 PE patients with ED were enrolled in the study. Patients were treated with daily paroxetine 20 mg and tadalafil 5 mg for 4 weeks. Pre- and post-treatment IELT, premature ejaculation profile (PEP), and International Index of Erectile Function-Erectile Function (IIEF-EF) scores of the patients were analyzed. RESULTS: The mean IELT and PEP index scores, and mean IIEF-EF values improved after combination therapy (p<0.001 for each). When lifelong and acquired PE+ED patients were compared, significant improvements were observed in IELT, PEP, and IIEF-EF scores in both group
Quiescent optical solitons with complex Ginzburg–Landau equation having a dozen forms of self–phase modulation
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The current study focuses on the recovery of quiescent optical solitons through the use of the complex Ginzburg–Landau equation when the chromatic dispersion is rendered to be nonlinear. A dozen forms of self-phase modulation structures are taken into consideration. The utilization of the enhanced Kudryashov's scheme has led to the emergence of singular, dark, and bright soliton solutions. The existence of such solitons is subject to certain parametric restrictions, which are also discussed in this paper
Oral health status of juvenile ınmates in a detention center in Turkey
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Purpose: There are very few studies about the oral health status of juvenile inmates. This study aimed to determine past dental attendance, medicament usage, and smoking habits, besides oro-dental status, including caries prevalence and periodontal health status of juvenile inmates in detention centers. Material and Methods: This cross-sectional study was conducted on 232 juvenile male inmates (mean-age:16.65±0.91) in a detention center in Istanbul-Turkey. After taking general demographic information, the subjects were clinically examined according to WHO criteria. In addition, the Plaque Index (PI) and Gingival Index (GI) were recorded at Ramfjord teeth to evaluate periodontal status. All data were statistically analyzed using the IBM Statistical Package for Social Sciences (SPSS) 22.0 programme, Pearson correlation coefficient, Spearman's rho correlation coefficient, chi-square test, Fisher's exact test, Kruskal-Wallis test, and One-way ANOVA test. Results: Average length of stay was 6.54±8.38 months. 44.4% of inmates have never visited a dentist. The mean DMFT, PI, and GI scores of the subjects were 6.78±4.07, 1.18±0.55, and 1.13±0.47, respectively. In addition, 80.2% of inmates smoked before being taken to the detention center. Conclusion: This study indicated that the oral health of detained inmates was poor. Prison health services should not be isolated but integrated into national and regional health systems
Parosmia and phantosmia: Managing quality disorders
Get PDFPurpose of Review The purpose of this review was to summarize the current knowledge on parosmia and phantosmia and introduce support and treatment algorithms for the two qualitative olfactory disorders. Recent Findings Recent literature regarding parosmia has revealed that patients with the disorder are mainly triggered by certain substances, including thiols and pyrazines. In 2015, the existing “olfactory training” regimen was improved to more efectively treat post-infectious olfactory loss and was named “modifed olfactory training” (MOT). It was also found in 2022 that MOT is also efective against COVID-19-induced parosmia. Summary Parosmia, the distortion of smells, is a symptom in qualitative olfactory disorders that severely afects patients’ mental well-being and enjoyment of their everyday lives. The condition was frst documented in 1895 and can afect up to 5% of the general population. Etiologies of parosmia include sinonasal diseases, viruses, surgeries, traumatic brain injury, neurological and psychiatric conditions, toxic chemicals, and medications. Parosmia has seen a surge in cases since the onset of the COVID-19 pandemic and is linked to changes in brain structure following an infection. The evaluation of the symptom is done using surveys, smell identifcation tests, fMRI, MRI, PET/CT, and gas chromatography. Treatment for parosmia can vary in duration, which makes it essential to focus not only on helping the patients regain normosmia, but also on supporting the patient through the recovery journey. Parosmia should not be confused with phantosmia, in which the distortion of smells occurs in the absence of olfactory stimuli. The etiology of phantosmia can vary from infections and traumatic brain injury to psychiatric disorders like schizophrenia. Unlike parosmia, the treatment of phantosmia is less straightforward, with an emphasis on determining the etiology and providing symptomatic relief
Investigation of nurses' fear of covid-19, psychological well-being levels and job satisfaction during the covid-19 pandemic period
No full textÖZET Bu çalışma pandemi döneminde, hemşirelerin COVİD-19’a karşı olan korkularını, psikolojik iyi oluş düzeylerini ve mesleklerine karşı olan iş doyumlarını inceleyebilmek ve ilişkili faktörleri belirlemek amacıyla yürütülmüştür. İstanbul ilinde yer alan bir eğitim ve araştırma hastanesinde Eylül – Kasım 2021 tarihleri arasında yapılmıştır. Araştırmaya 255 hemşire dahil edilmiştir. Veriler, “Google Formlar” platformu aracılığıyla online anket yöntemiyle dört bölümden oluşan veri toplama formu kullanılarak toplanmıştır. Araştırma verileri sosyodemografik özellikler, yaşam tarzı alışkanlıkları ve çalışma koşulları ile ilgili soruların yer aldığı “Kişisel Bilgi Formu”, “Hemşire İş Doyum Ölçeği”, “Psikolojik İyi Oluş Ölçeği” ve “COVİD-19 Korkusu Ölçeği” ile toplanmıştır. Araştırmaya katılan hemşirelerin yaklaşık %90’ının meslekteki çalışma süresinin 1-5 yıl arasında olduğu görülmüştür. Yaş ortalamasının 26,46±3.64 olduğu, hemşirelerin %77’sinin lisans mezunu, %24’ünün evli olduğu, %43’ünün mesleğini kendi isteği ile seçtiği, %85’inin hem gündüz hem gece karma çalıştığı görülmüştür. Araştırmanın sonucunda hemşirelerin COVİD-19 korku düzeyi düşük, psikolojik iyi oluş düzeyleri yüksek ve iş doyumu düzeyleri normal olarak bulunmuştur. Kadın hemşirelerin COVİD-19 korkuları erkek hemşirelere göre, evli olan hemşirelerin COVİD-19 korkuları bekar olanlara göre daha yüksek olarak bulunmuştur. İyi oluşluluğun, çalışma memnuniyetinin ve ayrılma isteğinin hemşire iş doyumu üzerinde istatiksel olarak anlamlı etkisi olduğu bulunurken, COVİD-19 korkusu değişkeninin istatiksel olarak anlamlı etkisi olmadığı görülmüştür. Hemşire iş doyumunun %18’inin iyi oluşluluk, %40’ının çalışma memnuniyeti ve %17’sinin ayrılma isteği değişkenleri tarafından açıklandığı bulunmuştur.ABSTRACT This study was performed to examine nurses' fear of COVID-19, their psychological well-being levels and their job satisfaction with their profession, and to determine related factors during the pandemic period. It was conducted between September and November 2021 in a training and research hospital in Istanbul. 255 nurses were included in this study. The data were collected through the "Google Forms" platform, using an online survey method and a data collection form consisting of four parts. The research data were collected with the "Personal Information Form" which included questions about sociodemographic characteristics, lifestyle habits and working conditions, "Nurse Job Satisfaction Scale", "Psychological Well-Being Scale" and "Coronavirus (COVID-19) Fear Scale". It was observed that approximately 90% of the 255 participants who participated in the research have a working period of 1-5 years. It was observed that the mean age is 26.46±3.64, 77% of the nurses are undergraduate graduates, 24% are married, 43% chose their profession voluntarily, and 85% worked in a mixed day and night shifts. As a result of the study, it was found that the level of fear of COVID-19 of the nurses is low, their psychological well-being level is high, and their job satisfaction level is normal. It was found that the fear of COVID-19 among female nurses is higher than the male nurses, and the fear of COVID-19 among married nurses is higher than the single nurses. While well-being, job satisfaction and desire to leave the profession were found to have a statistically significant effect on nurse job satisfaction, it was seen that the fear of COVID-19 variable has not a statistically significant effect on nurse job satisfaction. It was found that 18% of nurse job satisfaction is explained by the variables of well-being, 40% of work satisfaction and 17% of desire to leave the professio
Examination of nurses' fears of the COVID-19 outbreak and their compassion fatigue
No full textÖzet : Araştırma Covid-19 hastalarına bakım veren hemşirelerin merhamet yorgunluklarını, Covid-19 korku düzeylerini ve aralarındaki ilişkiyi incelemek amacıyla yapıldı. Tanımlayıcı türdeki araştırma Temmuz - Aralık 2021 tarihleri arasında, İstanbul' da bir Şehir Hastanesi'nde Pandemi döneminde aktif çalışan 217 hemşire örneklem ile yürütüldü. Veriler Kişisel Bilgi Formu, Covid-19 Korkusu Ölçeği ve Merhamet Yorgunluğu-Kısa Ölçeği kullanılarak toplandı. Verilerinin değerlendirilmesinde IBM SPSS Statistics 22 istatistik paket programından yararlanıldı. Etik kurul onayı, kurum izni ve ölçek sahiplerinden izin alındı. Verilerin değerlendirilmesinde tanımlayıcı istatistikler, Kolmogorov-Smirnov testi, Mann-Whitney U testi Kruskal-Wallis testi ve Spearman korelasyon analizi kullanıldı. Hemşirelerin %82.5'inin Covid-19 hastalığına yakalanan yakını olduğu; %32.3'ünün Covid-19 hastalığı kaynaklı bir kayıp yaşadığı görüldü. Hemşirelerin %84.3'ünün Covid-19 pozitif hastalarla empati kurduğu ve %79.3'ünün pandemide hastanın çektiği acıdan etkilediği saptandı. Kadın hemşirelerin erkek hemşirelere göre, gündüz çalışan hemşirelerin vardiya / sürekli gece çalışan hemşirelere göre, Covid-19 korkusu daha yüksek olduğu saptandı. Yaşı 36 ve üstü hemşirelerin, çocuk sayısı iki olan hemşirelerin, çalışma yılı 10 yıl üstü olan hemşirlerin, diğerlerine göre merhamet yorgunluğu daha düşük olduğu belirlendi. Araştırma sonucunda hemşirelerin Covid-19 korkusu ve merhamet yorgunluğu puanlarının orta düzeyde olduğu; hemşirelerin Covid-19 korkularının yaş ve çalışma yılına bağlı olarak değişmediği, merhamet yorgunluklarının ise etkilendiği; merhamet yorgunluğu yaşama ile Covid-19 korkuları arasında anlamlı pozitif ilişki olduğu belirlendi.Abstract : The research was carried out to examine the compassion fatigue of nurses who care for Covid-19 patients, their Covid-19 fear levels and the relationship between them. The descriptive study was conducted with a sample of 217 nurses who were actively working during the Pandemic period in a City Hospital in Istanbul between July and December 2021. Data were collected using the Personal Information Form, the Covid-19 Fear Scale, and the Compassion Fatigue-Short Scale. IBM SPSS Statistics 22 statistical package program was used to evaluate the data. Ethics committee approval, institutional permission and permission from the scale owners were obtained. Descriptive statistics, Kolmogorov-Smirnov test, Mann-Whitney U test, Kruskal-Wallis test and Spearman correlation analysis were used to evaluate the data. It was seen that 82.5% of the nurses had a relative with Covid-19 disease and 32.3% of them suffered a loss due to Covid-19 disease. It was determined that 84.3% of the nurses empathized with Covid-19 positive patients and 79.3% were affected by the patient's pain during the pandemic. It was determined that female nurses had a higher fear of Covid-19 compared to male nurses and daytime nurses had a higher fear of Covid-19 compared to shift / continuous night nurses. It was determined that nurses aged 36 and over, nurses with two children, and nurses with a working year of more than 10 years had lower compassion fatigue than the others. As a result of the research, it was determined that the Covid-19 fear and compassion fatigue scores of the nurses were moderate and the Covid-19 fears of the nurses did not change depending on age and working year. In addition, it was determined that nurses' compassion fatigue was affected and there was a significant positive relationship between experiencing compassion fatigue and fears of Covid-19
Elit Genç Atletlerin Beslenme Durumunun Değerlendirilmesi
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Giriş: Bu araştırma olimpik kamp sürecinde 15-22 yaş aralığında olan 24 genç elit atletin katılımı ile gerçekleştirilmiştir.
Amaç: Elit atletlerin beslenme alışkanlıklarını ve sporcuların beslenmeye ilişkin tutumlarını belirleyip değerlendirmek amaçlanmıştır.
Yöntemler: Elit genç sporculara ‘Sağlıklı Beslenmeye İlişkin Tutum Ölçeği (SBİTÖ) ’ uygulanmış. Katılımcıların besin tüketim sıklıkları ve 24 saatlik besin tüketim kayıtları alınmıştır. Elde edilen veriler çeşitli istatistik yöntemlerle değerlendirilmiştir
Bulgular: Genel olarak sporcuların sadece % 25’ inin 3 ana öğün tükettiği, % 25’nin 2 ana öğün ve % 50’sinin de bir ana öğün tükettiği belirlenmiştir. Çalışmamızda genç atletlerin toplam Sağlıklı Beslenmeye İlişkin Tutum Ölçeği ( SBİTÖ) ve alt boyutlarının puan ortalamaları incelendiğinde; toplam SBİTÖ puanı 70,75 olup yüksek bulunmuştur. Bu oran erkeklerde 77,55(p=0,032) olup kadınların oranından daha yüksektir ve istatistiksel olarak da önemlidir. Yine erkeklerde olumlu beslenme alt boyut oranı (20.09) kadınların oranından daha yüksek olup önemlidir (p=0,005). Bu çalışmada, diğer çalışmalara benzer olarak en fazla tüketilen besinler peynir, yumurta, sebze-meyve, et-yumurta-kuru baklagiller, beyaz ekmek, içecek çay şeklindedir.
Sonuçlar: Çalışma grubumuz, elit sporcular olup dünya çapında müsabakalara katılmalarına rağmen, beslenme konusunda uzman görüşü almadıkları, yeterli ve dengeli beslenmedikleri görülmüştür. Ülkemizde genç elit sporcuların beslenmesi ile ilgili verilerin yeterli olmadığı, araştırmanın evrenini daha geniş tutarak ve daha fazla bireye ulaşarak yararlı sonuçlar elde edilebileceği değerlendirilmekte ve bu çalışmanın yapılacak çalışmalara kaynak olacağı öngörülmektedir
Analyzing public interest in osteoarthritis and its minimally invasive treatments: A google trends analysis
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IntroductionIn recent years, online search engines have become a source of information about medical issues. We aimed to evaluate the public's interest in osteoarthritis and minimally invasive treatments of osteoarthritis in the last 10 years using Google Trends (GT).MethodsInterventional physiatrist analyzed 14 selected terms (joint pain, joint pain treatment, joint cartilage damage, narrowing of the joint, osteoarthrosis, osteoarthritis, intra-articular injection, intra-articular steroid, intra-articular hyaluronic acid, intra-articular plasma rich platelet (PRP), essential oil for joint pain, joint pain supplements, home remedies for joint pain, and stem cell for joint) related with osteoarthritis and minimally invasive treatments of osteoarthritis in physical medicine and rehabilitation discipline. All keywords were searched in the GT application using the 'all categories,' 'web search,' and 'worldwide' filters. The last 10 years have been divided into two equal parts, each spanning five years (from January 1, 2013 to December 31, 2017, and January 1, 2018 to December 31, 2022). Public interest in the 14 keywords mentioned above was recorded for these two periods, and the GT for all 14 keywords were compared across the two five-year periods.ResultsSearching rates for the terms 'joint pain,' 'joint pain treatment,' 'joint cartilage damage,' 'narrowing of the joint,' 'osteoarthritis,' 'intra-articular injection,' 'intra-articular PRP,' and 'joint pain supplements' have increased significantly in the last five years (p= 0.001, p= 0.001, p= 0.005, p= 0.001, p= 0.001, p= 0.004, p= 0.001, and p= 0.001, respectively). The average Google Trends (GT) score for all terms was 40 between January 1, 2013, and December 31, 2017, and the average GT score for all terms was 48 between January 1, 2018, and December 31, 2022 (p= 0.001).ConclusionThe present study stated that public interest in osteoarthritis and minimally invasive treatments for osteoarthritis has increased significantly in the last five years. Study outcomes demonstrated that public attention to 'joint pain,' 'joint treatment,' 'joint cartilage damage,' 'narrowing of the joint,' 'osteoarthritis,' 'intra-articular injection,' 'intra-articular PRP,' and 'joint pain supplements' has also significantly increased in the last five years
Salgın sonrası öğretmen-öğrenci-veli ilişkisinde duygusal zekaya yönelik hizmet içi eğitim uygulaması
Get PDFÖZ: Bu çalışma salgın sonrası okula dönüşte öğretmenlerin öğrenci ve velileri ile olan ilişkilerini iyileştirmek için duygusal zeka becerilerini artırmak ve bu amaca yönelik olarak hazırlanan hizmet içi eğitim uygulamasının sonuçlarını tespit etmek için yapılmıştır. Çalışma kapsamında öğretmenlerin duygusal zeka becerilerini artırmaya ve bu becerileri öğrenci ve velileri ile olan ilişkilerinde kullanmalarına yönelik olarak bir hizmet içi eğitim programı hazırlanmış ve bu programın uygulaması yapılmıştır. Araştırmanın çalışma grubunu özel bir ilkokulda çalışan 18 öğretmen oluşturmaktadır. Çalışmanın yöntemi, deneysel bir teknik olan yarı deneysel yöntem olarak belirlenmiştir. Bu kapsamda çalışma grubuna, uygulamadan önce ön test ve uygulamadan sonra son test olarak duygusal zeka ölçeği uygulaması yapılmıştır. Ayrıca çalışma grubuna uygulama sonunda, ön test ve son testten alınan sonuçların desteklenmesi amacı ile bir de çalışma için hazırlanan evet veya hayır olarak cevaplayabilecekleri anket uygulanmıştır. Çalışma grubu sayısı 30’dan az olduğu için Wilcoxon İşaretli Sıralar Testi uygulanmıştır. Çalışma sonucuna göre çalışma grubunun ön test ve son test verileri incelendiğinde, uygulama sonrasında çalışma grubunun duygusal zeka düzeylerinin, hizmet içi eğitim sonrasında artış gösterdiği saptanmıştır. Araştırma verilerinin desteklenmesi için araştırmacılar tarafından hazırlanmış olan kapalı uçlu anketten elde edilen veriler de bu sonucu desteklemektedir.ABSTRACT: This study was carried out to increase the emotional intelligence skills of teachers in order to improve their relations with students and parents after the pandemic, and to determine the results of the in-service training implementation prepared for this purpose. Within the scope of the study, an inservice training program was prepared and implemented to teachers in order to increase teachers' emotional intelligence skills and to use these skills in their relations with students and parents. The sample of the study consists of 18 teachers working in a private primary school. The method of the study was determined as the quasi-experimental method, which is an experimental technique. In this context, emotional intelligence scale was applied to the participants as a pre-test before the application and as a post-test after the application. In addition, at the end of the implementation, a questionnaire prepared for the study, which they could answer as yes or no, was applied to the participants in order to support the results obtained from the pre-test and posttest. Since the number of participent was less than 30, Wilcoxon Signed Ranks Test was applied. According to the results of the study, when the pre-test and post-test data of the participants were examined, it was determined that the emotional intelligence levels of the participants increased after the in-service training. The data obtained from the closed-ended questionnaire prepared by the researchers to support the research data also supports this result