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The effect of changing living conditions after covid-19 on compliance with a healthy diet in individuals receiving nutrition and diet consultancy
No full textCOVID-19 pandemi sürecinde değişen yaşam şartları bireylerin sağlıklı ve dengeli beslenmesini değiştirebilmektedir. Bu çalışmada COVID-19 Pandemi süreci sonrasında değişen yaşam şartları ile bireylerin sağlıklı diyete uyuma durumu arasındaki ilişkinin incelenmesi ve değerlendirilmesi amaçlanmaktadır. Çalışma kurum izni alınan danışmanlık merkezlerinde Temmuz- Ağustos 2023 tarihleri arasında 281 yetişkin birey üzerinde yürütülmüştür. Veriler çalışmaya katılan bireylerden yüz yüze anket formu ile araştırmacı tarafından alınmıştır. Araştırmada kullanılanveritoplamaaraçlarıise şuşekildedir;24saatlikbesintüketimkaydı,SYI- 2015, TÜBER Uyarlanmış SYI-2015, antropometrik ölçümler, genel beslenme alışkanlıklarına dair sorular,yaşamtarzı ile ilişki sorular,demogratik bilgiler. Araştırmaya katılan bireylerin COVID-19 öncesi ve sonrasına dair yaşam tarzları ve beslenmealışkanlıklarındaönemlifarklılıklargözlemlenmiştir.COVID-19öncesive sonrasında dışarıda yemek yeme sıklığı, açık besinlerin çok riskli olduğunu düşünme durumu, BKI ve bel çevresi ortalamaları arasında önemli düzeyde farklılıklar gözlemlenmiştir (p<0.05). Kadınlar ve erkeklerin SYI-2015 ve TÜBER Uyarlanmış SYI-2015 skorları arasında anlamlı düzeyde farklılık gözlemlenmiştir (p<0.05). Ruh halinin yemekle ilişkisi olduğunu düşünme durumu, 30 dk. içerisinde uykuya dalma durumu ve açık gıdaların hijyen açısından risk durumu ile SYI-2015 ve TÜBER uyarlanmış SYI-2015 puanları arasında önemli düzeyde ilişki saptanmıştır (p<0.05). Sonuçolarak pandemisürecindekikısıtlamalarve hastalığıninsanvücuduüzerindeki etkileri, yaşam şartları ve beslenme alışkanlıkları üzerine belirleyici bir unsur oluşturabilmektedir. Günümüzde değişen yaşam tarzı alışkanlıkları, bireylerin diyete uyum süreçlerini olumsuz etkileyebilir, bu sebeple sağlıklı beslenme alışkanlıkları sürdürülebilir hale getirilerek esnek ve pratik çözümler sunulmalıdır. AnahtarKelimeler:Beslenmealışkanlıkları,COVID-19,Değişenyaşamşartları, Sağlıklı beslenmeChanging living conditions during the COVID-19 Pandemic can change the healthy and balanced diet of individuals. This study aims to examine and evaluate the relationshipbetweenchanginglivingconditionsaftertheCOVID-19Pandemicperiod andindividuals'compliancewithahealthydiet.Thestudywasconductedon281adult individuals between July and August 2023 in counseling centers with institutional permission. The data were collected by the researcher from the individuals participating in the study using a face-to-face survey form. The data collection tools used in the research are as follows; 24-hour food consumption record, SYI-2015, TÜBER Adapted SYI-2015, anthropometric measurements, questions about general eating habits, questions related to lifestyle, demographic information. Significant differences were observed in the lifestyles and nutritional habits of the individuals participatingintheresearchbeforeandafterCOVID-19.Significantdifferenceswere observed between the frequency of eating out, thinking that open foods are too risky, BMI and waist circumference averages before and after COVID-19 (p <0.05). A significantdifferencewasobservedbetweentheSYI-2015andTÜBERAdaptedSYI- 2015 scores of women and men (p <0.05). Thinking that mood is related to food, 30 min.Asignificantrelationshipwasdetectedbetweenthestateoffallingasleepandthe hygiene risk of open foods and SYI-2015 and TÜBER adapted SYI-2015 scores (p<0.05). As a result, the restrictions during the pandemic process and the effects of the disease on the human body can be a determining factor on living conditions and eatinghabits.Today'schanginglifestylehabitsmaynegativelyaffectindividuals'diet adaptation processes, so flexible and practical solutions should be offered by making healthy eating habits sustainable. Keywords:COVID-19,Emerging,Healthynutrition,Lifelonglivingconditio
Investigating the Pharmacological Potential of Micromeria myrtifolia Boiss. & Hohen.: Phenolic Profiling and Biological Activity Assessments
No full textÖz:
Micromeria myrtifolia Boiss. & Hohen. is a valuable medicinal plant in Türkiye, recognized for its extensive applications across the country. In this study, plant samples were collected from Muğla, Türkiye and extracts from both the aerial parts and roots were prepared using ethanol. To elucidate their phytochemical composition, a comprehensive LC-MS/MS analysis was conducted. The results revealed that both extracts were quite rich in phenolic compounds. Notably, nicotiflorin was the major constituent in both extracts (12878.31355.44 μg/g extract in the aerial parts and 47512.41311.34 μg/g extract in the roots) along with significant phenolic acids such as rosmarinic acid and caffeic acid as well as flavonoids like hesperidin. Moreover, both extracts demonstrated substantial antioxidant activities compared to the synthetic antioxidant compounds as evaluated by DPPH free radical scavenging, ABTS cation radical scavenging, and CUPRAC activity assays. Both aerial parts and root extracts also exhibited meaningful anti-glucosidase activity with 73.030.16% and 47.060.41%, respectively, at 2 mg/mL concentration. The root extract also showed moderate butyrylcholinesterase inhibitory activity. This study contributes to the existing body of knowledge with valuable insights regarding the phytochemical profile and biological activities of M. myrtifolia, paving the way for future research aimed at exploring its medicinal properties and potential uses in traditional and modern medicine
Efficacy and Safety of Atezolizumab and updates Bevacizumab in Appendiceal Adenocarcinom
No full textABSTRACT
Purpose: Appendiceal adenocarcinoma (AA) remains an orphan disease
with limited treatment options for patients unable to undergo surgical resection. Evidence supporting the efficacy of combined VEGF and PD-1
inhibition in other tumor types provided a compelling rationale for investigating this combination in AA, where immune checkpoint inhibitors have
not been explored previously.
Experimental Design: We conducted a prospective, single-arm phase II
study evaluating efficacy and safety of atezolizumab in conjunction with
bevacizumab (Atezo+Bev) in advanced, unresectable AA.
Results: Patients treated with the Atezo+Bev combination had 100% disease control rate (1 partial response, 15 stable disease) with progression-free
survival (PFS) of 18.3 months and overall survival not-yet-reached with
median duration of follow-up of 40 months. These survival intervals were
significantly longer relative to a clinically and molecularly matched synthetic control cohort treated with cytotoxic chemotherapy designed for
colorectal cancer (PFS of 4.4 months, P = 0.041).
Conclusions: In light of recent data demonstrating a lack of efficacy
of 5-fluorouracil–based chemotherapy, Atezo+Bev is a promising treatment option for patients with low-grade unresectable AA; further study is
warranted.
Significance: AA remains an orphan disease with limited systemic therapy options for patients who are not candidates for surgical resection.
These data suggest activity from combined VEGF and PD-L1 inhibition that
warrants further study
Effects of isotretinoin on tooth movement, orthodontically induced and non-orthodontic root resorption: A micro-CT study
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Objectives: This study aims to investigate whether cumulative dose-dependent
isotretinoin (Roaccutane®) could affect orthodontic tooth movement (OTM) and root
resorption.
Materials and Methods: Ninety male Wistar Albino rats were divided into 4 groups.
While, the control (SALINE), solvent (SOYBEAN) and orthodontic drug (ISOTM)
groups underwent orthodontic force, the non-orthodontic drug group (ISO) did
not. The rats were administrated saline, soybean oil (SBO) and isotretinoin diluted
in SBO (ISOTM, ISO) for 30 days, respectively. Six rats were euthanized in each
orthodontic group. Fifty grams of orthodontic force was applied to the remaining rats' first molars using the incisors as anchorage. Six more rats in each group
were euthanized on the 7th, 14th and 21st days of the force application. In the ISO
group, six rats were euthanized on the 37th, 44th and 51st days of administration.
Six rats that were euthanized for ISOTM on the 30th day were also used for ISO
to reduce the number of rats used. Micro-computed tomography (micro-CT) and
histological analysis were performed.
Results: Independent of orthodontic force, isotretinoin caused root resorption in the
apical region. However, there was no statistically significant influence of isotretinoin
on OTM and orthodontically induced root resorption (OIRR).
Conclusions: Despite the lack of strong evidence supporting the orthodontically induced resorptive effect of isotretinoin, this study provided findings regarding the resorptive effects of isotretinoin on non-orthodontic root resorption. Therefore, the
present results underscore the importance of close monitoring during orthodontic
treatment to mitigate potential root resorption in patients who use isotretinoin because of acne complaints
Novel beta-lactam substituted benzenesulfonamides: in vitro enzyme inhibition, cytotoxic activity and in silico interactions
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In this study, a library of twelve beta-lactam-substituted benzenesulfonamides (5a–l) was synthesized
using the tail-approach method. The compounds were characterized using IR, 1
H NMR, 13C NMR and
elemental analysis techniques. These newly synthesized compounds were tested for their ability to
inhibit the activity of two carbonic anhydrases (hCA) isoforms, I and II, and acetylcholinesterase (AChE)
in vitro. The results showed that the synthesized compounds were potent inhibitors of hCA I, with KI
s
in the low nanomolar range (66.60–278.40 nM) than the reference drug acetazolamide (AAZ), which
had a KI of 439.17 nM. The hCA II was potently inhibited by compounds 5a, 5d–g and 5l, with KI
s of
69.56, 39.64, 79.63, 74.76, 78.93 and 74.94 nM, respectively (AAZ, KI of 98.28 nM). Notably, compound
5a selectively inhibited hCA II with a selectivity of > 4-fold over hCA I. In terms of inhibition of AChE,
the synthesized compounds had KI
s ranging from 30.95 to 154.50 nM, compared to the reference drug
tacrine, which had a KI of 159.61 nM. Compounds 5f, 5h and 5l were also evaluated for their ability to
inhibit the MCF-7 cancer cell line proliferation and were found to have promising anticancer activity,
more potent than 5-fluorouracil and cisplatin. Molecular docking studies suggested that the sulfonamide moiety of these compounds fits snugly into the active sites of hCAs and interacts with the Zn2þ
ion. Furthermore, molecular dynamics simulations were performed for 200 ns to assess the stability
and dynamics of each enzyme-ligand complex. The acceptability of the compounds based on
Lipinski’s and Jorgensen’s rules was also estimated from the ADME/T results. These results indicate
that the synthesized molecules have the potential to be developed into effective and safe inhibitors of
hCAs and AChE and could be lead agents
Comparison of wear and fracture resistance of additively and subtractively manufactured screw-retained, implant-supported crowns
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Statement of problem. Additively manufactured resins indicated for fixed definitive prostheses have been recently marketed. However,
knowledge on their wear and fracture resistance when fabricated as screw-retained, implant-supported crowns and subjected to artificial
aging is limited.
Purpose. The purpose of this in vitro study was to evaluate the volume loss, maximum wear depth, and fracture resistance of screwretained implant-supported crowns after thermomechanical aging when fabricated using additively and subtractively manufactured materials.
Material and methods. Two additively manufactured composite resins (Crowntec [CT] and VarseoSmile Crown Plus [VS]) and 2 subtractively manufactured materials (1 reinforced composite resin, Brilliant Crios [BC] and 1 polymer-infiltrated ceramic network, Vita Enamic
[EN]) were used to fabricate standardized screw-retained, implant-supported crowns. After fabrication, the crowns were cemented on
titanium base abutments and then tightened to implants embedded in acrylic resin. A laser scanner with a triangular displacement sensor
(LAS-20) was used to digitize the pre-aging state of the crowns. Then, all crowns were subjected to thermomechanical aging (1.2 million
cycles under 50 N) and rescanned. A metrology-grade analysis software program (Geomagic Control X 2020.1) was used to superimpose
post-aging scans over pre-aging scans to calculate the volume loss (mm3
) and maximum wear depth (mm). Finally, all crowns were
subjected to a fracture resistance test. Fracture resistance and volume loss were evaluated by using 1-way analysis of variance and Tukey
Honestly significant difference (HSD) tests, whereas the Kruskal-Wallis and Dunn tests were used to analyze maximum wear depth. Chisquared tests were used to evaluate the Weibull modulus and characteristic strength data (α=.05).
Results. Material type affected the tested parameters (P .001). CT and VS had higher volume loss and maximum wear depth than BC and
EN (P .001). EN had the highest fracture resistance among tested materials (P .001), whereas BC had higher fracture resistance than CT
(P=.011). The differences among tested materials were not significant when the Weibull modulus was considered (P=.199); however, VE had
the highest characteristic strength (P .001).
Conclusions. Additively manufactured screw-retained, implant-supported crowns had higher volume loss and maximum wear depth. All
materials had fracture resistance values higher than the previously reported masticatory forces of the premolar region; however, the higher
characteristic strength of the subtractively manufactured polymer-infiltrated ceramic network may indicate its resistance to mechanical
complications. (J Prosthet Dent 2024;132:154-164
The impact of calcium-binding protein S100P on temozolomide sensitivity in glioblastoma cells
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Aim: Glioblastoma (GBM), a highly aggressive primary brain tumor, often displays resistance to the standard chemotherapy agent Temozolomide (TMZ), presenting a formidable treatment challenge. This study aims to explore the impact of S100P, a calcium-binding protein linked to TMZ resistance in GBM cells, by investigating the consequences of S100P knockdown on TMZ resistance. The research, employing bioinformatics analysis and siRNA-mediated gene silencing, reveals a significant relationship between S100P and TRIM29 in the context of TMZ resistance.
Material and methods: Human GBM cells underwent transfection with S100P siRNA to achieve targeted suppression of S100P expression. The assessment of TMZ resistance was conducted through MTT cell viability assays, and the molecular mechanisms underlying the observed effects of S100P knockdown on TMZ resistance were explored using real-time PCR.
Results: Our findings reveal a significant reduction in TMZ resistance upon S100P knockdown in GBM cells. This effect is demonstrated by an increase in cell death and a concurrent decrease in the expression of proteins associated with TMZ resistance.
Conclusion: The study establishes S100P as a promising therapeutic target to overcome TMZ resistance in GBM. Silencing S100P expression emerges as a strategy to enhance the sensitivity of GBM cells to TMZ chemotherapy. These results advocate further investigations to unveil the clinical viability of targeting S100P in the treatment of GBM
Investigation of the relationship between vitamin D deficiency and vitamin D-binding protein polymorphisms in severe COVID-19 patients
Get PDFAbstract: This study explores the association of vitamin D-binding protein (VDBP) gene polymor-
phisms, vitamin D levels, and the severity of COVID-19, including the need for intensive care unit
(ICU) hospitalization. We analyzed a cohort of 56 consecutive age- and gender-matched adult COVID-
19-positive patients and categorized them into three groups: outpatients with mild illness, inpatients
with moderate disease, and ICU patients. We measured levels of free, total, and bioavailable 25-
hydroxyvitamin D [25(OH)D], VDBP, and albumin. VDBP polymorphisms rs5488 and rs7041 were
identified using real-time PCR. A significant proportion of ICU patients were vitamin D-deficient
(56.25%) compared to outpatients (10%) and inpatients (5%) (p = 0.0003). ICU patients also had
notably lower levels of VDBP (median: 222 mg/L) and total 25(OH)D (median: 18.8 ng/mL). Most pa-
tients carried heterozygous rs7041 (60.7%) and wild-type rs4588 (58.9%) genotypes. The distribution
of rs7041 SNP varied significantly among groups (p = 0.0301), while rs4588 SNP distribution did not
(p = 0.424). Heterozygous rs4588 patients had significantly lower VDBP levels (p = 0.029) and reduced
bioavailable 25(OH)D compared to those with wild-type rs4588 (p = 0.020). Our findings indicate
that VDBP gene polymorphisms, particularly rs7041 and rs4588, are associated with vitamin D status
and the severity of COVID-19. The lower VDBP levels and bioavailable vitamin D in ICU patients
suggest that these genetic variants may influence disease severity and hospitalization needs. These
results highlight the potential role of VDBP polymorphisms in COVID-19 severity, suggesting that
genetic screening could be valuable in assessing the risk of severe outcomes and guiding personalized
treatment strategies.
Keywords: vitamin D deficiency; rs7041; rs4588; vitamin D-binding protein; gene polymorphism;
severity of COVID-1
Evaluation of quality of life and anxiety status of patients applying clean intermittent catheter and affecting factors
No full textÖZET
Bu çalışma, temiz aralıklı kateterizasyon (TAK) uygulayan hastaların yaşamsal kalitesi ve anksiyete düzeylerini değerlendirmek ve etkileyen faktörleri belirlemek amacıyla tanımlayıcı-kesitsel tipte gerçekleştirildi. Çalışmaya, Kasım 2022 - Ocak 2023 tarihleri arasında İstanbul'da bulunan bir devlet hastanesinde tedavi gören ve TAK uygulanan 47 hasta dahil edildi. Araştırma verileri Hasta Bilgi Formu, Dünya Sağlık Örgütü, Yaşam Kalitesi Ölçeği-Kısa Formu (WHOQOL-BREF) ve Beek Anksiyete Ölçeği kullanarak toplandı. Katılımcıların yaş ortalaması 40.00-16.38 yıl olup çoğunluğu erkek (%76.6), evli (%51.1) ilkokul (%40.4). Hastaların%74.5'i günde yedi ve üzeri sayıda TAK kullandığını ve %68.1'i TAK uygulamada sorun yaşamadığını, %48.9'u TAK'ı kendisinin uyguladığını ve %74.5'i TAK uygulaması konusunda eğitim aldığını belirtti. Katılımcıların WHOQOL-BREF alt boyutlarına ilişkin en düşük puanı çevresel alan alt boyutundan (11.48-2.81), en yüksek puanı ruhsal alan alt boyutlarından (12.37-3.28) aldıkları bulundu. Beck anksiyete ölçeği toplam puan ortalaması 16.79-11.12 olarak belirlendi. Hastalarda yaş ile WHOQL-BREF alt boyutları arasında anlamlı ilişki (p<0.01); cinsiyete göre anksiyete düzeyleri arasında anlamlı fark saptandı (p<0.05). Çalışma durumu ve TAK konusunda eğitim veren kişiye göre ruhsal alan alt boyutu; bağımlılık durumuna göre fiziksel alan alt boyutu (r=0.356 p=0.014) arasında ise negatif yönlü anlamlı ilişki olduğu tespit edildi. Sonuç olarak TAK kullanan hastaların yaşam kaliteleri düşük ve anksiyete düzeyleri orta seviyededir. Hemşireler hastaların tanımlayıcı özelliklerini, hastalık ve TAK kullanım durumlarını dikkate alarak TAK konusunda teorik ve uygulamalı olarak eğitim vermeli ve hastayı TAK uygulaması konusunda cesaretlendirmelidir
An investigation into the effect of teaching the embedded instruction methid to parents of children with ASD on their children's learning of various concepts
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Özel gereksinimli çocukların akademik becerileri kazanmalarının temelinde kavram öğretimi vardır. Kavramları çocukların edinebilmesi için öncelikle çocuğun mevcut performansının ortaya konularak becerinin analizinin çocuğun ihtiyaç ve yeterliliklerine göre yapılması önemlidir (Uysal, 2000). OSB'li çocukların ihtiyaç duydukları eğitimi sadece okul ortamında değil en çok vakit geçirdiği ortamlarda da alıyor olmaları onların yoğun eğitim fırsatından yararlanmalarına katkı sağlayacaktır. Ebeveynlerin ayrıca eğitimci rolünü üstlendiği durumlarda OSB'li çocuklar hedef kazanımları sık tekrar ve pekiştirilmesinden ötürü rahat öğrenebilmekte hem de çok daha rahat genelleyebilmektedirler (Ingersoll and Dvortcsak, 2010). Araştırmada OSB'li çocuğu olan ebeveynlere gömülü öğretim yöntemini öğretmenin çocuklarının çeşitli kavramları öğrenmelerine etkisi incelenmektedir. Araştırmada tek denekli araştırma yöntemlerinden katılımcılar arası yoklama evreli çoklu yoklama modeli kullanılmıştır. Araştırmanın OSB'li çocuğu olan ebeveynlerin gömülü öğretim uygulamalarını öğrenmeleri ve çocukların kavram öğrenimi olmak üzere iki bağımlı değişkeni vardır. Bağımsız değişkeni ise Aile Eğitimi Programıdır. Araştırmaya yaşları 4-6 aralığında olan üç OSB'li çocuk ve onların ebeveynleri katılmıştır. Araştırmanın her aşamasında uygulama güvenilirliği ve gözlemciler arası güvenilirlik verileri toplanmıştır. Bu bağlamda araştırmanın uygulama güvenirlik katsayısı ile gözlemciler arası güvenirlik katsayısı %100 olarak hesaplanmıştır. Ayrıca araştırmaya katılan 25 diğer eğitimciden araştırma hakkındaki görüşleri öğrenmek amacıyla sosyal geçerlik verileri toplanmıştır. Bulgular, OSB'li çocuğu olan ebeveynlere gömülü öğretim yöntemini öğretmenin, çocukların çeşitli kavramları öğrenmelerinde etkili olduğunu göstermektedir. Ayrıca OSB'li çocuklar kazandıkları becerileri farklı uyaranlarla da genelleyebilmekte ve uygulama oturumları sona erdikten 7, 14 ve 21 gün sonra da kazandıkları bu becerileri sürdürdükleri görülmektedir. Kelimeler: Gömülü Öğretim, Kavram Öğretimi, Aile Eğitimi.
ABSTRACT
The foundation of acquiring academic skills for children with special needs lies in concept teaching. In order for children to acquire concepts, it is important to first identify the child's current performance and analyze the skill according to the child's needs and competencies (Uysal, 2000). The fact that children with special needs receive the education they need not only in school settings but also in the environments where they spend most of their time will contribute to their benefitting from intensive educational opportunities. Additionally, when parents take on the role of educators, children with special needs can learn comfortably and generalize much easier due to the frequent repetition and reinforcement of target achievements (Ingersoll and Dvortcsak, 2010). This study examines the effect of teaching embedded instruction method to parents of children with special needs on their children's learning of various concepts. The participant-interaction probe-repeated measures design, a single-case research method, was used in the study. The study has two dependent variables: parents of children with special needs learning embedded instruction practices and children's concept learning. The independent variable is the Family Education Program. Three children with special needs aged between 4-6 and their parents participated in the study. Throughout the study, data on application reliability and inter-observer reliability were collected. In this context, the application reliability coefficient and inter-observer reliability coefficient of the study were calculated as 100%. Additionally, social validity data were collected from 25 other educators participating in the study to learn their opinions about the research. The findings indicate that teaching embedded instruction method to parents of children with special needs is effective in helping children learn various concepts. Moreover, children with special needs can generalize the skills they acquire with different stimuli, and it is observed that they sustain these skills 7, 14, and 21 days after the end of the application sessions. Keywords: Embedded Instruction, Concept Teaching, Family Education