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Examination of Triazolinedione-Derived Dihydropyrrole Hybrid Compounds: ER Stress-Related Apoptosis in Breast Cancer Cells, Molecular Docking, and ADMET Analysis
No full textBackground In many types of cancer, uncontrolled growth and proliferation of cells occur due to abnormalities in their genes, mutations of pro-apoptotic proteins, or upregulation of anti-apoptotic proteins. Triazolinedione and pyrrole derivatives are compounds with anti-microbial, anti-fungal, anti-inflammatory, and anti-cancer activities. Pyrrole and its derivatives are critical heterocycle compounds that are significant in anticancer studies and highly preferred in research.Objective This study aimed to investigate the effects of dihydropyrrole derivatives substituted with triazolinedione on the MCF-7 (breast cancer) cell line's apoptosis, ER stress, and heat shock genes.Methods The mRNA levels of apoptosis, ER stress, and heat shock proteins were assessed by qRT-PCR method in the MCF-7 cell line. The investigation of ADMET features, crucial pharmacokinetic indices for the potential candidacy of compounds as drugs, has been meticulously designed. In silico-induced molecular docking studies were conducted to further explore the interaction and elucidate the orientation of hybrid compounds within the active sites of BCL-2, PARP, HSP70, HSP90, and GRP78.Results It was determined that the compounds caused cell death by modulating apoptotic (compound IV), ER stress, and heat shock proteins (compounds XI and XVI) through up- and down-regulation. Our findings have pointed to the effects of triazolinedione-substituted dihydropyrrole derivatives, exhibiting antitumor activity on apoptosis, ER stress, and heat shock genes in the MCF-7 cell line.Conclusion The compounds investigated in this study have been found to be promising for anticancer research.Amasya University [FMB-BAP 18-0321]This work was supported by Amasya University (FMB-BAP 18-0321)
Effects of spinal mobilisation in adolescent idiopathic scoliosis: A randomised controlled trial
No full textAim: The aim of this study was to evaluate the effects of spinal mobilisation on curvature magnitude, angle of trunk rotation (ATR) and pulmonary function in adolescents with idiopathic scoliosis (AIS). Methods: Conducted as a double-blind randomised controlled trial, the study included 40 patients with AIS (Cobb angles 10 degrees-25 degrees) randomised to experimental (n = 20; female = 12, male = 8; age = 12.9 +/- 1.8 mean +/- SD) and control (n = 20; female = 13, male = 7; age = 12.85 +/- 1.81 mean +/- SD) groups. The experimental group received spinal mobilisation for 30 min per session followed by 60 min of core stabilisation exercises (CSE), twice a week for 10 weeks. The control group received CSE only at the same frequency and duration. Evaluation of Cobb angle, ATR and pulmonary function tests (PEF: Peak Expiratory Flow, FEV1: Forced Expiratory Volume in 1 s, FVC: Forced Vital Capacity, and FEV1/FVC: Tiffeneau index) were performed at baseline and after the intervention. Results: Both groups showed significant improvements in Cobb angle, ATR, PEF and FVC, with the experimental group showing significantly greater improvements in Cobb angle (-7.65 +/- 3.17) and ATR (-2.5 +/- 1.43) compared to the control group (P < 0.05). In addition, while the control group showed no change in FEV1, the experimental group showed improvement. There was no change in FEV1/FVC ratio in either group. Conclusion: These results indicate that adding spinal mobilisation to treatment sessions can effectively reduce the magnitude of curvature and improve scoliosis-related problems in the short term.We would like to express our sincere gratitude to all participants for their invaluable contributions to this study. We would also like to express our special thanks to the patient and his parents for permission to include their images in this publication
Effect of Canary (Serinus canary) Semen Modified with Different Extenders on Fertilization in Artificial Insemination
No full textIn this study, the effect of Dulbecco's Phosphate Buffered Saline (DPBS) and Dulbecco's Modified Eagle's Medium (DMEM) extenders on artificial insemination was determined. For this purpose, the number of fertile eggs, the total number of eggs, the number of hatched eggs, and the number of hatchlings from fertile eggs were determined in the study. From these values, the fertility rate (%), egg hatch rate (%) and fertile egg hatch rate (%) were calculated. Twelve male and female canaries (Gloster breed; 1-2 years old) were used in each group. In the study, three groups, one control (C) and the other two treatment groups (T-1, T-2) were formed. Female canaries in group C were directly inseminated without using any extenders. Females in the T-1 group were diluted 1:1 with DPBS; females in the T-2 group were inseminated with semen diluted 1:1 with DMEM. Although there was a significant difference between the groups in terms of fertility rate (P0.05). The highest fertility rate (61.81%) was in group C; the lowest was in the T-1 (29.17%) group. (P<0.05). Using a DPBS extender, it was revealed that the fertility rate was negatively affected in insemination. Due to the limited number of studies on this subject, it is thought that it will be essential to investigate DPBS and DMEM diluents at different rates and methods in future studie
Numerical Coupling of Landau-Lifshitz-Gilbert Equation with Maxwell's Equations to Simulate Electromagnetic Wave Interaction with Ferromagnetic Materials
No full textIEEE ITNC-USNC-URSI Radio Science Meeting / IEEE International Symposium on Antennas and Propagation (AP-S) -- JUL 14-19, 2024 -- Florence, ITALY[No abstract available]Inst Elect & Elect Engineers,Int Union Radio Sci, Italian Natl Comm,Int Union Radio Sci, US Natl Comm,IEEE Antennas & Propagat So
Pregnant women’s depression and posttraumatic stress levels after the large-scale Turkey earthquakes: a cross-sectional study
No full textDepression and posttraumatic stress disorder are two common mental disorders after negative life events. This study was conducted to evaluate the depression and posttraumatic stress levels of pregnant women after the large-scale earthquakes that occurred in Turkey in 2023. The study was carried out with 395 pregnant women who visited maternity outpatient clinics of a public hospital in a province in southern Turkey. The data were collected with the Beck Depression Inventory (BDI) and the Post-Traumatic Stress Disorder Checklist–Civilian Version (PCL-C). Descriptive statistics, the independent-samples t-test, and the Pearson correlation test were used in the analyses of the data. Among all participants, 3.8 percent had a likely depression risk, and 31.9 percent exhibited posttraumatic stress disorder symptoms. A statistically significant relationship was found between the earthquake exposure of the participants and their BDI and PCL-C total scores (p <.05). The BDI scores of the participants also had statistically significant relationships to their PCL-C scores (p <.05). In this study, it was discerned that posttraumatic stress disorder symptoms were prevalent among pregnant women in the post-earthquake period. Psychological support is needed to improve the mental health of the pregnant women after earthquakes. © 2024 Taylor & Francis Group, LLC
Bebek spa merkezleri hakkında bir inceleme: Türkiye örneği
No full textAmaç: Bu çalışma, Türkiye’de faaliyet gösteren bebek spa merkezlerinin verdiği hizmetleri, spa terapisini gerçekleştiren kişilerin niteliklerini belirlemeyi amaçlamaktadır. Yöntem: Kesitsel ve tanımlayıcı bir çalışmadır. Çalışmanın evrenini, 9 Eylül 2021 tarihinde Türkiye’de faaliyet gösterdiği tespit edilen 180 bebek spa merkezi oluşturmaktadır. Çalışmanın verileri, araştırmacıların geliştirdiği anket formu kullanılarak telefonla görüşme yöntemiyle toplanmıştır. Anket formunda, kurum ve kurum yöneticisi, uygulayıcı ve uygulamalarla ilgili sorular bulunmaktadır. Bulgular: Çalışma 49 merkezin katılımı ile tamamlanmıştır. Kurumların ortalama hizmet süresi 2,27 yıl olup en eski kurum 5 yıldır faaliyet göstermektedir. Yaş ortalaması 29,07 olan uygulayıcıların (n=55) büyük çoğunluğu kadın (%98) ve ön lisans mezunudur (%80). Uygulayıcıların, %31’i çocuk gelişimi, %23’ü fizyoterapi, %16’sı hemşirelik mezunu olup, %96’sının masaj eğitimi, %33’nün hidroterapi ve %24’ünün ilk yardım eğitimi bulunmaktadır. Uygulamalar ayda ortalama 2,93 kez yapılıp, spa uygulaması ortalama 31,98 ve masaj 18,65 dakika sürmektedir. Sonuç: Bu çalışma, yakın zamanda faaliyete başlayıp popülerliği artan bebek spa merkezlerinin faaliyetleri ve uygulayıcıları ile ilgili bir profil sunmaktadır. Uygulayıcı eğitimlerinin geliştirilip, uygulamalar ile ilgili standardizasyon ve düzenli denetleme getirilmesi gerektiği sonucuna varılmıştır
Cyclotriphosphazenes: Pre-harvest foliar applications improve antioxidant activity by increasing phenolic compounds in Lavandula angustifolia Mill.
No full textThe versatile chemical structures of cyclotriphosphazenes (CTPs) and their derivatives make them useful for various applications, including serving as plant nutrients to enhance the production of bioactive compounds. Therefore, the effects of 30 and 60 mg/L concentrations of CTPs (Compound 4 and 5) sprayed foliar at two different stages (pre-flowering stage and full-flowering stage) on total flavonoids and phenolic content, antioxidant activity, and accumulation of phenolics in lavender (Lavandula angustifolia Mill.) were investigated. Compounds 4 and 5 were purified by using column chromatography. The structures of the compounds were verified using mass, 1H, 31P nuclear magnetic resonance (NMR) spectroscopy, and Fourier-transform infrared (FT-IR) spectroscopy methods. The highest total phenolic content and antioxidant activity were achieved with Compound 5 (60 mg/L) treatment by using Folin-Ciocalteu and 2,2-diphenyl-1-picrylhydrazyl (DPPH) tests. The phenolic profile was determined by using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Compound 4 treatment yielded a higher level of increase in total flavonoids, protocatechuic aldehyde, protocatechuic, caffeic acid, 4-OH benzoic, and salicylic acid, whereas Compound 5 treatment yielded a higher level of increase in vanillic, p-coumaric, ferulic, and rosmarinic acids. CTPs applied during the full-flowering stage resulted in significant increases, such as an 8.7-fold rise in protocatechuic acid, a 4.3-fold increase in protocatechuic aldehyde, and an 8.4-fold surge in caffeic acid. The caffeic acid was strongly and positively correlated with the 4-OH benzoic acid (,834**), vanillic acid (,955**), p-coumaric acid (,670**), and rosmarinic acid (,669**). The results showed that using a suitable cyclotriphosphazene compound(s) and selecting a suitable preharvest application time can significantly enhance and optimize the levels of phenolics
Disrupted harmony of the skull skeleton: Middle ear resonance in acromegaly
No full textObjectives: This study aims to investigate whether the middle ear resonance frequency (RF) is affected in acromegaly, which causes growth in the skull bone. Methods: Thirty acromegaly patients and 38 volunteers were included in the study. Pure tone average scores and middle ear RF values of the groups that underwent pure tone audiometry, tympanometry, and multifrequency tympanometry tests were compared. Results: The pure tone mean was 14.95 +/- 12.13 in acromegaly patients and 5.70 +/- 8.52 in the control group (p:0.18). Sensorineural hearing loss(SNHL) was observed in 16.6% of the patients. The average middle ear RF was calculated as 815 +/- 179.05 Hz in patients with acromegaly and 773 +/- 127.15 in the control group. ( p = 0.0001). Conclusion: This study is the first to evaluate middle -ear RF in acromegaly patients. Acromegaly-induced changes in soft tissues and bone structures impact middle ear functions. In this patient group, we found an increase in middle ear RF without conductive -type hearing loss and a 16.6% rate of SNHL
Traumatic Stress, Social Support, Resilience, and Posttraumatic Growth: Comparison of LBGT+ and Heterosexual Individuals in a Developing Country
No full textObjective: Posttraumatic growth (PTG) is a concept that may emerge after a traumatic experience and describes an experience that includes reaching a higher level of development in various areas of life compared to pretrauma. Although everyone is at risk for traumatic experiences, some populations such as minorities may be at more risk for stress, crisis, and trauma. However, there are limited studies that examine the difference between minority and majority groups in terms of variables related to trauma and PTG. The present study aims to investigate these variables between lesbian, gay, bisexual, and transgender (LGBT+), which is considered a minority group, and heterosexual individuals in a developing country like Turkey. Method: Participants were 40 LGBT+ and 73 heterosexual individuals aged between 18 and 60 (26.88 ± 8.21). PTG, posttraumatic stress disorder symptoms, psychological resilience, social connectedness, perceived available support, and psychological inflexibility were measured using self-report questionnaires. Results: All questionnaires were internally consistent (αs from.87 to.96). PTG showed a significant correlation only with the perceived available support both for all participants and for LGBT+ and heterosexual groups separately. All variables except PTG differed significantly between LGBT+ and heterosexual individuals. Conclusions: The results have implications regarding an LGBT+ community in a developing country, as they appear to have clinically significant traumatic symptoms. In addition, LGBT+ individuals also appear to have less social and individual resources, which should be considered for delivering treatments and providing support for this group. © 2024 American Psychological Associatio
Validity and Reliability Testing of the Turkish Version of the Self-Acceptance Scale for Pregnant Women
No full textObjective: This study was conducted to adapt the Self-Acceptance Scale for Pregnant Women (SAS-PW), which was developed in Brazil, to Turkish and test the psychometric properties of its Turkish version. Method: This methodological study was carried out with 576 pregnant women who presented to the pregnancy outpatient clinics of a Research and Training Hospital in northern Turkey between December 2021 and April 2022. The validity of the Turkish version of SAS-PW was tested by conducting linguistic, content, and construct validity analyses, while its reliability was tested by conducting internal consistency and test- retest analyses. Results: According to the results of the exploratory factor analysis, the factor load values of the items and the rates of the total variance in scale scores explained by the factors were sufficient. The confirmatory factor analysis results demonstrated that the goodness-of-fit indices of the scale were within suitable ranges. The 2-factor and 10- item construct of the original SAS-PW was confirmed based on the factor analyses. The item-total score correlations of the scale were found sufficient, and the total Cronbach's alpha coefficient of SAS-PW was determined to be 0.93. The test-retest analysis of the scale scores revealed a strong correlation between the scores of the two implementations. Conclusion: The Turkish version of SAS-PW is a valid and reliable measurement instrument to evaluate the self-acceptance levels of pregnant women in Turkish society