10137 research outputs found
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Technology is nothing, the terrain is everything: Factors influencing the implementation of point of care testing for Malaria, Human Immunodeficiency Virus (HIV) and Tuberculosis within East Africa.
Full text linkPoint-of-care testing is a central strategy for controlling the infectious diseases Malaria, Human Immunodeficiency Virus (HIV) and Tuberculosis (TB), especially in low and middle-income countries where access to laboratories is scarce. However, its routine implementation into frontline diagnostic practices remains inadequate to meet global targets. This study explored the factors influencing the implementation of malaria, HIV, and TB point-of-care (POC) testing by frontline health workers in primary healthcare settings in a rural county in Coastal Kenya. Adopting a pragmatic philosophical lens, this mixed-methods study drew on Normalisation Process Theory to explore how health providers implemented these POC testing interventions and how they became embedded in routine practice. Frontline health providers participated in a cross-sectional facility survey of 40 public and private primary health facilities, 11 semi-structured interviews, and 7 focus group discussions, providing a comprehensive understanding of the broad context and the in-depth experiences involved in implementing each POC testing process. Descriptive analysis of the survey data was performed using the statistical computing platform R. The qualitative data were analysed thematically using Ritchie & Spencer’s (1994) Social Framework Analysis Approach, with NVivo Version 11 software assisting in the management and systematic analysis process. Applying Cresswell's Convergent Mixed Methods Approach, the datasets were merged to provide a more comprehensive understanding of each POC testing process. The study identified three overarching contextual factors shaping the implementation of POC testing: the capacity to provide laboratory services, the value attributed to patient care and health providers’ work, and access to a supportive network, regardless of whether the POC testing focused on malaria, HIV or TB. In conclusion, the study highlights the dedication and resourcefulness of health providers who, despite the constraints typical of low and middle-income countries, work innovatively to embed the POC testing processes into routine diagnostic practices to enhance patient care
Dysfunctional pericellular hyaluronan deposition contributes to attenuated CD44/EGFR co-localization and impaired myofibroblast differentiation in chronic wound fibroblasts.
Full text linkFrom PubMed via Jisc Publications RouterHistory: received 2025-04-12, revised 2025-05-14, accepted 2025-06-07Publication status: aheadofprintNon-healing chronic wounds, such as venous ulcers and pressure sores, represent significant causes of patient morbidity and financial burden to Healthcare Services worldwide. During normal healing, dermal fibroblasts (DFs) mediate numerous responses to promote wound closure. However, phenotypic changes induced within chronic wound environments lead to dysfunctional fibroblast functions, which facilitate non-healing. Although the processes underlying impaired proliferative and migratory responses in chronic wound fibroblasts (CWFs) are established, the mechanisms that mediate impaired CWF-myofibroblast differentiation remain poorly understood. Fibroblast-myofibroblast differentiation is induced by transforming growth factor-β (TGF-β ) and downstream classical Smad2/3 and non-classical epidermal growth factor receptor (EGFR)/ERK1/2 signaling, initiated through hyaluronan (HA) receptor (CD44) binding to EGFR and dependent on elevated HA synthesis and its pericellular accumulation. Here, we demonstrate that these signaling pathways are dysregulated in venous ulcer- and pressure sore-derived CWFs, compared to DFs. CWFs exhibit increased susceptibilities to cellular senescence and impaired myofibroblast differentiation, accompanied by defective lysosomal/endosomal activities and dysfunctional activation of the HA/CD44/EGFR pathway. Irrespective of wound source, CWFs exhibited increased HAS1 versus HAS2 expression, altered HAS1 and HAS2 intracellular localization, and deregulated hyaladherin (CD44, TSG-6, and IαI heavy chain motifs, HC3, HC4 and HC5) induction, following TGF-β stimulation. These events attenuated HA pericellular coat formation and CD44/EGFR co-localization within membrane lipid rafts, essential for myofibroblast development. Our findings suggest that aberrant HAS1 and HAS2 expression and distributions cause reduced pericellular hyaluronan deposition, leading to attenuated CD44/EGFR co-localization and dysfunctional CWF-myofibroblast differentiation, which contributes to the impaired closure and healing of chronic wounds. [Abstract copyright: Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.]450pubpub
Failures in Impact Evaluation [Datasets]
No full textDatasets associated with: Jancovich, L., Pitches, C. and Stevenson, D. (2025) ‘Failures in Impact Evaluation’, Research Evaluation [Preprint]. https://eresearch.qmu.ac.uk/handle/20.500.12289/1432
More-than-human centred reflection: Addressing the fiction of reflective practice in teacher education
Full text linkCatriona Oates - ORCID: 0000-0001-9043-3122
https://orcid.org/0000-0001-9043-3122This paper seeks to extend the debate around the contested concept of the ‘reflective practitioner.’ This concept has influenced practice-based learning across a range of disciplines, including social work, nursing and teaching and although assumptions are commonly made about its value to the developing practitioner, it has also been subject to critique. From the perspective of Scottish teacher-education, we propose moving beyond commonly accepted reflective practices to arrive at a reframing of it as a ‘more than human’ (Strom and Viesca, 2021) endeavour, in a way that decentres the practitioner from the process of reflection. We firstly consider some benefits and limitations of commonly used, human-centric models of reflection in teacher education; both in practice and in regulation. We then use two familiar classroom scenarios to demonstrate how these models of reflection can constrain the reflective process, and student-teachers’ agentic possibilities. We explore how a theoretical reframing of the problem through connectivism (Downes, 2007; Siemens, 2005), offers a fresh perspective that challenges the practitioner to reflect in multiple dimensions; on their means of connecting with others and the ‘matter’ of their practices – the material, physical and conceptual objects that are drawn into the orbit of the day-to-day work of teaching and learning. The proposed approach invites student-teachers to decentre themselves from their reality and consider a range of realities, allowing their reflections to more genuinely, critically and authentically reflect the realities of their experiences in the classroom. Although situated in the context of Scottish teacher education, this provocation offers fresh consideration of a problem that is currently of relevance to student-teachers and those involved in teacher education in both a UK-wide and international context.The author(s) received no financial support for the research, authorship, and/or publication of this article.https://doi.org/10.1177/00345237251317373aheadofprintaheadofprin
A research conversation: Stephanie Arsoska and Andrew Morrish
No full textFrom Crossref journal articles via Jisc Publications RouterHistory: ppub 2024-12-01, issued 2024-12-01Publication status: PublishedFunder: Queen Margaret University; FundRef: https://doi.org/10.13039/100010033Item is embargoed in eResearch.This interview is a research dialogue between Stephanie Arsoska and Andrew Morrish, focusing on their exploration of Stephanie’s solo improvisation practice. Over the course of a year, they conducted ten, ten-minute solo improvisations via Zoom, analysing emerging patterns over time. Stephanie’s practice, which integrates movement and text, is deeply rooted in acting and physical theatre traditions. Rather than engaging in conceptual analysis, they adopted reflective and descriptive methods to gain insights through lived experience. Their goal was to better understand and articulate their creative processes. The conversation highlights the importance of cultivating a pedagogical awareness within artistic practice, fostering openness and mapping these practices to achieve a deeper understanding. Their methodology involved gathering data from multiple perspectives, promoting a reflective engagement with personal experiences and uncovering new insights through the process of improvisation.© S. Arsoska and A. Morrish (2024) The definitive, peer reviewed and edited version of this article is published in Choreographic Practices, 15(2), pp. 291–300. Available at: https://doi.org/10.1386/chor_00082_7.15pubpub
Education as gift: Challenging markets and technology and celebrating the spirit of education Damian Ruth. Brill, Leiden, 2024, 282pp. Education, Culture, and Society series, vol. 7. ISBN 978-90-04-68947-3 (hbk), ISBN 978-90-04-68946-6 (pbk), ISBN 978-90-04-68948-0 (eBook) [Book review]
No full textItem is not available in this repository.https://doi.org/10.1007/s11159-025-10145-6aheadofprintaheadofprin
Users' Perceived Service Quality of National Telemedicine Services During the COVID-19 Pandemic in Bangladesh: Cross-Sectional Study.
Full text linkFrom PubMed via Jisc Publications RouterHistory: received 2023-02-25, revised 2024-08-22, accepted 2024-08-26Publication status: epublishDaniel Reidpath - ORCID: 0000-0002-8796-0420
https://orcid.org/0000-0002-8796-0420COVID-19 created an opportunity for using teleconsultation as an alternative way of accessing expert medical advice. Bangladesh has seen a 20-fold increase in the use of teleconsultation during the pandemic. The aim of our study was to assess the influence of service quality and user satisfaction on the intention to use teleconsultation in the future among users of national teleconsultation services during the pandemic. A cross-sectional survey was conducted in 2020 among users of the national teleconsultation service-Shastho Batayon for acute respiratory infection. A validated mobile health service quality model based on structural equation modeling and confirmatory factor analysis was used to analyze the data with SmartPLS (version 3.0). Among the 2097 study participants, 1646 (78.5%) were male, 1416 (67.5%) were aged 18-39 years, 1588 (75.7%) were urban residents, 1348 (64.2%) had more than 10 years of schooling, and 1657 (79%) were from middle-income households. From a consumer perspective, the quality of the service platform (β=.946), service interaction (β=.974), and outcome (β=.955) contributed to service quality. Service quality was positively associated with user satisfaction (β=.327; P<.001) and intention to use teleconsultation services (β=.102; P<.001). User satisfaction was positively associated with the intention to use teleconsultation services (β=.311; P<.001). The increase in the use of teleconsultation during the pandemic indicated that such services were potentially used for emergencies. However, the future use of teleconsultation will be dependent on the quality of service and user satisfaction. Our findings are relevant for low-income contexts where teleconsultation services are used to address gaps in service delivery. [Abstract copyright: © Fatema Khatun, Novel Chandra Das, Md Rakibul Hoque, Kazi Nazmus Saqeeb, Monjur Rahman, Kyung Ryul Park, Sabrina Rasheed, Daniel D Reidpath. Originally published in JMIR Human Factors (https://humanfactors.jmir.org).]pubpu
DISORIENTATED AFFECTS: ENCOUNTERING QUEER TRAUMA THROUGH EXPERIMENTAL DOCUMENTARY FILM
Full text linkThis arts-based PhD investigates microaggressions against queer bodies through an experimental documentary film art process. While the idea of a spectacular, very violent, and rupturing trauma experience begins to take on more nuanced perspectives through inquiries of feminist, post/de/anticolonial and queer scholarship, the particular fragmented, embodied and subjective affects of an exposure to microaggressions have as of yet not been fully understood within trauma studies. What do microaggressions do with queer bodies? How do they change their shape and distort their appearance, thus enacting oppression on and beneath the surface of queer bodies? Thisstudy uses experimental film aesthetics and a queer film-phenomenological lens informed by Sara Ahmed (2006) and Katharina Lindner (2018) to question dominant understandings of trauma as rupture and demands a sensibility to forms of violence that are invisible, intangible, fragmented or purely embodied. Introducing a queer politics of encountering and sharing trauma on a sensory level, this study particularly explores what the cumulative, piercing nature of microaggressions takes out of queer people’s grasp, yet also the potentials of aesthetic and practical disorientation for building new lines of thought and action. The co-creative exhibition over/exposed acts as the main vehicle to (de)construct spaces of queerness, co-creation and trauma in experimental documentary film. over/exposed negotiates trauma through various filmic, bodily and spatial surfaces; its encounters disorientate, twist and trouble co-creators, viewers and researcher as a queer politics of encountering and sharing trauma on a sensory level is assembled. Through an affective analysis of the 10 artworks as well as the co-creative process, this study reveals a new understanding of trauma as overexposure that brings attention to abrasions, frictions and subtle intrusions to queer bodies, the (power) relations within and beyond an artistic process and the significance of an instable and disorientated body for producing new knowledge.Due to its artistic layout, chapter 4 of this thesis is best viewed in two-page view
Is the Past a Different Culture? Tracking Changes in Prosodic Features of Child-Directed Broadcasting Across Six Decades
Full text linkSonja Schaeffler - ORCID: 0000-0003-0493-9165 https://orcid.org/0000-0003-0493-9165Project data is available here: https://osf.io/59wsb/ .While research has explored cross-cultural variation in childdirected speech (CDS), little is known about if and how it may have changed over time. We explore whether CDS has undergone historical change by analyzing prosodic features in child-directed (CD) broadcasts from a German children’s bedtime program (1959–present) and comparing them to adultdirected (AD) weather forecasts from the same period. The program originated in East Germany and continued after German reunification in 1990, potentially reflecting a sociocultural shift toward more child-centric attitudes characteristic of Western liberal democracies. Pitch variation in CD broadcasts, although higher than in AD broadcasts, remained stable over time. In contrast, articulation rates showed no register difference pre-1990; only after 1990 did CD broadcasts exhibit the slower articulation rates typical of CDS. This suggests that some features of CDS may be subject to cultural evolution over historical time, which can be accelerated by major historical events.47inpressinpres
Health financing
No full textSophie Witter - ORCID: 0000-0002-7656-6188 https://orcid.org/0000-0002-7656-6188Item is not available in this repository.pubpu
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