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Denjin-Keikaku 2.0: Empowering Aviation Autonomy by Anthropomorphic Assistants
Get PDFThe rapid development and proliferation of emerging computing technologiesusing artificial intelligence (AI) have the potential to transform existing aviationoperations. Such technologies may be implemented by either a virtual or physicalagent; the latter called DENJIN. DENJIN supports Single Pilot Operation (SiPO)by retrofitting a physical humanoid robot possessing cognitive and physicalcapabilities of a typical human pilot, powered by AI, to existing aircraft. TheHuman-Robot Interaction literature indicates that the anthropomorphism of arobot influences trust in the robot, which is critical for successful humanautomationinteraction. Hence, this project aims to explore how human operators’trust varies across different levels of anthropomorphism
The Guardian the Month of July 2025
Get PDFNews articles from The Guardian for the Month of July 2025. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.https://corescholar.libraries.wright.edu/guardian/3679/thumbnail.jp
Creating Blood Analogs to Mimic Steady-State Non-Newtonian Shear-Thinning Characteristics Under Various Thermal Conditions
Get PDFBlood analogs are widely employed in in vitro experiments such as particle image velocity (PIV) to secure hemodynamics, assisting pathophysiological diagnoses of neurovascular and cardiovascular diseases, as well as pre-surgical planning and intraoperative orientation. To obtain accurate physical parameters, which are critical for diagnosis and treatment, blood analogs should exhibit realistic non-Newtonian shear-thinning features. In this study, two types of blood analogs working under room temperature (293.15 K) were created to mimic the steady-state shear-thinning features of blood over a temperature range of 295 to 312 K and a shear range of 1~250 s−1 at a hematocrit of ~40%. Type I was a general-purpose analog composed of deionized (DI) water and xanthan gum (XG) powder, while Type II was specially designed for PIV tests, incorporating DI water, XG, and fluorescent microspheres. By minimizing the root mean square deviation between generated blood analogs and an established viscosity model, formulas for both blood analogs were successfully derived for the designated temperatures. The results showed that both blood analogs could replicate the shear-thinning viscosities of real blood, with the averaged relative discrepancy \u3c 5%. Additionally, a strong linear correlation was observed between body temperature and XG concentration in both blood analogs (coefficient of determination \u3e 0.96): for Type I, 295–312 K correlates with 140–520 ppm, and for Type II, 295–315 K correlates with 200–560 ppm. This work bridges the gap between idealized steady-state non-Newtonian viscosity models of blood and the complexities of real-world physiological conditions, offering a versatile platform for advancing particle image velocimetry tests and hemodynamics modeling, optimizing therapeutic interventions, and enhancing biomedical technologies in temperature-sensitive environments
OntoInsight - A Metric-Guided Tool for Ontology Quality Evaluation with LLM-Powered Recommendations
No full textOntologies are foundational to conceptual modeling and semantic systems across diverse domains, yet evaluating and improving their quality remains a complex challenge. Existing tools often focus on syntactic correctness or complex metric reporting, lacking actionable and interpretable feedback, which is not very intuitive. We present an ontology quality evaluation tool, named OntoInsight, that caters to different types of users, from beginners to advanced, with custom recommendations, basic (simple suggestions), and advanced (involving deep technical insights) recommendations. It can handle ontologies of varying size with full ontology evaluation and modular evaluation (useful for large and complex ontologies). The pipeline automates all the stages in the tool, from metric computation (via frameworks such as OQuaRE) and seed-term-based modularization to controlled natural language (CNL) translation and targeted prompt generation for Large Language Models (LLMs). The user has the freedom to configure their own LLM API key and choose the type of evaluation and suggestions they want, according to their needs and expertise. The source code of OntoInsight is available under Apache 2.0 license at https://github.com/kracr/onto-insight
The Special Issue “The 20th Anniversary of Pharmaceuticals—Multi-Targeted Natural Products as Therapeutics” Editorial—Multi-Targeted Therapeutics from Natural Sources: What Do We Know?
No full textHerbal and marine products in the form of extracts, infusions, and decoctions have been used for centuries in folk and traditional medicine. Preparations typically contain multiple biologically active compounds. The World Health Organization (WHO) estimated that about 65% of consumers worldwide use natural remedies containing bioactive molecules to treat various diseases [1]. Most single-molecule drugs of natural origin were developed in the middle of the 20th century through the active screening of natural products for bioactive molecules [2]. Examples include artemisinin, cyclosporine, taxol, doxorubicin, and many others. However, at the beginning of the 21st century, we saw a decline in the number of “natural drugs” introduced to the market. A limiting factor could be explained by the pharmaceutical industry blockbuster model, implying the development of few drugs that make a bulk profit (e.g., USD 1 billion in sales for a drug per year [2]). Another reason for this decline could be the introduction of the high-throughput screening of synthetic libraries. A limitation to the large-scale production of “natural drugs” is the availability of herbal or marine sources for their production. However, the research community has expressed great interest in investigating new therapeutics from natural sources. The Special Issue “The 20th Anniversary of Pharmaceuticals—Multi-Targeted Natural Products as Therapeutics” has had great success, with 25 articles published. These comprise eight review articles and seventeen research articles. This Special Issue aimed to summarize and examine the latest research findings in identifying natural products targeting multiple pathways and body functions that can successfully treat multifactorial diseases. The Guest Editors are thankful for all contributors
Advances in Radiation Therapy Enhancement and Radio-Protection By Nano-Curcumins
No full textIntroduction/objective: Nano-curcumins (Nano-CUR) improve solubility, bio-availability, and stability of the release of CUR into the body. In this systematic review, we aiM.T.o investigate different CUR nanoformulations\u27 in targeting radiosensitizing path-ways and radioprotective mechanisms. Methods: We thoroughly searched electronic databases, including PubMed/MEDLINE, Web of Science, Scopus, Embase, and Cochrane Library to identify pertinent studies pub-lished before July 21, 2024. inclusion and exclusion criteria were set based on the study\u27s purposes. Two reviewers independently performed data extraction to ensure precision and minimize bias. Subsequently, the data were extracted and analyzed. Results: A total of 24 articles were included. Nano-CURs by scavenging the levels of re-active oxygen species (ROS), decrease malondialdehyde (MDA), improve superoxide dismutase (SOD), prevent DNA methylation, reduce tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-b and transforming growth factor-beta (TGF-β1), improve cell cycle, inhibit vascular endothelial growth factor (VEGF), attenuate cell cytotoxicity and modu-late cell apoptosis induce its radioprotective effects. In contrast, Nano-CUR induces oxida-tive stress and accumulation ROS, inhibits nuclear factor-κB (NF- κB), activates the ex-pression of TNF, TGF-β, phosphatidylinositol and FoxO, causing DNA damage, activat-ing proapoptotic pathways (boosted P53, P21 and BAX expressions), cell cycle arrest, re-ducing hypoxia-inducible factor (HIF-1α), revealed radiosensitizing effects. Conclusion: Nano-CURs improve CUR bioavailability and increase cancerous cells\u27 sen-sitivity to radiation. They also protect healthy cells from ionizing radiation without signifi-cant side effects
The Evolving Therapeutic Landscape of Nanoscale Cancer Drug Delivery Systems: Future Perspectives
No full textCancer is one of the main causes of deaths in the world. Conventional cancer therapeutic approaches such as chemo- and radiotherapy have burdened the cancer patients with arduous physical and psychological challenges. Moreover, in case of onset of this disease, huge amount is required against the medications (chemotherapy and radiotherapy). It is estimated that annually, the increasing cancer disease incidence rate is alarming. In developed countries, the health support is given by the nation. Therefore, the health managements in the developed nations are over-burdened due to heavy expanses against expansive cancer therapy treatments. Interestingly, tumor treatments have undergone a comprehensive and remarkable transformation. Scientists are working for finding out the effective possible treatments against various types of cancer. In this backdrop, in this review, we discussed recently developed cancer drugs targeting/ delivery techniques. It will provide a detailed explanation of each method, addressing their status of development, clinical challenges, and potential solutions. The aim is to assist clinicians and researchers in gaining a deeper insight of these diverse treatment options, enabling them to carry out effective treatment and advance their research more proficiently
The Guardian the Month of December 2025
No full textNews articles from The Guardian for the Month of December 2025. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.https://corescholar.libraries.wright.edu/guardian/3683/thumbnail.jp
Faculty Senate Meeting Agenda and Minutes, April 28, 2025
Get PDFAgenda and minutes from the Wright State University Faculty Senate Meeting held on, April 28, 2025