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    Efektivitas Terapi Tocilizumab Terhadap Mortalitas Pasien COVID-19 Derajat Berat di Rumah Sakit “X” Surabaya : Studi Observasional.

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    Tocilizumab merupakan agen inhibitor IL-6 yang direkomendasikan untuk terapi pasien COVID-19 derajat berat hingga kritis. Beberapa penelitian menunjukkan hasil yang bervariasi terkait waktu pemberian Tocilizumab yang optimal. Peningkatan kadar sitokin yang terjadi pada fase awal COVID-19 memunculkan hipotesis bahwa pemberian Tocilizumab lebih awal dapat menurunkan resiko mortalitas pasien. Penelitian ini bertujuan untuk mengetahui efektivitas pemberian Tocilizumab dalam waktu 72 jam setelah dirawat di rumah sakit dalam menurunkan angka mortalitas pasien COVID-19 derajat berat yang dirawat di rumah sakit X di Surabaya. Desain penelitian yang digunakan adalah observasional retrospektif pada pasien COVID-19 derajat berat. Subyek dipilih dengan menyamakan karakteristik demografi menggunakan metode propensity score matching untuk kelompok kontrol. Analisis hasil luaran mortalitas dianalisis menggunakan multivariable logistic regression. Sebanyak 98 pasien COVID-19 derajat berat diikutsertakan dalam penelitian, 49 subyek (50%) mendapatkan terapi Tocilizumab dan 49 subyek tidak mendapatkan Tocilizumab. Dari 49 subyek yang mendapat terapi Tocilizumab, sebanyak 30 subyek mendapatkan terapi Tocilizumab dalam waktu 72 jam setelah masuk rumah sakit. Hasil penelitian menunjukkan bahwa pemberian Tocilizumab dapat menurunkan angka mortalitas yang tidak signifikan (aOR: 0,79; 95% CI: 0,305-2,049; p: 0,629). Meskipun demikian, penurunan angka mortalitas yang lebih besar teramati pada subyek yang mendapatkan Tocilizumab lebih awal (aOR: 0,77; 95% CI: 0,42–1,85). Kesimpulan pada penelitian ini adalah pemberian Tocilizumab dalam waktu 72 jam pada pasien COVID-19 derajat berat dapat menurunkan resiko mortalitas yang tidak signifikan

    Agency cost dan persaingan perusahaan sektor non keuangan pada saat pandemi covid-19

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    Penelitian ini tentang pengaruh agency cost terhadap return on asset (ROA) dan menyelidiki pengaruh moderasi persaingan pasar produk pada pengaruh agency cost terhadap kinerja keuangan perusahaan dengan menggunakan leverage dan ukuran perusahaan sebagai variabel kontrol. Metode Purposive sampling mendokumentasikan sebanyak 715 data sampel penelitian perusahaan non keuangan periode tahun 2020-2022. Penelitian ini membuktikan bahwa agency cost berpengaruh negatif terhadap kinerja keuangan perusahaan dan persaingan memoderasi pengaruh negatif agency cost terhadap kinerja keuangan perusahaan

    Can indigenous peasants of Central Kalimantan live viably while conserving their forest lands?

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    Purpose – This study investigates the feasibility of a Community-Based Non-Timber Forest Products (NTFP) Enterprise, or CBNE, within the indigenous peasant communities in Manuhing Raya, Central Kalimantan, Indonesia. This includes assessing the potential for generating featured agricultural products from the region. Design/methodology/approach – This is a descriptive qualitative study that integrates ethnographic methods into the SLA analysis, in order to investigate the feasibility of a CBNE approach within an indigenous peasant community. A number of 13 peasant groups, which comprise 251 members, from the seven villages in Manuhing Raya participated in the study. Findings - The CBNE approach, when combined with OVOP method, is considered appropriate for the determination of featured agricultural products in a local community. In addition, the SLA analysis in this study contributes to identifying vulnerable aspects of CBNE development in the local communities, including weaknesses in social cohesion, leadership, and entrepreneurial orientation. Research limitation/implications - Efforts to preserve the rainforest lands in Central Kalimantan cannot be excluded from the involvement of the local peasant communities. The best livelihood strategy in this case is to adopt a CBNE approach. This shall be made possible by empowering the peasant communities to revive their local wisdom of Upun Pambelum, which means forest lands are their primary resources for life. Practical implications – This study highlights the importance of employing ethnographic investigation prior to the implementation of a CBNE development. Originality/value – The implementation of the CBNE approach should take into account socioeconomic aspects of the local community, especially the presence of social cohesion, leadership roles, and entrepreneurial orientations. In addition, the study demonstrates the potential of integrating traditional ecological knowledge with modern business models in CBNEs

    The Product-Service Systems Supply Chain Agility Readiness: an Exploratory Analysis of a Development of Construct and Instrument

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    Supply chain agility (SCA) has emerged as a significant focus for industries and businesses, serving as a cornerstone for gaining a competitive edge and playing a pivotal role in supply chain management. This importance is further underscored in the context of Product–Service Systems (PSS), which involve the development of both products and services. Despite the existing body of research on SCA and PSS, there has been a notable dearth of empirical studies examining the readiness of PSS SCA. This study makes a substantial contribution by developing a valid and reliable framework to assess the readiness of PSS for supply chain agility. The process involves defining domains, generating items, analyzing agreement among raters, testing for response bias, and conducting exploratory and confirmatory factor analyses. Using structural equation modeling, the model's validity and reliability were evaluated through an online survey with 405 participants from official motorcycle service partners. The findings identify six key capability constructs: collaboration, knowledge transfer, service partner development, information sharing, logistic integration and supply chain agility. This examination of PSS SCA readiness and its constructs provides a validated tool for industry practitioners to enhance their supply chain agility

    Metode preparasi, karakteristik fisikokimia, aktivitas antioksidan dan cemaran mikroorganisme kopi cold brew

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    Kopi cold brew merupakan salah satu tren metode preparasi kopi yang sedang bertumbuh. Kopi cold brew mengacu pada kopi yang diekstraksi pada suhu ruang atau pada suhu yang lebih rendah dari suhu ruang. Tujuan penulisan karya ilmiah, yaitu untuk meninjau metode preparasi kopi cold brew dan pengaruh cold brewing terhadap karakteristik fisikokimia, aktivitas antioksidan serta potensi cemaran mikroorganisme kopi cold brew. Ada beberapa metode yang dapat digunakan untuk preparasi kopi cold brew, yaitu metode imersi/konvensional, metode cold drip, metode siklus vakum dan metode Ultra High Pressure. Kopi cold brew menghasilkan seduhan kopi dengan warna yang lebih merah, viskositas, kadar kafein, total asam, total padatan terlarut, total fenol dan aktivitas antioksidan yang lebih rendah, nilai pH, intensitas rasa manis dan fruity yang lebih tinggi, serta intensitas rasa nutty, pahit dan sensasi sepat yang lebih rendah dibandingkan dengan kopi hot brew. Beberapa mikroorganisme yang umumnya dapat mencemari kopi cold brew, yaitu khamir, bakteri asam laktat dan bakteri asam asetat. Jumlah mikroorganisme tersebut dapat direduksi hingga < 1,0 × 10⁰ CFU/mL melalui pasteurisasi HTST seduhan kopi cold brew. Flavor yang lebih manis dan fruity, serta berkurangnya flavor pahit dan sensasi sepat dibandingkan kopi hot brew menunjang popularitas kopi yang diseduh dengan metode cold brew

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