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EFEK APLIKASI SERICIN PADA HIDROKSIAPATIT TERHADAP PERLEKATAN SEL OSTEOBLAS
Get PDFHydroxyapatite (HA) is often used as a human bone grai Modification of HA surface is developed to increase osseointegration process which is influenced by cells attachment surrounded the tissue. Sericin has polar side groups which acceleratecells attachment. The aim of this researchwas to determine the effectof sericin application over HA surface on the attachment of osteoblast cells. The research used HA synthesizedfrom gypsum (Kulon Progo, Yogyakarta). Sericin was extracted from silkworm cocoonsof Bombyx mori. Sericin of 0.01, 0.05, 0.1% were applied over HA discs surface (10 mm in diameter, 3 mm thick). The discs were inserted into osteoblastcells culture of MC3T3El for attachment test. The data were analyzed by ANOV A and LSD. The result showed that the amount of osteoblast cells attached to HA (7.60I0.42) was significantly difference (p0.05). In conclusion, sericin application over HA surface increased the amount of osteoblast cells attachment. Concentrations of sericin application over HA (0.01, 0.05, 0.1%) did not influence osteoblastcells attachment
ANALISIS SISTEM PENGEMBANGAN KAWASAN INDUSTRI TERPADU BERWAWASAN LINGKUNGAN STUDI KASUS: DI PT. KAWASAN INDUSTRI MEDAN (Analysis System of Integrated Industrial Estate Ecodevelopment Case Study: At PT. Medan Industrial E
Get PDFTujuan utama penelitian adalah menganalisis kinerja pengembangan kawasan industri terpadu berwawasan lingkungan. Cakupan aspek penelitian disinkronkan dengan konsep pembangunan berkelanjutan sekaligus dijadikan sebagai batasan kajian, yakni mempersekutukan aspek ekonomi, ekologi dan sosial. Data diperoleh dengan menggunkan metode survei melaluiobservasi, wawancara mendalam, dan pendapat pakar. Metodologi penelitian menggunakan metode survei dengan menggunakan perpaduan antara hard system (analisis sistem dinamis) dan soft system (Analisis Prospektif). Dari hasil uji statistik chi square (α= 0,01) diperoleh bahwa kelompok masyarakat yang bekerja di dalam PT. KIM mempunyai hubungan yang sangat signifikan dengan kelompok masyarakat yang bekerja di luat PT. KIM terhadap tingkat pendapatan, tingkat pendidikan dan faktor usia. Berdasarkan hasil analisis kualitas limbah cair unit IPAL PT. KIM terdapat 5 parameter yang masih berada diatas nilai baku mutu KepMenLHNo.5I/l997, yaitu: BOD, COD, TSS, klorida dan amoniak. Tingkat efisiensi pengolahan limbahcair unit IPALPT.KIM rata-rata 53,07%. HasHanalisis ketergantungan antar faktor dengan menggunakan Analisis Prospektif diperoleh sebanyak 5 faktor strategis masa depan yang mempengaruhi pengembangan kawasan industri terpadu berwawasan lingkungan, yaitu: jumlah industri, permintaan lahan, kebijakan pemerintah, model pengembangan, dan iklim investasi yang kondusif. Pengembangan kawasan industri terpadu berwawasan lingkungan dapat dilakukan dengan strategi moderat dengan kebijakan mencakup jumlah industri bertambah secara bertahap dengan meningkatnya permintaan lahan sertake bijakan pemerintah yang memfasilitasi peningkatan modal pengembangan dan didukung oleh iklim investasi yang kondusif
EVALUASI DAMPAK KEBIJAKAN HARGA OBAT GENERIK TAHUN 2010 TERHADAP HARGA JUAL, KETERSEDIAAN, DAN KETERJANGKAUAN OBAT DI APOTEK SWASTA KABUPATEN JEMBER
Get PDFOne of government\u27s efforts to guarantee people access on essential medicine is by applying a policy concerning with generic medicine prices. The purpose of the research was to find out the variation and the ratio of generik and branded medicine selling prices in comparison with Harga Jual Apotek (HJA) - Pharmacy Selling Price - based on the regulation of Health M inistry and International Reference Prices (IRPs) 2010 and their availability and affordability in some private pharmacios in Jember.
The research design was a descriptive non experimental. The data collected retrospectively toward generik and branded medicines mostly prescribe during April-August 2010 include their prices and affordability. Research result showed that the ratio of generik medicine selling price toward HJA was 0.14-9.09 times and 0.26- 114.06 times. On the other hand, the ratio of generic and branded medicine selling price toward IRPs 2010 was 0.03- 16.67 times and 0.09-501.88 times. In 50 kinds of mostly prescribed medicines, 35 of them were generik medicines with affordibility range 11.4%-93.2%. In the matter of affordability, it needs 1 working day to do a therapy using generik medicines for diabetes mellitus, hypertension, hypercholesterolemia, rheumatoid arthritis, and infection cases. In contrast, it requires 1-35 working days to do those therapies using branded medicines with Regional Minimum Salary of Rp.33.2200.OO for each working day
EVALUASI DOSIS DIGOKSIN PADA PASIEN GAGAL JANTUNG DENGAN DISFUNGSI GINJAL DI RSUP DR. SARDJITO, YOGYAKARTA
Get PDFDigoksin merupakan salah satu obat dengan kisaran terapi sempit yang paling banyak digunakan terutama pada penyakit yang berhubungan dengan jantung. Penyesuaian dosis digoksin pada pasien yang mengalami penurunan fungsi ginjal mutlak dilakukan agar kadar obat di dalam darah tepat. Penelitian ini dilakukan untuk mengevaluasi dosis digoksin pad a pasien gagal jantung dengan disfungsi ginjal.
Penelitian ini merupakan penelitian retrospektif sekaligus prospektif pada pasien gagal jantung dengan disfungsi ginjal di RSUP Dr. Sardjito Yogyakarta periode Januari 2010 - Maret 2011. Pengumpulan data dilakukan menggunakan rekam medik pasien rawat inap. Analisis data dilakukan secara deskriptif.
Hasil analisis dari 43 kasus yang diperoleh, pasien laki-laki mempunyai persentase yang lebih besar dibanding pasien perempuan (56 % : 44 %). Persentase pasien berdasarkan kelompok usia terbanyak pada pasien 50 - 59 tahun sebanyak 34,88 %. Pada perhitungan dosis secara farmakokinetik ditemukan bahwa dosis digoksin yang digunakan oleh pasien ada yang melebihi kadar maksimum digoksin di dalam darah. Dari 19 pasien wanita, 11 pasien menggunakan dosis yang melebihi kadar maksimum digoksin sedangkan dari 24 pasien pria, 14 pasien menggunakan dosis yang melebihi kadar maksimum digoksin. Metode perhitungan dosis ini menggunakan data literatur khususnya untuk nilai parameter farmakokinetika s eperti volume distribusi, waktu paro eliminasi, dan kliren digoksin. Oleh sebab itu, besar dosis yang tepat seperti yang dianjurkan dalam tesis ini dapat dianggap sebagai nilai teoritis. Selanjutnya ditemukan juga pasien tidak mendapatkan dosis muatan digoksin yang sesuai. Namun oleh karena penggunaan dosis digoksin bersifat individual maka dari keseluruhan ditemukan bahwa outcome clinic pasien umumnya membaik.
Digoxin is a medicine with narrow therapeutic index. Digoxin is widely used for heart failure treatment. Adjustment of digoxin dose is needed in patient with renal dysfunction. This research were done to evaluate digoxin dose in heart failure patient with renal dysfunction.
This research was retrospective and prospective research, performed in Dr. Sardjito hospital during January 2010 to March 2011. Data were collected from patient medical record and then evaluated with descriptive method. From 43 patients, percentage men compare to women were 56 % : 44 %. Most patients come from age of 50 - 59 (34.88%). Dose calculation based on pharmacokinetic concept found that some of digoxin dose in patients were exceed digoxin therapeutic concentration. From 19 women patients there were 11 patients use digoxin dose exceed djgoxin therapeutic concentration when calculate by pharmacokinetic while from 24 men patients there were 14 patients use digoxin dose exceed digoxin therapeutic concentration when calculate by phannacokinetic. Dose recalculation method was mostly based on literature data particularly for pharmacokinetic parameter values i.e. volume distribution, half life, and clearance. Therefore, the corrected doses suggested in this thesis should be regarded as theoretical estimates. Furthermore, it was also found that patients did not get appropriate lomling dose of digoxin. However, drug dosing for digoxin were individual dose, therefore overall found that patient clinical outcome was generally better
.-PINENE CATALVZED BY TCAIY-ZEOLITE
Get PDFThe hydration of a-pinene has been studied in the presence of TCA/Y-Zeolite catalyse. The catalyst was prepared by impregnating trichloroacetic acid (TCA) on support of Y-Zeolite. The TCA/Y-Zeolitecatalyst converted a-pinene into hydrocarbons, he TCA/Y-Zeolitecatalyst was active and selective for producing alcohols, with a conversion of 66% and showed 55% selectivity for a-terpineol at 10 min. The reaction taken place in a solid-liquid moae and most of the α-terpineol is extracted out by the organic phase during the course of the reaction. TCA/Y- Zeolite was found as good catalystfor hydrationof α-pinene to produceα-terpineol
EFFECT OF CROSSLINKING TO THE MECHANICAL PROPERTY OF APATITE GELATIN HYBRID FOR BONE SUBSTITUTION PURPOSES
Get PDFThe clinical success of current generation of synthetic bone substitute relies on bio-inspired design which has a performance level close to that of natural one. In this context, biomedical approaches are considered very important to result bio-functional hybrid for bone substitution purposes. In this study, effect of cross-linking to the mechanical properties of apatite gelatin hybrid has been investigated. Cross-linking was employed by 1-ethyl-3-3- dimethylaminopropyl carbodiimide (EDC) agent. The EDC agent creates a peptide bond between gelatin molecules inside the hybrid to the cross-linked structure. Cross-linked structure of gelatin increases physical property of the hybrid since it can hold the outer forces longer than that of without cross-linking
KAJIAN EKOSISTEM MANGROVE HASIL REHABILIT ASI PADA BERBAGAI TAHUN TANAM UNTUK ESTIMASI KANDUNGAN EKSTRAK TANIN DI PANTAI UTARA JAW A TENGAH
Get PDFThe research was conducted in the mangrove plantation areas of Pemalang and Rembang North coasts. From those two areas, mangrove vegetations with the same three plantation ages were chosen which were then divided into three zones from the sea. Tree density, height and diameter, the depth of sediment, water salinity and the content of organic matter were measured and assessed for each mangrove zones and plantation ages. In order to estimate the content of tannin extract of a mangrove tree, three mangrove trees of each plantation age were taken as samples. The wood of the trees were then peeled off, measured the weight and taken to the laboratory to analyze their tannin extract content. The content of tannin extract of the whole mangrove areas was obtained by multiplying the average of tannin extract content per tree with the vegetation density of those two mangrove areas. Varians analysis was employed to find out the significant different of the density three plantation ages of two mangrove rehabilitation areas. The results showed that for plantation years-of 2002, the tannin extract content at both mangrove plantation areas of Pemalang and Rembang in averages was estimated to have a higher amount than -those of plantation year 2003 and 2006. Respectively, the tannin extract content of plantation year of 2002 in Pemalang and Rembang were estimated to have 105.93 kg/ha and 159.23 kg/ha tannin extract. Mangrove vegetation with plantation year of 2006 in Pema~ang contained 80.90 kg/ha, while for Rembang is 146.36 kg/ha
Model Determinan Perilaku Inovatif pada Mahasiswa yang Berwirausaha
Get PDFEnt-erpreneurship has become one of the main pillars for t-he development of society\u27s welfare. University students who hold the future generations have a strategic role in becoming future enterpreneurs. The most dominant character of enterpreneurship is innovative behavior. The innovative behavior determinant model has been developed previously ~y the author and has been t-ested with universit-y st-udents in general and university students who were competing in a university students creativit-y grant competition. In this study, the author wanted to test the innovative behavior model particularly with university student enterpreneurs. By using this model, a model for developing innovative behavior in universit-y will be able fo be developed further. By using a phel\u27lOmenological method, 10 undergraduate studenfs who were also enterpreneurs in fhe Program Mahasiswa Wirausaha (Program of Enferpreneur Studenfs) participated in the sfudy. He result was fhen concluded as an innovative behavior determinant modelfor student enterpreneurs. The model was different-from the general innovative behavior determinant model. The most dominant psychological aspectsfound in this study were courage in taking risk and persistent high motivation. Whereas i1l the process aspect, \u27love\u27 aspect in doing enterpreneurship, was found as influencing the innovative behaviorof student enterpreneurs
EFFECTS OF LATIHAN PASRAH DIRI ON THE IMPROVEMENT OF DEPRESSIVE SYMPTOMS A study on Human Immunodeficiency Virus (HIV)/ Acquired Immune Deficiency Syndrome (AIDS) patients at RSUP Dr. Sardjito, Yogyakarta
Get PDFBackground. Depression is more prevalent in persons with chronic illnesses such as diabetes, epilepsy and infection of Human Immunodeficiency Virus (HIV). Depression can make HIV even. Antidepressant may be needed, interaction and side effect may occur when using Antiretroviral (ARV) and antidepressant in combination. Complementary and alternative medicine (CAM) include Latihan Pasrah Diri(LPD) may seem safe to treat depression in HIV patients.
Methods. This is a quasi experimental study, participant include outpatient dan inpatient at RSUP Dr. Sardjito, Yogyakarta. They were aged >18 years. After scoring with Zung Self Rating Scale for depression, participants allocated into two groups, with dan without Latihan Pasrah Diri program. Zung Self Rating Scale for depression was evaluated after 1 cycle of program.
Result. The means of Zung Self-Rating Depression Scale score before and after LPD were 42,21 ± 9,3 and 35 ± 10,73 (p 0,003). While in control group (without LPD / brief psychotherapy) the means of Zung Self-Rating Depression Scale score before and 3 weeks after brief psychotherapy were 42,93 ± 7.45 and 39,36 ± 7,69 (p 0,019). Statistically there was no significancy in the means of delta Zung Self-Rating Depression Scale in LPD group and control group.
Conclusion. It was concluded from this study that there is an influence on the improvement of depressive symptoms post- Latihan Pasrah Diri program to people with HIV / AIDS
SECONDARY PREVENTION OF ACUTE CORONARY SINDROME IN PATIENT WITH CHRONIC KIDNEY DISEASE
Get PDFPatients with Chronic kidney disease (CKD) have greater risk to experience cardiovascular events with poor outcome. Morbidity and mortality due to cardiovascular events increases associated with the reduced of GFR below 60 ml/min/1,73m2. In patients with hemodialysis the prevalence of coronary heart disease reach approximately 40% with 9% annual mortality rate. Patients with history of previous acute coronary syndrome (ACS) have greater risk of recurrence attack. Adequate secondary preventions are expected to increase survival in concise period of time and costly effective. We report a case of ACS in a patient with CKD stage V due to diabetic nephropathy who has undergone routine hemodialysi