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    THE ACTIVE FRACTION FROM Nigella sativa AND ITS ACTIVITY AGAINST T47D CELL LINE

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    Breast cancer is one of the main causes of death in women. Cancer treatment with surgery, chemotherapy, and radiology of ten cause undesirable side effects. Therefore, alternative cancer treatment by using plants as traditional medicine was expected to reduce side effects. Nigella sativa is one of the plants used as anticancer empirically. This study conducted to examine the cytotoxic activity of Nigella sativa seeds and identify its components on T47D breast cancer cells. Petroleum ether, chloroform, ethyl acetate, and ethanol were used to extract N. sativa seeds. The extracts were tested their cytotoxic activity on T47D cell line using MTT method. The active compound was separated using column chromatography. Cytotoxic test on T47D cell line was perform for extracts of each separation stage. Data were analyzed by probit analysis to obtain IC&#8325&#8320values. Components identification was performed using GC-MS analysis. The results showed that chloroformextract has cytotoxic activity better than other extracts w ith Ic &#8325&#8320of 124.206 µg/mL. The third fraction has cytotoxic activity better than other fractions with IC&#8325&#8320of 68.568 µglmL. The GC-MS analysis showed that in the third fraction of the chloroform extract contain linoleat acid, the major compound and tryptamine

    POTENSI PRODUKSI ARANG DARI HUT AN RAKY AT DESA BANGUNJIWO, KECAMATAN KASIHAN, BANTUL, DAERAH ISTIMEW A YOGYAKART A

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    Asam jawa (Tamarindus indica) and mahoni (Swietenia macrophylla) which predominantly grow on the community forests of Bangunjiwo Village are an ideal candidate as raw matterial of charchoal roduction because they\u27re hard wood makes good quality charchoal and income from its charchoal are an tractive source of supplemental revenue. Information on its charchoal production are needed, but this information is c:urrently lacking. The potential of charcoal production of woody perennial in the community forests were estimated by developing allometric equations for standing trees. To establish the equations 30 sample logs of tamarind and 29 sample logs of mahoni were made charcoal by traditional kiln to determine the relationships between the mechantable timber volume/log (Vkp) and its charcoal production (Pa). The raw material of charcoal production from the merchantable timber volume in the community forests was the ligneous material. contained in the bole and branches which both with a diameter of at least 7 em. The results showed that the merchantable timber volume was strongly related to the charcoal production (tamarind: Pa = 185.6180 (Vkpf0,9455, n = 30, r²= 0.9559mahoni: 321.2263 (Vkp1,0725, n = 29, r²= 0.9459mixed: = 235.0601 (Vkpl1, 0008, n = 59,r²= 0.9465). The potential of charcoal production in the community forests was then estimated based on the allometric equations. The potential of charcoal production in these community forests was 12.067 ton/ha, equal to Rp 21.117.250,00 /ha which contributing the forest to the regional income

    Penyesuaian Dusun Jangka Panjang Ditinjau dari Resiliensi Komunitas Pasca Gempa

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    Disasters always occur without can be predicted precisely. The need to use community\u27s strengths are very important component in new disaster-risk reduction effort. This study aims to find out the correlation between community resilience on long-termed community coping post-earthquake of May 26, 2006. Predictor variablein this study is community resilience, and the criterium variable is long-termed community coping. The instruments used in this study consisted of Community Coping Scale is modification of the Community Well-Being Scale developed by (Prawitasari et al., 2009Prawitasari, 2011), and Community Resilience Scale developed by Researcher. This research was held in the earthquake affected areas in Klaten. Data were collectedfrom 60 respondents (34 males and 26 females)age ranges from15-78 years old. Reliability test with Alpha Cronbach indicates both instruments were reliable (aCCS=0.930aCRS=0.925). This study hypothesized that there is a correlation between community resilience and long-termed community coping post-earthquake. Pearson- Product Moment Correlation Analysis was used to analyze the data. Result shows that there is a positive correlation between community resilience and long-termed community coping postearthquake (r = 0.571, P < 0.05)

    ANALISIS FINANSIAL INDUSTRI RUMAH TANGGA BAKPIA DI WILAYAH KOtA YOGYAKARTA = Financial Analysis Of Home Industry Of Bakpia In The Region City Yogyakarta

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    The purpose of this study was to determine the financial performance of home indutrsies bakpia (liquidity, solvency, profitability, and business feasibility) and the problems faced by the domestic industry bakpia of the city. The results indicate that the average total cost incurred by craftsmen bakpia in Yogyakarta during the year 2010 amounted to Rp 53.489.439. The average revenue earned Rp 138.384.272, the average income of Rp 84.894.833 and profit earned on average of Rp 6.624.991. Value of R/C ratio of more than 1, ie 2.587> 1, the productivity of capital is greater than the prevailing bank lending rate that is 149%> 11%. Breakeven analysis shows that the domestic industry revenues were above bakpia BEP value of Rp 138384272> Rp 28.185.652, bakpia production is above the BEP value 10 422 boxes of> 2125 boxes, and the price is above the value bakpia also BEP for Rp 13.269/boxes> Rp 5.132/boxes. Thus the domestic industry in the city of Yogyakarta bakpia profitable and worth the effort. The results of the liquidity of financial research shows that the quick ratio, current ratio and cash ratio shows bakpia domestic industry is able to immediately pay off the smooth, Solvency indicates the value of total debt to equity ratio and total debt to assets ratio is less than or equal to 100% so that companies able to pay all its debts, while the profitability of domestic industry shows bakpia able to make a profit because the value of profitability ratios is quite high. Tujuan dari penelitian ini adalah untuk mengetabui kinerja finansial (likuiditas, solvabilitas, profitibilitas dan kelayakan usaha) dan rnasalah yang dihadapi industri rumah tangga bakpia di Kota Yogyakarta. Hasil penelitian menoojukkan rata-rata total biaya pengrajin bakpia di Yogyakarta taboo 20I0 adalah Rp 53.489.439. Rata-rata penerimaan adalah Rp 138.384.~72, rata-rata pendapatan adalah Rp 84.894.833 sedangkan rata-rata keuntungan per orang adalah Rp 6.624.991. Rasio RfC lebih dari 1 yakni 2.587, nilai produktivitas modallebih tinggi dari suku bunga pinjarnan bank (11%) yakni 149%. Analisis BEP menunjukkan pendapatan industri domestik di atas BEP (Rp 28.185.652) yakni Rp 138 384 272, produksi bakpia di atas BEP produksi (2.125 kotak) yakni 10 422 kotak dan harga bakpia di atas harga BEP (Rp 5.132 per kernasan) yakni Rp 13.269 per kernasan. Hal ini menoojukkan bahwa industri bakpia di Kota Yogyakarta menguntungkan dan layak diusahakan. Hasil analisis finansial menoojukkan bahwa quick ratio, current ratio and cash ratio mampu ootuk membayar hutang, Solvabilitas menoojukkan bahwa rasio total hutang terhadap ekuitas dan rasio total hutang terhadap aset kurang dari atau sarna dengan 100% sehingga perusahaan rnampu memenuhi ootuk membayar seluruh hutang diman8 profitabilitas dari industri bakpia menoojukkan bahwa bakpia dapat untuk menghasilkan keuntungan karena nilai rasio profitabilitas yang tinggi

    Pelayanan antenatal care dalam pengelolaan anemia berhubungan dengan kepatuhan ibu hamil minum tablet besi

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    ABSTRACT Background: The prevalence of pregnant women with anemia is still one of nutrition problems in Indonesia. The main cause of this case is low iron supplementation compliance as the effect of lack of antenatal care (ANC) services and lack promotion of anemia prevention and iron tablet benefit. Objective: The study was aimed to know the relationship between ANC services in anemia management with iron supplementation compliance of pregnant women. Method: The study was observational with cross sectional design. Subjects were 202 pregnant women in the IIIII trimester period in Asahan District. Sampling interpretation was randomly performed by choosing 3 sub-districts with K4 &#880585% and &#880485% coverage. Data collection was carried out by interview based on structured questionnaire and KIA literature study while validity of iron supplementation compliance using stool test. Data analysed using chi-square and logistic regressions test. Results: The result showed that 41.1% of pregnant women were complied. Based on chi-square test, there were four significant variables related to pregnant womens compliance namely ANC services (ratio prevalence 1.82CI95%: 1.22-2.70), anemia assessment (ratio prevalence 1.79CI95%: 1.22-2.64), nutrition consultation (ratio prevalence 1.41CI95%: 1.12-1.76) and knowledge (ratio prevalence 1.42CI95%: 1.12-1.79). Meanwhile logistic regressions test showed that the most influencing variable was ANC services (OR 3.125) after controlling knowledge variable. Conclusion: There were positive relationship between ANC services, anemia assessment, and nutrition consultation with iron supplementation compliance. KEY WORDS ANC services, iron supplementation compliance, pregnant wome

    PENGATURAN ASURANSI KECELAKAAN JALAN DALAM UNDANG-UNDANG NOMOR 22 TAHUN 2009

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    Peningkatan kepemilikan kendaraan bermotor meningkatkan risiko terjadinya kecelakaan lalulintas. Asuransi Kendaraan Wajib Tanggung Jawab Hukum Pihak Ketiga berfungsi menciptakan efek jera bagi penyebab kecelakaan dan jaminan keterserjiaandana ganti rugi bagi korban. Skema ini dapat menurunkan jumlah kecelakaan maupun fatalitas dan korban kecelakaan, sebagaimana ditunjukkan dari adanyapenurunan klaimkorban kecelakaan jalan

    UPAYAPENCEGAHANDANPENANGGULANGANPENCEMARAN AIR AKIBAT PENAMBANGAN EMAS DI SUNGAI KAHAYAN

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    Belum adanya Wi/ayah Pertambangan Rakyat serta penggunaan merlcuri mendorong /erjadinya penambangan emas tanpa izin dan pencemaran air di Sungai Kahayan. Untuk mencegah dan menanggulangi pencemaran ini diperlukan koordinasi di tingkat pusat dan daerahpenyuluhan dan pendekatan di bidang sosial. ekonomi, budaya, hukum, dan teknologiserta penegakan hukum secara tegas melalui penerapan sanksi

    LIMITED LIABILITY DALAM LIMITED LIABILITY PADA KONSTRUKSI PERUSAHAAN KELOMPOK PIRAMIDA

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    Applicability of limited liability in corporate groups with pyramid construction creates a legal loophole in the form of a limited liability within a limited liability. To prevent moral hazard, it is necessary to stipulate new law that limits the number of levels in a corporate group. Berlakunya limited liability pada perusahaan kelompok dengan konstruksi piramida menciptakan celah hukum berupa limited liability dalam limited liability. Untuk mencegah munculnya moral hazard dari pemegang akhir atau induk perbuatan, perlu dilakukan terobosan hukum pembatasan jumlah lapisan anak perusahaan dalam konstruksi perusahaan kelompok

    KEBIJAKAN PERTANAHAN PADA ERA OTONOMI DAERAH DI BIDANG HAK GUNA USAHA PERKEBUNAN

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    Land policy in the right to cultivate (plantations) should be reorganized, because the politics of economic development law in the reformation era seems to favour free market. Therefore, agrarian reform is needed to create a balance of interests between holders of land tenures right to cultivate (plantation) and popular interests. Kebijakan pertanahan di bidang Hak Guna Usaha (HGU Perkebunan) perlu ditata kembali, mengingat politik hukum pembangunan ekonomi di era reformasi mengarah pada pasar bebas. Oleh karena itu, reforma agraria diperlukan untuk menciptakan keseimbangan kepentingan struktur penguasaan tanah antara pemegang HGU Perkebunan dengan kepentingan rakyat

    PERANAN KOORDINASI PENYELESAIAN PERMASALAHAN LINGKUNGAN HIDUP DALAM MENYELESAIKAN SENGKETA LINGKUNGAN DI DIY

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    The Environmental Dispute Resolution Coordination (KP2LH) plays significant roles in settling environmental disputes in DIY. It enjoys tremendous success as it has settled almost every environmental disputes brought to it. However, improvements shall be made, incuding equipping KP2LH members with mediation skills and sufficient knowledge on environmental law. Koordinasi Penyelesaian Permasalahan Lingkungan Hidup (KP2LH) memiliki peranan yang penting di DIY mengingat banyaknya sengketa lingkungan yang telah berhasil diselesaikan. Akan tetapi, diperlukan peningkatan kualitas KP2LH, terutama dalam bentuk pembekalan anggotanya dengan kemampuan mediasi dan pengetahuan hukum lingkungan yang cukup

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