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Navigating Menstruation with Disabilities: Unique Challenges and Empowerment
Get PDFThis abstract discusses the unique challenges faced by individuals with disabilities while menstruating and highlights empowerment strategies to address these challenges. It also examines the concept of menstrual leave in India and its pros and cons, as well as the disability rights landscape in the country. The abstract emphasizes the importance of recognizing the diverse experiences of disabled individuals and fostering an inclusive environment that supports their well-being and needs
First Report of Nigrospora sphaerica Associated with Leaf Spot Disease of Crossandra infundibuliformis in India
Get PDFStructural investigations and theoretical insights of a polymethoxy chalcone derivative: Synthesis, crystal structure, 3D energy frameworks and SARS CoV-2 docking studies
No full textChalcone derivatives with various functional groups have shown potent pharmacological and non-linear optical properties. A multi-methoxy substituted (E)-1-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl) prop-2-en-1-one, chalcone derivative has been synthesized and spectroscopically characterized by 1H and C-13 NMR, LC-MS and FT-IR techniques. A pale yellow colored rectangular shaped single crystals of the compound were obtained by slow evaporation method and the three dimensional structure was confirmed using X-ray diffraction studies. The compound crystallized in the monoclinic crystal system with P2(1)/a space group. The crystal and molecular structure is stabilized by C-H center dot center dot center dot O inter and intra molecular hydrogen bond interactions apart from the prominent C-H center dot center dot center dot pi and pi center dot center dot center dot pi stacking interactions. These interactions were studied using Hirshfeld surface analysis to understand the nature and strength of interactions; the 2D fingerprint plot quantifies each individual intermolecular contact and revealed that the H.H (49.2%) interactions have the major contribution to the molecular surface. The analysis of 3D molecular energy frameworks revealed that the dispersion energy (-208.16 kJ mol(-1)) dominates all other energies and their visualization identifies the packing order of the molecules in the crystalline environment. The lattice energy of the compound is found to be -398.1 kJ mol(-1). The electronic properties of the compound were quantified using theoretical quantum chemical computations with DFT-B3LYP/6-311+ G (d, p) level basis set. The electronic energy band gap of the chalcone molecule is found to be 3.6961 eV. The NBO and Mulliken atomic charges were computed and the molecular electrostatic potential map was plotted to identify the chemical reactive sites on the molecular surface. The second-order nonlinear optical properties of the molecule based on the first static hyperpolarizability (ss) have been investigated. Further, the molecular docking studies of the chalcone derivative against corona virus 2 (SARS-CoV-2) protein have been carried out to shed light on the possible significant molecular interactions. (c) 2022ElsevierB.V. Allrightsreserved
On-device context-aware misuse detection framework for heterogeneous IoT edge
Get PDFTraditional AI techniques for offline misuse network intrusion detection have performed well, assuming that the traffic from the datasets is sufficiently large for generalization, balanced, independently and identically distributed-exhibiting homogeneous behavior with little to no context change. However, the rapidly expanding IoT network is an ensemble of proliferating internet-connected devices catering to the growing need for handling highly distributed, heterogeneous, and time-critical workloads that conform to none of the above assumptions. Moreover, the evolving Botnet-based attack vectors exploit the non-standardized and poorly scrutinized architectural vulnerabilities of such devices-leading to compounding threat intensity, rapidly rendering the network defenseless. Furthermore, the memory, processor, and energy resource constraints of the IoT devices necessitate lightweight device-specific intrusion detection policies for effective and updated rule learning in real-time through the edge infrastructures. However, the existing methods proposed to solve such issues are either centralized, data and resource-intensive, context-unaware, or inefficient for online rule learning with smaller and imbalanced data samples. Thus, this paper addresses such issues through a context-aware expert system-based feature subset framework with minimal processing overhead and a decentralized on-device misuse detection scheme for IoT-called HetIoT-NIDS, capable of efficiently inferring over smaller data samples, tolerant to class imbalance, and deployable on the low-memory and low-power edge of IoT devices. Furthermore, HetIoT-NIDS facilitates threat localization within the deployed device, preventing threat progression and intensity compounding. The experiments and analyses of the propounded algorithms and the resulting training times and model sizes prove that the proposed approach is efficient and adaptable to online and offline misuse intrusion detection, especially on smaller data sample sizes
An investigation on spectroscopic, wavefunction dependent reactivity, docking and anti-Covid-19 ability of flupentixol dihydrochloride: DFT and MD simulations at different temperatures
Get PDFA detailed vibrational analysis of flupentixol dihydrochloride (FDC) is performed by Density Functional Theory (DFT) calculations. Wavefunction reactivity properties and Atoms In Molecules (AIM) analysis are also performed. There is enormous O1-H1B…Cl1, N1-H1A…Cl1 and C9-H9A…F3B intermolecular hydrogen bonding in FDC. Electrons were resonated on the aromatic rings without any interference with aliphatic moiety of both highest occupied molecular orbital (HOMO) and in least unoccupied molecular orbital (LUMO) which is due to participation of fluorine atom intermolecular hydrogen bonding with adjacent C–H. The electron localization function (ELF) shows under populated N-C single bonds of ring A owing to the strong electron withdrawing effect of nitrogen atoms. SARS-CoV-2 main protease with FDC had energy −80 kcal/mol. With the help of molecular dynamics (MD), radial distribution functions (RDF) are calculated to identify the most critical interaction with water molecules
Exploring the Complexities of the Russia-Ukraine Conflict: A Close Look from the Lens of International Law and Global Responses
No full textThis paper provides an overview of a comprehensive exploration of the Ukraine-Russia conflict through the lens of international law. It begins by introducing the context of the conflict and the 1997 treaty between Ukraine and Russia. The political and economic landscape of Ukraine is discussed, followed by an examination of the conflict's origins, with insights into the post-World War II and post-Cold War dynamics. The impact of the Ukraine-Russia conflict on international business and the world economy is considered, along with efforts towards peace talks between the two nations. The role of international law is highlighted, encompassing aspects such as international armed conflict, non-international armed conflict, the United Nations Charter, war crimes, and individual responsibility. The reactions of the European Union and the declaration of intervention by New Zealand are examined. The roles played by India and NATO in the conflict are explored, with a specific focus on NATO's approaches to Russia and its role in Ukraine. The article concludes by emphasising Russia's challenge to the UN and international order, the significance of Ukraine's Supreme Court, and the role of the International Court of Justice in addressing the complex Ukraine-Russia disput
Triazole derivatives as potential antifungal agents: A structure-activity relationship (SAR) studies
No full textToday's research is focused on developing new safe drugs of clinical importance. Nitrogen-containing heterocycles are abundant in the common of therapeutic scaffolds. Triazoles are heterocyclic compounds containing a five-membered ring of two carbon atoms and three nitrogen molecules. These structures have sparked enthusiasm for advancing new analogues with miscellaneous biological activities. The need for innovative antifungal drugs is an urgent issue in the current situation where the number of refractory suppressed patients is increasing. This review summarizes research leading to the innovation and progress of latest antifungal agents from a variety of resource during this time. This review primarily focuses on the in vitro and in vivo antifungal activity, design, and SAR of new antifungal agents. © 2023 Elsevier Lt
The potential of honey therapy for menstrual cramps
Get PDFPeriod cramps can cause significant discomfort and negatively impact a woman’s life. While painkillers are commonly used for relief, they may have side effects and potential addiction risks. However, natural remedies such as honey offer a promising alternative. Regular exercise, yoga, and a healthy lifestyle can help ease the pain, but honey provides additional relief without side effects. This article explores various ways to utilize honey to alleviate menstrual cramps naturally. Combining honey with cinnamon, ginger, fennel, or chamomile can provide effective solutions due to their anti-inflammatory properties. It is essential to choose natural, pure honey without added preservatives or sugar. Additionally, maintaining a balanced diet, staying hydrated, and avoiding caffeine, alcohol, and junk food during periods can contribute to overall well-being and minimize discomfort. This article is based on the secondary source of data and limited to effect of honey on women’s health during the menstruation
Protecting Creative Works: Exploring Copyright Protection Under Indian Copyright Law
Get PDFThis paper highlights the significance of copyright in the cultural and economic development of nations, emphasizing its role in preserving and enhancing cultural legacies. It traces the evolution of copyright law from its early beginnings in response to the printing press to the modern legal frameworks in different countries. This work mentions key milestones in the history of copyright, including the Licensing Act of 1662 in England, the Act of Queen Anne in 1704, and the development of copyright law in the United States and India. It underscores the multifaceted objectives of copyright, which go beyond rewarding authors to promoting innovation in science and the arts. This piece of work also explains the nature of copyright as a form of intangible property that grants creators exclusive rights over their works, highlighting the various rights covered by copyright law. It clarifies that copyright protects the expression of ideas, not the ideas themselves, and provides insights into the types of works eligible for copyright protection
China’s Belt-Road Initiative and Investment Strategies: A Two Pillar Approach to Afghanistan
Get PDFChinese investment in Afghanistan is part of the Belt and Road Initiative (BRI), the country's major foreign policy initiative
that aims to build land and maritime infrastructure links to support trade within and outside Asia. However, there are still significant
concerns regarding including Afghanistan in the Belt and Road initiative. This article examines the impact of the Chinese Belt and
Road Initiative and investment in the mineral resources of Afghanistan. The article concludes by discussing the challenges Kabul will
face in reaping the benefits of participating in this extensive connectivity and investment initiative