University of Cagliari

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    1359 research outputs found

    Birth registration and child undernutrition in sub-Saharan Africa

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    The database comprises data on malnutrition and birth registration rates in 33 sub-Saharan African Countries as retrieved by DHS (http://www.dhsprogram.com) and MICS (http://www.childinfo.org/mics.html) reports. The study protocol includes detailed information on data selection and statistical analyses

    Il profilo "statico" della pubblica amministrazione tra buona amministrazione e informatizzazione

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    This work analyses the impact of technology on the organization of public administration. It was prompted by the last Reform Acts (Anti-Corruption Act, in 2012, Transparency Act, in 2013, Decreto Renzi-Madìa, in 2014) which aim to harmonize the current Italian standards of bureaucratic efficiency with those of the European Union. I focused on the digitization effects for a new organization of public administration, necessary to ensure the citizen's right to the use of information technology in dealing with the public administration, introduced Code of Digital Administration (March 7, 2005 , n . 82 ). This new organization of the public administration should be regarded as an evolving process with the same dynamism historically considered the defining feature of the administrative activity. This is proved by the application of transparency directives, which typically consider the intrinsic transformation abilities of the administrative activity, to the public administration organization (Acts: June 18, 2009 n. 69 - Public Administration Business Plan; October 27, 2009, n. 150 - Decreto Brunetta; November 6, 2012, n. 190 - Anti-Corruption Act; March 14, 2013, n. 33 - Trasparency Act)

    Tecnologia del recupero dell’architettura tradizionale: gestire la coesistenza tra conservazione e innovazione

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    The main aim of this PhD Thesis was to develop meaningful data and information on how to address the fundamental question related to rehabilitation technologies of traditional architecture: managing the coexistence between innovation and conservation, in order to restore the functionality of the building according to the contemporary standards of quality and, at the same time, not to alter the historical - cultural identity of the building technology. The present study is an analysis of good practices. The criteria applied to managing the coexistence between conservation and innovation of the building technology in some successful rehabilitation processes of historical city nuclei have been systematized. The main expected outcome is to fill a gap in literature concerning the evaluation of rehabilitation results by the technological point of view, in order to adjust the criteria of intervention on the basis of the results of earlier experiences. A qualitative and inductive research methodology has been applied, based on an evaluative-comparative strategy focused on case studies. Three rehabilitation processes of historical nuclei have been analyzed: Genova in Italy, Guimarães in Portugal and Santiago de Compostela in Spain. It has been systematically analyzed how windows, floors and roofs were processed, and it has been highlighted which traditional building technology characteristics were usually maintained and which were altered. The applied methodology has proved to be incisive in revealing the rehabilitation dynamics of the case studies. The findings show that in all cases the applied criteria were conceived in line with the Nara Document on Authenticity. The problematic coexistence of technological conservation and innovation was addressed by upgrading the traditional building technology thanks to the preservation of some building characteristics, that represent traditional building technology logic, and the implementation of all required innovations that do not contrast with the abovementioned traditional characteristics. The homogeneity of criteria among the three case studies represents a relevant fact in rehabilitation, as it demonstrates the existence of a common, well developed, rehabilitation methodology that is internationally shared among rehabilitation experts

    Mesostructured metal oxide-based nanocomposites as sorbents for H2S removal from syngas coal gasification

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    Desulphurization of gas phase sulphur compounds has been receiving dramatic attention since hazardous, corrosive, and toxic gases that cause environmental damages (especially acid rain) and industrial challenges (i.e., corrosion of equipment and deactivation of catalysts). This dissertation presents results of R&D efforts to develop efficient MeOx/SBA-15-based sorbents for H2S removal in view of possible applications in hydrogen purification, air pollution control, and deep desulphurization of fossil fuels. It is precisely in the latter topic that the research project was born. The production of power, fuels and chemicals in most countries is predominantly based on oil and, to a minor extent, on natural gas. It is well-known that the reserves of both of these fuels are limited to a range of 40, 60 years. On the contrary, coal is a widely available fossil fuel, and it is expected to last for about 230 years. The imminent oil production limitations and the longer availability of coal, the wish to improve the security of the energy supply, and the possibility to reduce greenhouse gas emissions by means of carbon capture and sequestration (CCS) are sufficient motivations to increase the use of this resource. Integrated Gasification Combined Cycle (IGCC) process is a high efficiency power generation technology which gasifies coal to generate the fuel (syngas) for a high efficiency gas turbine. A key challenge for producing clean power or hydrogen via gasification is cost effective purification of the sour syngas. There are many commercial treatment techniques that are used to remove H2S, but their disadvantage is that hot coal gas must be cooled down near to ambient temperature for desulphurization. The cooling equipment required, and the need to reheat the clean syngas before its use in a gas turbine result in economic and thermodynamic penalties that decrease the efficiency of a gasification plant. It is for this reason that hot gas desulphurization technique has attracted more and more attention due to the fact that it can reduce H2S down to 100 ppm level and avoid heat loss. Mid-temperature desulphurization is achieved by the use of solid sorbents such as oxides of those metals that form stable sulphides, based on the non-catalytic reaction between a metal oxide and hydrogen sulphide. The optimum desulphurization temperature has been recommended in the range of 300 to 450 °C, also in according to the more favourable thermodynamic equilibrium of sulphur compounds removal. To accomplish this task, Zinc oxide- and Iron oxide-based materials have been successfully employed for decades in different domains of the chemical industry. The pure metal oxides used as sorbents, however, suffer from evaporation, loss in the surface area and porosity due to sintering and mechanical disintegration that affect their performance and life time adversely. With the purpose of overcoming this problem and to improve their performance, metal oxides can be confined into a support, where under such conditions the materials are stable. The main properties required for support materials are inertness, high surface area, large pores and good mechanical strength. The thesis reports some simple and versatile routes which can be proposed to prepare a great variety of MeOx/SBA-15 composites where the mesostructured SBA-15 silica, a high-surface area (up to 1000 m2/g) material, with 6–7 nm-wide regular channels and thick (3–4 nm) pore walls has been used as efficient and stable support. MeOx active phase, formed inside the mesochannels, can reach the maximum size of 6-7 nm physically imposed by the pore diameter. Such a structure provides an ideal reactor where the mesopores act as channels for the transport of reactant. As a consequence, enhancement of the active phase reactivity might be expected. The proposed “Two-solvents” incipient impregnation method is easily reproducible and easy to scale up. Furthermore, this method should provide, at least in principle, ideal systems to be compared, and therefore to understand how the active phase nature influence their performance. For the first time, a careful comparative study on the effect of the different nature of the nanostructured MeOx (Me = Zn, Fe) dispersed into a mesostructured silica matrix (SBA-15) on the H2S removal performance is carried out. The behaviour of the MeOx/SBA-15 composites in the removal of H2S is investigated in a fixed-bed reactor and compared with that of an unsupported ZnO commercial sorbent. The morphological, structural, and textural features of fresh, sulphided, and regenerated sorbents have been assessed by a multi-technique approach, including the study of the possible interactions between the guest oxide and the host silica support. Furthermore, the sorption-desorption behaviour, which is commonly justified only on the basis of the different nature of the active phase and of the textural features (surface area and pore volume), is discussed also considering the morphology and the crystallinity of the active phase. In the literature, to our best knowledge, no one have reported similar correlations. For this reason this work can give an important contribution to improve the basic knowledge in the field of sorbents for gas-removal

    Impatto del cormorano Phalacrocorax Carbo Sinensis sulle produzioni ittiche delle lagune sarde

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    The work aims to study the feeding habits of the Great Cormorant (Phalacrocorax carbo sinensis, (Blumenbach, 1798), a species wintering in the transitional environments of Sardinia, and to assess the impact of the cormorants colony on fish stocks, considering the different ecological and economic aspects. During the 2012-2015 period, several monitoring and censuses were carried out, in order to assess and identify the roost or feeding areas with the largest number of cormorants in the different lagoons examined. Numerically, during the three years was observed a significant increase in the number of individuals (rk, p <0.05), which was more than 40% between the first monitoring conducted in 2012 and those 2014. Indeed, in December 2011 was recorded a peak of 9637 animals while in December 2014, there were 13536 individuals. A total of 1402 bird flocks of Great Cormorant wintering in the Cabras and Mistras lagoons (central-western Sardinia), in the S'Ena Arrubia lagoon (southeast of Oristano), in the Sant'Antioco lagoon (south-west Sardinia), in the Santa Gilla lagoon (near to Cagliari), in the Colostrai lagoon (southeastern coast of Sardinia), in the Sa Praia pond (south-east coast of Sardinia) were analysed. Through the morphological analysis of undigested hard structures, such as otoliths, it was possible to describe the preyed species, their size and biomass and, thus, the average daily consumption of cormorants. The trophic spectrum was dominated almost exclusively by euryhaline, gregarious fish species. Mugilidae, and particularly Liza ramada, were the most important prey with a very high percentage index of relative importance (%IRI). The average Daily Food Intake (D.F.I.) for the different lagoons examined was estimated to be equal to 386.8. ± 31 g / day. Specifically, the highest daily requirement was found in the Cabras lagoon with a value of 478.4. ± 18 g / day (Buttu et al., 2013a). The overall amount of biomass preyed by the cormorants during the entire wintering season was estimated over 500 tons. The results obtained by the model applied to a predation economically and ecologically acceptable, specifically, indicate that predation in the Cabras lagoon is outside of economically sustainable levels. This kind of study represent a fundamental step for the development of integrated management plans and protection measures, taking into account both the production requirements, and the environmental factors related to these important ecosystems

    Karl R. Popper lettore dei presocratici

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    Can we evaluate Popper's attention to Presocratics in a broader and varied interpretative framework than that claimed so far by the critics? This work provides arguments to support a general reconsideration of this research question, mainly through a study of the sources used by Popper in reading the Presocratics philosophers, which prior literature has never addressed. Introduction summarizes, in 3 sections, the critical historiography on this subject. Comments are negative and focus on the notion of an instrumental projection of the falsificationism on the ancient philosophy and also on the paradoxical fall into the historicism by an avowedly anti-historicist philosopher. The only significant exception is the strong affinity of Giovanni Cerri with Popper, which however does not prevent points of divergence. We chose to devote Chapter I to the use of the sources in the reconstruction of Parmenides' thought, identifying six recurring topics: 1. Parmenides' Goddess; 2. Elea's Moon; 3. The elenchos and the apparent anachronism; 4. The fragment B 16; 5. Eleatic verisimilitude; 6. Theme of blindness and the language issue. Chapter II describes in five sections the use of the sources in the reading of the other Presocratics, with particular attention to rediscovery of Xenophanes (section 2), to the change in Heraclitus (section 3), as well as to the relationship between Parmenides, Xenophanes and Heraclitus (section 1). The two final sections are dedicated to reconstruction of Anaximander (section 4) and Democritus (section 5). Chapter III focuses on the presence of Presocratics' philosophy in the articulation of Popper's reflection, with the aim of searching for some implications of interpretive perspectives that Popper proposed within his own philosophy. The essay of 1965 Beyond the search for invariants (section 1) is not mentioned in the set of critical historiography addressing Popper's approach to Presocratics. However this essay is the only Popperian example of discussion of contemporary epistemological questions from the ancient age through a projection of Parmenides in the modern physic (section 1.2). The text is marked by a line oriented from the past to the present: this perspective can be framed as a counterexample compared to leitmotiv of the critics, which see in the Popper's attention for the ancients a mere projection of his falsificationism on the past to find full legitimacy. Section 1.1 reconstructs the use of different sources cited in this essay by comparing them with those referred to by Popper in his contributions of subsequent years, and shows the importance of Giorgio de Santillana in the cosmological popperian reading of the second part of the Pamenides' poem as well as in the hypothesis of Xenophanes' presence in Parmenides' cosmology. In section 2 we chose to show only a few examples, from the initial to the last Popper, to prove that the reference to Presocratics has remained for the author a constant of his philosophical proposal, whose threads are unravelled and intertwined in parallel with the pages dedicated, in an almost entirely private form, to the passionate philological and historiographical considerations discussed in this work

    Development and evaluation of a new biochip Nucleic Acid Test (NAT) multi-target for cervical cancer screening

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    Cervical cancer is the fourth most common cancer in women and the cytological screening represents the most diffuse method of prevention. Human papillomavirus (HPV) is an established essential etiological factor for this cancer. Persistence of HPV infection, particularly by those belonging to the high-risk types (HR-HPV), is associated with an increased risk for cervical cancer development. Low-risk HPV (LR-HPV) types are more often associated with benign warts. Most invasive carcinomas are caused by two HR-HPV types: HPV16 and 18. Recently, HPV tests are used as an adjunct test to decrease the falsenegative rate of cytological screening with Papanicolaou test (PAP Test), especially HR-HPV DNA detection tests are useful for primary screening of cervical cancer and for triage of patients with equivocal cytological findings. However, the roles and contributions of other uncommon and rare genotypes remain uncertain, especially in specific geographic areas or populations. Recently, microarray biochip technology has been introduced into the clinical laboratory for HPV detection. One such test is the ProDect® CHIP HPV TYPING KIT (bcs Biotech Srl, Italy), which has the ability to identify 19 HPV types (all HR-HPV and most common LR-HPV types) and detect the generic presence of E6/E7 HR-HPV sequences. The aim of this pilot study was design a new biochip (CHIP PLUS) for the cervical cancer screening able to detect a large number of HPV anogenital types (HR- and LR-HPV) using two regions of the viral genome (L1 and E6/E7 sequences) as targets. This report also presents the results of a preliminary validation study in preparation for an extended clinical validation of the medical diagnostic ProDect® CHIP HPV TYPING PLUS employing the above CHIP PLUS designed both for the simultaneous detection of 31 HPV types (both common and uncommon HPV types) and for the characterization of three E6/E7 consensus sequences belonging to the principal groups of HR-HPV. The preliminary results of the ProDect® CHIP HPV TYPING PLUS KIT validation had higher concordance and/or greater compatibility with those of the reference tests, underlining the importance of searching for uncommon HPV types, enabling good prevention of cervical cancer using HPV DNA as test screening

    I canonici ospedalieri di S. Antonio di Vienne e la Sardegna

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    The aim of the PhD research is that of reconstructing the documentary body relating to the presence and action of the hospitaller Order of St. Anthony of Vienne in Sardina (XIII-XVI centuries). Starting from the analysis of the state of the art of the studies on the history of the order and its presence in Sardinia, a first- hand research on the sources produced by the Antonines community and on other sources dating back to the same historical period has been carried out with the purpose of providing both a historical analysis and a critical edition of such documents. St. Anthony’s order, extremely powerful in the Late Middle Ages and widespread throughout Europe, collapsed in modern age to the extent that it was suppressed at the end of the XVIII century. Antonines were well known for their healing powers of a disease, the ‘St. Anthony’s fire’, identified during the XVIII-XIX centuries with ergotism (food poisoning), but actually related to all those illnesses of a gangrenous nature. The analysis of the existing literature on the subject has shown the long-standing difficulties encountered by Antonian historiography, due to the scattering of the sources of information and to the influence of popular myths surrounding the illness. For what concerns the activity of Antonines in Sardinia, the sources available to researchers were few in number and often suffered from a superficial and non in depth enough interpretation. In the past, indeed, the vacuum in the documentary body has led scholars to believe that their presence in Sardinia had been marginal and not well documented. A more recent investigation of unpublished documents has provided researchers with new sources which contribute to highlighting the real dimension of the Antonian presence in the island. The documents, in this regard, prove that the canons managed a number of properties, certainly in Cagliari, Oristano and Sassari, collecting donations and revenues to be sent to the headquarter in Dauphiné. Their presence, although discontinuous, is documented as much as the practice of certain activities which made them well known, from their begging to their pig farming. The new element emerging from the analysis is rather the fact that assisting ill Sardinians was never a priority for them. The body of documents collected and presented as an appendix to this research contributes to providing a fairly complete picture of this page of Sardinian history which had until now been left uncompleted and was not gravitating within the Iberian orbit as in the case of the rest of Middle Age and Modern eras. Through the comparison between different sources, this research shows how and to what extent Sardinian micro-history fits within the contest of European macro-history

    Markers immunoistochimici delle cellule staminali/progenitrici nel rene umano in via di sviluppo.

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    The aim of this study was to better define, by immunohistochemistry, the molecular markers of renal stem/progenitor cells localized in the different niches of ten human preterm kidneys with gestational age ranging from 11 up to 25 weeks. Our data evidence the existence of multiple stem/progenitor pools in different zones of the human developing kidney that are characterized by different phenotypes: capsular stem cells were EMA (MUC1)+, MDM2+, Vimentin+ and Wnt1+; progenitors of the sub-capsular nephrogenic zone were MDM2+ and Wnt1+; cap mesenchymal cells were EMA (MUC1)+, CD15+, vimentin+, Wt1+, CD10+, Bcl2+, Wnt1+ and PAX2+; interstitial progenitor cells were Vimentin+, Wt1+ and α1Anti-tripsin +. Our data evidence the existence of multiple stem/progenitor cell pools in the fetal and neonatal human kidney. Progenitors of these different pools are characterized by a peculiar phenotype, indicating a different differentiation stage of these renal progenitors. A better knowledge of the molecular markers expressed by renal stem/progenitors might represent a relevant datum for researchers involved in renal regenerative medicine

    Sustainable management of natural stone waste. A proposed re-use for the production of mortars and the assessment of their potential CO2 sequestration capacity

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    Quarrying activity usually generates significant amounts of waste. Generally, the processed quarrying production accounts for 30% of total stone extracted, whilst waste (quarrying waste and processing waste) amounts to about 70% of total stone extracted. Not only could coping with waste be environmentally damaging, but it is also economically expensive for the stone industry, which in addition has to deal with the economic loss caused by the lower efficiency of quarrying. Some re-uses of natural stone waste, such as the production of aggregates, have already been investigated, but they are not profitable for most quarrying companies. Other re-uses of stone waste are related to economic fields which are too distant from quarrying companies to foster their commitment on their re-use (such as agriculture; paper industry; etc.). In fact, they are encouraged to sell waste at increasingly lower prices so as to get rid of it, reducing landfill costs. This research identifies the re-use of stone waste in the construction industry as the most profitable use, since quarrying activity is strictly related to the building industry. Hence, quarrying companies have the necessary skills and expertise to evaluate the economic risks, thus they are more eager to undertake the production of new by-products. Therefore, the generic goal of this work is to convert natural stone waste into some by-products with a renewed environmental and economic value. To this purpose, the production of cementbased and lime-based materials such as mortars (mixtures of a binder, fine aggregates and water) was identified amongst the possible re-uses as the most suitable one, since stone waste can be reused to some extent as a substitute of the binder (cement or lime) fraction and for the production of the aggregate fraction, thus achieving a higher re-use rate. In fact, since mortars have no structural use, their requirements are far more flexible than materials such as concrete and it is possible to reuse higher percentages of waste in their manufacture. A further goal of this dissertation was to enhance the environmental advantages of re-using stone waste for the production of mortars by investigating their CO2 sequestration capacity, since a percentage of CO2 emissions from the production of mortars is reabsorbed as the mortar hardens, owing to carbonation. Indeed, Portland cement production is responsible for 7% of annual CO2 emissions, due to the calcination reaction. Nonetheless, a secondary effect of carbonation is the uptake of atmospheric CO2, which reacts with calcium hydroxide in mortars and precipitates as calcium carbonate. Although CO2 uptake figures are far from the performance of other materials (such as coal ash and industrial residues), it should be pointed out that mortars have great potential, since their use in all built-up environments is impressively widespread. Initially, the assessment of the CO2 uptake of some selected commercial mortars by means of accelerated carbonation tests was undertaken through an experimental procedure, in order that a standard methodology and a set of operative parameters could be established. Then, some mortar mixtures constituted by stone waste were manufactured and henceforth called “ecological mortars”. These mixtures underwent the same carbonation tests as the commercial mortars, so as to permit a comparison between their performance. The obtained experimental results showed that both the commercial and the ecological mortars are capable to take up CO2. In particular, despite showing fairly lower figures, the “ecological mortars” reported a carbon absorption during the first 28 days of curing exceeding 6% of that emitted in the calcination reaction occurring during the production process. Low though they may seem, this value could represent a significant amount considering the period of service life, and after the service life (i.e. after demolition) of mortars

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