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DUALBIGRU-UCSA: Deep Learning based Music Emotion Recognition Model
No full text308-323Music Emotion Recognition (MER) is a process to classify emotions perceived in a given piece of music with
computational models. There are several problems regarding existing models, due to subjective perception of emotions and
individual differences and culture diversity. To overcome these challenges, we developed a Dual Bidirectional Gated
Recurrent Unit with Unified Contextual Shuffle Attention Fusion (DualBiGRU-UCSA) model. Here, the primary
contribution lies in the practical implementation of bidirectional and gated recurrent units along with developed attention
mechanisms to address the requirements for understanding and perceiving complex musical features. Using Bidirectional
GRUs, the model taps the information of past and future contexts of music sequences in addition to refining the features of
temporal dynamics and feelings. The final model’s performance enhancements involve the integration of bidirectional GRU
outputs to the UCSA module through paying much attention and shifting through the feature representations, the module
consisting of Shuffle Attention and Multi-Head Location-Aware Attention performs by reducing the unimportant feature
representations while enhancing the important patterns and contextual cues. The proposed model performs better in terms of
high accuracy, f1-score, negative predictive values, positive predictive values and recall of 96.28%, 96.32%, 96.26%,
96.60% and 96.27% respectively as compared to recent State-of-the-Art techniques
Prioritizing Barriers to Circular Economy Implementation in Toy Industry using Analytical Hierarchy Process
No full text278-286The transition towards a circular economy has gained considerable attention as a promising strategy to mitigate environmental degradation and resource depletion. This study aims to prioritize barriers to circular economy implementation within the toy industry using the Analytical Hierarchy Process (AHP) methodology, driven by the need to identify and address obstacles hindering circular practices in a sector notable for its environmental impact and waste production. The methodology included a comprehensive literature review to identify relevant barriers, expert consultation, and AHP analysis to assign weights and ranks to each factor. The study identified and ranked factors influencing circular economy implementation based on their relative importance. Key findings highlight Lack of Collaboration (weight 0.351), Limited Market Demand (weight 0.109), and Economic Viability (weight 0.092) as primary barriers, with Lack of Infrastructure and Supply Chain Complexity also emerging as critical challenges. These findings emphasize the need for collaborative efforts, innovative solutions, and robust regulatory frameworks to overcome these barriers and promote sustainable practices in the industry. This study provides valuable insights for policymakers, industry stakeholders, and researchers to develop targeted strategies and initiatives for fostering circular economy principles in the toy industry. The novelty of this research lies in its application of the AHP methodology to systematically assess and rank barriers to circular economy implementation in a specific sector, offering a replicable framework for similar analyses in other industries
Effect of Vicia sativa L. allelochemicals on Lens culinaris L. growth and molecular docking against tryptophane synthase β subunit of Pyrococcus furiosus
No full text149-155Vicia sativa is a common weed that grows luxuriously with the lentil (Lens culinaris L.) crop. According to literature studies, the plant can produce a negative allelopathic effect on lentil crops. Because both of these plants have the same morphology, and removal through manually picking of the weed is very difficult. The present investigation was framed to identify the allelopathic effect of V. sativa by growing lentil plants under the different dilutions of its whole plant extract. We analyzed growth on the 5th and 20th day after seed germination. We estimated the total carbohydrate, nitrogen, and proline contents to assess the potential impact of weed on photosynthesis and respiration. All concentrations of the extract strongly inhibited the growth of the test plant, resulting in a reduction of 3.0 and 2.7 cm in shoot and root length, respectively. The carbohydrate, and nitrogen accumulations decreased in a similar way as compared to its control. The steady increase in free proline contents indicates that whole plant extracts have a negative allelopathic effect. LC/MS analysis of extract revealed presence of various allelochemicals, including luteolin, naringenin, ferulic acid, 3,4-dihydrocinnamic acid, vanillic acid, 3,4-dihydroxyactophenon, succinic acid, and benzaldehyde, among others. These allelochemicals were docked by the tryptophan synthase beta-subunit from Pyrococcus furiosus that stimulate tryptophane biosynthesis and auxin production and disturb the phytohormone balance in test plants. Luteolin and naringenin when docked with the target protein (PDB ID 5dw3), show high binding affinity (-9.2 kcal/mol) as compared to their natural ligands
Studies directed towards synthesis of leprostatic agent desoxyfructoserotonin
No full text148-153Leprosy is an infectious chronic disease and a neglected tropical disease induced by Mycobacterium leprae, and mainly
affects the skin, peripheral nerves, upper respiratory mucosa and eyes. The prolonged physical deformities associated with
leprosy get progressively worse with delayed diagnosis and increasing age. In this paper we report synthesis of
Desoxyfructoserotonin which is a leprostatic agent, using 5-methoxy indole and the desired chiral centres have been
incorporated using naturally obtained sugar moiety (D)-mannitol employing Vilsmeier-Haack reaction and Henry reactions
Ethnobotanical survey of medicinal plants used for the treatment of malaria by tribal communities of Anuppur district, Central India
No full text158-167Medicinal plants are abundant sources of bioactive secondary metabolites and play a crucial role in the treatment and management of various diseases. The present research involves the documentation of ethnomedicinal plants used by tribal people residing in the district of Anuppur, Madhya Pradesh, Central India. To obtain data on ethnomedicinal plants, a semi-structured interview schedule was conducted with the local tribal people, who have engaged in the folk practice and use ethnomedicinal plants to treat malaria disease. The obtained data were analyzed using statistical parameters like Relative Frequency Citation (RFC), Relative Importance Index (RI), Frequency Citation (FC), and Jaccard Coefficient of Similarity (JCS) etc. In the present study, a total of 44 respondents were exclusively interviewed, who revealed information about the medicinal plants used to treat malaria. A total of 24 medicinal plants, belonging to 20 plant families were documented, in this study. In conclusion, the majority of plants used by the tribal communities were used in combination form (24%) rather than a single plant. In order to conserve this important traditional knowledge, documentation is necessary which may provide new lead(s) for drug discovery in the future. Thus, the present research aims to demonstrate and document the importance of folk medicine in the study region as a novel source of anti-malarial drug(s)
Tracking the emergence and usage of farmer led innovations (FLIs) in maize ecosystem: A pan India exploration
No full text177-184The study was carried out, by using case study method, to investigate the distinctive characteristics of a few selected farmer-led innovations (FLIs) in maize cropping systems created at the grassroots level across India. A total of five maize-based innovations produced at the grassroots level in various parts of India were purposefully chosen. The originality of these innovations is that they are based on the culture from which they originate and are based on local expertise. This study discovered that all farmer-led innovations generated by farmers were more useful than other existing options since these innovations were built with farmers' needs in mind. Furthermore, these were discovered to be and determined to be sustainable, owing to the fact that these inventions were produced using local resources and wisdom. All five innovations were discovered to be less expensive than alternative market-available technologies. The majority of selected technologies were determined to be profitable, with farmers benefiting after a specified period of hard labor and investment. All of the chosen technologies were discovered to be compatible with the needs of local farmers. The ideas generated by respondents were not commercialized due to several difficulties faced by the farmers to translate the innovations into marketable items, combined with the low demonstrability of these technologies
Comprehensive DFT analysis on monosodium urate: Implications for gout pathophysiology
No full text299-305This research employs advanced Density Functional Theory (DFT) techniques to conduct a comprehensive analysis of
monosodium urate (NaC5H3N4O3), a pivotal molecule in gout pathophysiology. The B3LYP/6-311G** method is utilized to
explore conformational stability, molecular structure, UV-Vis and IR spectra, as well as electronic properties of
monosodium urate. The study reveals intricate information about electronic transitions, molecular vibrations, and orbital
interactions, providing a profound understanding of molecular dynamics associated with monosodium urate. Additionally,
Nuclear Magnetic Resonance (NMR) analysis predicts precise 1H and 13C chemical shifts, offering nuanced structural
insights. Quantum calculations contribute to a thorough characterization of monosodium urate, enhancing our understanding
of its molecular intricacies. The findings from this study significantly enhance our comprehension of the underlying
molecular mechanisms of gout, shedding light on potential therapeutic interventions. The detailed insights into electronic
properties and structural dynamics open new perspectives for the application of monosodium urate in environments
influenced by electrical factors. In essence, this research not only expands our knowledge of gout pathophysiology but also
presents innovative opportunities for targeted research and therapeutic development
Design and synthesis of novel triazole-isofroxadin molecules: Docking studies against inflammatory and tuberculosis targets
No full text285-2901,2,3-Triazole scaffolds are playing a vital role in various fields. These are not natural products but produced by
synthetic chemists. Isafroxadin natural product and its 1,2,3-triazole derivatives have been synthesized using Click protocol.
Thus, the newly generated scaffolds have been subjected to docking studies against inflammatory and tuberculosis activity
