25647 research outputs found
Sort by
„Leaving No One Behind: Female Criminality and Rehabilitation within the SDG Framework, national and international perspectives“
Full text linkThe principle of “Leaving No One Behind,” embedded in the 2030 Agenda for Sustainable Development (A/RES/70/1), requires states to prioritize those most marginalized in achieving the Sustainable Development Goals (SDGs). Within this framework, women in conflict with the law represent one of the most overlooked and rapidly growing populations worldwide - the global female prison population has risen by over 60% since 2000. This presentation explores the interconnection between female criminality, rehabilitation, and the SDG framework through national and international perspectives. It examines structural drivers such as poverty, gender-based violence, limited education and employment opportunities, and mental health disparities that contribute to women’s pathways into crime. The analysis further identifies the urgent need for gender-responsive rehabilitation and re-entry programs aligned with SDGs 1 (No Poverty), 3 (Good Health and Well-being), 4 (Quality Education), 5 (Gender Equality), 8 (Decent Work), 10 (Reduced Inequalities), and 16 (Peace, Justice and Strong Institutions). Particular attention is given to strengthening family support, community engagement, and legal reforms inspired by the UN Bangkok Rules and CEDAW recommendations. Drawing on recent UNODC, UNDP, and Penal Reform International data, the study argues that inclusive justice policies—rooted in empowerment, equity, and cross-sector collaboration—are essential to sustainable reintegration and social resilience. Ensuring that women offenders are visible in SDG monitoring and justice reform processes is not only a human rights imperative but also a measure of societies’ genuine commitment to sustainable development and the universality of justice
Примена на повеќекритериумско одлучување за избор на оптимална рута за транспорт на комунален отпад
Full text linkЕден од најважните аспекти во процесот за нормално функционирање на едно општество е управувањето со комуналниот отпад, односно изборот на локација на депонија и изборот на оптимална рута за транспорт на комуналниот отпад до депонијата. При изборот на оптимална рута за транспорт е потребно да се земат во предвид голем број на влијателни параметри, бидејќи во тој случај ќе се добие најсоодветната рута за транспорт. Примената на методите за повеќекритериумско одлучување се од голема важност за решавање на сложени и капитални проблеми, бидејќи овозможуваат разгледување на голем број влијателни параметри.
Во овој труд ќе бидат споменати неколку методи за повеќекритериумско одлучување, кои се имаат користено за избор на оптимална рута за транспорт, а потоа може да се изврши споредување на добиените резултати за да се одреди просечното рангирање на транспортните рути
Approach to neurorehabilitation in median nerve lesion
Full text linkLesions of the median nerve represent common peripheral neuropathies that lead to motor and sensory impairments in the hand and forearm. Patients experience functional limitations, pain, loss of fine motor skills, and a reduced quality of life. This paper describes the neurorehabilitation approach, with emphasis on kinesitherapy, sensory re-education, and multidisciplinary collaboration. The aim of this study is to investigate the effect of a structured kinesitherapy program on motor and sensory function in patients with median nerve lesions. Material and methods: The study included 12 patients with diagnosed median nerve lesion (7 men and 5 women), with an average age of 52 ± 8 years. Inclusion criteria were age 30–65 years, confirmed diagnosis by EMG and clinical tests, and absence of severe comorbidities (uncontrolled diabetes, severe cardiovascular disease). Each patient participated in 15 individual treatments (3 times a week for a period of 5 weeks). Preparatory part: breathing, manual stretching, relaxing massage. Main part: active and passive exercises, thumb opposition, tendon-gliding exercises, functional activities. Final part: relaxation and home program. Patients were evaluated at baseline, on day 15, and after 1 month using the following parameters: Grip strength (dynamometer), Pinch strength (pincer grip), QuickDASH score (functional disability), VAS (pain) and sensory discrimination (monofilaments, two-point test). The results demonstrate significant improvements in strength, sensory function, and pain reduction (p < 0.001). Conclusion: The application of a structured neurorehabilitation approach in patients with median nerve injury has the potential to lead to significant improvement in motor and sensory function, as well as pain reduction. The study confirms the importance of kinesitherapy as a fundamental element in the rehabilitation process and sets the basis for future real-world research.
Keywords: median nerve, neurorehabilitation, kinesitherapy, sensory re-education, peripheral neuropathy
Field: Public Health and Medicin
Суплементи со β-хидрокси-β-метилбутират (HMB) и нивните ефекти врз пациенти со саркопенија
Full text linkСаркопенијата претставува состојба која се карактеризира со прогресивна загуба на мускулна маса и сила, која вообичаено се јавува кај постари лица. Суплементите со β-хидрокси-β-метилбутират (HMB) се применуваат за поддршка на мускулното здравје кај пациенти со оваа состојба. Целта на овој труд е да се направи преглед на познатите ефекти на HMB кај саркопенични пациенти, користејќи литература од релевантни извори, со пребарување по клучни зборови. Како метаболит на леуцинот, HMB стимулира протеинска синтеза преку активација на mTOR патеката и го инхибира мускулниот катаболизам преку
намалување на активноста на системот за деградација на протеините во клетката. Спроведените клинички испитувања покажуваат дека суплементацијата со HMB, особено во комбинација со структурирана физичка активност, можат значајно да ја подобрат мускулната сила, функционалната подвижност и квалитетот на живот, особено кај постари
лица со саркопенија. Утврдено е дека дневни дози од 2 до 3 g се ефикасни, со минимални несакани ефекти, а суплементацијата покажува синергетски ефект со адекватна исхрана богата со протеини. Утврдено е и дека HMB може да влијае врз намалување на маркерите на воспаление, како што е C-реактивниот протеин, што е важно, особено кај оваа
популација. Ефектите од суплементацијата со НМВ кај саркопенични пациенти зависат од возраста, стадиумот на болеста, нутритивниот статус и комбинираните придружни
интервенции, вклучувајќи исхрана и вежбање. Иако податоците се охрабрувачки, потребни се долгорочни истражувања за оптимизација на терапевтските протоколи и проценка на
безбедноста при продолжено користење на суплементи кои ја содржат оваа супстанција
The isotomic disc and the isogonal disc conjecture
No full textWe prove and disprove conjectures for the isotomic and isogonal disc
Свечено затворањето на фестивалот „Денови на македонска музика 2025“
Full text linkЗатворањето на фестивалот „Денови на македонска музика 2025“ се одржа на 16 октомври со оркестарот на Македонската филхармонија под диригентската палка на маестро Борјан Цанев и беше во знакот на одбележувањето на 100-годишнината од раѓањето на композиторите – академик Властимир Николовски (1925 – 2001) и м-р Кирил Македонски (1925 – 1984).
Традиционално на концертот на Филхармонијата, Сојузот на композитори на Македонија – СОКОМ ги доделува наградите „Георги Божиков“ и „Панче Пешев“
Dental Plaque And Its Role In The Cause Of Plaque Associated Diseases
Full text linkBackground: The human oral cavity harbors diverse communities of microbes that live as biofilms: highly
ordered, surface-associated assemblages of microbes embedded in an extracellular matrix. Oral microbial
communities contribute to human health by fine-tuning immune responses and reducing dietary nitrate. Dental
caries and periodontal disease are together the most prevalent microbially mediated human diseases, worldwide.
Materials and Methods: Both of these oral diseases are known to be caused not by the introduction of exogenous
pathogens to the oral environment, but rather by a homeostasis breakdown that leads to changes in the structure
of the microbial communities present in states of health. Both dental caries and periodontal disease are mediated
by synergistic interactions within communities and both diseases are further driven by specific host inputs: diet
and behavior in the case of dental caries and immune system interactions in the case of periodontal disease.
Results: Changes in community structure (taxonomic identity and abundance) are well documented during the
transition from health to disease. In this review, changes in biofilm physical structure during the transition from
oral health to disease and the concomitant relationship between structure and community function will be
emphasized.
Conclusion: Dental caries and periodontal disease are the most prevalent microbially mediated diseases in
humans. Dental plaque has a highly ordered structure mediated by intercellular interactions, the environment,
and the host. Periodontal disease is associated with changes in microbial community structure, i.e., taxonomic
membership and abundance. Periodontal disease is thought to be mediated by synergistic interactions between
subgingival microbial communities and the host.
Key Word: microbes, dental caries, periodontal disease
Primary and permanent teeth pulp stem cells - biological characteristics and therapeutic indications
Full text linkStem cell research has opened new avenues in regenerative medicine, offering promising solutions for
tissue restoration and regeneration. Among the various sources of stem cells, dental pulp has emerged as a rich
reservoir of mesenchymal stem cells (MSCs) with remarkable regenerative potential. Pulp stem cells derived from
primary and permanent teeth have attracted attention due to their unique biological properties and clinical
applications. Primary teeth, despite being temporary structures, contain a rich source of MSCs during early
childhood development, while permanent teeth provide a more abundant and accessible reserve of stem cells during
adulthood. The aim of this paper is to investigate the biological characteristics and therapeutic potential of pulp stem
cells derived from primary and permanent teeth. Stem cells extracted from the dental pulp represent a significant
interest in regenerative medicine due to their unique properties and accessibility. Through a comprehensive review
of the existing literature and empirical research, this paper aims to clarify the different qualities of pulp stem cells
from both primary and permanent teeth, exploring their regenerative capacities and therapeutic indications. By
evaluating their potential for differentiation, immunomodulatory effects and clinical applications, this thesis
provides valuable insights into the use of dental pulp stem cells for tissue and regenerative therapies. For the
realization of this paper, we compiled a survey questionnaire that contained several questions for the respondents.
According to the data obtained from a total of 100 respondents, of whom 53 were female and 47 were male. Of the
male population, 47, 17 were medically educated, 30 were medically uneducated. We obtained data that most of
them are not familiar with the procedure. Women are more susceptible with 53%. Despite the significant therapeutic
potential of stem cells dental pulp cells, several challenges remain to be overcome to fully realize their clinical
potential and maximize their impact in regenerative medicine. The application of dental pulp stem cell-based
therapies from preclinical research to clinical applications requires rigorous validation of their safety, efficacy, and
scalability in clinical trials. Collaborative efforts between researchers, clinicians, regulators, and industry partners
are essential to navigate regulatory pathways, secure funding, and advance dental pulp stem cell-based therapies
toward clinical adoption.
Keywords: stem cells, primary teeth, permanent teeth, indications, therapy
Comparative analysis of the problem of defining the criminal offense of terrorism in international law
Full text linkThe issue of defining terrorism as a criminal offense in international law raises numerous
controversies, and recent efforts to reach a consensus remain challenging and complex. This
article presents a comparative analysis of different approaches to defining terrorism within the
framework of international legal order. Taking into account various documents and
conventions, such as the UN Convention on Terrorism and General Assembly resolutions, the
article analyzes the issues that arise in attempts to establish a globally acceptable uniform
definition. The article also considers the differences between legal systems and the influence of
political interests on the definition of terrorism, as well as the legal consequences stemming
from various conceptual approaches. The primary aim of this paper is to examine the
shortcomings of international law and propose potential solutions that could contribute to
greater legal clarity and effectiveness in the global fight against terrorism.
Keywords: terrorism, international law, definition of terrorism, criminal offense, legal
comparison, legal systems, global consensu
A case of sarcoidosis in a forensic setting – what has been found as case of death
Full text linkSarcoidosis is a multisystem inflammatory disease of unknown etiology with a particular
clinical and pathological picture. Pathologically can be confirmed with the finding of noncaseating
(non-necrotizing) granulomas containing epithelioid cells and large multinucleated
giant cells. Sarcoidosis is associated with an increased risk of premature death; it is twice as
high as the general population. The common cause of death includes: cardiac failure due to
cardiac sarcoidosis, lung disease associated with pulmonal hypertension, infection etc. In this
case presentation we show finding of another and not so common cause of cardiac death in a
patient with sarcoidosis i.e. bacterial myocarditis represented by clusters of bacterial colonies
throughout the myocardial tissue