Goce Delcev University

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    Artificial intelligence in intact tooth model creating and strength testing

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    Aim or purpose: Artificial intelligence (AI) is becoming an increasingly common, widely used tool for intact tooth 3 modeling from CBCT scans. Also, AI could be used for biomechanics testing, with high value of accurate. Materials and methods: CBCT of the patient was made. After exporting the DICOM format of CBCT in 3D Slicer the upper left central incisor was isolated as volumetric finite element model from the maxilla and then its mesh was corrected and refined in 3D Slicer and Meshmixer. The next step was to convert the exported ASCII code from Mesh mixer into appropriate ASCII code for SOFiSTiK with the help of artificial intelligence. The 3D intact tooth model was made with all biological tissue properties. With that, the volumetric model was ready and subjected to strength testing with SOFiSTiK. Results: The fracture resistance testing was conducted in SOFiSTiK. The results have shown that the intact tooth has a high value of strength, around 1350 N. This value is near to value of in vitro testing with Universal Testing Machine. Conclusions: Today, in vitro fracture resistance studies have been totally replaced with artificial intelligence algorithms studies. This way of testing the fracture strength could save moneyandtimewithvalueofaccurate asinvitro testing. Key Words: finite element model, finite element analysis, artificial intelligence, intact tooth, strength testing

    Камерен Концерт на Дејан Лазаревски -Гитара и Александра Кировска-Гитара ОУЦК "Ацо Караманов" Радовиш 2025

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    Програма 1.Вања Николовски Ѓумар-Макитар 2.J.K.Mertz-Tarantelle 3.A.Piazzola-Zita -Libertango 4.M.D.Pujol-Tango de Abril -Cafe para dos 5.J.T.Morales-Milonga Argentina 6.Z.Abreu-Tico Tico 7.V.Ivanovic-Balkan Expres

    Сметководствено евидентирање и анализа на трошоците во производство

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    Овој труд има за цел детално да ја истражи сметководствената евиденција и анализата на трошоците во производствените компании, со посебен осврт на процесот на производство. Целта е да се прикаже значењето на прецизното водење на сметководствените податоци и нивната улога во управувањето со производствените ресурси и донесувањето на економски одлуки. Во рамките на трудот се разгледуваат видовите трошоци што се јавуваат во производствениот процес, нивната класификација според природата, местото на настанување и нивната функција, како и начинот на нивно сметководствено евидентирање. Посебно внимание е посветено на влијанието што трошоците го имаат врз цената на чинење на производот, како и врз профитабилноста на претпријатието. Преку практична анализа и табеларен приказ, се прикажува структурата и распределбата на трошоците во производствениот процес. На тој начин се нагласува значењето на точната и навремена сметководствена евиденција за рационално користење на ресурсите, зголемување на продуктивноста и подобрување на управувањето. Добиените резултати укажуваат дека правилната распределба и анализа на трошоците претставуваат клучен фактор за постигнување поголема економска ефикасност, поуспешна контрола на производствениот процес и зголемена конкурентност на пазарот. Ваквиот пристап овозможува подобро планирање на производството, оптимизирање на трошоците и зголемување на вкупната деловна успешност на компанијата

    From Jim Crow to Today's American Culture: The Enduring Impact of Segregation

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    This paper researches the cultural consequences of Jim Crow still unmasked in America today and how racial segregation is legally integrated within society. It delves into the evolution of Jim Crow laws and examines how such legislation took creation racism and enforced white supremacy while forcing African Americans to endure systemic suppression in domain of existence. It also analyses the etiquette oversaw social interactions supporting segregation that restricted interracial contact including public interaction. Drawing ways to modern-day America, this paper highlights the need for cultural consciousness concerning discrimination. Societies can work towards advocating for greater understanding of historical discrimination injustices by conquering the ghost of racial segregation while empowering disenfranchised groups, aiding societies combat the remnants of racial divides through transforming them into more inclusive narratives. Keywords: Culture, awareness, segregation, impact, societ

    The role of pharmacists in asthma management: patient opinions and expectations in North Macedonia

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    This study aimed to assess patients’ perceptions of inhaler technique education and the pharmacist’s role in asthma care in North Macedonia. A cross-sectional survey was conducted from July to September 2024 at the University Clinic for Pulmonology and Allergology in Skopje, involving 187 adult asthma patients. Most participants (69%) reported adherence to therapy, but 13.9% had never received inhaler training, and only 27.3% had been instructed by a pharmacist. While 96.3% expressed interest in pharmacist counseling on medications, only 48.7% were open to pharmacist-led inhaler training. Significant associations were found between adherence and both gender (p = 0.040) and inhaler training. These findings suggest limited awareness of the pharmacist’s clinical role. Expanding pharmacist-led education in community pharmacies and fostering collaboration with physicians could improve asthma outcomes and promote more effective use of healthcare resources

    Analyses of the trade relations between the Republic of North Macedonia and the Republic of Bosnia and Herzegovina

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    The trade of the Republic of North Macedonia with the Republic of Bosnia and Herzegovina takes place in accordance with the multilateral regional agreement CEFTA 2006, which means that it is completely liberalized. Taking into account this fact, in this paper it has been made an analysis of the value, dynamics and structure of the foreign trade between the Republic of North Macedonia and the Republic of Bosnia and Herzegovina for the time period of 2014- 2023. It has been also analyzed the competitiveness of Macedonian products at the Bosnia and Herzegovina market so that the product categories with a comparative advantage can be determined, using the Standard International Trade Classification and the Balassa Index. The results of the analysis point to the fact the Republic of Macedonia has a comparative advantage in the export of food and live animals, as well as the beverages and tobacco. Key words: The Republic of North Macedonia, Republic of Bosnia and Herzegovina, CEFTA 2006 foreign trade, comparative advantage, Balassa Inde

    Biosigurnosne prakse na farmama autohtonih rasa domaćih životinja

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    Biološka bezbednost je ključna u upravljanju stočarskom proizvodnjom i usmerena je na sprečavanje unošenja, širenja i prenošenja uzročnika bolesti. Za autohtone rase domaćih životinja, biosigurnosne prakse su posebno važne zbog njihovih jedinstvenih genetskih osobina i prilagođavanja specifičnom okruženju. Autohtone rase su poznate po izdržljivosti i otpornosti na lokalne bolesti, ali i dalje zahtevaju odgovarajuće upravljanje radi obezbeđenja njihove održivosti i produktivnosti. Cilj rada je da se ukaže na najznačajnije biosigurnosne principe i prakse biosigurnosti u proizvodnji autohtonih rasa domaćih životinja, koji uključuju: izolaciju i karantin, monitoring zdravstvenog stanja životinja, sanitaciju i održavanje higijene, kontrola kretanja životinja, ljudi, i opreme, gazdovanje otpadom, očuvanje genetike i otpornosti na bolesti, nadzor i vođenje evidencije, obuka i podizanje svesti i izradu planova za vanredne situacije. Pravovremeno i sistematsko sprovođenje biosigurnosnih procedura je neophodno za održavanje zdravlja i produktivnosti autohtonih rasa domaćih životinja. Uključivanjem ovih praksi u svakodnevno upravljanje proizvodnjom na farmi, odgajivači mogu puno doprineti očuvanju ovih rasa; one su neprocenjive u smislu njihove prilagodljivosti, otpornosti na lokalne bolesti i genetske raznolikosti. Održavanje biosigurnosti na najvišem mogućem nivou ne samo da štiti životinje već doprinosi zdravlju farmske populacije, zdravlju potrošača, stanju okruženja i bezbednosti hrane

    Implementing good practices in language policy in North Macedonia: experiences and challenges

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    The linguistic diversity of North Macedonia offers a solid foundation for the development of an inclusive and sustainable language policy. A key example of a good practice is the 2019 Law on the Use of Languages, which expanded the official use of Albanian at the national level. Its implementation in public administration, education, and healthcare has led to initial positive outcomes, including bilingual documentation, dual-language signage in public institutions, and training programs for bilingual staff. At the local level, multilingual municipalities such as Tetovo and Kumanovo have introduced pilot initiatives that promote functional bilingualism – for example, multilingual citizen services, language-sensitive educational programs, and community media in multiple languages. One notable practice is the integration of language mediators in schools with mixed-language student populations, which has proven effective in improving communication and fostering intercultural understanding. This paper documents these concrete practices and assesses their effectiveness in promoting social cohesion and actual language equality. The analysis draws on recent field observations, interviews with professionals in administration and education, and official implementation reports. The goal is to identify which measures have long-term potential, what conditions support their sustainability, and how they might serve as transferable models for other multilingual societies

    In silico report on five high-risk protein C pathogenic variants: G403R, P405S, S421N, C238S, and I243T

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    In this study, we propose reclassification of 5 out of 16 PROC VUS (variants of uncertain significance): C238S, I243T, G403R, P405S, and S421N, as pathogenic variants, associated with thrombophilia due to PROC deficiency. The obtained results are based on in silico analysis, which enables a detailed assessment of variants’ impact, despite limited clinical evidence. In particular, the G403R substitution, next to the S402-active site, is expected to reduce the flexibility of the local coil domain, affecting the catalytic activity of serine protease. The P405S substitution may imply B-factor gain (P = 0.24; p-value=0.040). On the other hand, the S421N variant causes phosphorylation site disruption at S421, which serves as a target for CK2 phosphorylation. C238S substitution alters metal binding, while the I243T variant may alter transmembrane properties (P = 0.27, P-value=0.00071). All five PROC variants hold promise as diagnostic markers for protein C deficiency and may also serve as potential drug targets for therapeutic intervention

    Smart city: a review of current developments and implementation of smart grid technology

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    To ensure better living standards for the population, it is necessary to develop smart cities that utilize modern technology and operational efficiency to facilitate daily life. The primary goal of implementing (or creating) a smart city is to maintain, balance and continuously upgrade economic, social, and environmental resources while managing cost. Emphasis is placed on maximizing the use of natural resources through energy conservation (utilizing renewables), efficient water usage, time savings, land optimization, environmental quality, traffic management, and the extensive use of information and communication technology systems and services for effective management and their ongoing enhancement. This paper aims to create improved functionality, smart connections, and better organization among people, while maximizing the use of natural resources, minimizing environmental pollution, and enhancing public awareness

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