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Applied, Connected, Entrepreneurial and Engaged European University (ACE2-EU)
Full text linkThe mission of the Applied, Connected, Entrepreneurial and Engaged European University (ACE2-EU) is to equip our students, staff, researchers, and external stakeholders with the knowledge, skills, and competencies needed to collectively address future challenges. Addressing these challenges, including the twin digital and green transitions and socio-economic issues, will deliver sustainable societal transformation, benefiting not only our regions and the EU, but society in general.
To fulfil our mission, we employ our distinctive ACE2-EU approach, collaborating with external stakeholders to create joint learning opportunities and activities that engage all mission areas of our universities. We embrace challenge-based and work-based methodologies in partnership with external stakeholders to develop flexible and innovative educational, research, innovation, and service to society learning opportunities. These are crafted by multidisciplinary European knowledge creation teams comprising students, staff, researchers, and stakeholders.
Our European inter-university campus is dedicated to a common vision and shared values, incorporating an inclusive student-centred joint governance and management structure, and a shared pool of resources that includes staff and operational units.
Key operational units and systems include our: APP Factory which develops joint student-centred, challenge-based learning opportunities, including short programmes and full degrees; ARIES Incubator focused on stimulating and creating joint research & innovation activities, nurturing entrepreneurship, and supporting the development of our research community; SPACE Centre which co-creates joint service to society activities and promotes cultural awareness; and our e-Campus digital platform.
In living our mission, we will foster and promote the core European Union values and objectives, including multiculturalism and multilingualism, thereby strengthening European identity across our alliance
Simulations for Logistic Training in Military Operations
Full text linkSimulations for logistic training play a vital role in modern military operations by enhancing preparedness, coordination, and resource management without the risks and costs associated with real-world exercises. Through virtual and computer-based simulation systems, military personnel can train in realistic scenarios that replicate dynamic operational environments, including supply, transportation, maintenance, and medical support. These simulations improve decision-making, interoperability, and efficiency at both tactical and operational levels. By integrating advanced modeling and virtual technologies, logistic simulations contribute significantly to the effectiveness, safety, and sustainability of military training and operational planning
Leveraging AI for Adaptive Narratology in Children's Literature: Enhancing Reader Engagement through Interactive Storytelling
Full text linkA vital component of children's development is literature. Children's literature is an effective means of promoting kids' societal, emotional, and mental growth. It helps kids to recognize legal and moral quandaries by seeing the lifestyles, encounters, and moral difficulties of others. Outside the traditional position of passive individuals, interaction elements in visual storytelling encourage people to thoroughly engage with the narrative. Engagement and emotions are two important factors that greatly impact a reader's perspective throughout a reading job. One statistical technique that aids in determining and evaluating an individual's emotions through written material is sentiment evaluation. Various instruments and approaches were used to analyze text data employing artificial intelligence methods to identify mixed emotions. Employing the Random Forest (RF) method, a 5-fold cross-validation method was used to distinguish between optimistic and sad emotions. In the end, the grid-search strategy was used to adjust the hyperparameters, and the outcomes were contrasted with those of five standard methods: AdaBoost, XGBoost, Support Vector Machine (SVM), LSTM, and Naïve Bayes (NB). According to the research results, the suggested framework outperformed all five cutting-edge techniques with corresponding margins of 4.64%,10.80%,19.45%,21.1%, and 56.6 %, achieving an accuracy percentage of 99.64% on the 4000 stories database. It's noteworthy to note that the suggested approach also produced better outcomes in terms of additional traditional efficiency criteria, including temporal complication, recall, precision, and specificity. All things considered, the suggested framework has enormous possibilities for use in academic settings, child psychology studies, and the monitoring of kid-friendly material, typically aiding in the comprehension of kids' emotions and activities in the electronic sphere
100 евра и ChatGPT – дали ова е доволно за успех на глобалниот инвестициски пазар?
No full textВештачката интелигенција станува сè поприсутна во светот на финансиите. Од апликации што „оптимизираат“ портфолио до алгоритми што тргуваат наместо вас – прашањето е: дали ВИ е најголемата револуција во историјата на финансиите или само нова алатка во рацете на човекот
Hyperkeratosis of the Oral Mucosa – a case report
No full textIntroduction: Hyperkeratosis of the oral mucosa is a condition characterized by excessive thickening of the keratin layer of the mucous membrane, most often as a result of chronic irritation or injury. Although not typically considered serious, this condition can be caused by various factors such as smoking, alcoholism, or poor oral hygiene. Aim: Aim of this article is to present a clinical case of hyperkeratosis of the oral mucosa in a 23-year old female patient. Hyperkeratosis can be a precursor to malignant diseases. A histopathological biopsy of the oral mucosa is necessary for a definitive diagnosis. Material and methods: A sample of the oral mucosal lesion was sent for histopathological analysis to the Institute of Pathology. Results: The biopsy section showed hyperkeratotic stratified squamous epithelium with acanthotic thickening, indicating hyperkeratosis. Conclusion: Early diagnosis and appropriate
treatment of this condition are important to prevent serious complications.
Key words: hyperkeratosis, keratin, irritations, injuries, oral mucos
Гостување на Миниартура 2025 во Кавадарци
Full text linkПоради голем интерес, изложбата на ДЛУМ, Миниартура 2025 беше претставена пред кавадаречката публика. Изложбата се отвори на 23.01.2026 година
Macroamylasemia in a two year old boy as the first manifestation of celiac disease: A Case Report
Full text linkIntroduction: Macroamylasemia is a rare biochemical disorder in which the amylase molecule binds to other
macromolecules, most commonly immunoglobulin A or G. The increased molecular weight of this complex
reduces renal excretion of the enzyme, resulting in chronically elevated serum amylase levels. It can be associated
with various non-pancreatic conditions, including celiac disease. In some reported cases, macroamylasemia
resolved with a gluten-free diet. We present a pediatric case in which macroamylasemia was the initial
manifestation of celiac disease. Case Presentation:A two-year-old boy presented with a three-month history of
abdominal pain, anemia, and, constipation. Physical examination revealed paraumbilical tenderness. Laboratory
tests showed hypochromic anemia; elevated serum amylase (171 U/L); low serum iron (2.5 µmol/L); vitamin D3
deficiency (15.9 ng/mL), and low urine amylase with an amylase/creatinine clearance ratio below 1%, confirming
macroamylasemia. Imaging studies were normal. HLA typing revealed the HLA-DQ2 haplotype. Celiac serology
was positive for tTG-IgA (87.55 IE/mL) and EMA-IgA (1:>100). Duodenal biopsy confirmed Marsh type IIIb
histology. A gluten-free diet wasinitiated alongside iron and vitamin D3 supplementation. Symptoms resolved
within two months, accompanied by normalization of serum amylase levels and a weight gain of over 1 kg.
Vitamin D3 therapy was continued until serum levels normalized. Conclusion: Celiac disease should be considered
in patients with unexplained macroamylasemia, even in the absence of classical gastrointestinal symptoms. The
primary treatment in such cases is a strict gluten-free diet, which can lead to the normalization of serum amylase
levels when macroamylasemia is associated with celiac disease
Gluten and gluten-free biscuits with functional components: physicochemical, nutritional and antioxidant properties
Full text linkThis study aims to determine the effect of different compounds on the nutritional, antioxidant, microstructural, and color characteristics of biscuits classified as gluten and gluten-free. Namely, biscuits are enriched with dietary fibers, acacia fibers, spent coffee grounds, and anthocyanins. The addition of these functional components to biscuit matrix affected the physical properties of the biscuits; namely, the spread factor value of all biscuits ranged from 2.98 to 7.88, the content of total polyphenols increased, the highest polyphenol content was obtained in the gluten-free biscuits with added coffee grounds (77.98 mg), while in the biscuits with wheat flour has in the range of 44.62–128.63 mg. All gluten- free biscuits can be labeled as products with "rich in fiber" (6.32–7.68 g/100 g) and with a higher antioxidant content compared to biscuits without added ingredients. The total number of microorganisms in the tested cookies is below acceptable limits. The findings of this study show that the inclusion of raw nutritional components in the recipe of traditional gluten and gluten-free biscuits leads to an improvement in the nutritional value and other quality characteristics of the fortified food products
Hypertrophic gingivitis as a consequence of oversized crowns – Case report
Full text linkIntroduction: Hypertrophic gingivitis is a form of chronic gingivitis common among patients with prosthetic restorations, especially when these are oversized. This condition leads to reduced pink aesthetics, pain, and bad breath, which often drive patients to seek professional help.
Objective: The purpose of this study is to determine if replacing old crowns with new ones can alter the condition of the gingiva and to assess if the state of gingiva in hypertrophic gingivitis is completely reversible.
Materials and Methods: The materials for this case study come from private practice, focusing on a 38-year-old female non-smoker without allergies or chronic diseases. Research methods include comparing gingival and periodontal indices before and after replacing inappropriate prosthetic restorations.
Results: Replacing the old, poorly fitted crowns resulted in significant improvement in the gingival health of the patient.
Keywords: Oversized crowns, Hypertrophic Gingivitis, Periodontiti
Limitations in utilization of sodium fluorescein as a contrast agent during brain surgery
Full text linkAlthough today’s neurosurgery worldwide accepts the use of sodium fluorescein as a useful
intraoperative contrast agent, there are several limitations and disadvantages of its utilization. Human medicine
requires continuous research and development. Thus we made a clinical study that will provide useful information
about some specific details about the use of sodium fluorescein intraoperative for brain tumors. In advance, we
are looking forward in improving the fluorescent surgery and overcoming these disadvantages. Sodium fluorescein
has a great potential as an intraoperative contrast agent and overcoming these limitations will lead to a more
successful outcome.
Material and methods: Specific information about sodium fluorescein’s characteristics was gained from 39 patients
operated with its utilization during surgery of brain tumors. All of these patients were injected intravenously
sodium fluorescein at a dose of 5mg/kg prior to skin incision. During surgery, operative microscope Zeiss Kinevo
900 with “white” (daylight) and “yellow” (with 560nm filter) was used. The data was collected during a period of 3
years from year 2022 to 2025. Details were discussed during surgery and notes were taken weather tumor margins
are clear or blur. Patients’ neurological status was assessed after surgery. Imagine methods such as MRI and CT
scans pre and post operatively were compared in order to assess the extent of tumor resection. Days of hospital
stay were used as an indirect indicator of postoperative complications. All this data was helpful in estimating
surgical success using sodium fluorescein intraoperative. However, the goal of this study is to emphasise the
problems and disadvantages that we encountered utilizing sodium fluorescein. Thus, the analytical part is of
greater value, than the numerical.
Conclusion: Sodium fluorescein is useful adjunct for brain tumor surgery. However, in some specific cases and
situations it can guide the neurosurgeon in wrong direction and cause unwanted damage. Therefore, every
neurosurgeon who utilizes sodium fluorescein for tumor resection need to receive thorough education for its
characteristics first. In the hands of skilled and experienced neurosurgeon these limitations can be overwhelmed
and sodium fluorescein guided surgery can contribute to greater overall surgical success