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How to Launch and Grow Your Real Estate Agency: A Detailed Guide
Get PDFThe real estate market offers tremendous opportunities for entrepreneurs with its high-value transactions and steady demand for housing. Owning a real estate agency means tapping into a sector where property values often appreciate and clients seek expert guidance for life-changing purchases. It can be a highly rewarding venture both financially and professionally. At the same time, starting an agency comes with challenges. It’s important to weigh the advantages and disadvantages before diving in
The Role of Institutional Investors in Financing Infrastructure Projects: Opportunities and Risks
Get PDFInstitutional investors play a vital role in the global financial system by mobilizing large pools of capital and contributing to market stability. Their suitability for long-term development financing makes them key players in funding infrastructure and sustainable growth projects. With a large and stable capital base, they can weather market fluctuations and support consistent investment flows. Their diversified portfolios help reduce risk and enhance returns, while their growing focus on sustainable and responsible investing promotes ethical standards and long-term value creation
A Generic Taxonomy for Steganography Methods
No full textA unified understanding of terms is essential for every scientific discipline: steganography is no exception. Being divided into several domains (e.g., network and text steganography), it is crucial to provide a unified terminology as well as a taxonomy that is not limited to few applications or areas. A prime attempt towards a unified understanding of terms was conducted in 2015 with the introduction of a pattern-based taxonomy for network steganography. In 2021, the first work towards a pattern-based taxonomy for all domains of steganography was proposed. However, this initial attempt still faced several shortcomings, e.g., remaining inconsistencies and a lack of patterns for several steganography domains.
As the consortium who published the previous studies on steganography patterns, we present the first comprehensive pattern-based taxonomy tailored to fit all known domains of steganography, including smaller and emerging areas, such as filesystem, IoT/CPS, and AI/ML steganography. To make our contribution more effective and promote the use of the taxonomy to advance research, we also provide a unified description method joint with a thorough tutorial on its utilization
Formulation and characterization of propranolol hydrogel with sodium alginate for the treatment of infantile hemangioma
Get PDFThis study focuses on the development and characterization of a sodium alginate hydrogel as a topical formulation for release of propranolol hydrochloride (PPL HCl). Our research indicates that local or transdermal drug administration is a viable alternative to oral administration, especially for drugs like oral propranolol, which undergoes first-pass metabolism. The primary objective of this study was to formulate a product for the local delivery of propranolol hydrochloride for the treatment of infantile hemangioma, exhibiting favorable physicochemical properties. It was conducted in two phases: preformulation and formulation. In the preformulation phase, initial gel formulations were developed with different concentrations of propranolol hydrochloride (1%; 1.5%; 2%; 3%) gelled at various temperatures and stirring rates. The results demonstrated that high preparation temperatures disrupted the gel structure, whereas gradual and controlled gelation led to mechanically more stable gels. The inclusion of CaCl₂ in the matrix improved the mechanical properties and consistency of the hydrogels. Gel structure degradation (syneresis) was observed after the addition of propranolol hydrochloride, necessitating the use of a buffer in further formulation development. Buffer systems (NaOH and NaHCO₃) regulated the pH value of the medium, leading to improved mechanical properties of the gel structure while also exhibiting surfactant-like effects. They did not interact with the active substance and contributed to nearly identical physicochemical characteristics in the formulation analyses. In the formulation phase, two optimized formulations were developed with 2% sodium alginate and 1% propranolol hydrochloride, where the pH value was adjusted to physiological values (6.98 and 7.04) by adding NaOH and NaHCO₃. The analyses demonstrated pH stability over 14 days, good spreadability, maintained texture, and аппроприате microbiological purity. Spectrophotometric analysis confirmed the presence and stability of propranolol hydrochloride within the hydrogel matrix. Due to the observed higher absorption in the gel where
NaOH was used as a buffer (pH 7.04) compared to the other with NaHCO₃ (pH 6.98), we concluded that this
formulation potentially exhibits better stability or a different interaction of propranolol with the gel matrix
depending on the pH value of the system
Fibrous epulis - a case report
Get PDFFibrous epulis is a benign tumour of the gingiva, commonly appearing in the area of the interdental papilla as a result of local chronic irritation, improper dental restorations, carious teeth, subgingival deposits, or a combination of all these factors. The aim of our research is to present a clinical case of fibrous epulis in the upper jaw. A 66-year-old male patient was admitted to the Oral Surgery Clinic due to the presence of a nodular formation localized in the
anterior region of the left edentulous alveolar ridge in the upper jaw. Clinical examination revealed the presence of a tumoroid lesion measuring approximately 10 mm. The treatment is surgical excision of the lesion when it presents a functional or aesthetic problem for the patient or when there is a need for differential diagnosis in relation to gingival hyperplasia, papilloma or other benign or malignant neoplasms. Clinical findings and histopathological analysis confirm the diagnosis. The histopathological finding is the golden standard that concludes the initial clinical diagnosis and differentiate possible histopathological types of epulis.
Keywords: fibrous epulis, gingiva, maxilla, surgical treatment, histopathological analysi
Evaluation of dental and facial midlines among dental students
Get PDFObjectives: Ensuring the alignment of the facial midline with the maxillary dental arch midline is considered as essential aesthetic principle in dental prosthetic rehabilitation, as symmetry plays a key role in achieving facial harmony and the overall success of esthetic treatments. The objective of this study was to determinate the coincidence of the dental and facial midlines in young individuals.
Methods: The study included 110 dental students of both sexes aged 18-22 years who had never been subjected to any dental treatment. Frontal full-face photos were taken with teeth in occlusion using professional digital camera Nikon Z6 II–24.5 MP from distance of 100cm each. Specialized software programs were utilized to analyze the alignment of the facial and dental midlines. SPSS Version 23.0 was used for data analysis with level of significance set at 0.05.
Results: The results indicate that the midline is situated in the exact middle of the mouth in approximately 60% of the students. Most of the study participants displayed a deviation of 0–1 mm between the facial midline and the midline of the anterior teeth. The coincidence of the maxillary and mandibular midlines was 38.1%. Left-sided deviations were also recorded more frequently.
Conclusion: The coincidence of the maxillary and mandibular midlines was observed in just over one-third of the participants. The facial midline aligned with the anterior teeth midline in approximately 60% of the sample, with left sided deviations being more frequent.
Keywords: Dental midline, Facial midline, Facial esthetic
Two essays in optimal taxation and one in common knowledge and bounded rationality
Get PDFThis book contains three essays that were written by the authors in 2024:Optimal taxation policy, monetary policy and state-contingent debt, time inconsistency in Ramsey problem, tax smoothing, non-CRRA preferences and taxation in LQ economy, Kripke semantics, Common knowledge, bounded rationality and Aumann’s agreement theorem, and the third essays has title: Optimal taxation without state-contingent debt, the Ramsey allocation for a given multiplier, and tax smoothing of consumption and taxes in complete and incomplete markets. Three papers are also part of the computational economics project or interest in the computational economics of the authors. This paperback will be part of the repository at Faculty of Tourism and Business Logistics, Goce Delcev University, Stip, North Macedonia
Сашо Поповски Квартет
Get PDFВоден од идејата за континуирано истражување и создавање на современа авангардна музика со музичари кои веќе дипломирале на Џез Одделот при Универзитетот „Гоце Делчев Штип“, Сашо Поповски го формира овој квартет во соработка со српскиот саксофонист Кристијан Џорџевиќ, Емил Ејупи бас гитара и Теодор Јаневски тапани.
Квартетот изведува авторски композиции од Поповски и Џорџевиќ како и композиции од современи џез автори.
Јавна Соба Скопје 2025 (Public Room
Сашо Поповски и Херцел
Get PDFКонцерт во рамките на фестивалот Зимска Приказна Битола 2025
Концертна промоција на албумот 22 Денови
Сашо Поповски - гитара, миди и глокеншпил
Александар Гроздановски (Херцел) - електроника и програмирањ
Индивидуализирана фитотерапија и модерни аспекти на улогата на фармацевтот во издавање на хербални лекови во аптека
Get PDFИндивидуализираната терапија станува основа на модерниот пристап во лекувањето, со цел обезбедување грижа која ги зема предвид специфичните потреби на секој пациент. Овој вид на персонализираната медицина претставува една од најактуелните теми во поново време која се стреми со посебен пристап преку имплементација на omics – алатките (геномикс, метаболомикс, протеомикс и сл.) да даде насоки за конкретна фармакотерапија на даден пациент.
Оваа тенденција постепено завзема се позначајно место во рационалната фитотерапија, која сè повеќе се вклучува како значаен дел од терапевтските протоколи. Хербалните лекови кои опфаќаат повеќе категории на производи (готов хербален лек и традиционален хербален лек), како и другите производи од хербално потекло (суплементи и гранични производи) стануваат сѐ попознат избор за пациентите кои бараат природни и често помалку инвазивни алтернативи за третман на хронични состојби, анксиозност, несоница и имунодефицитни состојби. Овој тренд ја нагласува потребата за добро информирани и обучени фармацевти, кои играат клучна улога во советување, издавање и индивидуализација на хербалните препарати