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    The impact of membrane stabilization for alveolar ridge preservation in periodontally compromised extraction sockets: a non-inferiority randomized controlled trial

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    Aim: The aim of this study was to investigate the non-inferiority of alveolar ridge preservation (ARP) with membrane stabilization compared with non-stabilization, focusing on changes of soft-tissue contour in periodontally compromised extraction sockets. Secondary outcomes included changes in hard-tissue contour, patient-reported outcomes and new bone formation. Materials and Methods: Twenty-four patients with periodontally compromised teeth were randomly assigned to ARP with (test group) or without (control group) membrane stabilization. To assess profilometric and hard-tissue dimensional changes, dental impressions and cone beam computed tomography scans were performed at baseline (T0), immediately after ARP (T1) and 4 months post surgery (T2). Soft-tissue healing in open healing sites was evaluated at T2, and wound closure was assessed 10 days post surgery. Patient-reported outcomes were documented, and core biopsies were obtained for histomorphometric analysis. Results: The absolute profilometric horizontal width change at 3 mm below the crest in the test group was not inferior to that in the control group. For the relative values, horizontal width reduction (3 and 5 mm below the crest) and volumetric shrinkage (3–5 mm below the crest) were lower in the test group. No significant differences were observed in bone dimensional changes, wound healing, pain and swelling or histomorphometric outcomes. Conclusion: ARP with membrane stabilization in periodontally compromised extraction sockets is non-inferior in terms of soft-tissue contour changes to those without membrane fixation. Trial Registration: Clinical Research Information Service (CRIS), KCT0005280. Registered 4 August 2020, https://cris.nih.go.kr/cris/search/detailSearch.do?seq=19165&search_page=L. © 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

    Impact of visual stimulus complexity on associative learning and associated reaction times in migraine patients

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    The semantic complexity and verbalizability of visual stimuli can influence associative learning. The Rutgers Acquired Equivalence Test (RAET) uses semantically rich stimuli (faces and colored fish) to assess associative learning and generalization, while a modified version, the Polygon test, employs simpler stimuli with reduced semantic content (grayscale circles and geometric shapes). Although cognitive alterations are well-documented in migraine patients during interictal periods, the impact of visual stimulus complexity on associative learning and reaction times has not been studied. Forty-one migraine patients without aura completed both the RAET and Polygon tests. Performance metrics included acquisition error ratios, retrieval and generalization error ratios, and reaction times. The two tests were compared using non-parametric statistical methods. Migraine patients demonstrated comparable acquisition performance on the RAET and Polygon test. However, reaction times were significantly longer in the Polygon test across both acquisition and test phases. Retrieval and generalization performance were also similar between tests, despite longer reaction times with semantically reduced stimuli. Migraine patients showed consistent learning performance across visual stimuli of varying semantic complexity. Prolonged reaction times with simpler stimuli suggest increased cognitive demands, potentially mitigated by cortical compensatory mechanisms that maintain learning ability under challenging conditions

    Advancements in the Field of Protein-Based Hydrogels: Main Types, Characteristics, and Their Applications

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    Regenerative medicine is a challenging field in current research and development, whilst translating the findings of novel tissue regenerative agents into clinical application. Protein-based hydrogels are derived from various sources, with animal-derived products being primarily utilized to deliver cells and promote cell genesis and proliferation, thereby aiding in numerous indications, including bone tissue regeneration, cartilage regeneration, spinal cord injury, and wound healing. As biocompatible and biodegradable systems, they are tolerated by the human body, allowing them to exert their beneficial effects in many indications. In this review article, multiple types of animal-derived proteins (e.g., collagen, gelatin, serum albumin, fibrin) were described, and a selection of the recent literature was collected to support the claims behind these innovative systems. During the literature review, special indications were found when applying these hydrogels, including the therapeutic option to treat post-myocardial infarct sites, glaucoma, and others. Maintaining their structure and mechanical integrity is still challenging. It is usually solved by adding (semi)synthetic polymers or small molecules to strengthen or loosen the mechanical stress in the hydrogel’s structure. All in all, this review points out the potential application of value-added delivery systems in regenerative medicine

    Application of Co3O4 as anode catalyst in CO2 electrolyzer cells

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    Replacing Ir with anode catalyst materials that are more abundant is a long-sought objective within the CO 2 electrolysis community. The chemical environment (near-neutral pH, carbonate buffer electrolyte) that inherently develops during long-term operation, however, limits the pool of applicable candidates. In this contribution, Ir was replaced with a porous Co 3 O 4 nanosheet catalyst layer as the anode of a zero-gap CO 2 electrolyzer cell. The catalyst was directly deposited on the Ti porous transport layer via hydrothermal synthesis, which allowed the precise control of the catalyst loading. Under optimal conditions (7 mg cm -2 Co 3 O 4 loading), 300 mA cm -2 current density was reached at 3.4 V applied cell voltage. The electrolyzer cell with the Co 3 O 4 anode was operated continuously for 50 hours at 250 mA cm -2 current density with stable cell voltage and CO 2 reduction selectivity

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