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Plastic contamination from latex and nitrile disposable gloves has the potential to influence plant productivity and soil health
Get PDFLetter: Real-Life Evaluation of Effectiveness of Mesenchymal Stem Cell Treatment in Fistulising Crohn's Disease Emphasises Importance of Appropriate Patient Selection and Centre Expertise-Authors' Reply
No full textThe potential role of university community engagement in supporting transformative social innovation – experiences from Hungary
Get PDFLooking beyond students' exploration and learning strategies: The role of test-taking effort in complex problem-solving
Get PDFFine‐scale diversity models reveal impacts of invasive Gaillardia pulchella on regenerating vegetation in a sand dune grassland
No full textAbstract Premise Gaillardia pulchella is native to North America but invasive in Central Europe, including Hungary, and can significantly alter vegetation dynamics, thereby affecting biodiversity and community structure. This study explored the fine-scale effects of G. pulchella invasion on the regeneration of old sandy fields in open dune grasslands in Kiskunság National Park, Hungary, within the Pannonian biogeographic region. The impact of invasion on vegetation association structures was estimated by investigating the early stages of the effects of invasion on plant communities. Methods Diversity models were used to assess compositional diversity (CD) and the number of realized species combinations (NRC) in invaded versus noninvaded stands. Plexus graphs were used to analyze the spatial relationships between G. pulchella and neighboring species at a fine scale (5 × 15 cm). Results Invasion-free stands had higher species richness and greater structural complexity at fine spatial scales, as indicated by CD and NRC functions. Significantly higher CD values in invasion-free stands compared to invaded stands emphasize the negative impact of G. pulchella on coexistence among native species. Plexus graphs illustrated both negative and positive associations between G. pulchella and native species, suggesting a nuanced competitive role in invaded stands. Conclusions Gaillardia pulchella invasion, though not strongly characterized, has negatively impacted vegetation structure at fine spatial scales, which may potentially intensify over time. The study underscores the importance of early detection and long-term monitoring for a comprehensive understanding of invasive processes and their effects on plant communities in sandy habitats
Molecular profiling reveals novel gene fusions and genetic markers for refined patient stratification in pediatric acute lymphoblastic leukemia
Get PDFRisk-adapted treatment protocols conferred remarkable improvement in the survival rates of pediatric acute lymphoblastic leukemia/lymphoma (ALL/LBL). Nevertheless, clinical management is still challenging in certain molecular subgroups and in the presence of alterations associated with an increased rate of relapse. In this study, disease-relevant genomic and transcriptomic profiles were established in a prospective, multicenter, real-world cohort involving 192 children diagnosed with ALL/LBL. Gene fusions were detected in 34.9% of B-ALL and 46.4% of T-ALL patients, with novel chimeric genes involving JAK2, KMT2A, PAX5, RUNX1 and NOTCH1, and with KMT2A-rearranged patients displaying the worst 3-year event-free survival (p=0.019). Non-synonymous mutations were uncovered in 74.9% of the analyzed patients, and a pairwise scrutiny of genetic lesions revealed recurrent clonal selection mechanisms commonly converging on the same pathway (e.g. Ras, JAK/STAT and Notch) in individual patients. Investigation of matched diagnostic and relapse samples unraveled complex subclonal variegation, and mutations affecting the NT5C2, TP53, CDKN2A, and PIK3R1 genes, emerging at the time of relapse. TP53 and CREBBP mutations, even as subclonal aberrations, were associated with shorter 3-year event-free survival among all patients with B-ALL (TP53 mutant vs wild-type: p=0.008, CREBBP mutant vs wild-type: p=0.010); and notably, B-ALL patients showing no measurable residual disease on day 33 could be further stratified based on TP53 mutational status (p<0.001). Our in-depth molecular characterization performed across all risk groups identified novel opportunities for molecularly targeted therapy in 55.9% of high-risk and in 31.6% of standard/intermediate-risk patients
Risk perception, health behavior and mental health of women living with polycystic ovary syndrome
Get PDFA Parallel Mediation Model of Career Adaptability, Career Self-Efficacy, and Future Career Choice Among University Students: The Role of Basic Psychological Needs Satisfaction and Mindfulness
Get PDFThis study aims to explore the importance of basic psychological needs satisfaction (BPNS) and mindfulness of university students in their career adaptability (CA), career self-efficacy (CSE), and future career choice (CC). The sample consisted of 1026 undergraduate students, of which 495 (48.2%) were female and 531 (51.8%) male, from three public universities in the Amhara Region, Ethiopia. The assessments, such as the Career Decision-Making Self-Efficacy Scale-Short Form, the Five Facet Mindfulness Questionnaire Short Form, the Career Adapt-Ability Short Form Five Scale, the Basic Psychological Needs Satisfaction Scale, and the Career Choice scale instruments were used. Findings from a parallel mediation model showed that both CA and CSE had a direct positive effect on the BPNS of university students. Additionally, this study found that both BPNS and mindfulness had a substantial and positive direct effect on the students’ CC. Importantly, we found that both CA and CSE significantly and indirectly predicted the future CC through BPNS and mindfulness. In addition, BPNS and mindfulness also partially mediate the relationship between CA, CSE, and the students’ future CC. Importantly, we found that mindfulness and BPNS fully and partially mediated the relationship between CA, CSE, and CC. These results support the notion that both psychological constructs (BPNS and mindfulness) play a crucial role in explaining the relationship between CA, CSE, and CC. By enhancing students’ BPNS and mindfulness, institutions can empower students to make informed decisions about their future career paths, ultimately nurturing their personal and professional growth
