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A telerehabilitáció lehetőségei az egyensúlyozó képesség fejlesztésében és az esésmegelőzésben a neuromuszkuloszkeletális rehabilitációban
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The Dimensions of the Aortic Valve Annulus Are Not Associated with Systolic Excursion of Its Plane in the Same Healthy Adults: Detailed Insights from the Three-Dimensional Speckle-Tracking Echocardiographic MAGYAR-Healthy Study
Get PDFBackground/Objectives: The aortic valve has a prominent role in regulating blood flow and is of exceptional importance in clinical cardiological practice, as it can be affected by numerous abnormalities, so any clinical study that examines its physiological properties may be of significance. It is known that the dimensions of the aortic valve annulus (AVA) not only change during the cardiac cycle, but also undergo spatial displacement. Considering this, the question arises as to whether the AVA’s dimensions and their spatial displacement, represented by aortic annular plane systolic excursion (AAPSE), are related or not. Therefore, these parameters were simultaneously assessed using three-dimensional speckle-tracking echocardiography (3DSTE) in healthy adults. Methods: The present study’s cohort consisted of 148 healthy adults (mean age: 34.8 ± 12.4 years, 80 men). In all cases, two-dimensional Doppler echocardiography and 3DSTE were performed, the latter being used to assess the aortic valve. Results: In all subjects, end-diastolic and end-systolic AVA dimensions showed no association with an increase in AAPSE. In subjects with a greater end-diastolic AVA area (AVA-A), end-systolic AVA dimensions tended to decrease with increasing AAPSE; this trend reached statistical significance for end-systolic minimum AVA diameter, when comparing participants with AAPSE below versus above the mean. With increasing end-diastolic AVA-A, all other AVA parameters increased accordingly in all subjects and regardless of which AVA-A proved to be greater. In all subjects, and in those with a greater end-systolic AVA-A, the AAPSE proved to be similar regardless of the size of the end-diastolic AVA-A. In cases with a greater end-diastolic AVA-A, only one subject showed a very small end-diastolic AVA-A. With increasing end-systolic AVA-A, all other AVA dimensions were increased in all subjects and in cases with a greater end-diastolic or end-systolic AVA-A. AAPSE showed no significant differences between the subgroups examined, although it tended to be lower in cases with a greater end-diastolic AVA-A and the largest end-systolic AVA-A, and in subjects with a greater end-systolic AVA-A and the smallest end-systolic AVA-A. Moreover, individuals with a greater end-diastolic AVA-A and the smallest end-systolic AVA-A had a tendency for increased AAPSE. No correlations were present between AVA dimensions and AAPSE. Conclusions: 3DSTE-derived AVA dimensions showed no obvious associations with AAPSE in the same healthy adults
Validation of the de Morton Mobility Index for measuring mobility related activities in Hungarian institutionalized older adults
Get PDFIn old age, decline in mobility has a significant impact on performing activities of daily living, participating in society, and on quality of life. Mobility changes should be measured and monitored using measures with appropriate psychometric properties. The psychometrically sound de Morton Mobility Index (DEMMI) assesses a broad range of mobility related activities. The aim of this study was to develop a valid and reliable, cross-culturally adapted Hungarian version of the DEMMI scale (HU-DEMMI) among institutionalized older people. Development of the HU-DEMMI was conducted using a cross-sectional study design with an overall of 170 participants. Validity was tested via construct (established by hypothesis testing) and structural validity (explored with structural equation modeling (SEM)). Reliability was assessed using three measurement properties: internal consistency (determined by Cronbach’s alpha), test-retest reliability (by intraclass correlation coefficients (ICC)), and measurement error (standard error of measurement (SEM), minimally detectable change (MDC), limits of agreement (LoA)). Linguistic and cultural adaptation was realized successfully. As for construct validity, the HU-DEMMI showed a strong correlation with mobility related measures and a weak correlation with non-mobility measure. Significant differences in the DEMMI score were found across groups being at various levels of assistive device use. Internal consistency by Cronbach’s alpha was 0.906; the dimensionality testing revealed no violation of unidimensionality. However, a three-dimensional structure uncovered a better fit. The inter- and intra-rater ICC of DEMMI scores were 0.981 and 0.989, respectively. The SEM for inter-rater reliability test was 2.924 and the MDC 90 was 6.803 points on the 100-point DEMMI scale. The 95% LoA showed a mean inter-rater difference of 0.2115 (− 11.252; 11.675), while a mean intra-rater difference of -1.0577 (− 9.809; 7.694). Four data points (7.69%) were identified as outliers in both cases. Maintaining institutionalized older people’s functional capacity and delaying its decline requires effective interventions. Valid and reliable determination of mobility levels is necessary to address mobility decline in a personalized way. The psychometrically robust HU-DEMMI scale developed in this study would provide this and allow for future comparisons of Hungarian research results with those of other countries and for contribution to international, multicenter research
Comparative micro-CT analysis of internal adaptation and closed porosity of conventional layered and thermoviscous bulk-fill resin composites using total-etch or universal adhesives
Get PDFTheoretical foundations of money laundering and terror financing : conceptual analysis of legal frameworks and global challenges
Get PDFMoney laundering (ML) and terrorism financing (TF) remain major threats to the financial stability of the global financial system. These
illicit activities exploit transnational networks and take advantage of the interconnectedness of an increasingly globalized world. While
international framework models were adapted in the form of conventions, treaties, recommendations, and directives, the gap between the
theoretical model and its actual application remains significant, particularly in less-developed countries (LDCs). These problems are
aggravated by globalization, which makes complex transnational financial crimes easy. This study critically examines global instruments,
such as the Vienna, Palermo, and Merida Conventions. I employ doctrinal legal research and a legal narrative analysis method to explore
how these frameworks address the challenges posed by transnational financial crimes. The results indicate considerable variation in term
implementation, especially in LDCs, where limited resources and institutional capacity erode international Anti-Money Laundering (AML)
and Counter-Terrorism Financing (CTF) progress. Moreover, financially motivated crimes are constantly evolving, and advancements and
regulatory loopholes outpace the existing enforcement mechanisms. Moreover, this study demonstrates that a harmonized approach
integrating legal and financial perspectives is essential for effectively combating ML and TF. This study highlights the importance of strong
international cooperation, consistent legal standards, and technological tools. This study addresses the gap between theory and practice,
supporting the formulation of adaptive policies regarding AML and CTF that increase resilience to transnational financial crimes. The
implications of these findings for global policymaking are significant, and they provide a roadmap for reconciling international frameworks
and mechanisms in domestic framing and policing. More needs to clarify the refinement of risk-based approaches, enhancement of
regulatory compliance in LDCs, and promotion of collaborative networks between states to counter dynamic threats posed by ML and TF in
the future
Statistics and behavior of clinically significant extra-pulmonary vein atrial fibrillation sources: machine-learning-enhanced electrographic flow mapping in persistent atrial fibrillation
No full textTruncating CYLD pathogenic variants in CYLD cutaneous syndrome distinctly influence CYLD proteostasis and NF-κB signaling
Get PDFActive stabilization for ultralong acquisitions in an attosecond pump-probe beamline
Get PDFAttosecond time-resolution experiments using noncollinear interferometers require precise and active control of the optical delay to prevent instabilities—including both slow drifts and rapid vibrations—that can obscure the time evolution of the physical system under investigation. In this work, we present the design and results of stability measurements for a double interferometer setup, consisting of a two-color interferometer for extreme ultraviolet-infrared pump-probe spectroscopy complemented by a single color auxiliary interferometer designed for active delay stabilization. The attosecond pump-probe setup is driven by a high-average-power, high-repetition-rate laser system and offers sub-optical-cycle (±81 as) stability with a fast feedback rate over extended periods (up to several days). Due to the noncollinear arrangement, the setup enables independent control of both amplitude and phase, such as controlling the XUV spectrum or attochirp, or the IR dispersion and carrier-envelope phase in the two arms, even across significantly different spectral regions. As a proof of concept, we demonstrate attosecond beating in angle-resolved photoemission during two-photon, two-color photoionization, highlighting the broad potential of the system for kinematically and dynamically complete studies of atomic-scale light-matter interactions. © 2025 Author(s)