MTA-SZTE Research Group on Artificial Intelligence
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Recent developments in the examination of the biology and antibiotic resistance mechanisms of anaerobic pathogens
Get PDFRecent developments in the examination of the biology and antibiotic resistance mechanisms of anaerobic pathogens have significantly advanced our understanding of these organisms. Studies utilizing genomic and proteomic approaches have uncovered specific genetic determinants linked to virulence and resistance, revealing how pathogens like *Bacteroides fragilis* and *Clostridium difficile* adapt to antibiotic pressures. Mechanisms such as enzymatic degradation, efflux pumps, and biofilm formation have been identified as key contributors to their resilience against treatment. Additionally, the interplay between anaerobic pathogens and the human microbiome is being explored, highlighting how dysbiosis can lead to opportunistic infections. As antibiotic resistance continues to pose a major public health challenge, ongoing research is crucial for developing novel therapeutic strategies and improving diagnostic methods to effectively combat these resilient pathogens
The Addition Of Left Atrial Linear Ablation To Pulmonary Vein Isolation Causes Organized Atrial Tachycardia Recurrence: A Meta-Analysis
Get PDF1853 - Megindul a Délibáb: Nemzeti Szinházi lap : A magyar irodalmi lapok hálózatának délibábja
No full textThe effect of different levels of heat stress on the behaviour of cows at different stage of lactation
Get PDFNucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation
No full textChemokines play an important role in the pathogenesis of skin diseases, such as psoriasis, atopic dermatitis, vitiligo, and alopecia areata. Recently literature data supports the theory that alternatively spliced isoforms of these molecules may serve as potential regulators in these diseases. Since self-derived nucleic acids are main culprits in chronic skin diseases we compared the effects of synthetic RNA- and DNA-induced inflammation on the expression levels of chemokines in human keratinocytes. We found that cytoplasmic nucleic acids are potent inducers of monocyte chemoattractant protein-1 (CCL2), interferon gamma inducible protein-10 (CXCL10) and fractalkine (CX3CL1) mRNA-expression, mainly through NF-κB activation, but the pattern recognition receptors responsible for inducing this activation are still unknown. Alternative splicing of these chemokines in keratinocytes was not detected, suggesting other regulatory mechanisms for chemokine activity
The role of kindling mechanism: A validation study of the Hungarian version of the Prediction of Alcohol Withdrawal Severity Scale
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