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Practical Management of Cardiovascular Adverse Events with BTKi Treatment in Patients with Chronic Lymphocytic Leukemia : A Consensus Report by Hematologists and Cardiologists
No full textCardiovascular (CV) adverse events (AEs), especially atrial fibrillation (AF) and hypertension, have been reported in patients receiving treatments for chronic lymphocytic leukemia (CLL), including Bruton's tyrosine kinase inhibitors (BTKis). Although these AEs are managed effectively in most cases and AE management guidelines exist, practical management approaches are inconsistent across regions and practices. We aimed to address these inconsistencies by developing consensus recommendations.A European expert panel was assembled comprising eight hematologists and six cardiologists. Literature analysis, expert interviews, and the Delphi method were used to gain consensus on screening, monitoring, and treatment of AF and hypertension statements.Maintaining BTKi treatment is paramount to maximize time to next treatment; for patients at high risk of progression, this can be achieved by appropriately treating hypertension and AF and adjusting the BTKi dose. Patients should be risk-stratified as low, moderate, high, or very high risk of cancer therapy-related CV toxicity and treated according to their disease status so that CLL treatment can be maintained. Patient education on symptom monitoring, home blood pressure monitoring, and electrocardiograms (baseline, every 3 months) are recommended to detect/monitor AF and hypertension. Close collaboration between hematologists and cardiologists is vital to achieve optimal patient outcomes
Soil Types and Erosion in Iraq: A Critical Discussion
Get PDFIraq includes different tectonic zones and different physiographic provinces; accordingly, different types of soils, and erosion types and intensities are developed in different parts of Iraq. There were many attempts to compile a map of soil types in Iraq by different authors, which we mentioned very briefly. The main soil types are alluvial, colluvial, residual, and eolian. Also, a brief description of the physiographic provinces is given. We have presented the active erosion types in Iraq, with a discussion of the reasons for soil erosion and degradation in different parts of Iraq excluding the northern and northeastern parts that belong to the Kurdistan Region of Iraq (KRI). The main erosion agents are water and wind. The active erosion types are sheet, rill, and gully erosion; respectively; however, wind erosion cannot be ignored. We also discussed the factors that control soil degradation in Iraq. Moreover, we presented different relevant maps and field photos, which express relevant data about erosion types and damages
Gellan Gum-Based In Situ Hydrogels for Nasal Delivery of Polymeric Micelles Loaded with Risperidone
Get PDFNasal drug delivery faces numerous challenges related to the ineffectiveness of most nasal formulations without a mucoadhesive nature, prolonging residence time on the nasal mucosa. Another challenge is the low administrable dosage strength, which can be solved via nano-encapsulation techniques, including the utilization of polymeric micelles. In this study, gellan gum–cellulose derivative complex in situ gelling matrices were formulated to test their effect on the colloidal characteristics of polymeric micelles, their respective rheological behavior, and nasal applicability. It has been proven that these complex matrices can form gels upon contact with nasal fluid without disrupting the micellar structure. Changes in the drug release and permeation profile have been shown in a concentration-dependent manner to hinder the burst-like drug release profile of polymeric micelles. Formulations show concentration- and composition-dependent mucoadhesive features under nasal conditions. Most of the hydrogels possess a soft gel characteristic, making them suitable for nasal administration. In conclusion, this descriptive study provides useful insights for conscious, nasal dosage form design
Vertical stratification of the soil seed bank in wet grasslands and its implications for restoration
Get PDFThis study aimed to examine the vertical stratification of the soil seed bank in wet grasslands, with a special emphasis on seeds in deeper soil layers that are generally not considered in seed bank studies. We studied the soil seed bank at four depths: 0–10 cm, 10–30 cm, 30–50 cm, 50–70 cm in five study sites in Central Hungary. The seedling emergence method was used to detect viable seeds. The relationship between the vertical stratification of the seed bank and species traits was studied using generalized linear mixed models. We also sampled the aboveground vegetation and applied non-metric multidimensional scaling to evaluate the species composition of the seed bank and vegetation. The species richness and the seed density of different layers were significantly different; both decreasing with increasing depth. Although most viable seeds were found in 0–10 cm depth (22,632 seeds/m 2 ), an unexpected large number of seeds germinated also from the deepest soil layer (50–70 cm; 4170 seeds/m 2 ). Species without morphological specializations for spatial seed dispersal (i.e., Allium dispersal type), lower water requirements, and heavier seeds occurred in great abundance in the deeper soil layers. The dominance of species without specialized spatial dispersal suggests that they invest more in temporal dispersal by the soil seed bank. Forbs and perennial species dominated both the seed bank and the aboveground vegetation; however, the dominant species in the seed bank did not correspond to the dominant species in the aboveground vegetation. Our results suggest that the seed bank of wet grasslands does not contain the full habitat-specific species pool despite its high seed density and species richness. The restoration of the studied wet grasslands cannot rely solely on the local seed banks
Gyeprekonstrukciók - Magvetéssel és szénaráhordással végzett, több üde gyepközösség létrehozására irányuló rekonstrukció a Peszéradacsi-réteken
Get PDFComparison of the inhibitory effects of Lactobacillus supernatant and coculture on Gardnerella vaginalis
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