MTA-SZTE Research Group on Artificial Intelligence
SZTE Publicatio Repozitórium - SZTE - Repository of PublicationsNot a member yet
32192 research outputs found
Sort by
Unveiling the Anticancer Potential of Verbascum aydogdui : Isolation, Characterization, and In Vitro Studies
No full textCytotoxic activity‐guided fractionation of the ethanolic extract of Verbascum aydogdui , an endemic halophyte plant to Türkiye, resulted in the isolation of 16 secondary metabolites, including eight triterpene saponins, mulleinsaponins III ( 1 ), ilwensisaponin A ( 2 ), buddlejasaponin I ( 3 ), mulleinsaponin IV ( 4 ), ilwensisaponins D ( 5 ), ilwensisaponin C ( 6 ), craniosaponin A ( 7 ) and buddlejasaponin Ia ( 8 ), six iridoid glycosides, aucubine ( 9 ), eurostoside ( 10 ), geniposidic acid ( 11 ), nigroside III ( 13 ), 6‐ O ‐β‐D‐glucopyranosylaucubine ( 12 ), 6‐ O ‐[3‐ O ‐( E ‐feruloyl)‐α‐L‐rhamnopyranosyl]‐aucubine ( 14 ), and two phenylethanoid glycosides, verbascoside ( 15 ) and alyssonoside ( 16 ). Compounds 1 – 5 displayed significant cytotoxicity against PC3, HEPG2, HGC27, A375, MCF7, and SW480 cancer cell lines with half‐maximal inhibitory concentration values of 17.6–85.1 µM, being 2 and 3 the most cytotoxic ones. Thus, 2 and 3 were further assayed for their cell death mechanisms, including apoptosis and necrosis. Compound 2 exerted anti‐cancer effects in all cancer cell lines tested, except for MCF7, especially via inducing apoptosis. Its apoptotic activity was predominantly mediated by a significant increase in p53 and p21 expressions in all cancer lines tested, but for SW480. This is the first bioactivity and phytochemical study on V. aydogdui . Our results indicated that 2 could be a potential anticancer natural product that merits further in vitro and in vivo studies
Expression of kynurenine aminotransferase-2 in different mouse brain-derived cells : A comprehensive study in cell cultures
Full text linkThe kynurenine pathway is the principal route of tryptophan metabolism in the brain, generating several neuroactive metabolites, including kynurenic acid (KYNA). KYNA functions as both a neuromodulator and a neuroprotective compound, and its dysregulation has been associated with numerous neurological and psychiatric disorders. Kynurenine aminotransferase-2 (KAT-2) is the key enzyme responsible for KYNA synthesis, yet its precise cellular localization in the mouse brain remains insufficiently characterized. In this study, we systematically compared KAT-2 expression in primary astrocytic, microglial, and neuronal cultures derived from mouse brain, complemented by in situ immunolabeling of brain sections. Immunocytochemistry combined with quantitative colocalization analysis revealed that KAT-2 is expressed in all three major brain cell types, with significant overlap with cell type-specific markers. Furthermore, KAT-2 immunoreactivity was largely restricted to the soma, showing a perinuclear distribution in glial cells and partial extension into dendritic compartments in neurons. These findings provide the first parallel characterization of KAT-2 distribution across astrocytes, microglia, and neurons in the mouse brain. Overall, our results indicate that KAT-2 is widely expressed in neural cells, a finding that supports the hypothesis that KAT-2 contributes broadly to kynurenine metabolism. Taken together, our findings provide a foundation for future studies aimed at defining the cell type-specific functional roles of KAT-2
Influence of fiber type on fatigue performance of fiber-reinforced inlay-retained dental prostheses
Full text linkVernomigeodiins A–D, highly oxygenated stigmastane-type steroids isolated from Vernoniastrum migeodii with anti-herpes simplex virus activity
Full text linkUrban Responses to the Covid-19 Pandemic : Perspectives of the Visegrad Group Countries
Full text linkLanguage Assessment Literacy Development: A Case Study of Three EFL Teachers
Full text linkLanguage Assessment Literacy (LAL) is critical for teachers to perform their assessment tasks, but many teachers in low-resource contexts do not receive adequate assessment training. This qualitative multiple-case study examined the impact of a short-term Professional Development (PD) program on three in-service English as a Foreign Language (EFL) teachers in developing their LAL and in shaping their assessment conceptions, knowledge and practices as assessors. The PD training program consisted of a 30 h workshop delivered over one week and integrated theory, practice, collaborative learning, reflection, and feedback. Data collection instruments included classroom observations and interviews. Findings showed that the PD program improved teachers’ LAL by developing their assessment conceptions, knowledge, skills, and confidence, although the degree of improvement varied across participants. The findings also identified challenges teachers encountered in their assessment practices, including limited time, large class sizes, insufficient resources, and sociocultural factors that constrained teachers’ assessment conceptions and restricted their LAL development. The findings showed that PD programs could strengthen teachers’ professional identity as assessors by incorporating relevant content, practice opportunities, feedback, a supportive learning community, and self-reflection. The study findings have broader implications for professional development of LAL in other low-resource and exam-oriented EFL contexts with strong sociocultural constraints
Il tempus lugendi nell’era del DNA: l’eccezione italiana e i modelli europei di presunzione di paternità
Full text linkDistal Versus Conventional Transradial Artery Access for Coronary Catheterization in Patients With STEMI (DR-STEMI) : Rationale and Design of an International, Multicenter, Randomized Trial
Full text linkTransradial access (TRA) constitutes the cornerstone for cardiac catheterization and is recommended by the multiple recent guidelines, irrespective of clinical presentation. The existing literature has evaluated distal transradial access (dTRA), as a feasible and safe approach in patients with chronic and acute coronary syndrome, excluding although patients presenting with ST- elevation myocardial infraction (STEMI).The current randomized clinical trial compares dTRA versus conventional TRA access in patients with STEMI undergoing coronary angiography and interventions regarding peri- and post-procedural characteristics.DR-STEMI is a prospective, open label, European, multicenter randomized-control trial which will include 554 patients (277 patients in each treatment arm). Patients with STEMI, will be screened on an all-comers basis for study inclusion and exclusion criteria, and those eligible will be allocated randomly (1:1), to dTRA versus TRA approach. The primary hypothesis of the study is that dTRA is non-inferior to conventional TRA regarding the required time between the puncture of the radial artery and wire crossing of the infarct-related artery (i.e., needle-to-wire time).Enrollment for the DR-STEMI trial began in May 2024, and as of April 15th, 2025, 309 patients have been enrolled in the study. Recruitment is expected to continue for approximately 12 months.clinicaltrials.gov: NCT05605288