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Radiation-Induced Synchronous Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Clinical, Morphological, and Genetic Insights
Get PDFThe clinicopathological and molecular features of synchronous parathyroid carcinoma (PC) and thyroid carcinoma in a male patient are presented. At 11, he received mantle field radiotherapy for Hodgkin lymphoma. He had a 26-year adulthood history of recurrent nephrolithiasis treated five times with lithotripsy. At 52, he was referred to our clinic for hypercalcemia. Primary hyperparathyroidism was diagnosed (calcium: 3.46 mmol/L, parathormone: 150 pmol/L, preserved renal function, nephrolithiasis, and osteoporosis). Neck ultrasound revealed a 41 × 31 × 37 mm nodule in the left thyroid and smaller nodules in the right thyroid. Enlarged cervical lymph nodes were not observed. The large nodule was interpreted as parathyroid adenoma on 99Tc-pertechnetate scintigraphy/99Tc-MIBI scintigraphy with SPECT/CT. Total left-sided and subtotal right-sided thyroidectomy were performed. Histopathology confirmed locally invasive, low-grade PC (pT2; positive for parafibromin and E-cadherin, negative for galectin-3 and PGP9.5; wild-type expression for p53 and retinoblastoma protein; Ki-67 index 10%) and incidental papillary thyroid carcinoma (pT1b). Genetic profiling revealed no loss in CDC73, MEN1, CCND1, PIK3CA, CDH1, RB1, and TP53 genes. Deletions in CDKN2A, LATS1, ARID1A, ARID1B, RAD54L, and MUTYH genes and monosomies in nine chromosomes were identified. The tumor mutational burden and genomic instability score were low, and the tumor was microsatellite-stable. The thyroid carcinoma exhibited a TRIM24::BRAF fusion. Following surgery, the parathormone and calcium levels had normalized, and the patient underwent radioiodine treatment for thyroid cancer. The follow-up of 14 months was eventless. In summary, the clinical, laboratory, and imaging features of hyperparathyroidism taken together could have suggested malignancy, then confirmed histologically. The synchronous carcinomas were most likely caused by irradiation treatment diagnosed 41 years after exposure. It seems that the radiation injury initially induced parathyroid adenoma in young adulthood, which underwent a malignant transformation around age fifty
Hydrogel–Nanolipid Formulations for the Complex Anti-Inflammatory and Antimicrobial Therapy of Periodontitis
Get PDFEndothelial–Mesenchymal Transition and Possible Role of Cytokines in Streptozotocin-Induced Diabetic Heart
Get PDFBackground: Although endothelial mesenchymal transition (EndMT) has been characterized as a basic process in embryogenesis, EndMT is the mechanism that accelerates the development of cardiovascular diseases, including heart failure, aging, and complications of diabetes or hypertension as well. Endothelial cells lose their distinct markers and take on a mesenchymal phenotype during EndMT, expressing distinct products. Methods: In this study, type 1 Diabetes mellitus (T1DM) was induced in rats with streptozotocin (STZ) by intraperitoneal injection at a 60 mg/kg dose. Diabetic rats were randomly divided into two groups, namely, control and diabetic rats, for 4 weeks. Heart, aorta, and plasma samples were collected at the end of 4 weeks. Sequentially, biochemical parameters, cytokines, reactive oxygen species (ROS), protein expression of EndMT markers (Chemokine C-X-C motif ligand-1 (CXCL-1), vimentin, citrullinated histone H3 (H3Cit), α-smooth muscle actin (α-SMA), and transforming growth factor beta (TGF-β) and versican), components of the extracellular matrix (matrix metalloproteinase 2 (MMP-2), tissue inhibitor of metalloproteinase-1(TIMP-1), and discoidin domain tyrosine kinase receptor 2 (DDR-2)) were detected by ELISA or Western blot, respectively. Results: Cytokines and ROS were increased in diabetic hearts, which induced partial EndMT. Among EndMT markers, histone citrullination, α-SMA, and CXCL-1 were increased; vimentin was decreased in DM. The endothelial marker endothelin-1 was significantly higher in the aortas of DM rats. Interestingly, TGF-β showed a significant decrease in the diabetic heart, plasma, and aorta. Additionally, MMP-2/TIMP-1 levels also decreased in DM. Conclusions: To sum up, the identification of molecules and regulatory pathways involved in EndMT provided novel therapeutic approaches for cardiac pathophysiological conditions
MRI-based image-guided adaptive brachytherapy for locally advanced cervical cancer in clinical routine: a single-institution experience
Get PDFUstavnopravni položaj Hrvatske na temelju hrvatsko-ugarske nagodbe s aspekta teorije države I prava
Get PDFThe Hungarian-Croatian state union, which existed for more than eight centuries, was one of the most enduring state formations in European constitutional history before it ended in 1918 with the collapse of the then Austro-Hungarian Monarchy. When the joint state was created, its two members did not lay the legal foundations of the state union, so the conflict that arose in 1848 and the unilateral secession of Croatia (de facto, because de iure the person of the king still connected the two states) created a new situation. The alliance was renewed in 1868 with the conclusion of the Croatian-Hungarian settlement as a compromise solution. It was modelled after the Austro-Hungarian settlement, but some of its provisions offer the possibility of different interpretations, which led to frequent disputes between Budapest and Zagreb.From the point of view of legal comparatists and theoreticians of the state and law, it remains doubtful whether the Kingdom of Hungary was a unitary state, formed a federation with Croatia, or a real union. The heated political debates in the era of dualism (conducted mainly in parliament) could not give a unique answer to that question, and there was no opportunity for an objective analysis in the period between the two world wars and then in the era of socialism. Only the independence of Croatia provided the basis for comparative research by sine ira et studio. In this paper, from the perspective of the theory of the state and law, we analyse the Croatian-Hungarian state law model created on the basis of the Croatian-Hungarian settlement
Csontfejlődési rendellenességek a Kunfehértó - Templomdomb területén feltárt temető embertani anyagában
Get PDFThe impact of COVID-19 on the social and cultural integration of international students: a literature review
Get PDFThis systematic literature review summarises the state-of-the-art evidence on the impact of COVID-19 on the integration of international students in their host countries and institutions. Conducted between January and May 2022, it analyses the responses to COVID-19 of the key actors involved in international student mobility: national/regional authorities, higher education institutions, and students. Findings reveal that governmental action and institutional measures were decisive in shaping international students’ integration experiences. Regarding governmental action, criticism of the policies adopted by Australia and the USA in relation to immigration and/or support stand out, in contrast to policies adopted by the Canadian authorities. Higher education institutions played an important role in mitigating the negative effects of COVID-19 on international students’ integration. These targeted different needs– material, well-being, and social– through different types of support: logistical and financial support, psychological support, and the provision of platforms for ongoing social interaction and exchange. Most studies, however, focus on the students themselves, the challenges they faced during the pandemic and their coping strategies. Common to international students’ lived experience was (dis)connectedness, with the following themes emerging as obstacles to their social and cultural integration: distress during lockdown periods, disruption of their social life and support networks, mental health issues, discrimination and racialised prejudice, and language barriers. The review concludes by proposing recommendations and by identifying avenues for future research
Effects of in vivo chlorobenzene exposure on bone tissue in a rat model
Get PDFCalcipaenic bone disorders (e.g., osteoporosis) are becoming an epidemic as a significant public health concern. The underlying genetic, epigenetic, and homeostatic factors and the determinants of bone tissue expression are triggered by environmental exposures. Endocrine disruptor compounds are important in the development of pathological bone alterations. The aim of this study is to design an in vivo subtoxic chlorobenzene exposure model that can be used to explore certain bone changes and their consequences. Male Wistar rats were treated via gastric tube with a 1:1 mixture of hexachlorobenzene + 1,2,4-trichlorobenzene at a dose of 1.0 μg/kg bw; in a final volume of 1 mL, for 30, 60 and 90 days. Blood serum and bone samples were obtained from the femur diaphysis. The results of the treatments (n = 10/group) were interpreted as related to the controls. Serum levels of γGT, SGOT, SGPT were determined, along with bone tissue morphology, as well as the total mineral content of the bone and the mobilizable anorganic content. ANOVA was used to analyze the measurement data. As a result of the treatment protocol, histological examinations of bone morphology showed osteoid degeneration, as well as an altered state of the bone matrix. These findings are supported by the DEXA images, which showed a time-dependent decrease in surface mineral content, in parallel, an increase in the mobilizable anorganic content of the bone was detected. These results suggest that chlorobenzene administered may be a causal factor and changes in bone tissue structure can be traced
Developmental remodelling of Drosophila flight muscle sarcomeres: A scaled myofilament lattice model based on multiscale morphometrics
Get PDFThe indirect flight muscle is a widely used model for studying sarcomere structure and muscle development due to its extremely regular architecture. Nevertheless, precise measurement of the basic sarcomeric parameters remains a challenge even in this greatly ordered tissue. In this study, we identified several factors affecting measurement reliability and developed a software tool for precise, high-throughput measurement of sarcomere length and myofibril width. The accuracy of this new tool was validated against simulated images and blinded manual measurements. To extend the scope of this morphometric analysis to the sub-sarcomeric scale, we used electron and super-resolution microscopy to quantify myofilament number and filament length during myofibrillogenesis. Our findings revealed the dynamics of thin and thick filament elongation, as well as the addition of myofilaments at the sarcomere periphery during myofibrillogenesis. We precisely measured the dimensions of the Z-disc, I-band and H-zone during development, enabling us to construct refined models of sarcomere growth at the level of individual myofilaments, providing a spatial framework for interpreting nanoscopic localization data. These models deepen our understanding of sarcomere growth and lay the groundwork for future studies on the molecular mechanisms driving myofilament elongation and assembly. © 2025 The Authors