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Simultaneous Assessment of Left Ventricular Volumes and Aortic Valve Annular Dimensions by Three-Dimensional Speckle-Tracking Echocardiography in Healthy Adults from the MAGYAR-Healthy Study—Is There a Relationship?
Get PDFIntroduction: Three-dimensional speckle-tracking echocardiography (3DSTE) can be used to accurately measure the dimensions of the left ventricle (LV) and aortic valve anulus (AVA) at the same time. The present study aimed to conduct an extensive 3DSTE-based investigation of simultaneously assessed end-diastolic and end-systolic LV volumes and AVA dimensions in healthy adults with LVs and AVAs of different sizes. Methods: One hundred and seven healthy adults (mean age 35.4 ± 12.2 years, 67 males) were voluntarily enrolled in the present study. Results: With increasing end-diastolic AVA area, tendentious increase in both end-diastolic and end-systolic LV volumes could be detected, resulting in preserved LV-EF. With increasing end-systolic AVA area, similar findings were present. Comparing the smaller than mean and the larger than mean end-systolic AVA area subgroups, the end-systolic LV volume proved to be significantly increased in the latter group. With the increase in end-diastolic LV volume, the AVA dimensions remained preserved. With the increase in end-systolic LV volume, only the highest end-systolic LV volume was associated with larger end-systolic AVA area and perimeter; the other parameters remained preserved. In certain circumstances, end-systolic AVA area and perimeter proved to be significantly increased compared to their end-diastolic counterpart. Conclusions: With the increase in end-diastolic and end-systolic AVA areas, a tendentious increase in both LV volumes could be detected in healthy adults. Larger end-diastolic LV volume was not associated with dilated AVA dimensions, while larger end-systolic LV volume was associated with dilated end-systolic AVA area and perimeter
The 12-Year Experience of the Hungarian Pancreatic Study Group
Get PDFThe Hungarian Pancreatic Study Group (HPSG) was established with the aim of advancing pancreatology. Our summary outlines the methodologies, key results, and future directions of the HPSG. Methodological elements included, the formation of strategic national and international collaborations, the establishment of patient registries and biobanks, and a strong focus on education and guideline development. Key results encompassed, pioneering research on pancreatic ductal function and the role of cystic fibrosis transmembrane conductance regulator (CFTR) in inflammation, significant advancements in understanding acute and chronic pancreatitis, and the execution of numerous clinical trials to explore new therapeutic approaches. Despite challenges, such as securing funding and translating research into clinical practice, the HPSG’s commitment to patient care and scientific innovation has been unwavering. The group aims to deepen research into pancreatic cancer and chronic pancreatitis, conduct more randomized controlled trials (RCTs), and expand its efforts internationally by involving global staff and patients. The authors hope that this summary inspires others to undertake similar initiatives and contribute to the global advancement of medical research and patient care in pancreatology
Insights into the relationship between mitral annular dimensions, derived sphincter-like features and systolic longitudinal excursion of the mitral annular plane in healthy adults from the MAGYAR-Healthy Study
Get PDFSafety of a gastropexy device in infants and young children in percutaneous endoscopic gastrostomy tube placement
Get PDFIn our practice, there is a growing need to perform gastrostomy tube placement in infants and young children with feeding difficulties. To avoid possible complications arising from pull-through method (pull-through PEG) we began to perform a one-step endoscopic gastrostomy with a gastropexy device (push GT). This study aimed to evaluate the safety of this technique in infants and young children. In our study, 60 pull-through PEG and push GT procedures were retrospectively analysed in patients between 2.83 and 8.6 kg. We analysed the adverse events in both groups. Age, sex, weight, diagnosis, early (occurring ≤ 7 days after the procedure) and late (occurring > 7 days after the procedure) complications were compared in the two groups. Median follow-up duration was 12 months. Early minor complications occurred only in the push GT group, but this was not statistically significant. There was no significant difference between the groups regarding early major complications. Late minor complications were significantly more common in the push GT group. There were no late major complications in the push GT group, which is statistically significant. In infants and young children, push GT with a gastropexy device is a safe method to perform gastrostomy even in patients unsuitable for pull-through PEG placement
Emlőrákkérdés Magyarországon – egy onkológus észrevételei : 2. rész : Ellátási szempontok [Breast cancer burden in Hungary – Critical reflections by an oncologist. Part 2: Aspects of care]
Get PDFAz emlôrák korszerû ellátása számos szakmaés szervezet összehangolt együttmûködéséreépül. A sugárterápiás és onkológiai kezelések a beteg és betegsége sajátosságai szerintválaszthatóak meg, ideálisan egyénre szabottak: a hatékonyság szempontja melletta legkisebb megterhelés is vezérelv. Ezt atörekvést támogatja a „precíziós onkológiai”ellátás, melyhez nélkülözhetetlen a különféle biomarkerek, illetve a molekuláris diagnosztika egyénileg indokolt alkalmazása.Speciális segítséget jelent a betegellátáshozaz onkokardiológiai gondozás, mely lehetôséget ad a gyógyszeres kezelések és/vagysugárterápia következtében fellépô káros,életminôséget és egészséget érintô következmények kivédésére vagy menedzselésére. Abetegellátás több ok miatt is elônyösen alakul klinikai vizsgálatban. A betegek normáliséletbe történô visszavezetését nagyban segítia jó minôségû utógondozás és a betegszervezetek hozzáértô tevékenysége. Sajnos Ma -gyarországon a felsorolt lehetôségekhez valóhozzáférés nagy különbséget mutat, esetleges. Ennek hátterében kapacitás- és szervezettségbeli hiányosságok állnak, a legdrámaibb az onkológiai ellátáshoz rendelkezésreálló orvosi genetika kapacitásának elégtelensége. A bôvítést, áthangolást, átképzést eredményezô korrekciót a cikkben bemutatottnemzetközi tapasztalatok és példák segít -hetik
An upper temporal limit of action-effect integration as reflected by motor adaptation
Get PDFMotor parameters of simple, repetitive actions like tapping, pinching, or pushing a button differ as a function of their action effects – adding a consistent, immediate sound-effect to such actions leads to a decrease in applied force. This action-effect related motor adaptation occurs only, however, when the sound-effect follows actions within about 200 ms, which has been hypothesized to reflect a temporal limit of action-effect integration. Using a university student sample, the present study replicated the effect of action-sound effect delays on force application. Furthermore, given that the perception of action-effect contingencies, and that of temporal relations are deteriorated in schizophrenia, we explored the relationship between the schizotypy trait and the duration of the action-effect related motor optimization window. Participants pinched a force sensitive device every 3 s on their own volition, which elicited a tone with a delay increasing from block to block in 70 ms steps from 0 to 560 ms. The applied force gradually increased with action-effect delay, with an estimated force optimization window size of 290 ms, confirming the importance of temporal contiguity in action-effect related motor adaptation. A Bayes-factor based analysis provided evidence for no correlation between the motor optimization window size and schizotypy
A renális denerváció aktualitásai [Update on renal denervation]
No full textA renális denerváció 2024-ben is kiemelt figyelmet kap ahypertonia kezelésében. Az elmúlt években számos klinikai vizsgálat igazolta arenális denerváció hatékonyságát mind gyógyszeres kezelés mellett, mind attólfüggetlenül, miközben a biztonságossági profilja továbbra is kedvező. Az innovatív technológiák, például a rádiófrekvenciás és ultrahangos rendszerek alkalmazása révén az eljárás pontossága és eredményessége tovább javult. Az FDA általjóváhagyott eszközök és a legújabb irányelvek is támogatják a renális denervációalkalmazását mint a hypertonia kezelésének ígéretes, minimálisan invazív kiegészítését
