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Efek Protektif Kombinasi Minyak Jintan Hitam dan Madu terhadap Hepatotoksisitas pada Tikus Akibat Sisplatin
No full textSisplatin merupakan agen antikanker dengan berbagai efek samping, terutama hepatotoksisitas. Minyak jintan hitam (MJH) dan madu (M) merupakan bahan alam yang kaya akan antioksidan dan memiliki efek hepatoprotektif. Penelitian ini bertujuan untuk mengetahui efek protektif kombinasi minyak jintan hitam dan madu pada jaringan hepar tikus yang diberi pajanan sisplatin Penelitian merupakan studi in vivo dengan pendekatan eksperimental yang menggunakan 30 tikus yang dibagi menjadi 10 kelompok, yaitu kelompok kontrol (K), kelompok tunggal MJH dosis I (1 mL/kgBB) (P1), MJH dosis II (2 mL/kgBB) (P2), M dosis I (3,7 mL/ kgBB) (P3), M dosis II (7,4 mL/kgBB) (P4), kelompok kombinasi MJH dosis I dan M dosis I (P5), MJH dosis I dan M dosis II (P6), MJH dosis II dan M dosis I (P7), MJH dosis II dan M dosis II (P8) serta kelompok sisplatin (C). Penelitian dilakukan di Laboratorium Farmakologi dan Farmasi Klinis dan Laboratorium Mikroskopik Fakultas Kedokteran Universitas Tanjungpura pada bulan April-Desember 2017. Minyak jintan hitam dan madu diberikan secara oral selama 21 hari. Pada hari ke-18, semua kelompok, kecuali kelompok kontrol, diberi sisplatin 8 mg/ kgBB secara intraperitoneal. Organ hepar diambil pada hari ke-22 untuk pembuatan preparat dan dilakukan penilaian histopatologi. Analisis data menggunakan Compusyn dan IBM SPSS v.24 dengan Uji One-Way Anova dilanjutkan Uji LSD. Didapatkan gambaran kerusakan hepatosit yang lebih ringan pada semua kelompok perlakuan dibandingkan dengan kelompok sisplatin (p<0,05). Kelompok kombinasi (P5-P8) menunjukkan nilai CI <1 yang mengindikasikan efek protektif yang sinergis. Kombinasi minyak jintan hitam dan madu menghasilkan efek protektif yang sinergis terhadap jaringan hepar tikus yang diberi pajanan sisplatin. Kata Kunci: Antioksidan, minyak jintan hitam, madu, sisplatin, sinergis. Protective Effect of Commercial Black Seed Oil and Honey Combination against Cisplatin-Induced Hepatotoxicity in Rat Abstract Cisplatin is one of anticancer agents that has various side effect, mainly hepatotoxicity. It is known that black seed oil (BSO) and honey (H) are natural ingredients rich in antioxidants and have hepatoprotective effect. To assess the protective effect of the combination of black seed oil and honey on liver histopathology tissue of rats induced with cisplatin This study used a randomized post-test only control group experimental design. Thirty rats were divided into 10 groups: control group; single-treatment groups which were given BSO dose I (1 ml/kgBW) (P1), BSO dose II (2 mL/kgBW) (P2), H dose I (3.7 mL/kgBW) (P3), H dose II (7.4 mL/kgBW) (P4); combination groups which were given BSO dose I and H dose I (P5), BSO dose I and H dose II (P6), BSO dose II and H dose I (P7), BSO dose II and H dose II (P8); and cisplatin group (C). Black seed oil and/or honey were given orally for 21 days. On the 18th day, cisplatin group and all treatment groups were given cisplatin 8 mg/kgBB intraperitoneally. On the 22nd day, the livers were dissected for histopathologic preparations and scoring. Statistical analysis was done by One-Way Anova and LSD Test. Combination index was analyzed by using Compusy.There were significantly reduced damage of hepatocytes in all treatment groups compared to cisplatin groups (p<0.05). The combination groups (P5-P8) showed CI value of less than 1 that indicated synergistic protective effect.Combinations of black seed oil and honey exert a synergistic protective effect on rats liver tissue that is induced with cisplatin. Keywords: Antioxidant, black seed oil, honey, cisplatin, synergis
The Use of Vitamin D Supplement as a Treatment for Knee Osteoarthritis
No full textOsteoarthritis is a chronic degenerative disease that causes functional disability with no diseasemodifyingtreatment available. Management of osteoarthritis currently focuses on symptomatic relief or jointreplacement. Recent studies have shown the involvement of vitamin D deficiency affecting the progressionof knee osteoarthritis. However, the clinical use of vitamin D in the management of osteoarthritis remainsunknown. The aim of the study is to investigate the efficacy of vitamin D supplement in management ofknee osteoarthritis. Literature searching on Pubmed and ScienceDirect. The selection was made by title andabstract screening and applying inclusion and exclusion criteria. There were two randomized controlled trialstudies selected for this report. Sanghi et al, reported that vitamin D supplement improves the Western Ontarioand McMaster Universities Osteoarthritis Index (WOMAC) score in patients with osteoarthritis and vitamin Ddeficiency (p<0.02). McAllindon et al, reported there is no improvement of knee pain in the general population(p<0.17). There is no clinical significance of vitamin D supplementation in patients with osteoarthritis withoutproven vitamin D deficiency. However, the use of vitamin D as a therapy for vitamin D deficiency patients hasproven to reduce the pain in osteoarthritis. Keywords: vitamin D, supplementation, knee osteoarthritis. Penggunaan Suplemen Vitamin D sebagai Tata LaksanaOsteoartritis Lutut AbstrakOsteoartritis merupakan penyakit degeneratif kronik yang mengakibatkan kecacatan fungsional tanpaterapi modifikasi penyakit yang tersedia. Penatalaksanaan osteoartritis saat ini fokus kepada pengurangangejala klinis atau penggantian sendi. Penelitian terbaru menunjukkan keterlibatan defisiensi vitamin D yangmemengaruhi terjadinya osteoartritis, namun, penggunaan vitamin D dalam pengelolaan osteoartritis lututmasih belum jelas. Tujuan penelitian ini adalah menilai efektivitas penggunaan suplemen vitamin D sebagaitatalaksana osteoartritis lutut. Pencarian literature di Pubmed dan ScienceDirect. Pemilihan dilakukan denganskrining judul dan abstrak, menerapkan kriteria inklusi dan eksklusi. Dua studi percobaan acak terkontroldipilih untuk laporan ini. Studi oleh Sanghi et al menunjukkan bahwa suplementasi vitamin D meningkatkanskor WOMAC pada pasien osteoartritis dengan defisiensi vitamin D (p<0,02). McAllindon et al melaporkanbahwa tidak ada perbaikan nyeri lutut pada populasi umum (p<0,17). Tidak ada bukti klinis suplementasivitamin D pada pasien osteoartritis tanpa kekurangan vitamin D namun, penggunaan vitamin D sebagai terapibagi pasien kekurangan vitamin D terbukti mengurangi rasa nyeri pada osteoartritis. Kata kunci: vitamin D, suplementasi, osteoartritis lutut
Peran Ultrasonografi dalam Diagnosis Pneumotoraks pada Kasus Henti Jantung: Laporan Kasus
No full textMesin ultrasonografi (USG) saat ini telah berkembang menjadi lebih ringkas dan mudah dibawa sehingga membuat evaluasi cepat pada pasien dengan keadaan tidak stabil lebih mudah dilakukan. USG memiliki sensitivitas tinggi dibandingkan foto polos toraks dalam deteksi pneumotoraks. Pada laporan kasus ini yang terjadi di Rumah Sakit Umum Pusat Nasional (RSUPN) Cipto Mangunkusumo pada bulan November 2018 hendak menggambarkan peran penting USG dalam deteksi dini pneumotoraks. Bayi laki-laki berusia 4 bulan dengan tumor di regio palatum dijadwalkan untuk menjalani eksisi tumor elektif. Pasien memiliki riwayat code blue karena trakeostomi yang bergeser. Pasien mengalami desaturasi intraoperatif dari 100% hingga 80% hingga bradikardia dan akhirnya henti jantung. Dengan menggunakan USG yang diletakkan di hemitoraks kanan dan kiri dapat menemukan bahwa lung sliding tidak ada di paru sebelah kanan. Dengan keadaan pasien yang tidak stabil, dilakukan needle thoracosyntesis dengan jarum 14 Gauge pada celah interkostae kedua sejajar garis midklavikula. Sirkulasi spontan kembali dan saturasi oksigen meningkat hingga 100%. Kata kunci: Ultrasonografi, pneumotoraks, hemitoraks The Role of Ultrasound in Pneumothorax Diagnosis in Cardiac Arrest Patient Abstract As ultrasound machines have become more portable and easier to use, thus allows a rapid evaluation of an unstable patient, at the bedside. Ultrasound has a higher sensitivity than the traditional upright anteroposterior chest radiography for the detection of a pneumothorax. In this report which happened on November 2018 in Cipto Mangunkusumo Hospital would like to highlight the use of ultrasound to detect pneumothorax. A four-months old baby boy with tumor in palatum region was scheduled to undergo elective tumor excision. This patient also with history of code blue because of tracheostomy displacement. After surgery the patient’s oxygen saturation gradually decreased from 100% into the low 80s until bradycardia and cardiac arres. Using ultrasound, the right and left hemithoraces were examined. The ultrasound probe was placed on the anterior chest wall at multiple intercostal spaces. Lung sliding was demonstrated on the left lung after the exam, but not on the right lung. Because of the patient’s unstable condition, a 14-gauge intravenous catheter was placed superior to the rib at the second intercostal space along the midclavicular line. An immediate return of spontaneous circulation resulted. A chest tube was placed, and the patient’s oxygen saturation returned to 100%. Keywords: Ultrasound machines, pneumothorax, hemithorax
Comparison of Topical Nepafenac 0.1 % and Prednisolone Acetate 1% as an Anti-Inflammatory after Vitrectomy in Rhegmatogenous Retinal Detachment
No full textPost-operative ocular inflammation is treated with topical steroids but with side effects. Nepafenac isan effective NSAID with minimal side effects. This study aims to compare effectiveness topical nepafenac0.1% (nepafenac) and prednisolone acetate 1% (prednisolone) post-pars plana vitrectomy (PPV) forrhegmatogenous retinal detachment (RRD). This is a prospective, single blind, randomized, single centerclinical study performed on December 2015 to May 2016 at dr. Cipto Mangunkusumo Hospital, Jakarta. Atotal of 46 eyes (n=46) with RRD underwent PPV were included and randomized to topical nepafenac (23eyes) or prednisolone 1% (23 eyes). The median of anterior chamber inflammation, scores of pain, centralmacular thickness (CMT), and intraocular pressure (IOP) were evaluated at day 1, followed by 1st, 2nd, and4th week post-surgery. Median anterior chamber inflammation was grade 2 (1-4) in prednisolone group andgrade 3 (0.5-4) in nepafenac group at day 1 (p>0.05). Number of cell of anterior chamber inflammation andpain perception were not significantly different between groups (p>0.05) on follow-up. At day 1, nepafenacand prednisolone groups showed median CMT of 206 μm (131-299) and 208 μm (129-451). At 4th week, meanCMT were 174.9±30.7μm in prednisolone and 185.5±50.1μm in nepafenac group (p>0.05). Post-operativetopical nepafenac was equal to prednisolone in reducing inflammation in eyes undergoing PPV. Nepafenaccould be an alternative for post-PPV in RRD. Keywords: inflammation, nepafenac, prednisolone acetate, vitrectomy. Perbandingan Topikal Nepafenak 0,1% dan Prednisolon Asetat 1% sebagaiAnti-Inflamasi setelah Vitrektomi pada Ablasio Retinae Regmatogen Abstrak Steroid topikal digunakan untuk inflamasi mata setelah operasi namun memiliki efek samping. Nepafenakmerupakan NSAID yang efektif dengan efek samping minimal. Studi ini bertujuan membandingkan efektivitasnepafenak 0,1% (nepafenak) dan prednisolon asetat 1% (prednisolon) topikal post-pars plana vitrectomy(PPV) pada ablasio retina regmatogen (RRD). Desain studi klinis ini adalah prospektif, single blind,randomized, single center, yang dilakukan pada bulan Desember 2015 sampai Mei 2016 di Rumah Sakitdr. Cipto Mangunkusumo, Jakarta. Sebanyak 46 mata (n=46) dengan RRD yang melalui PPV diikutsertakandalam penelitian ini. Subjek dirandomisasi untuk mendapatkan nepafenak (23 mata) dan prednisolon (23mata) topikal. Median inflamasi bilik mata depan (BMD), skor nyeri, ketebalan makula sentral (CMT) dantekanan intraokular (IOP) diukur pada hari pertama, minggu ke- 1, ke-2, dan ke-4 setelah operasi. Medianinflamasi BMD hari pertama adalah tingkat 2 (1-4) pada grup prednisolon dan tingkat 3 (0,5-4) pada grupnepafenak. Jumlah sel inflamasi BMD dan persepsi nyeri pada kedua grup tidak berbeda bermakna (p>0,05).Pada hari pertama, grup nepafenak dan prednisolon menunjukkan CMT 206 μm (131-299) dan 208 μm (129-451). Pada minggu ke-4, CMT 174,9±30,7 μm pada grup prednisolon dan 185,5±50,1 μm pada nepafenak(p>0,05). Penggunaan nepafenak topikal dan prednisolon sama dalam meredakan inflamasi setelah operasi.Nepafenak dapat menjadi alternatif setelah tindakan PPV pada RRD. Kata kunci: inflamasi, nepafenak, prednisolon asetat, vitrektomi
The Influence of Coconut Oil and Palm Oil on Body Mass Index, Abdominal Circumference, and Fat Mass of Wistar Male Rats
No full textOverweight is one of the risk factors for degenerative diseases, one of which is due to excessive oil consumption.
Coconut oil consists mostly of saturated fatty acids of 90% and medium chain
fatty acids, making it easier to metabolize into energy, compared to palm oil.
This study aims to compare the effect of coconut oil and palm oil on body mass
index, abdominal circumference, and fat mass in male wistar rats. This study
was conducted in November–December 2017 in Animal Laboratory Department of
Pharmacology and Therapy in Fakultas Kedokteran Universitas Padjadjaran
Bandung. This study was an experimental study conducted for 28 days in 3
groups, each consisting of 7 rats fed standard diet ad libitum (G0), standard
diet plus coconut oil supplementation (G1), and standard diet plus palm oil
supplementation (G2). The result showed that the difference of BMI before and
after treatment G0=0.06±0.050, G1=0.04±0.032, G2=0.05±0.027 (p=0.553).
Difference in mean abdominal circumference before and after treatment
G0=1.85±0.852, G1=0.71±1.318, and G2=0.42±1.789 (p=0.149). Mean fat mass group
G0=4.61±1.318, G1=4.02±3.439, and G2=6.03±2.568 (p=0.179). There were no
significant differences in BMI, abdominal circumference, and fat mass among the
experimental groups. In conclusion, supplementation of coconut oil and palm oil
in rats can increases BMI, abdominal circumference, and fat mass
Mewujudkan Terobosan dan Kemandirian Reparasi, Restorasi, Regenerasi, Rekonstruksi, serta Replacement Tulang, Sendi Panggul, dan Lutut di Indonesia
No full textThe Effectivenes of Combined Surgery Cataract and Glaucoma One Step and Two Steps in Primary Angle Closure Glaucoma Patients
No full textPrimary angle closure glaucoma (PACG) caused a second blindness in Indonesia. The aim of this study to evaluate the efficacy and safety of surgical outcome between phacotrabeculectomy in one step procedure if the intra ocular pressure less than 26 mmHg (group A) or in two steps procedure if the IOP more than 26 mmHg (group B) in PACG coexisted with cataract. This was retrospetive desain study conducted at Dr Cipto Mangunkusumo, Jakarta with follow up within one year periode. The variables were noted such as age, gender, lateralitas, visual acuity (LogMAR), intraocular pressure (IOP), number of glaucoma medications, cup disc ratio, visual field and post-operative complications and duration of follow up.The complete success defined as IOP remained below 21 mm Hg, with no medications required, while qualified success defined as IOP below 21 mmHg with medications. A total of 39 eyes underwent phacotrabeculectomy one step-group A (22 eyes) vs phacotrabeculectomy two steps-group B (17 eyes). The mean follow-up period was 24.5 (range 12 to 49 mo) with complete success was achieved in 63.6% of group A and 70,6% of group B.. While Qualified success occured in 36.4% of group A and 2.,4% of group B. The mean IOP of between group A and group B at final follow up was not significantly different 12.45±2.97 vs 12.45 ± 2.97; p;0.13. There was reduction of number glaucoma medication in both group and hypotony was revealed in 1 eye after trabeculectomy. Conclusion; phacotrabeculectomy either one or two steps demonstrated comparable success rate and reduces number of glaucoma medication post-operatively. 
The Potential of Hibiscus sabdariffa Linn. for Treatment of Obesity: Focus on FGF21 in Liver and Adipose Tissue
No full textObesity is one of the health problems associated with FGF21 resistance. FGF21 is a hormone secreted in the liver and plays a role in energy homeostasis in adipose tissue. FGF 21 is used as an alternative for treating obesity. While the potential of H. sabdariffa for weight loss has been acknowledged, H. sabdariffa’s ability to handle FGF 21 is still unknown. This study aims to determine the potential of H. sabdariffa in FGF 21 resistance by measuring FGF 21 in adipose and liver tissue. This study was conducted at Biochemistry Animal House Laboratory at Faculty of Medicine Universitas Indonesia in January until May 2019. This experimental studies using 24 male rats for 6-10 weeks were divided into four groups, namely the normal control group (N), the obese control group (Ob), the obese group with H. sabdariffa dose 200 mg/kgBW/day (Ob-Hib 200), and obese groups with H. sabdariffa dose 400 mg/kgBW/day (Ob-Hib 400). H. sabdariffa is given every day for 5 weeks in a row. Examination of FGF21 protein in white adipose tissue and liver using the ELISA test. ANOVA test results showed an increase in FGF21 levels in adipose tissue in obese rats given H. sabdariffa extract dose of 400 mg/kgBW/day (p<0.05) and even significantly different than normal conditions (p<0.05). The results showed that a dose of 400 mg/kgBW had the potential to increase FGF21 levels in the liver (p<0.05). In conclusion, giving extract of H. sabdariffa has the potential for handling FGF21 resistance because H. sabdariffa is able to increase FGF 21 levels in adipose and liver tissue. Keywords: FGF21, H. sabdariffa, obese. Potensi Hibiscus Sabdariffa untuk Mengobati Obesitas: Fokus pada FGF21 di Jaringan Hati dan Adiposa Abstrak Obesitas berhubungan dengan resistensi FGF21. FGF21 merupakan hormon yang disekresikan oleh hati dan berperan dalam homeostasis energi di jaringan adiposa. FGF21 digunakan sebagai alternatif dalam penanganan obesitas, namun potensi H. sabdariffa dalam menurunkan berat badan belum pernah dilakukan dan potensinya dalam pengaturan FGF21 juga belum diketahui. Penelitian bertujuan mengetahui potensi H. sabdariffa dalam mengatasi resistensi FGF21 melalui pengukuran kadar FGG21 di jaringan adiposa dan hati. Penelitian dilakukan di Laboratorium Hewan Biokimia Fakultas Kedokteran Universitas Indonesia pada bulan Januari-Mei 2019. Studi eksperimental ini menggunakan 24 tikus jantan 6-10 minggu yang dibagi menjadi 4 kelompok, yaitu kelompok normal (N), kelompok kontrol obese (Ob), kelompok obese dengan pemberian H. sabdariffa 200 mg/kgBB/hari (Ob-Hib 200), dan kelompok obese dengan pemberian H. sabdariffa 400 mg/kgBB/hari (Ob-Hib 400). H. sabdariffa diberikan selama 5 minggu berturut-berturut sehari sekali. Pemeriksaan protein FGF21 di jaringan adiposa dan hati menggunakan metode ELISA. Uji ANOVA menunjukkan peningkatan FGF21 di jaringan adiposa pada tikus obese yang diberikan H. sabdariffa dengan dosis 400 mg/kgBB (p<0,05) dan memiliki perbedaan signifikan dengan kelompok normal (p<005). Selain itu, pemberian H. sabdariffa dengan dosis 400 mg/kg BB pada jaringan hati meningkatkan kadar FGF21 (p<0,05). Disimpulkan H. sabdariffa memiliki potensi untuk mengatasi resistensi FGF21 karena meningkatkan kadar protein FGF21 baik di jaringan adiposa maupun hati. Kata kunci: FGF21, H. sabdariffa, obesitas
The Effectiveness of Health Education in the Waiting Room of Pensioners Bank in Improving Elderly Health Perspective, Behavior and Morbidity
No full textElderly need intensive exposure to health education to recognize and prevent diseases, like a degenerativeand infectious disease. Any chance when elderly gather and spend significant time, like 30-60 minutes of waitingtime for withdrawing pension money in the bank can be utilized as an opportunity to deliver health educationmessage. This initiated collaboration among pension bank and general practitioners to perform specific healtheducation program to elderly in their waiting room. This study investigates how health education and consultationprogram in the pension bank would be useful to change elderly health perspective, behavior, and morbidity. Across-sectional comparative study was conducted to 438 elderlies in 10 cities of 14 pension bank branchesin Indonesia in 2014-2015. We divided them into two groups: health education participants (n=345) and nonparticipants(n=93) to compare their health perspective, behavior, and morbidity after six months of educationexposure. Elderly perspective on healthy lifestyle was elicited using a set of 11 questions that were graded on aLikert scale of 1-5 where one = less important to 5 = most important. We also recalled whether they conductedactive lifestyle and had a history of illness in the last three months. Participants group had a significant increasein health perspectives, especially about the importance of regular health checking and maintaining a healthy diet(p<0.05). They also had fewer case of chronic illnesses (p=0.01, OR 0.51 IK95% 0.30-0.89). Their active lifestylewas also increased but not significant (p=0.164). Health education in the waiting room of pension bank wasproven effective to improve health perspective and decrease long term illnesses in the elderly. With standardizededucation module and cooperation with the trained health educator, this approach of optimizing queuing time inthe waiting room of pension bank can be applied to intensify access to health education for elderly. Keywords: health education, elderly, morbidity, health behavior. Efektivitas Edukasi Kesehatan di Ruang Tunggu Bank dalam MeningkatkanPersepsi Kesehatan dan Perilaku serta Menurunkan Morbiditas Lansia Abstrak Lanjut usia (lansia) memerlukan edukasi kesehatan intensif sehingga dapat mengenali serta mencegah penyakitdegeneratif dan infeksi. Kesempatan lansia berkumpul dan menghabiskan waktu bersama, seperti menunggu di bank30-60 menit saat pengambilan uang pensiun dapat digunakan untuk edukasi kesehatan. Hal tersebut menginisiasikerja sama antara bank dengan perhimpunan dokter umum untuk menerapkan program edukasi kesehatan di ruangtunggu bank. Studi ini meneliti efektivitas edukasi dan konsultasi kesehatan di bank dalam mengubah persepsikesehatan dan perilaku lansia, serta menurunkan morbiditasnya. Studi potong lintang komparatif dilakukan pada438 orang lansia di 10 kota di 14 cabang bank di Indonesia tahun 2014-2015. Subyek dibagi dua grup: lansia yangberpartisipasi dalam edukasi kesehatan (n=345) dan tidak berpartisipasi (n=93) untuk membandingkan persepsi,perilaku, dan riwayat penyakit 6 bulan pasca edukasi kesehatan. Persepsi lansia tentang hidup sehat dan aktifdianalisis menggunakan 11 pertanyaan dengan gradasi skala Likert 1-5 dari kurang penting sampai paling penting.Lansia juga ditanyakan mengenai penerapan hidup sehat aktif dan apakah memiliki riwayat penyakit selama 3 bulanterakhir. Kelompok lansia yang berpartisipasi mengalami peningkatan persepsi pentingnya pemeriksaan kesehatansecara teratur dan mengatur pola makan (p<0,05) dan penurunan riwayat penyakit kronik (p=0,01; RO 0,5 IK95%0,30-0,89). Gaya hidup sehat meningkat namun tidak signifikan (p=0,164). Edukasi lansia di ruang tunggu bankpensiun efektif meningkatkan persepsi kesehatan dan menurunkan morbiditas penyakit kronik. Dengan moduledukasi terstandar dan penyuluh kesehatan yang terlatih, pendekatan optimalisasi waktu menunggu di bank dapatditerapkan sebagai contoh model untuk meningkatkan akses edukasi kesehatan kepada lansia. Kata kunci: penyuluhan kesehatan, lanjut usia, morbiditas, perilaku kesehatan
Luaran Nilai Fungsional Kasus Tumor Primer Spinal Intradura Ekstramedula Pascaoperatif di RSUPN Dr. Cipto Mangunkusumo 2014-2016
No full textTumor spinal primer memiliki morbiditas dan disabilitas yang tinggi. Profil demografi dan luaran nilai fungsional penderita tumor primer spinal intradural ekstramedular 60% dari seluruh tumor spinal primer sehingga penting dinilai karena dapat dijadikan parameter keberhasilan operasi dan dapat digunakan dalam memberikan informasi kepada pasien dan keluarga sebelum operasi. Studi retrospektif deskriptif analitik ini menggunakan data rekam medis penderita tumor spinal intradural ekstramedular yang baru menjalani operasi pertama kali di RSUPN dr. Cipto Mangunkusumo tahun 2014 – 2016. Skor luaran fungsional Medical Outcome Study 36-item Short-form Health Survey (SF-36) pra dan pasca-operasi dievaluasi dan dibandingkan menggunakan uji korelasi Friedman. Rerata usia subjek adalah 46,3 tahun (min-maks 15-71 tahun), dengan 31% penderita berusia 50-60 tahun, 69% penderita perempuan, dan rerata lama awitan keluhan hingga operasi adalah 7,79 bulan. Sebanyak 65% menderita Schwannoma dan 34,5% meningioma. Dibandingkan dengan skor pra-operasi, skor pasca-operasi kuesioner SF-36 memperlihatkan peningkatan bermakna pada kedelapan aspek kuesioner. Nilai fungsional SF-36 penderita tumor primer spinal intradural ekstramedular menunjukkan perbaikan bermakna pada masa 1 tahun pasca-operasi. Kata kunci: Tumor primer spinal, intradura ekstramedula, SF -36. Evaluation of Functional Outcome of Primary Extramedullar Intradura Spine Tumor Operated in Dr. Cipto Mangunkusumo General Hospital, 2014–2016 Abstract Spinal tumor is one of the neural disorders that contributes to high number of morbidities disabilities. Demographic profile and functional outcome of primary intradural extramedullary spinal tumor patient is important to be evaluated for the purpose of providing holistic information for patients and their family prior to surgery, as well as measuring surgical results. This analytical descriptive retrospective study utilized medical record of primary intradural extramedullary spinal tumor patient who underwent first surgery in dr. Cipto Mangunkusumo General Hospital from 2014-2016. Pre- and postsurgical Medical Outcome Study 36-item Short-form Health Survey (SF-36) functional score were evaluated and compared using Friedman correlation test. The mean age of study participants is 46,3 years old (min-max: 15-71 years old), with 31% participants included in the age group of 50-60 years old, 69% participants were female, and the mean of onset-to-surgery time is 7,79 months. The dominant histopathological finding was Schwannoma (65%). Compared to the pre-surgical score, post-surgical SF-36 showed significant improvements in all eight aspects of the questionnaire. SF-36 functional score of primary intradural extramedullary spinal tumor patient presented significant improvement in 1 year after surgery. Keywords: Primary spinal tumor, intradural extramedullar, SF-36