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Schede bibliografiche 2019-2020
Get PDFLibri ricevuti dalla Biblioteca della Società Siracusana di Storia Patria (donazioni e scambi) relativi al biennio 2019-2020
Una fotografía de la imagen social de la Enfermería
No full textObjective: to determine the Nursing’s social image of the Asturian population. Methods: Multicentric descriptive study with quota sampling by self-administered questionnaire, conducted in the Principality of Asturias (Spain) between 11/01/2017 – 03/31/2018. It realizes an univariate analysis of the 8 social spheres and bivariant analysis with sociodemographic variables and relationship with Nursing. Results: We obtained a final sample of 335 questionnaires. Nursing is the second health profession best valued, behind Medicine. 80,9% associate us with a university career. Around 75% believe that Nursing is well trained and that their skills have improved in the last decade, as well as Specialist Nurses should only work in their specific area. 71,3% would not trust the Nurse’s prescription without consulting it with their doctor later. The Nurse’s main attributes are: vocation, responsibility and being skillful; as well as the functions of healing wounds, techniques and helping the doctor. The answers about stereotypes and salary are neutral. Conclusions: Although some results are better than previous studies, certain stereotypes and beliefs persist in the professional image. Therefore, we can’t stop working so population knows and recognizes us.Objetivo: determinar la imagen social que tiene la población asturiana de la Enfermería. Metodología: Estudio descriptivo multicéntrico con muestreo por cuotas mediante cuestionario autoadministrado, realizado en el Principado de Asturias (España) entre el 01/11/2017 – 31/03/2018. Realización de análisis univariante de las 8 esferas de la imagen social y bivariante con las variables sociodemográficas y de relación con la profesión. Resultados: Obtuvimos una muestra final de 335 cuestionarios. Es la segunda profesión sanitaria mejor valorada, por detrás de la Medicina. El 80,9% nos asocian con carrera universitaria. Alrededor del 75% de encuestados cree que las Enfermeras están bien formadas y que sus competencias han mejorado en la última década, así como que las Enfermeras Especialistas sólo deben trabajar en su área específica. El 71,3% no confiaría en la prescripción enfermera sin consultarlo posteriormente con su médico. Los principales atributos con los que las relacionan son: vocación, responsabilidad y ser habilidoso; así como las funciones de curar heridas, técnicas y ayudar al médico. Las respuestas a las preguntas de estereotipos y salario son neutrales. Conclusiones: Aunque algunos resultados son mejores que en estudios previos, persisten ciertos estereotipos y creencias en la imagen profesional; por tanto, debemos seguir trabajando para que la población nos conozca y reconozca
"Cuando sumamos... las pequeñas cosas"
No full textRelato corto sobre las vivencias de una enfermera imaginaria de Atención Primaria durante la pandemia de la covid-1
The receptor activator of nuclear factor jB ligand receptor leucine-rich repeat-containing G-protein-coupled receptor 4 contributes to parathyroid hormone-induced vascular calcification
No full textBackground. In chronic kidney disease, serum phosphorus (P) elevations stimulate parathyroid hormone (PTH) production, causing severe alterations in the bone–vasculature axis. PTH is the main regulator of the receptor activator of nuclear factor jB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system, which is essential for bone maintenance and also plays an important role in vascular smooth muscle cell (VSMC) calcification. The discovery of a new RANKL receptor, leucine-rich repeat-containing G-proteincoupled receptor 4 (LGR4), which is important for osteoblast differentiation but with an unknown role in vascular calcification (VC), led us to examine the contribution of LGR4 in high P/high PTH–driven VC.
Methods. In vivo studies were conducted in subtotally nephrectomized rats fed a normal or high P diet, with and without parathyroidectomy (PTX). PTX rats were supplemented with PTH(1–34) to achieve physiological serum PTH levels. In vitro studies were performed in rat aortic VSMCs cultured in control medium, calcifying medium (CM) or CM plus 10_7 versus 10_9MPTH.
Results. Rats fed a high P diet had a significantly increased aortic calcium (Ca) content. Similarly, Ca deposition was higher in VSMCs exposed to CM. Both conditions were associated with increased RANKL and LGR4 and decreased OPG aorta expression and were exacerbated by high PTH. Silencing of LGR4 or parathyroid hormone receptor 1 (PTH1R) attenuated the high PTH–driven increases in Ca deposition. Furthermore, PTH1R silencing and pharmacological inhibition of protein kinase A (PKA), but not protein kinase C, prevented the increases in RANKL and LGR4 and decreased OPG. Treatment with PKA agonist corroborated that LGR4 regulation is a PTH/PKA-driven process.
Conclusions. High PTH increases LGR4 and RANKL and decreases OPG expression in the aorta, thereby favouring VC. The hormone’s direct pro-calcifying actions involve PTH1R binding and PKA activation.This study was supported by Instituto de Salud Carlos III (ISCIII)—Fondo de Investigación Sanitaria (FIS 17/00715, FIS16/00637 and FIS 10/00896), Fondo Europeo de Desarrollo Regional (FEDER), Plan de Ciencia, Tecnología e Innovación 2013–2017 y 2018-2022 del Principado de Asturias (GRUPIN14-028, IDI-2018-000152), Fundación Renal Íñigo Álvarez de Toledo and ISCIII Retic REDinREN (RD06/0016/1013, RD12/0021/0023 and RD16/0009/0017 and RD16/0009/0007). Panizo S has been supported by FINBA-REDinREN and IDI-2018- 000152; and Carrillo-López N by GRUPIN14-028 and IDI-2018- 000152, Martinez-Arias L by ISCIII-FINBA (PI16/00637), Alonso-Montes C by ISCIII FINBA-REDinREN and Martín Carro B by ISCIII-FINBA (PI17/00384)
One-pot two-step chemoenzymatic deracemization of allylic alcohols using laccases and alcohol dehydrogenases
No full textA series of enantioenriched (hetero)aromatic secondary allylic alcohols has been synthesized through deracemization of the corresponding racemic mixtures combining a non-selective chemoenzymatic oxidation (laccase from Trametes versicolor and oxy-radical TEMPO) and a stereoselective biocatalyzed reduction (lyophilized cells of E. coli overexpressing an alcohol dehydrogenase, ADH). Both steps were performed in aqueous medium under very mild reaction conditions. After optimization, a sequential one-pot two-step protocol was set up, obtaining the corresponding chiral alcohols in moderate to high conversions (48-95%) and enantiomeric excess (65->99% ee). Depending on the ADH stereopreference, both antipodes from these valuable chiral synthons could be prepared, even at preparative scale (119-178 mg), in a straightforward manner
L'archeologia medievale
Get PDFITALIANO: Dopo un excursus sulle esperienze ottocentesche nel campo di un’archeologia su contesti medievali viene illustrata la più recente evoluzione della disciplina e la sua affermazione come scienza storica. / ENGLISH: A recollection of nineteenth century experiences in the field of medieval archaeology is followed by the presentation of recent development of the discipline as a historical science
La genesi storiografica di un nuovo Kunstlandschaft: l'arte medievale dell'Italia meridionale
Get PDFITALIANO: Nell’articolo si ricostruisce il punto di avvio ottocentesco della storiografia sull’arte medievale dell’Italia meridionale, cioè un vasto territorio, politicamente autonomo rispetto al resto della Penisola, rimasto al margine degli studi specialistici almeno
fino agli anni Trenta del XIX secolo. Si prende in esame in particolar modo la figura di Heinrich Wilhelm Schulz (1808-1855), provando a individuare l’originario contesto di formazione intellettuale e storica, e confrontando le sue indagini storico-artistiche, ma prima di tutto storiche in senso lato, con l’interesse che quel territorio suscitò in Italia e in Europa negli anni a cavallo tra Ottocento e Novecento. / ENGLISH: The article deals with the beginning of historiography on medieval art in Southern Italy during the nineteenth century. This vast territory, which was politically independent from the rest of the Peninsula, remained on the sidelines of specialist studies at least
until the thirties of the nineteenth century. The figure of Heinrich Wilhelm Schulz (1808-1855) is discussed in particular. His intellectual and historical background is
attempted to reconstruct and his art-historical investigations, to be considered historical in a broad sense, are compared to the interest for the South that arose in Italy and Europe between the nineteenth and twentieth centuries
La riedizione dei Rerum italicarum scriptores, "un dovere della nuova Italia". Prime ricerche nel carteggio di Vittorio Fiorini
Get PDFITALIANO: Il saggio è basato su un’ampia analisi (per gli anni 1890-1925 circa) della corrispondenza di Vittorio Fiorini, storico e organizzatore culturale. Esso descrive le discussioni di metodo e i progressi della nuova edizione dei “Rerum italicarum scriptores”, la grande collezione di cronache medievali italiane edita nel Settecento da Ludovico Antonio Muratori. / ENGLISH: The essay is based on an extensive analysis (for the years 1890-1925) of the correspondance network of Vittorio Fiorini, historian and cultural organizer. It describes the discussion of method and the progress of the new edition of “Rerum italicarum scriptores”, the great edition of Italian medieval chronicles published in the XVIIIth century by Ludovico Antonio Muratori