University of Naples Federico II

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    Dall'Archivio civico antico al Museo civico di Padova. Andrea Gloria e la tutela dei monumenta per la storia locale

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    ITALIANO: Il contributo ricostruisce la carriera e l’attività di Andrea Gloria, che per circa mezzo secolo (sino alla fine dell’Ottocento) fu – oltre che docente di Paleografia all’Università di Padova – responsabile delle istituzioni culturali della città di Padova. Tali istituzioni (Museo, Archivio civico antico, Biblioteca Civica, Pinacoteca) presero forma nei primi decenni dell’Ottocento e confluirono poi nel Museo Civico, diretto dal Gloria. / ENGLISH: Il contributo ricostruisce la carriera e l’attività di Andrea Gloria, che per circa mezzo secolo (sino alla fine dell’Ottocento) fu – oltre che docente di Paleografia all’Università di Padova – responsabile delle istituzioni culturali della città di Padova. Tali istituzioni (Museo, Archivio civico antico, Biblioteca Civica, Pinacoteca) presero forma nei primi decenni dell’Ottocento e confluirono poi nel Museo Civico, diretto dal Gloria. The article reconstructs the career and activities of Andrea Gloria, who from around the 1850s to the end of the century was not only lecturer in Paleography at the University of Padua, but also in charge of the cultural institutions of the city. These institutions (the museum, the Archivio civico antico, the civic library, the art gallery) took shape in the early decades of the nineteenth century and were later integrated in the Museo Civico, directed by Andrea Gloria. The article reconstructs the career and activities of Andrea Gloria, who from around the 1850s to the end of the century was not only lecturer in Paleography at the University of Padua, but also in charge of the cultural institutions of the city. These institutions (the museum, the Archivio civico antico, the civic library, the art gallery) took shape in the early decades of the nineteenth century and were later integrated in the Museo Civico, directed by Andrea Gloria

    Tra due patrie. Erudizione a Napoli tra i Borbone e l'Unità (1840-1880)

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    ITALIANO: Il contributo verte sull’erudizione a Napoli tra il 1840 e il 1880. Si parte dal VII Congresso degli scienziati (1845), occasione eccezionale di aggregazione per gli studiosi meridionali, per poi illustrare i luoghi principali del dibattito culturale napoletano: gli archivi cittadini e la Società napoletana di storia patria. / ENGLISH: The article addresses antiquarianism in Naples between 1840 and 1880. It starts from the VII Congress of Scientists (1845), an exceptional gathering opportunity for southern scholars, and then illustrates the main venues for cultural debate in Naples: the city archives and the Società napoletana di storia patria

    Locale e nazionale nell'Italia del lungo Ottocento: cultura storica, organizzazione delle fonti e assetto amministrativo

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    ITALIANO: L’intervento sottolinea il nesso tra erudizione cittadina, organizzazione della cultura e costruzione dello Stato unitario italiano. In particolare l’accento viene posto sulla necessaria problematizzazione del rapporto centro-periferia nella storia italiana, a partire proprio dalla funzione svolta dalle istituzioni culturali locali (in primis biblioteche e archivi) e dalla densità delle reti intellettuali che mettono in comunicazione i diversi territori della Penisola. / ENGLISH: The paper emphasizes the importance of the connection between urban antiquarianism, the organization of culture and the construction of the Italian unitary state. Particular emphasis is placed on the necessary problematization of the center-periphery relationship in Italian history, starting precisely from the role played by local cultural institutions (libraries and archives) and the density of the intellectual networks that connected the various territories of the Italian Peninsula

    The Middle-Class Entrepreneurial Elite in Šibenik and Split (15th Century)

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    The paper explores the entrepreneurial elite of late medieval Šibenik and Split, based on the examples of prominent businessmen in the historical records preserved in the notarial records of the two cities

    La cultura figurativa in Sicilia tra vita pubblica e vita privata

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    I conti in tasca ai notai. Ricerche sul notariato ligure: Genova e Savona (1154-1225)

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    ITALIANO: Le due principali città della Liguria, Genova e Savona, grazie a una situazione conservativa particolarmente fortunata per antichità e consistenza del materiale, costituiscono un eccezionale punto di partenza per cercare di stabilire il reddito effettivo di un notaio nel medioevo. La ricerca è stata condotta su frammenti di registri, editi e inediti, appartenenti a 24 professionisti a partire dal più antico pervenuto (il cartolare di Giovanni scriba del 1154) sino ad arrivare al primo quarto del secolo XIII. Attraverso la rilevazione delle indicazioni relative ai compensi delle diverse tipologie contrattuali si è ricostruita una bozza del tariffario allora esistente. Sulla base di questa bozza è stato possibile calcolare approssimativamente il ricavo annuale e quindi rapportarlo con il “costo della vita” in quegli anni in modo da valutare l’effettivo stato economico di questa categoria professionale, le eventuali modalità di investimento delle somme ricavate dall’attività notarile e la collocazione sociale del notariato. / ENGLISH: Thanks to a particularly fortunate situation in terms of documentary preservation (as concerns both the antiquity and the amount of available material), Liguria’s two chief cities, Genoa and Savona, are an exceptional starting point for an attempt at establishing the actual income of a medieval notary. The research has been conducted on the fragments, both edited and unpublished, of registers belonging to 24 notaries, beginning from the oldest surviving cartulary (of Giovanni scriba, 1154) up to those dating from the first quarter of the thirteenth century. By collecting references to fees paid for different types of contracts it has been possible to reconstruct a draft of a “price list”. This draft has been used as a basis to calculate an approximate income. A comparison of this data with the “cost of living” during this period allows to evaluate the economic status of this professional category, the way notaries invested their incomes, and their social status

    Dominae in claustro: San Zaccaria tra politica, società e religione nella Venezia altomedievale

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    ITALIANO: Attraverso il confronto con gli altri monasteri femminili e maschili esistenti in laguna negli stessi secoli, il presente intervento indaga il ruolo rivestito dal cenobio femminile di San Zaccaria all’interno delle vicende politiche, sociali e religiose del dogado veneziano nei secoli cruciali dell’alto medioevo. L’analisi evidenzia da un lato l’esistenza di una chiara scansione cronologica entro la quale la comunità monastica esplica in maniera più o meno incisiva una funzione di rappresentanza dapprima della famiglia dogale poi della città stessa, dall’altro in che misura tale funzione sia determinata da vicende esterne al dogado o da elementi interni al monastero stesso. / ENGLISH: This paper analyses the role played by the female religious community of San Zaccaria in the political, social and religious context of the Venetian Dogado during the Early Middle Ages. On the one hand, by comparing the convent with the other Venetian male and female monasteries, the study clarifies that the community exercised a more or less incisive role in representing first the doge’s family, then the entire city, during a specific timeframe. On the other hand, the analysis reveals to what extent the functions the monastery exercised were influenced by events external to the Dogado or by developments within San Zaccaria itself

    Il poeta Francesco Arrigoni: per un profilo biografico e culturale

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    Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment

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    Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. Here we show that this lysine is massively hyperacetylated in peripheral neutrophils. Genome-wide mapping of H4K16ac in terminally differentiated blood cells, along with functional experiments, supported a role for this histone post-translational modification in the regulation of cell differentiation and apoptosis in the hematopoietic system. Furthermore, in neutrophils, H4K16ac was enriched at specific DNA repeats. These DNA regions presented an accessible chromatin conformation and were associated with the cleavage sites that generate the 50 kb DNA fragments during the first stages of programmed cell death. Our results thus suggest that H4K16ac plays a dual role in myeloid cells as it not only regulates differentiation and apoptosis, but it also exhibits a non-canonical structural role in poising chromatin for cleavage at an early stage of neutrophil cell death

    Barley-ss-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition

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    In chronic kidney disease (CKD), hyperphosphatemia-induced inflammation aggravates vascular calcification (VC) by increasing vascular smooth muscle cell (VSMC) osteogenic differentiation, ADAM17-induced renal and vascular injury, and TNFa-induction of neutral-sphingomyelinase2 (nSMase2) to release pro-calcifying exosomes. This study examined anti-inflammatory beta-glucans efficacy at attenuating systemic inflammation in health, and renal and vascular injury favoring VC in hyperphosphatemic CKD. In healthy adults, dietary barley beta-glucans (B beta glucans) reduced leukocyte superoxide production, inflammatory ADAM17, TNF alpha, nSMase2, and pro-aging/pro-inflammatory STING (Stimulator of interferon genes) gene expression without decreasing circulating inflammatory cytokines, except for gamma-interferon. In hyperphosphatemic rat CKD, dietary Bssglucans reduced renal and aortic ADAM17-driven inflammation attenuating CKD-progression (higher GFR and lower serum creatinine, proteinuria, kidney inflammatory infiltration and nSMase2), and TNF alpha-driven increases in aortic nSMase2 and calcium deposition without improving mineral homeostasis. In VSMC, B beta glucans prevented LPS- or uremic serum-induced rapid increases in ADAM17, TNF alpha and nSMase2, and reduced the 13-fold higher calcium deposition induced by prolonged calcifying conditions by inhibiting osteogenic differentiation and increases in nSMase2 through Dectin1-independent actions involving B beta glucans internalization. Thus, dietary B beta glucans inhibit leukocyte superoxide production and leukocyte, renal and aortic ADAM17- and nSMase2 gene expression attenuating systemic inflammation in health, and renal injury and aortic calcification despite hyperphosphatemia in CKD

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