Jurnal Ilmiah Manuntung
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No full textMalay apple (Syzygium malaccense L.) is a plant that can be used for treatment. Antioxidants have the activity to reduce free radical compounds which is one of the causes of the emergence of various diseases in humans. The purpose of this study to determine the comparison of methods of maceration and socletation extraction of antioxidant activity of malay apple leaf. Research stages include sampling, plant determination, making of simplisia, maceration extraction and socletation with 70% ethanol solvent and determine the antioxidant activity by UV-Vis spectrophotometry with DPPH (1,1-diphenyl-2-picrylhydrazyl) as free radical. The parameter is IC50 value that is the concentration of antioxidant compound which can cause 50% loss of DPPH free radical activity. Although both methods show very strong antioxidant activity, it can be concluded that the difference in extraction methods has an effect on the antioxidant activity produced. The results of antioxidant activity test showed that socletation methods gave an average IC50 value of 37.67 ppm, this value is higher than maceration methods with an average IC50 value of 47.80 ppm. Malay apple leaf has the potential as a natural antioxidant, although it has a lower IC50 value than vitamin C which is 9.72 ppm
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN ASUPAN SERAT PENDERITA DM DI POLI PENYAKIT DALAM RSUD Dr. Hi. ABDUL MOELOEK PROVINSI LAMPUNG TAHUN 2014
Get PDFIndonesia is now facing degenerative diseases such as diabetes. From previous studies found fiber intake patients with DM is still much less than that recommended, while the fiber is very useful to control blood sugar levels in diabetic patient. The purpose of this study was to determine the factors associated with fiber intake in patients with diabetes mellitus disease in internist clinic Dr H. Abdul Moeloek Hospital Lampung 2014? The experiment was used analytic research by cross sectional approach, a sample of 48 respondents. Data were analyzed by univariate and bivariate. The study concluded the most respondents: (1) age 46-65 years 66.7%; (2) 70.8% of the female sex; (3) sufficient knowledge of fiber 56.2% (4) never received nutritional counseling; (7) 85.4% less fiber intake. From the results of the bivariate analysis found no relationship between gender, knowledge, attitudes, education, and nutrition counseling with fiber intake respondents. Relative levels for respondents with knowledge and attitude toward less fiber, and fiber intake respondents are less good then advice the authors need to increase cooperation between the clinic personnel in order to refer all patients with DM to nutrition clinic in order to obtain nutritional counseling. Other suggestions in order to do further research to find out why fiber intake of diabetic patients are still lacking, and the study of other factors such as psychological, social culture, physical state, and the state of nutrition associated with fiber intake in diabetic patien
FORMULASI EKSTRAK ETANOL GAMBIR (Uncaria gambir Roxb.) DALAM BEDAK ANTI JERAWAT
Get PDFAcne occurs due to blockage of pilosebaseus (oil glands) and inflammation causing by Propionibacterium acne, Staphylococcus epidermidis and Staphylococcus aureus. The purpose of the study was to test the antibacterial activity of gambir (Uncaria gambier Roxb.) ethanol extract toward Staphylococcus epidermidis and to formulate gambir ethanol extract into a loose powder dosage form that meets the standards of physical powder quality. Gambir was macerated with 95% ethanol. Activity of gambir ethanol extract against Staphylococcus epidermidis was tested by diffusion method using varying concentrations 3%, 6% and 9% of gambir etanol extract. Afterward, gambir ethanol extract formulated into powder. Analyze of powder physical properties including organoleptic test, homogeneity and particle size distribution. The results showed gambirethanol extract 3%, 6%, 9% has inhibition zone diameter 3.6 mm, 4.2 mm, and 6.8 mm respectively. Gambir ethanol extract powder has a homogeneous, fine size with a light brown color and a distinctive gambir aroma. The average particle size of the powder is 236.17 μ
FORMULASI GELHAND SANITIZER DARI KITOSAN DENGAN BASIS NATRIUM KARBOKSIMETILSELULOSA
Get PDFChitosan has been widely used in industrial, food, pharmaceuticals and agriculture. Chitosan is a natural biocompatible polymers means that as nature does not have the side effect, non-toxic, can not be easily digested and broken down by microbes (biodegradable). This study aims to determine whether the chitosan may be formulated into dosage gel hand sanitizer that meets the requirements of the physical stability of the gel.Chitosan is formulated with 3 varying concentrations of Na CMC basis of 3%, 4.5% and 6%. Tests conducted gel formulation is the physical stability test which includes organoleptic test, homogeneity, pH test, test dispersive power, viscosity test and test consistency. Testing is done every week for 4 weeks of storage.Results of testing physical properties of chitosan gel hand sanitizer has the shape and color stable but the resulting aroma change during storage. pH gel meet the requirements, the consistency test of phase separation does not occur, the homogeneity test showed no homogeneous gel, gel dispersive power does not meet the requirements, the viscosity of the gel preparation third formula does not meet the requirements of viscosity ge
OPTIMASI FORMULA MATRIKS KITOSAN DENGAN METILSELULOSA PADA PELEPASAN TERKENDALI SEDIAAN GRANUL TEOFILIN
Get PDFThe in vitro study was carried out on the release of active ingradient theophylline from granules prepared by moist granulation method. The granule matrix was prepared from the mixture of chitosan isolated from SwaIIo shrimp (Metapenaeus monoceros) (in accordance with the Protan Laboratories, Inc standard requirement) and methylceliuiose 1500 cps. The granules were filled into 850 mg capsules containing 200 mg theophylline. The maximum weight of chitosan and methylcellulose for each capsule was determined by factorial design 22.The result showed that, when the amount of chitosan was kept constant, an increase in the amount of methylcellulose will increase the release rate of theophylline from granules. The optimum weight of chitosan and methyIceIIuIose are 609.24 mg and 20.00 mg, respectively for one capsule
PERBANDINGAN PELARUT ETANOL DAN AIR PADA PEMBUATAN EKSTRAK UMBI BAWANG TIWAI (Eleutherine americana Merr) MENGGUNAKAN METODE MASERASI
Get PDFBawang tiwai (Eleutherine americana Merr) is one kind of medicinal plant. To obtain an active substances with good physical and chemical properties, it is needs to do optimization of making extracts, one with solvent optimization. Type of solvent will determine the types of extracted substances in accordance with the polarity. On this research, extraction of bawang tiwai bulbs simplicia by maceration method using ethanol and water as solvent. This research is an experimental research with varying ethanol and water in a three comparison solvent that is water, ethanol, and mixture of water-etanol, then the yields is calculated. Furthermore, the data were analyzed statistically using ANOVA program to determine significant differences in the three yields. In each extract was conducted phytochemical screening to determine the content of secondary metabolites. The results showed significant differences in the yield of bawang tiwai extract with three treatments and two repetitions. The results of average yields using water as solvent is 8.75%, ethanol 5.3%; and water-etanol 8.31
EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) MENURUNKAN KADAR GULA DARAH MENCIT DIABETES
Get PDFDiabetes mellitus is one of desease that have a large population and trend to increase. sulfonylurea and biguanide are almost used treatment but have unexpected side effects. The research still necessary to seek alternative medicine, such as Piper crocatum.This study aimed to determine the effect of ethanol extract of red betel leaves on blood sugar levels and body weight of mice (Mus musculus L.) diabetes. This riset was started to produce simplicia and drilled become powders, continued extract with 70% ethanol. The extract was evaporated with rotary evaporator until obtaine crude extract. And then screen it that determine phytochemical. To continued test on tolerance of level of glucose then mice diabetes induced aloxan.In summary, extract of red betle ethanolic has contained alkaloid, quercetin flavonoid, steroid and fenolic compounds and decreased level of glucose in blood mice diabetes. Besides, it can reduce lose of weight symptom
UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN KEREHAU (Callicarpa longifolia Lam.) TERHADAP MENCIT PUTIH
Get PDFLeaves kerehau (Callicarpa longifolia Lam.) is one of the plants used for the treatment of malaria, ulcers, diarrhea, treatment after delivery, and fever, by drinking boiled water. Report usage and security kerehau leaves are still very few. The purpose of this study to determine the potential for acute toxicity by determining the value of LD50 (Lethal Dose 50) in 4 dose-rise that dose I, II, III, and IV of the ethanol extract of the leaves kerehau against this mice. The Research. Pharmacologically using experimental methods using a completely randomized design pattern is undirectional in the selection of test animals, They are 25 mice were divided into five groups (5 mice each group), with observed 4 hours to determine the toxic symptoms and continued observation every 24 hours for 7 days to see death. Results from this study show from 4 dose levels, dose group I = 16g / kg, group II = 8g / kg, group III = 4g / kg and group IV = 2g / kg and control = 0.5 ml Na-CMC. Symptoms namely the observation of behavior and neuromuscular but not on observations of the autonomic nervous, respiratory, gastrointestinal, and skin. LD50 value obtained is expressed by the LD50 (16g / kg) were categorized as practically non-toxic (> 15g / kg
HUBUNGAN PEMBERIAN SUPLEMEN ZAT BESI (FE) PADA IBU HAMIL DENGAN BERAT BADAN LAHIR RENDAH (BBLR) DI RSUD ABDUL WAHAB SJAHRANIE SAMARINDA
Get PDFBabies of low birth weight is a baby who weighed less than 2500 grams. Low birth weight is caused by several factors i.e. a premature birth, small size baby, and IUGR (intra-uterine growth retardation). The purpose of this study was to determine the correlation between supplemental iron (Fe) in pregnant women and low birth weight. The design research is quantitative method with Case Control approach using 116 samples from 58 cases and 58 control groups with a ratio of 1:1 for both sexes. The sampling method is purposive Sampling. Dana analyzed using Chi Square correlation test with CI 95% at value of α of 5%. The results showed that there was a correlations between supplemental Fe in pregnant women (ρ value = 0,001 with OR = 8.25) with low birth weight. To reduce the high incidence of low birth weight, pregnant women are suggested to take Fe supplements or taking high content Fe meal everyday
OPTIMASI FORMULA EKSTRAK JAHE MERAH (Zingiber officinale) DENGAN METODE KEMPA LANGSUNG MENGGUNAKAN ANALISIS SIMPLEX LATTICE DESIGN
Get PDFProcessing of medicinal plants into the appropriate dosage form can ensure security during use. It is a motivation in making acceptable dosage form which is easy and convenient to use, especially the manufacture of ethanol extract red ginger tablets using a combination of starch 1500 and amprotab.The study begins with the manufacture of dry extract of red ginger. Optimization of making tablets using a combination of starch 1500 and disintegrator with simplex lattice design using three formulas is done by direct compaction method. Further testing on the tablet hardness, friability and disintegration time.The results showed starch 1500 has a greater influence increase hardness and disintegration time of tablets, as well as lowering the fragility of the tablet. While the interaction of starch 1500 and disintegrator has no effect on the physical tablet. The optimum proportion of the combination of starch 1500 and disintegrator meet the physical requirements of tablets with a ratio of 4: 6 with 7.99 kg hardness, the friability of 0.32% and disintegration time of 2.42 minute