Jurnal Ilmiah Manuntung
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No full textSGPT and SGOT activity from ethanol extract of cakar setan root (Martynia annua L) was investigated. Phytochemical screening was carried out on ethanol extract of cakar setan root (Martynia annua L). The animals were grouped into five groups which consist of 5 rats for each group. The normal/healthy group was only given food and drink the negative control group was given an aqueous suspension of 1 % CMC , the positif control group was given tablets Curcuma at a dose of 200 mg/Kg BB, the group ethanol extract Martynia annua L were each given extract at a dose of 200 mg/Kg BB and 400 mg/Kg BB. All groups were treated for 21 days orally. On day 22 were given injection of CCl4 1.0 mL/kg intraperitoneally except healthy group. The rats blood was taken and analyzed through eye orbitalis sinus AST and ALT activities. The result were statistically analyzed using One Way ANOVA test followed by LSD test. Phytochemical screening ethanolic extract of Martynia annua L root positively contains flavonoids, alkaloids, tannin, phenolic, and terpenoids. The result study that ethanol extract of cakar setan root (Martynia annua L) has hepatoprotective effect of being able to reduce activities of SGPT and SGOT in CCl4 induce white rats
No full textThis study aimed to test the anti-inflammatory effect of ethyl acetate fraction of akway bark (Drymis piperita) on male mice (Hundred norvegicus) and look at pain responses in test animals. The use of akway bark by the local community by boiling and boiling water is then drunk, there are also local people who directly use by chewing. Akway bark anti-inflammatory test and pain response to male rats with a test sample concentration of 200 mg/kg. The method to be used in the study for anti-inflammatory test of akway bark is by the formation of artificial inflammation in the soles of the left foot of male rats while the pain response method uses the Tail flick Method. The test animals were made in 3 groups in each test with a total of 5 heads per group. Group 1 was given positive control (anti-inflammatory testing using mefenamic acid, while pain response test using Na Diclofenac), group 2 was given negative control (CMC) and and group 3 was given a test solution. The test results showed anti-inflammatory activity of ethyl acetate fraction of the skin had anti-inflammatory activity with a percent anti-inflammatory power of 48.47%, while percent pain resistance of ethyl acetate fraction of the bark akway by 33.02%
No full textThe content of marine algae Sargassum hystrix includes polysaccharides (alginates), polyphenols, proteins, peptides, amino acids, lipids, minerals, and several vitamins. However, the use of natural ingredients has limitations, namely that it often fails in the clinical phase due to low bioavailability. One effort that can be done to overcome this problem is to formulate nanoparticles using chitosan polymer and sodium tri-polyphosphate. This study aims to formulate nanoparticles from the methanol extract of Sargassum hystrix with various chitosan concentration ratios. The methanol extract of Sargassum hystrix was obtained by extraction using the maceration method with 50% methanol as a solvent. The results of the extract were made colloidal nanoparticles using ionic gelation techniques using a variation of the methanol extract of Sargassum hystrix: chitosan: NaTPP: Tween 80, Formulation 1 (0.75 gram: 0.1% 18 mL: 0.1% 9 mL: 0.5% 3 mL); Formulation 2 (0.75 gram: 0.2% 18 mL: 0.2% 9 mL: 0.5% 3 mL); Formulation 3 (0.75 gram: 0.1% 18 mL: 0.2% 9 mL: 0.5% 3 mL); Formulation 4 (0.75 gram: 0.2% 18 mL: 0.1% 9 mL: 0.5% 3 mL). The nanoparticle colloids formed were characterized by particle size (nm), and the zeta potential (mV), Formula 1 (212.65 ± 45.32; -11.4 ± 5.65), Formula 2 (514.55 ± 56.35; -8.85 ± 1.34), Formula 3 (219.35 ± 43.76; -14.5 ± 1.83), Formula 4 (326.5 ± 3.39; -1.25 ± 17.88). All formulas show that they can form nanoparticle formulas between 1-1000 nm., But the preparation that will be more stable is formula 3 because it has a zeta potential that is close to +/- 30 mV
No full textThere are some relationships between cognitive impairment with elevation of triglycerides and reduction of leptin concentration in elderly. The elevation of serum triglycerides concentration leads to leptin resistance resulting in impairment of leptin ability to cross blood brain barrier and decrease leptin concentration in brain. The aim of this study is to determine the correlation between triglycerides serum concentration towards leptin concentration in elderly with cognitive impairment. This was a cross sectional study conducted at Neurology Clinic Dr. M. Djamil Hospital. Cognitive function was assessed by using MoCA-Ina, concentration of triglycerides was measured by using enzymatic GPO-PAP method and concentration of leptin was measured by using ELISA. The correlation between two variables was analyzed by using Mann-Whitney test and correlation between triglycerides concentration with leptin was analyzed by using Spearman test. The p value ≤ 0.05 was statistically significant. There are mean triglycerides differences between elderly groups with cognitive impairment (160 (54 – 397)) and elderly groups with normal cognitive function (107 (53 – 249)) with p= 0.005. There are no leptin concentration differences between elderly with cognitive impairment (8,6 (0,96-36,92)) and elderly with normal cognitive function (11,73 (0,71 -36,66 )) with p= 0.45. There are negative correlations between triglycerides concentration with leptin concentration in groups with cognitive impairment, but the correlation is weak (r=0,347, p=0,134). There is negative correlation between triglycerides concentration with cognitive function. There is no correlation between leptin concentration in elderly with cognitive impairment
No full textCandlenut (Aleurites Moluccana (L.) Willd) is a plant commodity that has the potential to be developed. Candlenut processing also varies, one of which is that candlenut oil can be made and then its benefits can be taken. In making the candlenut oil, it uses the oil press method with a press machine that has previously been roasted using black sand or white sand media. The characteristics of the candlenut oil include yield and acid number. The yield of hazelnut oil on black sand is 47.55% and on white sand is 46.80%. And the results of the acid number on black sand are 1.8% while on white sand is 2.1%. Based on these results, it can be concluded that the use of black sand and white sand as a roasting medium affects the yield characteristics and acid number of candlenut oil
No full textHarendong fruit (Melastoma affine D. Don) is empirically used by the community in the Mount Ciremai National Park as an anti-diarrheal medicine. Based on the results of research conducted by Safitri, et al, it is known that the extract of raw harendong fruit contains flavonoid and phenolic compound. Phenolic compound that is commonly found in fruit is tannin. Additionally, based on the literature, tannin has been proven to be useful as anti-diarrheal while flavonoid is useful as anti-bacterial. This study aims at determining the activity of harendong fruit extract syrup as anti-diarrheal in mice (Mus musculus L.). The research method in this study is carried out by giving oleum ricini as an anti-diarrheal inducer compared to positive control (loperamid HCl 11 mg / kg bw suspension) and negative control (Na CMC suspension). The harendong fruit lyophilisate syrup is made with different concentrations, namely 0.5%, 1% and 1.5%. Evaluation of the anti-diarrheal effect includes consistency of slimy / watery stools, soft and normal stools (including water absorption diameter, time of occurrence of diarrhea and stool weight), frequency of diarrhea and duration of diarrhea. The results of the test for the antidiarrheal effect of harendong fruit lyophilisate syrup at a dose of 0.5% has a weaker effect in suppressing the occurrence of diarrhea than the positive control. Then, harendong fruit lyophilisate syrup at a dose of 1% shows almost the same antidiarrheal effect compared to the positive control, while harendong fruit lyophilisate syrup with a dose of 1.5% has a stronger effect in suppressing the occurrence of diarrhea than the positive control
No full textAmbon banana peel contains flavonoid chemical compounds that can moisturize facial skin. Flavonoids are powerful antioxidants. A sheet mask formulation of Ambon banana peel extract that can be used more practically and is able to moisturize facial skin. This study aims to formulate a mask sheet preparation containing ethanol extract of Ambon banana peel as well as better skin maintenance for four weeks of treatment and measuring the moisture content of the skin. The research method used is an experimental method, namely the extract is obtained using the maceration method, then formulated into a sheet mask preparation, consisting of glycerin, butylene glycol, sodium polyacrylate, nipagin, PEG-40 Hydrogenated Castrol oil, aquadest, perfume, and banana peel ethanol extract. Ambon with concentrations of F1 (1%), F2 (3%), F3 (5%), F4 (7%), F5 (9%), respectively. As blank (F0) sheet mask preparation without the addition of extract. The preparation is evaluated including homogeneity test, pH test, stability test, irritation test, Moisture effectiveness test using Moisture Checker and preference test. The treatment is carried out for 4 weeks by applying the mask twice a week. Data obtained from the analysis using the SPSS program. The results showed that the ethanol extract of Ambon banana peel can be formulated in a homogeneous sheet mask preparation, does not change color and remains stable in 4 weeks of storage with a pH of 4.6 - 6.6. Conclusion The ethanol extract of Ambon banana peel can be formulated into sheet masks with concentrations of 1%, 3%, 5%, 7% and 9% with a positive control ratio
No full textSenggugu leaf (Cloredendrom serratum[L.]Spr.) is one of the natural ingredients that has a pharmacological effect in overcoming cancer since it contains flavonoid componds that prevents the development of cancer cells. However, the application of senggugu leaf extract through oral is not acceptable. Therefore, it requires the development of SNEDDS (Self- Nanoemulsifying Drug Delevery Sytem). Objectives: This study aims to formulate SNEDDS of senggugu leaf extract by using tween 80 surfactant and PEG 400 cosurfactane and Virgin Coconut Oil Phase in order for the optimal SNEDDS character to be obtained. Before making the DX 12 formula, a formula trial was made to determine the lower an upper values of each component. After that, a formula was made bases on the DX12. In order to make the optimal formula characterization, it is carried out of the optimal formula of SNEDDS, including particle size, zeta potential, and nanoemulsion stability in the artificial digestive system for 4 hours. The optimal characteristics that have been obtained has a transmitance percentage of 97,99±0,39 % within the emulsification time of 23,57 ±1,06 seconds, a droplet size of 12,5 ±0,436 nm, a polidispersity index of 0,320±0,005, a zeta potensial value of -30,6 ± 0,3 mV, and a stable nanoemulsion formed in the artifical disgetive tract. The results showed that the proportion of VCO 10,55%, tween 68%, and 21,45% PEG400 and 200 mg/mL extract was able to form a good formula for senggugu leaf extract SNEDDS
No full textThe corona virus which infects humans in almost all corners of the world changes new habits in human life. One of the highly recommended habits is washing your hands with soap. Turi leaves have active substances such as flavonoid compounds and saponins which can be used for making handwash. The purpose of this study was to determine the effectiveness of liquid soap (handwash) from turi leaf extract against Staphylocous aureus bacteria. This research was conducted in the microbiology laboratory of the Harapan Bersama Tegal Polytechnic. Turi leaves were extracted using the maceration method with 95% ethanol solvent, then the extract was made by hand washing soap with 3 formulas. The three formulas were then tested on S. aureus bacteria using the well diffusion method with three replications. The results of this study indicate that formula 1 has a diameter of inhibition of 13.72 ± 0.57mm, formula 2 is 16.36 ± 0.58 mm and formula 3 is 20.36 ± 1.13 mm. Thus it can be concluded that the liquid soap of formula 3 turi leaf extract is the best in inhibiting S.aureus bacteria
No full textCoronary Heart Disease (CHD) is a cardiovascular disease that can caused by the presence of coronary artery plaque blockage. Clopidogrel is one of antiplatelet therapy in CHD patients. CYP2C19 *2 polymorphisms can reduce the effectiveness of clopidogrel active metabolites. This research was conducted at RSUD Sidoarjo East Java from November to December 2017continued monitoring of cardiovascular events to March 2018. The research method used is a method Polymerase Chain Reaction (PCR) and the Light Transmittance Aggregometry (LTA) method for platelet aggregation measurement. From 25 sample inclusion,there are wild type alleles (bp values around 120 bp; 1 patient), homozygous alleles (bp values around 169 bp; 18 patients) and allele heterozygotes (bp values around 120bp, 169bp; 6 patients). The most common type of polymorphism is allele homozygotes. There is one patient hyperaggregation and cardiovascular events after being monitored for 3 months. Analysis relationship between CYP2C19*2 genetic polymorphisms with platelet aggregation and cardiovascular events, using the kruskal wallis test. The result is no significant relationship between CYP2C19*2 polymorphisms with platelet aggregation (p=0.512), as well as cardiovascular events did not make any difference which is also significant (p=0.426). The results of the association of platelet aggregation with cardiovascular events showed significant differences (p=0.027)