Journal of the Medical Sciences (Berkala ilmu Kedokteran)
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Intoleransi terhadap, air susu sapi (milk intolerance)
No full textCow's milk has been recognised as an almost ideal food because it serves as a source of complete nutrients. Unfortunately, there are some people who cannot drink milk (milk intolerance) because lack of lactase.. High frequency of milk intolerance is found in developing or tropical countries and non-Caucasian race. It is a problem for public nutrition in those countries. Lactase is an inducible enzyme. The inductor is lactose, a major carbohydrate in milk. Some studies suggested that milk intolerance was influenced by genetic factors, diet and milk drinking habit. Efforts to overcome milk intolerance by providing low lactose milk had been done, but the result was not yet successful.Key words: protein calori malnutrition - cow's milk - lactase deficiency - milk intoleranc
Culture of lymphocytes with a medium of green coconut juice
No full textThe study was aimed at investigating whether there were any difference on lymphocyte growth in in vitro by using RPMI 1640 and green coconut juice as medium. Lymphocytes were collected from spleen and bone marrow of 8 weeks old albino rats (Rattus norvegicus). Rats were sacrificed, subsequently spleen and bone marrow were taken and prepared for single cell suspension. Cells were counted using vital dye (Tripan biru) at 5x106 cells/ml. Twenty petri dishes were used. Half of them were used for spleen and the rest for bone marrow cell culture. In every group of those cells, petri were divided into two groups. One group used RPMI 1640 and the other a green coconut juice. Every petri dish was filled with 2 ml of suspension in cell media. All of the petri dishes were incubated in the incubator at 37°C, 5% CO2 for seven days. After 48 hours and 72 hours culture cells were examined and the percentage of viable cells was counted. Analysis of the viable cells between lymphocyte culture and bone marrow cells using RPMI .1640 and a green coconut juice was compared using Student's t-test and Anava. The results showed the increase of proliferation of viable cells from lymphocyte culture and bone marrow culture in both media hours were observed an after 72. As conclusion there is no significant difference between the growth of lymphocyte and bone marrow using RPMI 1640 and a green coconut juice (p>0,05).Key words: lymphocytes - cell culture - coconut juice - spleen cells - bone marrow cell
Liver Function Test in Chronic Hemodialyzed Patients with Anti Hepatitis C Virus Antibody
No full textUntuk mengetahui fungsi hepar pada penderita gagal ginjal terminal dengan antibodi terhadap virus hepatitis C (anti HCV) positif yang menjalani hemodialisis, suatu penelitian potohOlintang telah dilakukan di Unit Hemodialisis. Rurnah Sakit Umum Pusat Dr: Sardjito, Yogyakarta.Selama penelitian ditemukan 58 penderita (42 laki-laki. 16 perempuan) dengan 32 (55%).anti HCV positif. Tidak ditemukan perbedaan yang bermakna antara kelompok dengan anti HCV positif dan kelompok dengan anti HCV negatif dalam kadar aspartate amino transferase (AST) (46,22 ± 20,85 UI/1 vs 40,15 ± 20,37 U1/1, p > 0,05), kadar alanine amino transferase (ALT) (45,44 ± 26,26 IU/1 vs 37,04 ± 23,03 U1/1, p > 0,05), kadar alkaline phosphatase (ALP) (156, 31 ± 141,141U/1 vs 144,57 ± 82,15.1y/l, p > 0,05),. dan jumlah hemodialisis (8 sampai dengan 733 kali). Kadar AST yang rneningkat di afas 1,5 kali nilai normal cenderung ditemukan lebih besar tapi secara statistik tidak signifikan pada kelompok dengan anti HCV positif dibanding dengan kelompok dengan anti HCV negatif (56.0% vs 30,7%, p > 0,05) yang mungkin akibat jumlah sampel yang kecil. Frekuensi transfusi ditemukan lebih tinggi secara bermakna pada kelompok dengan anti HCV positif dibanding kelompok dengan anti HCV negatif (3,53 ± 3,47 vs 2,23 ± 1,47 kali, p < 0,05).Key Words : hepatitis C virus-anti HCV antibodies -end stage renal disease-blood transfusion- hemodialysi
Disproportional changes of glucose, lactic acid and haemoglobin level as parameters for physical performance test
No full textLevels of blood Hb, glucose and lactic acid were estimated two times to 49 athletes of badminton and tennis (13-27 years old). The estimations were done before and after physical performance test. The loads of physical performance test for the subjects were different to each other, depending on their capacities. The changes of Hb concentration were used to correct the changes of glucose and lactic acid concentrations due to the changes of blood volume. The Hb concentrations of 35 subjects increased and the rest of 14 decreased; they were called group A (n=35) and group B (n=14) respectively. When blood glucose concentrations were observed from group A, 24 of them decreased (group At) while the remaining 11 increased. After it had been adjusted to the changes of blood volume, the blood glucose concentration of 4 among the 11 persons (group A2) became lower, while the other 7 subjects remained high (group A3). Blood glucose concentrations of group B increased even after adjusted to the changes of blood volume. The lactic acid concentrations of all subjects also increased after adjusted to the changes of blood volume.Key words: athletes blood haemoglobin glucose lactic acid physical performanc
Insulin receptor and insulin resistance in type -2 diabetes
No full textResistance to the glucoregulatory effects of insulin is well-documented in type -2, non-insulindependent diabetes. Two separate factors may contribute in the pathogenesis, namely the obesity-related and the non-obesity-related.Obesity-related insulin resistance is associated with hyperinsulinemia, reduced numbers of insulin receptors on target cells. The mechanism by which the insulin receptor number is decreaSed is not clearly understood. This phenomenon is called "down regulation". If the defect in glucose transport can not be overcome at any insulin concentration, insulin unresponsiveness is present. This is caused by unidentified abnormalities distal to the receptor, "postreceptor defect".In non-obesity-related, a-cell dysfunction, secretion of abnormal insulin, failure to convert proinsulin to insulin, or hormonal antagonist to insulin, is thought to be responsible for the resistance.Key Words: type -2 diabetes mellitus - insulin receptor - insulin resistance - insulin antagonist - obesity-related and non-obesity-related factor
Management of premature rupture of the membrane
No full textA literature study on the management of premature rupture of the membrane (PROM) is carried out to find out the best method and its impact on maternal and neonatal morbidity.PROM is defined as rupture of the fetal membrane before the onset of true labor. The incidence of PROM varies from 0,7 to 10%. Premature labor and its consequences to the newborn as well as maternal and neonatal infections are complications attributed to early rupture of the membrane.Conservative management for PROM before 37 weeks of gestation is a method used by most obstetricians. Patients should be staying in bed as long as the amniotic fluid is still coming out, no vaginal examination performed, and she should be closedly monitored for signs of infection and prophylac tic antibiotics given. Once the signs of i nfection develop, termination of pregnancy should be carried out and massive antibiotics should be given. Risk of infection becomes evident if rupture of the membrane goes beyond 12 to 24 hours so that prophylactic antibiotics should be given before 12 hours of rupture. Most of the cases will go to labor before 48 hours, although in some cases labor can be postponed for 19, 33, 39, 44, and 55 days. If labor can be postponed for more than 48 hours, the risk of suffering From respiratory distress syndrome (RDS) in neonates is getting lower.The management of premature rupture of the membrane after 37 weeks of gestation depends on the condition of the cervix. Patients with ripe cervix can be induced immediately, but patients with unripe cervix should be managed conservatively.Key Words: PROM - RDS - prophylactic antibiotics - perinatal mortality - maternal infectio
Medical Biotechnology : Its Impact on Society's
No full textKarangan ini memberi pandangan bioanthropologis tentang dampak sosial bioteknologi medis. Dimulai dengan definisi bioteknologi dalam arti luas dan sempit, lalu diteruskan dengan tinjauan tentangcara, balk yang modern maupun yang tradisional, kemudian diakhiri dengan uraian tentang dampak biososial, ekologis, evolusioner, demografis, ekonornis, politis, militer, hukum, sosiokultural dan agama, yangdapat men imbulkan perubahan-perubahan mendasar4alam masyarakat dunia.Di antara cara-cara bioteknologi yang disinggung adalah eufenetika, eugenetika, transplantasi dan substitusi organ, genoteknologi dan teknologi reproduksi. Ke dalam yang terakhir termasuk peijodohan terpimpin, pengendalian pembuahan, pembuahan anumerta, dan in vitro, fusi embryo dan pencangkokan nukleus, hybridisasi sel dan klonasi. Di antara cara-cara tradisional dikemukakan system Itasca, pengebirian, pengguguran, infantisida, perjodohan terpimpin dan manipulasi lingkungan.Diingatkan tentang dampak negatif yang merugikan manusia dan ekos-ystemnya, karena alchimya aspekteknologis kehidupan tidal( dapat di pisah kan dari aspek-aspek politis,sosial dan ethis.Key Words: biotechnology - euphenics - eugenics - reproductive technology -- guided matin
