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Las células senescentes como factores patogénicos y posibles dianas terapéuticas en osteoporosis
Get PDFCellular senescence is a process induced by various types of stress that irreversibly cause cell cycle arrest and changes to the characteristics and functionality of cells, as well as the acquisition of a secretory phenotype that generates a pro-in-flammatory environment. While, in certain contexts, it is beneficial for tissues and promotes organism development, senes-cence is a cellular fate implicated in the process of aging and age-related degenerative conditions. Senolytics are drugs that specifically eliminate senescent cells, and senomorphics are drugs that suppress their senescence-associated secretory phenotype (SASP) without inducing cell death. Therefore, therapeutic strategies targeting senescent cells (senolytics and senomorphics) as an underlying mechanism of aging emerge as an alternative with great potential to fight age-related diseases as a whole rather than individually. One of these conditions is osteoporosis where it has been experimentally described that drugs such as zoledronic acid have effects on preosteoblasts and act on senescent cells extending survival and opening up the possibility of treating age-related diseases with drugs already used in practice, which may have effects beyond the bone itself and increase overall survival. In this study, a review will be conducted in this rapidly growing field in recent years of undeniable translational interest.Instituto de Investigación Sanitaria del Principado de Asturias (ISPA
Effects of mass casualty incidents on anxiety, depression and PTSD among doctors and nurses: a systematic review protocol
Get PDFABSTRACT
Introduction Both doctors and nurses showed a greater
risk of being exposed to different mental health conditions
following mass casualties. This systematic review aims
to synthesise the existing evidence on the prevalence of
anxiety, depression and post-traumatic
stress disorder and
their associated risk factors among doctors and nurses
following mass casualty incidents.
Methods and analysis Seven electronic databases
(PubMed, PsycINFO, MEDLINE Ovid, Embase, CINAHL, Web
of Science and Nursing & Allied Health database) will be
searched from 2010 to 2022 with peer-reviewed
articles
in English language using the predefined keywords.
Two reviewers will independently screen the titles and
abstracts, as well as review the full texts using the
eligibility criteria, then extract data independently. The
National Institutes of Health Quality Assessment Tools
(NIH-QAT)
for quantitative studies, the Critical Appraisal
Skills Programme (CASP) Checklist for qualitative studies
and the Mixed-Methods
Appraisal Tool (MMAT) for mixed-method
studies will be used to measure the quality
appraisal of eligible studies. A third reviewer will resolve
the discrepancies when the two reviewers cannot reach an
agreement in any step. The result from the eligible studies
will be described following narrative synthesis with the key
characteristics and findings of the included studies, and
meta-analysis
will be performed, if applicable.
Ethics and dissemination This systematic review deals
with existing published studies without any personally
identifiable information of participants. Therefore, ethical
approval from the research committee is not required.
Findings from this review will be disseminated in peer-reviewed
journals and presented at relevant international
conferences.Instituto de Investigación Sanitaria del Principado de Asturias (ISPA
Hospital Disasters Preparedness for Mass-Casualty Incidents at Emergency Units in Northwest of Ethiopia: A Cross-Sectional Study
Get PDFAbstract
Background: Ethiopian policy and strategy aim to make health care systems capable of
dealing with emergencies. However, Ethiopian health care still lacks a comprehensive
“all-hazard” approach and a disaster preparedness program. Thus, this study aimed to assess
the level of disaster preparedness in selected public hospitals for mass-casualty incidents
(MCIs) in Amhara Regional State, Northwest Ethiopia.
Methods: A descriptive cross-sectional study was conducted at general and comprehensive
specialized hospitals (CSHs) in Amhara Regional State, Ethiopia using a World Health
Organization (WHO) hospital emergency response checklist that included a domain on
mass-casualty management (MCM) adapted from a literature review.
Results: Seventeen (17) hospitals were evaluated (response rate: 81%). Five (29.4%) were
teaching hospitals (tertiary health care) and 12 (70.5%) were non-teaching (secondary health
care) hospitals. With an average mean of 97.3 (SD = 33.68; range 31-160), most hospitals
underWHOrequired an Acceptable level of preparedness. Two were at an Unacceptable (0-
67) level of preparedness, 12 (70.5%) hospitals were at an Insufficient (68-134) state, while
the other three had an Acceptable (135-192) level of preparedness.
Conclusion: The preparedness level of hospitals is Insufficient for potential MCIs in this
region and needs prior attention in implementing existing strategic guidelines to develop
and activate hospital disaster plans if and when needed.Instituto de Investigación Sanitaria del Principado de Asturias (ISPA
Role of Crystalline Si and SiC Species in the Performance of Reduced Hybrid C/Si Gels as Anodes for Lithium-Ion Batteries
Get PDFIn recent years, the research around lithium-ion batteries (LIBs) to improve their lifetime, efficiency and energy density has led to the use of silicon-based materials as a promising anode alternative to graphite. Specifically, crystalline silicon (cSi) and silicon carbide (SiC) obtained from deposition or reduction processes (e.g., magnesiothermal reduction) stand out for their electrochemical properties. However, the synthesis routes proposed until now have limitations that make them difficult to afford or operate on a large scale. For this reason, in this work carbon-silicon (C-Si) hybrid materials synthesized through an efficient route, are evaluated as the potential precursor for the obtention of both cSi and SiC species in a single material. The feasibility and influence of the magnesiothermal reduction process were evaluated, and materials with 10 wt.% of reduced Si and 10-26 wt.% of SiC were obtained. Both species show a role in the improvement of the performance of silicon-based materials as anodes in lithium-ion batteries. In comparison with materials obtained by reduction of silica gels and composites, the reduced C-Si hybrid gels stand out thanks to the homogeneous distribution and stability of the species developed
Transition of patients with metabolic bone disease from paediatric to adult healthcare services: current situation and proposals for improvement
Get PDFAbstract
Background There are currently no models for the transition of patients with metabolic bone diseases (MBDs)
from paediatric to adult care. The aim of this project was to analyse information on the experience of physicians
in the transition of these patients in Spain, and to draw up consensus recommendations with the specialists involved
in their treatment and follow-up.
Methods The project was carried out by a group of experts in MBDs and included a systematic review of the literature
for the identification of critical points in the transition process. This was used to develop a questionnaire
with a total of 48 questions that would determine the degree of consensus on: (a) the rationale for a transition
programme and the optimal time for the patient to start the transition process; (b) transition models and plans; (c)
the information that should be specified in the transition plan; and (d) the documentation to be created and the training
required. Recommendations and a practical algorithm were developed using the findings. The project
was endorsed by eight scientific societies.
Results A total of 86 physicians from 53 Spanish hospitals participated. Consensus was reached on 45 of the 48
statements. There was no agreement that the age of 12 years was an appropriate and feasible point at which to initiate
the transition in patients with MBD, nor that a gradual transition model could reasonably be implemented
in their own hospital. According to the participants, the main barriers for successful transition in Spain today are lack
of resources and lack of coordination between paediatric and adult units.
Conclusions The TEAM Project gives an overview of the transition of paediatric MBD patients to adult care in Spain
and provides practical recommendations for its implementation.Instituto de Investigación Sanitaria del Principado de Asturias (ISPA
On the role of continuing currents in lightning-induced fire ignition
Get PDFLightning flashes are an important source of wildfires worldwide, contributing to the emission of trace gases to the atmosphere. Based on experiments and field observations, continuing currents in lightning have since a long time been proposed to play a significant role in the ignition of wildfires. However, simultaneous detections of optical and radio signals from fire-igniting lightning confirming the role of continuing currents in igniting wildfires are rare. In this work, we first analyze the optical signal of the lightning-ignited wildfires reported by the Geostationary Lightning Mapper over the Contiguous United States (CONUS) during the summer of 2018, and we then analyze the optical and the Extremely Low Frequency signal of a confirmed fire-igniting lightning flash in the Swiss Alps. Despite data uncertainties, we found that the probability of ignition of a lightning flash with Continuing Current (CC) lasting more than 10 ms is higher than that of cloud-to-ground lightning in CONUS. Finally, we confirm the existence of a long CC (lasting about 400 ms) associated with a long-lasting optical signal (lasting between 2 and 4 s) of a video-recorded fire-igniting lightning flash
Environmental variables and species traits as drivers of wild bee pollination in intensive agroecosystems—A metabarcoding approach
Get PDFOportunidades en la misión regional de reducción de emisiones y gases de efecto invernadero habilitada por la investigación en tecnologías W3C
Get PDFEl proyecto SLOW se plantea con el objetivo general de diseñar una metodología analítica de estimación
de gases de efecto invernadero (GEI) mediante la investigación y aplicación de tecnologías avanzadas en
un entorno hiper-sensorizado bajo estándares W3CThe SLOW project is conceived with the general objective of designing an analytical methodology for estimating greenhouse gases (GHG) through the research and application of advanced technologies in a hyper-sensorized environment under W3C standards
Serum and Urinary Soluble α-Klotho as Markers of Kidney and Vascular Impairment
Get PDFAbstract: This study was designed to investigate the controversy on the potential role of sKlotho as an early biomarker in Chronic Kidney Disease–Mineral Bone Disorder (CKD-MBD), to assess whether sKlotho is a reliable marker of kidney -Klotho, to deepen the effects of sKlotho on vascular smooth muscle cells (VSMCs) osteogenic differentiation and to evaluate the role of autophagy in this process. Experimental studies were conducted in CKD mice fed a normal phosphorus (CKD+NP) or high phosphorus (CKD+HP) diet for 14 weeks. The patients’ study was performed in CKD stages 2–5 and in vitro studies which used VSMCs exposed to non-calcifying medium or calcifying medium with or without sKlotho. The CKD experimental model showed that the CKD+HP group reached the highest serum PTH, P and FGF23 levels, but the lowest serum and urinary sKlotho levels. In addition, a positive correlation between serum sKlotho and kidney -Klotho was found. CKD mice showed aortic osteogenic differentiation, together with increased autophagy. The human CKD study
showed that the decline in serum sKlotho is previous to the rise in FGF23. In addition, both serum sKlotho and FGF23 levels correlated with kidney function. Finally, in VSMCs, the addition of sKlotho prevented osteogenic differentiation and induced autophagy. It can be concluded that serum sKlotho was the earliest CKD-MBD biomarker, a reliable indicator of kidney -Klotho and that might protect against osteogenic differentiation by increasing autophagy. Nevertheless, further studies are needed to investigate the mechanisms of this possible protective effect.Instituto de Investigación Sanitaria del Principado de Asturias (ISPA
Solución basada en tecnologías blockchain para la trazabilidad de productos de calidad protegida
Get PDFEl proyecto DOPCHAIN se plantea con el objetivo general de desarrollar una solución de trazabilidad
basada en tecnologías Blockchain para mejorar la confianza de los consumidores en los productos
agroalimentarios de calidad protegida.The DOPCHAIN project is conceived with the general objective of developing a traceability solution based on Blockchain technologies to enhance consumer trust in protected quality agri-food products