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Análisis técnico, interpretativo y musical de Thème et variations Op. 73 para piano solo de Gabriel Fauré
Get PDFTrabajo fin de estudiosIn the present work it has been tried, first of all, to establish the importance of Thème
et variations, for Fauré, realizing a biographical and stylistic context as well as its relation with other works by the author. However, the main objective has been to carry out an Analysis stylistic, formal and harmonic combined with an interpretative and pedagogical analysis. Both one as the other, previous studies of a more general nature have been taken into account.
Finally, we have tried to determine the reception and success of this work, the influences received from previous variations, as well as the possible influence of Thème et variations in series later. One of the main conclusions is that, despite its key role in history musical genre, in the long run this work has not had a fair recognition.Conservatorio Superior de Música "Eduardo Martínez Torner"En el presente trabajo se ha pretendido, en primer lugar, establecer la importancia de Thème et variations, para Fauré, realizando un contexto biográfico y estilístico así como su relación con otras obras del autor. Sin embargo, el principal objetivo ha sido realizar un Análisis estilístico, formal y armónico combinado con un análisis interpretativo y pedagógico. Tanto en
uno como otro se han tenido en cuenta estudios previos de carácter más generalista.
Por último, se ha intentado determinar la recepción y éxito de esta obra, las influencias recibidas de variaciones previas, así como la posible influencia de Thème et variations en series posteriores. Una de las principales conclusiones es que, a pesar de su papel clave en la historia musical del género, a largo plazo esta obra no ha tenido un justo reconocimiento
Twitter como herramienta para la historia de la Dermatología
No full textComunicación presentada al IV Seminario de Historia de la Dermatología realizado el 16 de septiembre de 2019 en Lerma, BurgosTwitter as a tool for the history of Dermatology. List of benefits and precautions for use. Examples of its potential.Twitter como herramienta para la historia de la Dermatología. Ventajas y precauciones sobre su utilización. Ejemplos de su potencial
Epigenetics in cancer therapy and nanomedicine
Get PDFThe emergence of nanotechnology applied to medicine has revolutionized the treatment of human cancer. As in the case of classic drugs for the treatment of cancer, epigenetic drugs have evolved in terms of their specificity and efficiency, especially because of the possibility of using more effective transport and delivery systems. The use of nanoparticles (NPs) in oncology management offers promising advantages in terms of the efficacy of cancer treatments, but it is still unclear how these NPs may be affecting the epigenome such that safe routine use is ensured. In this work, we summarize the importance of the epigenetic alterations identified in human cancer, which have led to the appearance of biomarkers or epigenetic drugs in precision medicine, and we describe the transport and release systems of the epigenetic drugs that have been developed to date
The Differential Impact of SRC Expression on the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma
Get PDFAberrant SRC expression and activation is frequently detected in multiple cancers, and hence, targeting SRC has emerged as a promising therapeutic strategy. Different SRC inhibitors have demonstrated potent anti-tumor activity in preclinical models, although they largely lack clinical efficacy as monotherapy in late-stage solid tumors, including head and neck squamous cell carcinomas (HNSCC). Adequate selection and stratification of patients who may respond to and benefit from anti-SRC therapies is therefore needed to guide clinical trials and treatment efficacy. This study investigates the prognostic significance of active SRC expression in a homogeneous cohort of 122 human papillomavirus (HPV)-negative, surgically treated HNSCC patients. Immunohistochemical evaluation of the active form of SRC by means of anti-SRC Clone 28 monoclonal antibody was specifically performed and subsequently correlated with clinical data. The expression of p-SRC (Tyr419), total SRC, and downstream SRC effectors was also analyzed. Our results uncovered striking differences in the prognostic relevance of SRC expression in HNSCC patients depending on the tumor site. Active SRC expression was found to significantly associate with advanced disease stages, presence of lymph node metastasis, and tumor recurrences in patients with laryngeal tumors, but not in the pharyngeal subgroup. Multivariate Cox analysis further revealed active SRC expression as an independent predictor of cancer-specific mortality in patients with laryngeal carcinomas. Concordantly, expression of p-SRC (Tyr419) and the SRC substrates focal adhesion kinase (FAK) and the Arf GTPase-activating protein ASAP1 also showed specific associations with poor prognosis in the larynx. These findings could have important implications in ongoing Src family kinase (SFK)-based clinical trials, as these new criteria could help to improve patient selection and develop biomarker-stratified trials
"Hortus conclusus": tradición y reescritura en la poesía de posguerra de Carmen Conde
Get PDFTe literary work of Carmen Conde (Cartagena, 1907-Madrid,1996) written during the post-war period carried out a profound dialogue aboutthe topos of
locus amoenus
by means of one of the spaces to which it is frequentlyattributed, the garden or
hortus conclusus
, and through one of its main elements,the flower. In poems that appear in
Ansia de la gracia
(1945) and
Iluminada tierra
(1951), the garden and the floral imaginary serve to suggest models of femaleidentity that transgress both the passive image of women portrayed by male au-thors and the national identity imposed on women by the Francoist regime. Myarticle develops a theoretical framework from the perspective of feminist literarycriticism in order to study this rewriting and analyzes texts by Conde that arerepresentative of this rewriting.Programa Severo Ochoa (referencia PA-17-PF-BP16126) de Ayudas predoctorales para la investigación y la docencia del Gobiernodel Principado de AsturiasLa obra de Carmen Conde (Cartagena, 1907-Madrid, 1996) escritaen el período de posguerra establece un profundo diálogo con el tópico del
locusamoenus
a través de uno de los espacios con los que frecuentemente aparece rela-cionado, el jardín u
hortus conclusus
, y de uno de sus elementos constitutivos, laflor. En algunos de los poemas pertenecientes a
Ansia de la gracia
(1945) e
Ilumi-nada tierra
(1951), el jardín y el imaginario floral servirán para plantear modelosde identidad femenina que transgreden tanto la imagen pasiva de la mujer pro-yectada por la literatura patriarcal a través de los tópicos, como la impuesta por elproyecto identitario nacional del Régimen de Franco. En este artículo se elaboraun marco teórico desde la teoría literaria feminista para el estudio de esta reescri-tura y se analizan algunos de los textos de Carmen Conde que son representativosde la mism
Domino Synthesis of Benzo-fused β,γ-Unsaturated Ketones from Alkenylboronic acids and N-Tosylhydrazone-tethered Benzonitriles
Get PDFThe transition-metal-free domino reaction between alkenylboronic acids and N-tosylhydrazones from o-(2-oxoalkyl)- and o-(3-oxoalkyl)benzonitriles leads to β,γ-unsaturated indanones and tetralones featuring an α-“all-carbon” quaternary center. The employment of derivatives of α-substituted cyclopentanones and cyclohexanones led to the stereoselective preparation of β,γ-unsaturated tetrahydrocyclopenta[a]inden-8(1H)-ones, hexahydrofluorenones, and hexahydroanthracenones as cis-fused single stereoisomers. A domino sequence involving diazo compound formation/reductive alkenylation/1,3-borotropic rearrangement/intramolecular bora-aza-ene reaction is proposed to justify the formation of the products as well as the stereoselectivity
Atención de enfermería en pacientes con artritis reumatoide
Get PDFIntroduction and justification. Rheumatoid arthritis is an autoimmune disease of unknown etiology that causes damage to the joints causing symptoms such as joint destruction, pain and swelling. It affects the 0.5% of the Spanish population and its onset is more likely between 40-60 years, especially in women.
Objective. To know the role of nursing in the approach to arthritis rheumatoid and the impact of the disease in affected people.
Method. The literature review has been carried out in electronic databases, repositories, resources based on scientific evidence, catalogues, journals and web pages for associations of both patients and professionals.
Development. Taking into account that this disease don´t have cure, it is essential to act on the modifiable risk factors, symptoms and try to prevent complications. Also, the nurse should carry out group educational interventions that contribute to promoting the correct management of the disease.
Conclusions. The only widely studied and recognized risk factor is tobacco. The nursing intervention is necessary in primary, secondary and tertiary prevention. The studies reviewed about quality of life agree that the physical function is the most affected.Introducción y justificación. La artritis reumatoide es una enfermedad autoinmune de etiología desconocida que origina daño en las articulaciones provocando síntomas como destrucción articular, dolor y tumefacción. Afecta a un 0,5% de la población española siendo más probable su aparición entre los 40-60 años especialmente en mujeres.
Objetivo. Conocer la actuación de enfermería en el abordaje de la artritis reumatoide y el impacto de la enfermedad en los afectados.
Método. Se ha llevado a cabo la revisión bibliográfica a partir de bases de datos electrónicas, repositorios, recursos basados en evidencias científicas, catálogos, revistas y páginas web de asociaciones de pacientes y profesionales.
Desarrollo. Al tratarse de una enfermedad crónica y degenerativa que no tiene cura es imprescindible actuar sobre los factores de riesgo modificables así como, ante sus síntomas e intentar prevenir complicaciones. La enfermera también debe llevar a cabo las intervenciones educativas que contribuyan a fomentar el correcto manejo de la enfermedad.
Conclusiones. El único factor de riesgo ampliamente estudiado y reconocido es el tabaco. La intervención enfermera es necesaria en prevención primaria, secundaria y terciaria. Los estudios revisados acerca de calidad de vida coinciden en que la función física es la más afectada
Hemorragia postparto. Hospital Universitario Central de Asturias
Get PDFProtocolo del Servicio de Obstetricia y Ginecología el HUCA. Área Sanitaria I
Guía de manejo clínico de la paciente con historia de abortos de repetición. Hospital Universitario Central de Asturias
Get PDFProtocolo del Servicio de Obstetricia y Ginecología el HUCA. Área Sanitaria I
