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Bibliografía científica. Anexo 2022
No full textBibliografía que contiene la producción científica publicada por el personal investigador y colaborador del SERIDA a lo largo del año 2022 en revistas incluidas en la Web of Science. Está ordenada alfabéticamente por el primer autor, e incluye además un abstract del contenido del artículo referenciado, además de un índice alfabético de los autores pertenecientes al SERIDA , de los títulos de las revistas en las que aparecen publicados los artículos con indicación de su factor de impacto, y un índice de los artículos segun el área de investigación del SERIDA a la que se encuentran adscritos los investigadores. El repertorio se completa también con una serie de gráficos
A comparison of live versus kill pitfall traps to assess the diet of carabids through a metabarcoding approach
Get PDFInforme técnico final (Programa Asturias) Proyecto I+D+i
No full textSe desarrolla una metodología para la obtención de una preparación alimenticia, análoga organolépticamente a un producto de origen animal, elaborada con proteína texturizada húmeda de guisante como ingrediente vegetal, y caracterizado por sus propiedades nutricionales en cuanto al contenido en proteína y omega 3.Fondos FEDER, FICYT, Gobierno del Principado de Asturia
Oportunidades en la misión regional de longevidad y envejecimiento activo habilitadas por la investigación en Inteligencia Artificial
Get PDFEl proyecto SENIOR.IA se plantea con el objetivo general de promover una longevidad saludable, abordando diferentes retos que actualmente limitan esta meta, aplicando para ello técnicas avanzadas de Inteligencia Artificial (IA) sobre conjuntos de datos poblacionales existentes que aporten evidencias para la prevención bajo un enfoque de medicina personalizada de precisión.The SENIOR.IA project is conceived with the overarching goal of promoting healthy longevity, addressing various challenges that currently hinder this goal by applying advanced Artificial Intelligence (AI) techniques to existing population datasets, providing evidence for prevention under a precision personalized medicine approach
Plan de Acción de Gobierno Abierto 2022-2023 (Presentación)
Get PDFEl pasado mes de mayo de 2022, el Principado de Asturias se incorporó a la Alianza para el Gobierno Abierto Local (OGP, por las siglas del inglés Open Government Partnership), una organización que incluye a más de un centenar de gobiernos de todo el mundo que trabajan con organizaciones de la sociedad civil para promover la transparencia y la rendición de cuentas e impulsar una gestión pública participativa, inclusiva y responsable.
Formar parte de esta alianza internacional supone la renovación del compromiso de esta administración para
seguir avanzando en materia de gobernanza pública, con el firme propósito de ser cada vez más transparente,
colaborativa, participativa, ética y con una clara vocación de rendición de cuentas a la ciudadanía
Sudden-Onset Disaster Mass-Casualty Incident Response: A Modified Delphi Study on Triage, Prehospital Life Support, and Processes
Get PDFAbstract
The application and provision of prehospital care in disasters and mass-casualty incident response in Europe is currently being explored for opportunities to improve practice. The objective of this translational science study was to align common principles of approach and action and to identify how technology can assist and enhance response. To achieve this objective, the application of a modified Delphi methodology study based on statements derived from key findings of a scoping review was undertaken. This resulted in 18 triage, eight life support and damage control interventions, and 23 process consensus statements. These findings will be utilized in the development of evidence-based prehospital mass-casualty incident response tools and guidelines.Instituto de Investigación Sanitaria del Principado de Asturias (IP
Reduced Graphene Oxide Aerogels Cartridges for Solid Phase Extraction of Benzotriazoles
Get PDFUV-benzotriazoles have been identified as water micropollutants that cause serious problems
for human health and the environment. Their low concentration in water bodies complicates
their detection by direct water analysis, slowing the corrective actions to avoid bioaccumulation. In
this regard, the use of graphene-based materials with a high affinity for non-polar molecules has
been demonstrated to be a potential tool for the optimal separation and concentration of this type
of molecules in solid phase extraction (SPE) processes. This work evaluates the potential of novel
reduced graphene oxide aerogels (rGO) as extractants of mixtures of three UV-benzotriazoles in water
at low concentrations. These rGO aerogels incorporate graphenic domains into a tough structure of
polymeric chains by adding graphene oxide during the synthesis of resorcinol-formaldehyde gels.
Aerogels with a different content and ordering of graphenic domains were obtained and characterized
using Raman, XRD, SEM and nitrogen adsorption isotherms (196 ºC). The rGO aerogels that
performed better as solid phase extractants were those containing 60% rGO. Aerogels with lower
rGO contents (40%) required a high-temperature (2000 C) treatment to render competitive results.
The SPE methodology using selected rGO aerogels was optimized by varying the elution solvent,
elution time and volume. The best performances, i.e., recoveries of 80–100% and enrichment factors
of 12.5–50, were accomplished when using 0.8 mL of tetrahydrofuran (THF) as an elution solvent. As
a result, a fast (10 min) and simple extraction method of UV-benzotriazoles in water was attained,
achieving a detection limit of 1 ng /mL. Selected aerogels were finally tested for the SPE of spiked
samples of river waters, showing a similar performance to that observed with synthetic mixtures
Non-thyroidal illness syndrome and its relationship with mortality risk in critically ill children
Get PDFIntroduction: Non-thyroidal illness syndrome (NTIS) is considered to be associated with adverse outcomes in critically ill children.The hypothesis that thyroid hormones and inflammatory markers are associated with increased prediction of mortality risk scores is tested in this paper.
Methods: A prospective observational study was set up in a pediatric intensive care unit (PICU). One hundred and three patients were included. NTIS was defined as a low free triiodothyronine (FT3) value for the patient’s age. Thyroid hormones levels and inflammatory markers were determined at admission: FT3, FT4 (free
thyroxine), TSH (thyroid-stimulating hormone), rT3 (reverse triiodothyronine), CRP (C-reactive protein) and PCT (Procalcitonin). They were compared between children with a pediatric risk of mortality score PRISM-III >75th percentile (group A, n= 25) and the rest (group B, n = 78).
Results: A FT4 value lower than 16.6 pmol/L showed an area under the curve (AUC) of 0.655 (0.56–0.78, p = 0.02), with 76% sensitivity and 61.5% specificity to detect a high risk of mortality. A multiple regression analysis revealed that a FT4 lower than 16.6 pmol/L [OR: 4.92 (1.60–18.19), p = 0.009] and having NTIS
[OR: 6.04 (1.45–27.93), p = 0.016] could predict a high risk of mortality.
Conclusions: In unselected critically ill children, FT4 and FT3 values at admission could be used as a good predictor of a high mortality risk. We have not achieved a predictive model that combines hormones with inflammatory markers.Instituto de investigación Sanitaria del Principado de Asturias (ISPA
Redox Metabolism and Vascular Calcification in Chronic Kidney Disease
Get PDFAbstract: Vascular calcification (VC) is a common complication in patients with chronic kidney
disease which increases their mortality. Although oxidative stress is involved in the onset and
progression of this disorder, the specific role of some of the main redox regulators, such as catalase,
the main scavenger of H2O2, remains unclear. In the present study, epigastric arteries of kidney
transplant recipients, a rat model of VC, and an in vitro model of VC exhibiting catalase (Cts)
overexpression were analysed. Pericalcified areas of human epigastric arteries had increased levels
of catalase and cytoplasmic, rather than nuclear runt-related transcription factor 2 (RUNX2). In
the rat model, advanced aortic VC concurred with lower levels of the H2O2-scavenger glutathione
peroxidase 3 compared to controls. In an early model of calcification using vascular smooth muscle
cells (VSMCs), Cts VSMCs showed the expected increase in total levels of RUNX2. However, Cts
VMSCs also exhibited a lower percentage of the nucleus stained for RUNX2 in response to calcifying
media. In this early model of VC, we did not observe a dysregulation of the mitochondrial redox
state; instead, an increase in the general redox state was observed in the cytoplasm. These results
highlight the complex role of antioxidant enzymes as catalase by regulation of RUNX2 subcellular
location delaying the onset of VC.Instituto de Investigación Sanitaria del Principado de Asturias (ISPA
Guía de autoarchivo para depositar documentos en el RIA. ¿Cómo puedo depositar mis trabajos en el Repositorio Institucional de Asturias (RIA)? (edición 2023)
No full textDiseño y maquetación: Adela Rodríguez Somoano