2958 research outputs found
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[Informe sobre la indagación, investigación y localización de fosas de la Guerra Civil]
Get PDFInforme realizado por la Sociedad de Ciencias Aranzadi por encargo del Gobierno del Principado de Asturias sobre el servicio de indagación, investigación y localización-delimitación de víctimas de la Guerra Civil y de la dictadura franquista en fosas ubicadas en el Principado de Asturias: fosas de Bimeda, Vega de Rengos, Leitariegos, Alto del Palomo, Gúa, Molín de Xilu y El Fitu
Grazing farms differentiation through the expression of microARNs and AI algorithm
No full textMilk production based on grazing is being promoted over cattle housed indoors, because of the advantages
regarding animal welfare, milk quality and the environment. Cows’ milk is rich in miRNAs, molecules
that regulate gene expression in eukaryotes. Their profiles may vary depending on environmental factors such as farm management and feeding. We hypothesize that miRNA can be used as a certification tool for dairy farms whose milk production is based on grazing. The objective is to apply an artificial intelligence algorithm to the results of miRNA expression in milk to evaluate the possibility of designing a fast and
cheap traceability tool that can differentiate the milk produced in a grazing-based system from milk
produced in indoor systems. Cells and fat fractions were isolated from seventy-three milk tank samples from ‘No-Grazing’ (n=47) vs ‘Grazing’ (n=26) farms. MiRNA expression was analysed in the cells and
the fat fractions of the milk samples. Following miRNAs expression analysis, decision trees were built for their expression results using the C4.5 machine learning algorithm. The algorithm was not able to
correctly classify each sample in its group, nor was it able to identify relevant miRNAs. We assume that the enormous internal variability (diets, botanical composition of the pastures, and grazing duration, etc.)
in commercial grazing farms could be the cause of the difficulty in machine learning of how to classify milk from grazing farms.-L. Abou Qassim tiene una beca Severo Ochoa financiada por el Principado de Asturias (Bp17-049)
- Grupin IDI2021/000102 Cofinaciado FEDER29th General Meeting of the European Grassland Federatio
Bibliografía científica. Anexo 2021
Get PDFBibliografía que contiene la producción científica publicada por el personal investigador y colaborador del SERIDA durante el año 2021 en revistas incluidas e indizadas por la Web of Science. Esta ordenada alfabéticamente por el primer autor, e incluye un abstract en inglés del contenido del artículo referenciado, además de un índice alfabético de los autores pertenecientes al SERIDA, de los títulos de las revistas en las que aparecen publicados con indicación de su factor de impacto, así como un índice de los artículos según el área de investigación del SERIDA al que se adscriben los investigadores. El repertorio se completa con una serie de gráficos
Cepas autóctonas de Metschnikowia pulcherrima como posibles agentes de control biológico
Get PDFEn este artículo se expone la evaluación, mediante ensayos in vitro, de la capacidad de cepas de M. Pulcherrima como BCA contra los hongos Monilinia fructigena, Penicillium expansum y Botrytis cinerea.INIA; Fondo Europeo de Desarrollo Regional del Principado de Asturias (RM2006-00008,RM2009-00005 y RTA2012-00075
IL6 gene polymorphism association with calcific aortic valve stenosis and influence on serum levels of interleukin-6
Get PDFAortic valve stenosis is the most frequent valve disease in developed countries and its prevalence will increase with population aging. There is still no pharmaceutical treatment nor biomarker to determine the susceptibility to develop aortic stenosis. Therefore, we analyzed the association of polymorphisms in risk loci with calcific aortic stenosis. Patients with aortic valve disease were genotyped for PALMD rs6702619, LPA rs10455872, and IL6 rs1800795 polymorphisms and circulating levels of interleukin-6 (IL-6) were measured. Calcium content of leaflets obtained in valve replacement surgeries was determined by micro-computed tomography. In the genotyping of 578 individuals, we found significant association between PALMD and IL6 polymorphisms and aortic stenosis in patients with tricuspid aortic valve, independently of other potentially confounding variables such as age and dyslipidemia. There was no association of these polymorphisms with valve calcium content, but this value correlated with the mean aortic pressure gradient (r = 0.44; P < 0.001). The CC genotype of IL6 polymorphism was associated with higher levels of serum IL-6 compared to other genotypes (23.5 vs. 10.5 pg/ml, respectively; P = 0.029). Therefore, patients carrying the CC genotype of IL6 rs1800795 polymorphism present higher levels of circulating IL-6 and this could contribute to the severity of the aortic valve stenosis. Our results agree with the identification of IL6 as a locus risk for stenosis and also with the intervention of this cytokine in aortic valve calcification. A more exhaustive follow-up of those patients carrying risk genotypes is therefore recommended
Protocolo terapia hormonal en menopausia. Hospital Universitario Central de Asturias
Get PDFProtocolo del Servicio de Obstetricia y Ginecología el HUCA. Área Sanitaria I
Protocolo para el Manejo Ambulatorio de la Maduración Cervical con Métodos Mecánicos Previo a la Inducción.Servicio de Obstetricia.HUCA.
No full textProtocolo del Servicio de Ginecología y Obstetricia. Hospital Central de Asturias. Área I
Database on holdover time of lightning-ignited wildfires
No full textThis database contains open, harmonized, and ready-to-use global data on holdover time. Holdover time is defined as the time between lightning-induced fire ignition and fire detection. The first version of the database is composed of three data files (censored data, non-censored data, ancillary data) and three metadata files (description of database variables, list of references, reproducible examples). These data were collected through a literature review of LIW studies and some datasets were assembled by authors of the original studies, covering more than 150,000 LIW from 13 countries in five continents and a time span of a century from 1921 to 2020. Censored data are the core of the database and consist of frequency data reporting the number or relative frequency of LIW per interval of holdover time. Ancillary data provide additional information on the methods and contexts in which the data were generated in the original studies. Potential contributors to the database are encouraged to contact the corresponding author in the readme file
Chronic Treatment with Melatonin Improves Hippocampal Neurogenesis in the Aged Brain and under Neurodegeneration
Get PDFoai:ria.asturias.es:123456789/14605Adult hippocampal neurogenesis is altered during aging and under different neuropsychi atric and neurodegenerative diseases. Melatonin shows neurogenic and neuroprotective properties
during aging and neuropathological conditions. In this study, we evaluated the effects of chronic
treatment with melatonin on different markers of neurodegeneration and hippocampal neurogenesis
using immunohistochemistry in the aged and neurodegenerative brains of SAMP8 mice, which
is an animal model of accelerated senescence that mimics aging-related Alzheimer’s pathology.
Neurodegenerative processes observed in the brains of aged SAMP8 mice at 10 months of age in clude the presence of damaged neurons, disorganization in the layers of the brain cortex, alterations
in neural processes and the length of neuronal prolongations and β-amyloid accumulation in the
cortex and hippocampus. This neurodegeneration may be associated with neurogenic responses
in the hippocampal dentate gyrus of these mice, since we observed a neurogenic niche of neural
stem and progenitor/precursors cells in the hippocampus of SAMP8 mice. However, hippocampal
neurogenesis seems to be compromised due to alterations in the cell survival, migration and/or
neuronal maturation of neural precursor cells due to the neurodegeneration levels in these mice.
Chronic treatment with melatonin for 9 months decreased these neurodegenerative processes and the
neurodegeneration-induced neurogenic response. Noticeably, melatonin also induced recovery in the
functionality of adult hippocampal neurogenesis in aged SAMP8 mice
Inflammaging: Implications in Sarcopenia
Get PDFIn a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade systemic
inflammation known as “inflammaging” is linked with many age-associated diseases. Considering
sarcopenia as a loss of strength and mass of skeletal muscle related to aging, correlations between these
two terms have been proposed. Better knowledge of the immune system players in skeletal muscle
would help to elucidate their implications in sarcopenia. Characterizing the activators of damage
sensors and the downstream effectors explains the inference with skeletal muscle performance.
Sarcopenia has also been linked to chronic diseases such as diabetes, metabolic syndrome and
obesity. Implications of inflammatory signals from these diseases negatively affect skeletal muscle.
Autophagic mechanisms are closely related with the inflammasome, as autophagy eliminates stress
signaling sent by damage organelles, but also acts with an immunomodulatory function affecting
immune cells and cytokine release. The use of melatonin, an antioxidant, ROS scavenger and immune
and autophagy modulator, or senotherapeutic compounds targeting senescent cells could represent
strategies to counteract inflammation. This review aims to present the many factors regulating
skeletal muscle inflammaging and their major implications in order to understand the molecular
mechanisms involved in sarcopenia