International Journal of Integrated Health Sciences
Not a member yet
95 research outputs found
Sort by
Social Determinant Factors of Elderly as an Input in Enhancing Primary Health Care in Indonesia
Get PDFObjective: To analyze the differences of social determinant factors among elderly according to gender, in urban and rural areas in Indonesia. Indonesia is one of the most populated countries in the world, faces an increased number of elderly. This situation leads to the increase of degenerative diseases and demands of caregivers as well. The identification of social determinant factors of elderly has an important role in enhancing primary health care.Methods: A comparative study was carried out in 33 provinces in Indonesia using secondary data from Statistics Indonesia 2013. The variables included in this study were percentage of elderly according to education, marital status, occupation, income and living arrangements, divided in gender, urban and rural areas. The normally distributed data were analyzed using unpaired T test and not normally distributed data were analyzed using Mann-Whitney test. Results: This study showed that there were differences in education, occupation and income between urban and rural areas. In urban area, most of the elderly worked in industry and trade and in rural area they worked in agricultural, indicated huge risks of occupational haxards. Most of them were poor, still married, lived with spouses and family of three generations.Conclusions: It can be concluded that there were differences of social determinant factors (education, occupation and income) in elderly who live in urban and rural areas that can contribute to the risks of disease in elderly and these situations must be considered as an input to enhance the primary health care.Keywords: Elderly, gender, rural, social determinants, urba
Adherence to Antihypertensive Medication in Patients with Hypertension in Indonesia
Get PDFObjective: Adherence to medication is crucial for hypertension patients in order to control and prevent complications. This study aimed to describe the adherence to antihypertensive drugs among patients with hypertension in Bandung District, West Java, Indonesia.Methods: This was a cross-sectional observational study on patients with hypertension in the work area of Cileunyi Public Health Center (PHC), Bandung District, West Java, Indonesia. The inclusion criteria used were patients with hypertension who were prescribed an antihypertensive drug by a physician, above 18 years old, and had been using an antihypertensive medication for at least two months before the study. Data were obtained through interviews during the month of July to August 2018 using a modified MMAS-8 questionnaire of the Morisky Medication Adherence Scale (MMAS-8), which includes Likert-type scale questions. Data collected were then analyzed using the Rasch Model, and the mean logit person was used as a cut off between adherence and non-adherence categories.Results: A total of 75 patients with hypertension were recruited. The prevalence of adherence to medication was 59%. Most patients who adhered to the medication were > 55 years old (31%), female (59%), had been diagnosed with hypertension for < 5 years (31%), and received support from family/social environment (40%).Conclusion: Many factors support the adherence to antihypertensive medication, including age, gender, time of hypertension diagnosis, and support from family or social environment. The adherence to antihypertensive medication among patients with hypertension visited Cileunyi Primary Health Care, Bandung District, West Java, Indonesia is good
Antibiotic Utilization Pattern in the Intensive Care Unit of Tertiary Hospital in West Java, Indonesia
No full textObjective: To find out the pattern of antibiotic utilization in intensive care unit (ICU). The high use of antibiotics in intensive care may increase antibiotic resistance.Methods: This was a retrospective study with total sampling method from patients who were treated in ICU in the period of January to June 2016. Selected data is processed using the Anatomical Therapeutic Chemical (ATC) Classification/Defined Daily Dose (DDD) system as an international measurement standard for analyzing and comparing usage applied by the WHO.Results: The results showed that of the 57 medical records collected, the total antibiotic use was 295.72 DDD/100 bed-days. Levofloxacin, meropenem, ceftriaxone, ceftazidime, and metronidazole were the five maximally utilized antibiotics with 143.18, 49.88, 30.62, 19.74, dan 16.99 DDD/100 bed-days respectively.Conclusion: The most frequently used of antibiotics is ceftriaxone, used in 54.39% of patients. Whereas in number, the most widely used antibiotic is levofloxacin with a total of 143.18 DDD/100 bed-days
Elevated Endothelin-1 in Intradialytic Hypertension
Get PDFObjective: To determine the relative change in endothelin-1 (ET-1) during hemodialysis procedure in Stage Five Dialysis-Dependent Chronic Kidney Disease (CKD-5D)patients with and without intradialytic hypertension (IDH).Methods: This was a cross-sectional, observational study involving 40 CKD-5D patients who received two hemodialysis per week for at least three months at the dialysis unit of Dr. Hasan Sadikin Hospital General Bandung, Indonesia during September 2016. Subjects were divided two groups: with IDH (n=20) and without IDH (n=20). Plasma ET-1 level was examined before and after hemodialysis.Results: There was a significant elevation of ET-1 level (mean±SD pg/mL) between pre- and post-dialysis state in patients with IDH (3.33±1.28 vs. 3.84±1.75; relative changes: 15.32%, p=0.013). No change was observed in patients without IDH (3.99±2.30 vs. 4.38±1.81; relative changes: 9.77% p=0.083). The post-dialysis absolute ET-1 level was significantly lower in CKD-5D patients with IDH (3.84±1.75 vs. 4.38±1.81; p=0.024).Conclusion: There was a significant elevation of ET-1 level in CKD-5D patients with IDH during hemodialysis procedure at the dialysis unit of Dr. Hasan Sadikin General Hospital Bandung
Acute and Sub-chronic Toxicity Studies of Combination of Physalis angulata L. (Cecendet) Extract and Methylprednisolone on Animals
Get PDFObjective: To evaluate the safety of combination of Physalis angulata L. (Cecendet) extract and methylprednisolone through a single dose in mice (acute toxicity) and repeated doses within 90 days in rats (subchronic toxicity).Methods: Acute toxicity test was conducted to 2 groups of female mice by monitoring their behavior and death at 4 hours and 24 hours after cecendet adminstration. While subchronic toxicity test was conducted to 6 groups of rats as normal group, control group, and receive varoius cecendet dose. Each group was combined with methylprednisolone 5 mg/kg b.w. at first month and gradually taperred to 3.2 mg/kg b.w. at third month. Subchronic toxicity was evaluated by monitoring rats’ behavior, mortality, blood biochemistry, blood cell count, urinalysis, and organ macroscopic and histologic.Results: The study showed cecendet extracts did not affect mice behavior in single dose therapy up to 5 g/kg b.w. and had LD50 of more than 5 g/kg b.w., which was categorized as practically non-toxic. The sub-chronic toxicity study showed that up to 1 g/kg b.w. of cecendet extracts that was administered for 90 days did not cause death, was not organ toxic, did not affect blood biochemistries, blood cell count, and urinalysis.Conclusions: Cecendet extract and methylprednisolone combination was safe based on acute and sub-chronic toxicity data.Keywords: Acute toxicity, LD50, Lupus, Physalis angulata L, subchronic toxicity
Osteoporosis Prevention Exercise Effects to Bone Density in Children with Thalassemia
Get PDFObjective: To discover recommendation of osteoporosis prevention exercise (OPE) for children with thalassemia.Methods: This study was conducted in the period of April–June 2017 by using quasi experimental and pretest-posttest designs. Eleven thalassemia patients who were the members of a thalassemia patient foundation and an association of parents of thalassemia patients, Yayasan Thalassaemia Indonesia and Perhimpunan Orangtua Penderita Thalassemia Indonesia, were enrolled in the study as the subjects. Sample calculation was carried out by using consecutive sampling method. The subjects were given OPE intervention 2 times per week during 12 weeks with 35 minutes of each session. BMD of spinal lumbar examination was performed before and after practicing OPE. Collected data were analyzed statistically by using paired t and Wilcoxon tests with p value <0.05.Results: After the intervention, BMD value of L1, L2, and L3 segments did not improve significantly while BMD value of L4 segment and average Z-score showed significant improvement (p<0.05).Conclusions: Osteoporosis prevention exercise can improve BMD in children with thalassemia. Continuous OPE program can be recommended for children with osteoporosis-induced thalassemia.Keywords: Bone mineral density, osteoporosis, osteoporosis prevention exercise, thalassemia, Z-score DOI: 10.15850/ijihs.v6n2.134
Relationship between Gymnastics Exercise and Insomnia in Elderly
Get PDFObjectives: To analyze the relationship between gymnastics exercise and insomnia in elderly.Methods: This study involved 60 elderly as the respondents. The respondents were divided into two groups: group 1 consisting of elderly who practiced gynmastics exercise and group 2 consisting of elderly who did not practice gymnastics exercise. The members of group 1 were enrolled from 3 gymnastic groups in 3 villages in Jatinangor, West Java, Indonesia and the members of group 2 were elderly who lived in the same villages as the elderly in group 1. The inclusion criteria were elderly women who could communicate effectively and with a Mini Mental State Examination (MMSE) score of >23. Particularly for group 1, additional criteria were applied, i.e. elderly who did gynmastics exercise minimal once a month and each exercise lasted for at least one hour. Insomnia level was determined using the insomnia severity index (ISI). This study was carried out in June 2017. Homogeneity of the groups was examined using proportion difference test and data were analyzed using chi-square test and one way ANOVA.Results: Insomnia prevalence was 56.6% but insomnia prevalence in group 2 was higher (43.3%) than that of group 1 (13.3%). This study discovered that there was significant relationship between gymnastics exercise and insomnia in elderly (p=0.000). Referring to the frequency of the gymnastics exercise, significant relationship between gymnastics exercise and insomnia in elderly was also found (p=0.040). Conclusions: Gymnastics exercise is a promising nonpharmacologic therapy to treat insomnia in elderly.Keywords: Elderly, insomnia, gymnastics exercise DOI: 10.15850/ijihs.v6n1.113
Pregnancy Rate after Intrauterine Insemination with the Presence or Absence of Leukocytospermia in Sperms Prepared using Density Gradient Method
Get PDFObjective: To examine the association between different concentrations of leukocyte and sperm recovery rate after sperms are prepared using density gradient method and pregnancy rate after intrauterine insemination (IUI). Increased leukocytes in semen have been associated with increased reactive oxygen species (ROS) that reduces sperm quality.Methods: Semen samples that were collected from 31 male partners of couples undergoing infertility investigation were analyzed for sperm concentration, motility, and leucocytes concentration. Semen samples were then divided in two groups based on their leucocytes concentrations (category A: >0 to 1 x 106/mL. Semen samples were processed using density-gradient centrifugation technique. Results: There was a significant difference in the number of sperms harvested and sperm motility after preparation. Interestingly, pregnancy rate after IUI was higher (p<0.05) in non-leukocytospermia semen (39%) when compared to leukocytospermia semen (30%).Conclusions: Seminal leukocytes (PMNL) concentration affects pregnancy rate after intrauterine insemination. Keywords: Density gradient method, sperm recovery rate, intrauterine insemination, pregnancy rate DOI: 10.15850/ijihs.v6n2.131
Cervical Stump Fibroidpost Supra-cervical Hysterectomy
Get PDFObjective: To describe of a rare case of cervical stump fibroid presenting as a late complication of supra-cervical hysterectomy.Methods: A 68-year old-female with a history of lower abdominal pain and distention for six months with increasing intensity was referred from a local clinic to the department of radio-diagnosis for evaluation. She had a history of subtotal hysterectomy previously. On ultrasonography and computerized tomography imaging studies, a large adnexal lesion was noted suggesting the possibility of a cervical stump leiomyoma. The patient underwent an elective surgery and the diagnosis was confirmed in the context of histological findings.Results: Patient was operated for the radiologically diagnosed large cervical stump leiomyoma which was laterhistologically confirmed with an uneventful recovery.Conclusions: Imaging investigations like computerized tomography and magnetic resonance imaging are valuable in the diagnosis of rare adnexal masses from cervical stump arising as late delayed complications of supra-cervical hysterectomy. Keywords: Cervical stump leiomyoma, computerized tomography, magnetic resonance imaging, supra-cervical hysterectomy DOI: 10.15850/ijihs.v6n2.125
Ethanol Extract of Stylissa carteri Induces Cell Death in Parental and Paclitaxel-Resistant Cervical Cancer Cells
Get PDFObjective: To evaluate the cytotoxic effects of ethanol extract from marine sponge Stylissa carteri in both parental and paclitaxel-resistant HeLa cervical cancer cells. Methods: This was an experimental in-vitro study subjected ethanol extract from Stylissa carteri obtained from Pramuka Island, Kepulauan Seribu National Park, Jakarta. Both parental and paclitaxel-resistant HeLa cells were treated with ethanol extract followed by microscopic observation and MTT assay. The IC50 and drug curves were analyzed using four-parametric logistic regression by SigmaPlot for Windows version 12.0 from Systat Software Inc., USA.Results: Ethanol extract from Stylissa carteri triggered cell death-associated morphological changes in parental Hela cells. It demonstrated cytotoxic activities with an IC50 value of 1 ppm. Importantly, this extract also triggered cell death in paclitaxel-resistant HeLa cells. The IC50 of ethanol extract of Stylissa carteri was 4 ppm in paclitaxel-resistant HeLa cells.Conclusions: There is a potential cytotoxic activity of Stylissa carteri that is not only confirmed in parental HeLa cells but also in paclitaxel-resistant HeLa cells.Keywords: Cervical cancer, paclitaxel resistance, HeLa cells, cytotoxicity assay, Stylissa carteri DOI: 10.15850/ijihs.v6n2.137